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Items: 1 to 50 of 1042

1.

The potential of metabolic profiling for vaccine development.

Weiner J 3rd, Mohney RP, Kaufmann SHE.

Semin Immunol. 2018 Jul 19. pii: S1044-5323(18)30027-7. doi: 10.1016/j.smim.2018.07.002. [Epub ahead of print] Review.

PMID:
30033150
2.

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.

Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, Sakwa I, Stervbo U, Ries S, Jouneau L, Boudinot P, Tsubata T, Adachi T, Hutloff A, Dörner T, Zimber-Strobl U, de Vos AF, Dahlke K, Loh G, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S.

Immunity. 2018 Jul 17;49(1):120-133.e9. doi: 10.1016/j.immuni.2018.06.007. Epub 2018 Jul 10.

3.

Mycobacterium tuberculosis Invasion of the Human Lung: First Contact.

Maertzdorf J, Tönnies M, Lozza L, Schommer-Leitner S, Mollenkopf H, Bauer TT, Kaufmann SHE.

Front Immunol. 2018 Jun 12;9:1346. doi: 10.3389/fimmu.2018.01346. eCollection 2018.

4.

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts.

Duffy FJ, Thompson E, Downing K, Suliman S, Mayanja-Kizza H, Boom WH, Thiel B, Weiner Iii J, Kaufmann SHE, Dover D, Tabb DL, Dockrell HM, Ottenhoff THM, Tromp G, Scriba TJ, Zak DE, Walzl G; GC6-74 Consortium.

Front Immunol. 2018 Apr 13;9:661. doi: 10.3389/fimmu.2018.00661. eCollection 2018.

5.

Indole Propionic Acid: a Small Molecule Links between Gut Microbiota and Tuberculosis.

Kaufmann SHE.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e00389-18. doi: 10.1128/AAC.00389-18. Print 2018 May. No abstract available.

PMID:
29700005
6.

Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis.

Suliman S, Thompson E, Sutherland J, Weiner Rd J, Ota MOC, Shankar S, Penn-Nicholson A, Thiel B, Erasmus M, Maertzdorf J, Duffy FJ, Hill PC, Hughes EJ, Stanley K, Downing K, Fisher ML, Valvo J, Parida SK, van der Spuy G, Tromp G, Adetifa IMO, Donkor S, Howe R, Mayanja-Kizza H, Boom WH, Dockrell H, Ottenhoff THM, Hatherill M, Aderem A, Hanekom WA, Scriba TJ, Kaufmann SH, Zak DE, Walzl G; and the GC6-74 and ACS cohort study groups.

Am J Respir Crit Care Med. 2018 Apr 6. doi: 10.1164/rccm.201711-2340OC. [Epub ahead of print]

PMID:
29624071
7.

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression.

Ho MF, Correia C, Ingle JN, Kaddurah-Daouk R, Wang L, Kaufmann SH, Weinshilboum RM.

Biochem Pharmacol. 2018 Jun;152:279-292. doi: 10.1016/j.bcp.2018.03.032. Epub 2018 Apr 3.

PMID:
29621538
8.

Progress and challenges in TB vaccine development.

Voss G, Casimiro D, Neyrolles O, Williams A, Kaufmann SHE, McShane H, Hatherill M, Fletcher HA.

F1000Res. 2018 Feb 16;7:199. doi: 10.12688/f1000research.13588.1. eCollection 2018. Review.

9.

Correction: Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

McDonald JS, McDonald RJ, Ekins JB, Tin AS, Costes S, Hudson TM, Schroeder DJ, Kallmes K, Kaufmann SH, Young PM, Lu A, Kadirvel R, Kallmes DF.

PLoS One. 2018 Feb 23;13(2):e0193634. doi: 10.1371/journal.pone.0193634. eCollection 2018.

10.

Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice.

Reece ST, Vogelzang A, Tornack J, Bauer W, Zedler U, Schommer-Leitner S, Stingl G, Melchers F, Kaufmann SHE.

