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Items: 1 to 50 of 466

1.

Biosynthesis, structure, and folding of the insulin precursor protein.

Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P.

Diabetes Obes Metab. 2018 Sep;20 Suppl 2:28-50. doi: 10.1111/dom.13378. Review.

PMID:
30230185
2.

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.

Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M.

Cell. 2018 Sep 20;175(1):133-145.e15. doi: 10.1016/j.cell.2018.08.020. Epub 2018 Sep 13.

PMID:
30220454
3.

IRE1α nucleotide sequence cleavage specificity in the unfolded protein response.

Poothong J, Sopha P, Kaufman RJ, Tirasophon W.

FEBS Lett. 2018 Aug;592(15):2669. doi: 10.1002/1873-3468.13195. Epub 2018 Jul 25. No abstract available.

PMID:
30168599
4.

IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.

Wang JM, Qiu Y, Yang Z, Kim H, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yang L, Zhang K.

Sci Signal. 2018 May 15;11(530). pii: eaao4617. doi: 10.1126/scisignal.aao4617.

PMID:
29764990
5.

High-content screen for modifiers of Niemann-Pick type C disease in patient cells.

Pugach EK, Feltes M, Kaufman RJ, Ory DS, Bang AG.

Hum Mol Genet. 2018 Jun 15;27(12):2101-2112. doi: 10.1093/hmg/ddy117.

PMID:
29659804
6.

HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency.

Zhang S, Macias-Garcia A, Velazquez J, Paltrinieri E, Kaufman RJ, Chen JJ.

Blood. 2018 Jan 25;131(4):450-461. doi: 10.1182/blood-2017-08-799908. Epub 2017 Nov 3.

PMID:
29101239
7.

Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response.

Chandrahas VK, Han J, Kaufman RJ.

Curr Top Microbiol Immunol. 2018;414:103-130. doi: 10.1007/82_2017_41. Review.

PMID:
28900680
8.

Physiological/pathological ramifications of transcription factors in the unfolded protein response.

Han J, Kaufman RJ.

Genes Dev. 2017 Jul 15;31(14):1417-1438. doi: 10.1101/gad.297374.117. Review.

9.

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.

Choi WG, Han J, Kim JH, Kim MJ, Park JW, Song B, Cha HJ, Choi HS, Chung HT, Lee IK, Park TS, Hatzoglou M, Choi HS, Yoo HJ, Kaufman RJ, Back SH.

Nutr Metab (Lond). 2017 Aug 1;14:48. doi: 10.1186/s12986-017-0202-6. eCollection 2017.

10.

ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis.

DeZwaan-McCabe D, Sheldon RD, Gorecki MC, Guo DF, Gansemer ER, Kaufman RJ, Rahmouni K, Gillum MP, Taylor EB, Teesch LM, Rutkowski DT.

Cell Rep. 2017 May 30;19(9):1794-1806. doi: 10.1016/j.celrep.2017.05.020.

11.

Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response.

Poothong J, Tirasophon W, Kaufman RJ.

Biosci Rep. 2017 Mar 2;37(2). pii: BSR20160574. doi: 10.1042/BSR20160574. Print 2017 Apr 30.

12.

Achromatopsia mutations target sequential steps of ATF6 activation.

Chiang WC, Chan P, Wissinger B, Vincent A, Skorczyk-Werner A, Krawczyński MR, Kaufman RJ, Tsang SH, Héon E, Kohl S, Lin JH.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):400-405. doi: 10.1073/pnas.1606387114. Epub 2016 Dec 27.

13.

Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia.

Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J, Liu T, Williams KW.

Diabetes. 2017 Mar;66(3):663-673. doi: 10.2337/db16-0533. Epub 2016 Dec 27.

14.

IRE1α nucleotide sequence cleavage specificity in the unfolded protein response.

Poothong J, Sopha P, Kaufman RJ, Tirasophon W.

FEBS Lett. 2017 Jan;591(2):406-414. doi: 10.1002/1873-3468.12546. Epub 2017 Jan 17. Erratum in: FEBS Lett. 2018 Aug;592(15):2669.

15.

eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.

Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjević K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M.

Elife. 2016 Dec 13;5. pii: e17517. doi: 10.7554/eLife.17517.

16.

ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.

Jin JK, Blackwood EA, Azizi K, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC.

Circ Res. 2017 Mar 3;120(5):862-875. doi: 10.1161/CIRCRESAHA.116.310266. Epub 2016 Dec 8.

17.

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, Bourdel G, Popovic N, Rezende FA, Kaufman RJ, Mallette FA, Sapieha P.

Sci Transl Med. 2016 Oct 26;8(362):362ra144.

PMID:
27797960
18.

Selective Assembly of Na,K-ATPase α2β2 Heterodimers in the Heart: DISTINCT FUNCTIONAL PROPERTIES AND ISOFORM-SELECTIVE INHIBITORS.

Habeck M, Tokhtaeva E, Nadav Y, Ben Zeev E, Ferris SP, Kaufman RJ, Bab-Dinitz E, Kaplan JH, Dada LA, Farfel Z, Tal DM, Katz A, Sachs G, Vagin O, Karlish SJ.

J Biol Chem. 2016 Oct 28;291(44):23159-23174. Epub 2016 Sep 13.

19.

Read-