J Infect Dis. 2018 Apr 23;217(10):1667-1671. doi: 10.1093/infdis/jiy041.

11.

Editorial: Reassessing Twenty Years of Vaccine Development against Tuberculosis.

Schaible UE, Kaufmann SHE.

Front Immunol. 2018 Feb 7;9:180. doi: 10.3389/fimmu.2018.00180. eCollection 2018. No abstract available.

12.

Next-Generation Vaccines Based on Bacille Calmette-Guérin.

Nieuwenhuizen NE, Kaufmann SHE.

Front Immunol. 2018 Feb 5;9:121. doi: 10.3389/fimmu.2018.00121. eCollection 2018. Review.

13.

Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

Chegou NN, Sutherland JS, Namuganga AR, Corstjens PL, Geluk A, Gebremichael G, Mendy J, Malherbe S, Stanley K, van der Spuy GD, Kriel M, Loxton AG, Kriel B, Simukonda F, Bekele Y, Sheehama JA, Nelongo J, van der Vyver M, Gebrexabher A, Hailu H, Esterhuyse MM, Rosenkrands I, Aagard C, Kidd M, Kassa D, Mihret A, Howe R, Cliff JM, Crampin AC, Mayanja-Kizza H, Kaufmann SHE, Dockrell HM, Ottenhoff THM, Walzl G; AE-TBC consortium.

Sci Rep. 2018 Feb 8;8(1):2675. doi: 10.1038/s41598-018-20855-7.

14.

Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma.

Kabashima A, Hirsova P, Bronk SF, Hernandez MC, Truty MJ, Rizvi S, Kaufmann SH, Gores GJ.

J Hepatol. 2018 Jun;68(6):1228-1238. doi: 10.1016/j.jhep.2018.01.026. Epub 2018 Mar 9.

PMID:
29408314
15.

IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.

Ahsan F, Maertzdorf J, Guhlich-Bornhof U, Kaufmann SHE, Moura-Alves P.

Sci Rep. 2018 Jan 24;8(1):1520. doi: 10.1038/s41598-018-19476-x.

16.

Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model.

Platteel ACM, Nieuwenhuizen NE, Domaszewska T, Schürer S, Zedler U, Brinkmann V, Sijts AJAM, Kaufmann SHE.

Front Immunol. 2017 Dec 11;8:1744. doi: 10.3389/fimmu.2017.01744. eCollection 2017.

17.

Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

McDonald JS, McDonald RJ, Ekins JB, Tin AS, Costes S, Hudson TM, Schroeder DJ, Kallmes K, Kaufmann SH, Young PM, Lu A, Kadirvel R, Kallmes DF.

PLoS One. 2018 Jan 8;13(1):e0190890. doi: 10.1371/journal.pone.0190890. eCollection 2018. Erratum in: PLoS One. 2018 Feb 23;13(2):e0193634.

18.

The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.

Pei G, Buijze H, Liu H, Moura-Alves P, Goosmann C, Brinkmann V, Kawabe H, Dorhoi A, Kaufmann SHE.

Autophagy. 2017;13(12):2041-2055. doi: 10.1080/15548627.2017.1376160. Epub 2017 Dec 17.

19.

Hemostasis and Lipoprotein Indices Signify Exacerbated Lung Injury in TB With Diabetes Comorbidity.

Dong Z, Shi J, Dorhoi A, Zhang J, Soodeen-Lalloo AK, Tan W, Yin H, Sha W, Li W, Zheng R, Liu Z, Yang H, Qin L, Wang J, Huang X, Wu C, Kaufmann SHE, Feng Y.

Chest. 2018 May;153(5):1187-1200. doi: 10.1016/j.chest.2017.11.029. Epub 2017 Dec 7.

PMID:
29224833
20.

Histone deacetylase inhibitors reduce differentiating osteoblast-mediated protection of acute myeloid leukemia cells from cytarabine.

Sterner RM, Kremer KN, Al-Kali A, Patnaik MM, Gangat N, Litzow MR, Kaufmann SH, Westendorf JJ, van Wijnen AJ, Hedin KE.

Oncotarget. 2017 Oct 10;8(55):94569-94579. doi: 10.18632/oncotarget.21809. eCollection 2017 Nov 7.

21.

Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination.

Haks MC, Bottazzi B, Cecchinato V, De Gregorio C, Del Giudice G, Kaufmann SHE, Lanzavecchia A, Lewis DJM, Maertzdorf J, Mantovani A, Sallusto F, Sironi M, Uguccioni M, Ottenhoff THM.

Front Immunol. 2017 Nov 15;8:1563. doi: 10.3389/fimmu.2017.01563. eCollection 2017. Review.

22.

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.

Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SHE, Anton-Leberre V, O'Garra A, Sasiain MDC, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):801-813. doi: 10.1164/rccm.201707-1475OC.

PMID:
29161093
23.

A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors.

Wahner Hendrickson AE, Menefee ME, Hartmann LC, Long HJ, Northfelt DW, Reid JM, Boakye-Agyeman F, Kayode O, Flatten KS, Harrell MI, Swisher EM, Poirer GG, Satele D, Allred J, Lensing JL, Chen A, Ji J, Zang Y, Erlichman C, Haluska P, Kaufmann SH.

Clin Cancer Res. 2018 Feb 15;24(4):744-752. doi: 10.1158/1078-0432.CCR-17-1590. Epub 2017 Nov 14.

PMID:
29138343
24.

Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals.

Herzmann C, Ernst M, Lange C, Stenger S, Kaufmann SHE, Reiling N, Schaberg T, van der Merwe L, Maertzdorf J; Tb or not Tb consortium.

PLoS One. 2017 Nov 10;12(11):e0187882. doi: 10.1371/journal.pone.0187882. eCollection 2017.

25.

Doubling Down on BRCA-Mutated Cancer.

Wahner Hendrickson AE, Kaufmann SH, Swisher EM.

Trends Cancer. 2017 Nov;3(11):743-744. doi: 10.1016/j.trecan.2017.09.005. Epub 2017 Sep 29. Review.

PMID:
29120748
26.

Measurement of BH3-only protein tolerance.

Dai H, Ding H, Peterson KL, Meng XW, Schneider PA, Knorr KLB, Kaufmann SH.

Cell Death Differ. 2018 Feb;25(2):282-293. doi: 10.1038/cdd.2017.156. Epub 2017 Oct 20.

PMID:
29053140
27.

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.

Kaufmann SHE, Dockrell HM, Drager N, Ho MM, McShane H, Neyrolles O, Ottenhoff THM, Patel B, Roordink D, Spertini F, Stenger S, Thole J, Verreck FAW, Williams A; TBVAC2020 Consortium.

Front Immunol. 2017 Oct 4;8:1203. doi: 10.3389/fimmu.2017.01203. eCollection 2017. Review.

28.

Mycobacterium tuberculosis infection modulates adipose tissue biology.

Beigier-Bompadre M, Montagna GN, Kühl AA, Lozza L, Weiner J 3rd, Kupz A, Vogelzang A, Mollenkopf HJ, Löwe D, Bandermann S, Dorhoi A, Brinkmann V, Matuschewski K, Kaufmann SHE.

PLoS Pathog. 2017 Oct 17;13(10):e1006676. doi: 10.1371/journal.ppat.1006676. eCollection 2017 Oct.

29.

The SysteMHC Atlas project.

Shao W, Pedrioli PGA, Wolski W, Scurtescu C, Schmid E, Vizcaíno JA, Courcelles M, Schuster H, Kowalewski D, Marino F, Arlehamn CSL, Vaughan K, Peters B, Sette A, Ottenhoff THM, Meijgaarden KE, Nieuwenhuizen N, Kaufmann SHE, Schlapbach R, Castle JC, Nesvizhskii AI, Nielsen M, Deutsch EW, Campbell DS, Moritz RL, Zubarev RA, Ytterberg AJ, Purcell AW, Marcilla M, Paradela A, Wang Q, Costello CE, Ternette N, van Veelen PA, van Els CACM, Heck AJR, de Souza GA, Sollid LM, Admon A, Stevanovic S, Rammensee HG, Thibault P, Perreault C, Bassani-Sternberg M, Aebersold R, Caron E.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1237-D1247. doi: 10.1093/nar/gkx664.

30.

The Recombinant Bacille Calmette-Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing.

Nieuwenhuizen NE, Kulkarni PS, Shaligram U, Cotton MF, Rentsch CA, Eisele B, Grode L, Kaufmann SHE.

Front Immunol. 2017 Sep 19;8:1147. doi: 10.3389/fimmu.2017.01147. eCollection 2017. Review.

31.

Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia.

Webster JA, Tibes R, Morris L, Blackford AL, Litzow M, Patnaik M, Rosner GL, Gojo I, Kinders R, Wang L, Doyle LA, Huntoon CJ, Karnitz LM, Kaufmann SH, Karp JE, Smith BD.

Leuk Res. 2017 Oct;61:108-116. doi: 10.1016/j.leukres.2017.09.005. Epub 2017 Sep 20.

PMID:
28957699
32.

Host-directed therapies for bacterial and viral infections.

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R.

Nat Rev Drug Discov. 2018 Jan;17(1):35-56. doi: 10.1038/nrd.2017.162. Epub 2017 Sep 22. Review.

PMID:
28935918
33.

Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis.

Domaszewska T, Scheuermann L, Hahnke K, Mollenkopf H, Dorhoi A, Kaufmann SHE, Weiner J Rd.

Sci Rep. 2017 Sep 21;7(1):12094. doi: 10.1038/s41598-017-11812-x.

34.

Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection.

Zimmermann M, Kogadeeva M, Gengenbacher M, McEwen G, Mollenkopf HJ, Zamboni N, Kaufmann SHE, Sauer U.

mSystems. 2017 Aug 22;2(4). pii: e00057-17. doi: 10.1128/mSystems.00057-17. eCollection 2017 Jul-Aug.

35.

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans.

Gengenbacher M, Duque-Correa MA, Kaiser P, Schuerer S, Lazar D, Zedler U, Reece ST, Nayyar A, Cole ST, Makarov V, Barry CE III, Dartois V, Kaufmann SHE.

Sci Rep. 2017 Aug 18;7(1):8853. doi: 10.1038/s41598-017-09177-2.

36.

Accelerating tuberculosis vaccine trials with diagnostic and prognostic biomarkers.

Kaufmann SHE, Weiner J Rd, Maertzdorf J.

Expert Rev Vaccines. 2017 Aug;16(8):845-853. doi: 10.1080/14760584.2017.1341316. Epub 2017 Jun 19. Review.

PMID:
28608729
37.

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.

Kondrashova O, Nguyen M, Shield-Artin K, Tinker AV, Teng NNH, Harrell MI, Kuiper MJ, Ho GY, Barker H, Jasin M, Prakash R, Kass EM, Sullivan MR, Brunette GJ, Bernstein KA, Coleman RL, Floquet A, Friedlander M, Kichenadasse G, O'Malley DM, Oza A, Sun J, Robillard L, Maloney L, Bowtell D, Giordano H, Wakefield MJ, Kaufmann SH, Simmons AD, Harding TC, Raponi M, McNeish IA, Swisher EM, Lin KK, Scott CL; AOCS Study Group.

Cancer Discov. 2017 Sep;7(9):984-998. doi: 10.1158/2159-8290.CD-17-0419. Epub 2017 Jun 6.

38.

Emil von Behring: translational medicine at the dawn of immunology.

Kaufmann SHE.

Nat Rev Immunol. 2017 Jun;17(6):341-343. doi: 10.1038/nri.2017.37. Epub 2017 Apr 10.

PMID:
28393925
39.

Assessment of Drug Sensitivity in Hematopoietic Stem and Progenitor Cells from Acute Myelogenous Leukemia and Myelodysplastic Syndrome Ex Vivo.

Knorr KL, Finn LE, Smith BD, Hess AD, Foran JM, Karp JE, Kaufmann SH.

Stem Cells Transl Med. 2017 Mar;6(3):840-850. doi: 10.5966/sctm.2016-0034. Epub 2016 Nov 7.

40.

Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical Outcomes.

Wang C, Armasu SM, Kalli KR, Maurer MJ, Heinzen EP, Keeney GL, Cliby WA, Oberg AL, Kaufmann SH, Goode EL.

Clin Cancer Res. 2017 Aug 1;23(15):4077-4085. doi: 10.1158/1078-0432.CCR-17-0246. Epub 2017 Mar 9.

41.

Remembering Emil von Behring: from Tetanus Treatment to Antibody Cooperation with Phagocytes.

Kaufmann SH.

MBio. 2017 Feb 28;8(1). pii: e00117-17. doi: 10.1128/mBio.00117-17.

42.

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.

Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, Kojima Y, Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ.

Nucleic Acids Res. 2017 May 5;45(8):4564-4576. doi: 10.1093/nar/gkx107.

43.

Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.

Tornack J, Reece ST, Bauer WM, Vogelzang A, Bandermann S, Zedler U, Stingl G, Kaufmann SH, Melchers F.

PLoS One. 2017 Jan 3;12(1):e0169119. doi: 10.1371/journal.pone.0169119. eCollection 2017.

44.

Mitochondrial apoptosis and BH3 mimetics.

Dai H, Meng XW, Kaufmann SH.

F1000Res. 2016 Dec 1;5:2804. doi: 10.12688/f1000research.9629.1. eCollection 2016. Review.

45.

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa.

Loxton AG, Knaul JK, Grode L, Gutschmidt A, Meller C, Eisele B, Johnstone H, van der Spuy G, Maertzdorf J, Kaufmann SH, Hesseling AC, Walzl G, Cotton MF; VPM Study Group.

Clin Vaccine Immunol. 2017 Feb 6;24(2). pii: e00439-16. doi: 10.1128/CVI.00439-16. Print 2017 Feb.

46.

Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants.

Olafsdottir TA, Lindqvist M, Nookaew I, Andersen P, Maertzdorf J, Persson J, Christensen D, Zhang Y, Anderson J, Khoomrung S, Sen P, Agger EM, Coler R, Carter D, Meinke A, Rappuoli R, Kaufmann SH, Reed SG, Harandi AM.

Sci Rep. 2016 Dec 13;6:39097. doi: 10.1038/srep39097.

47.

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, Sun J, Konecny GE, Coleman RL, Tinker AV, O'Malley DM, Kristeleit RS, Ma L, Bell-McGuinn KM, Brenton JD, Cragun JM, Oaknin A, Ray-Coquard I, Harrell MI, Mann E, Kaufmann SH, Floquet A, Leary A, Harding TC, Goble S, Maloney L, Isaacson J, Allen AR, Rolfe L, Yelensky R, Raponi M, McNeish IA.

Lancet Oncol. 2017 Jan;18(1):75-87. doi: 10.1016/S1470-2045(16)30559-9. Epub 2016 Nov 29.

48.

Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells.

Ding H, Peterson KL, Correia C, Koh B, Schneider PA, Nowakowski GS, Kaufmann SH.

Leukemia. 2017 Jul;31(7):1593-1602. doi: 10.1038/leu.2016.357. Epub 2016 Nov 28.

49.

Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis.

Perdomo C, Zedler U, Kühl AA, Lozza L, Saikali P, Sander LE, Vogelzang A, Kaufmann SH, Kupz A.

MBio. 2016 Nov 22;7(6). pii: e01686-16. doi: 10.1128/mBio.01686-16.

50.

High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers.

Weiner J, Kaufmann SH.

Int J Infect Dis. 2017 Mar;56:258-262. doi: 10.1016/j.ijid.2016.10.017. Epub 2016 Nov 9. Review.

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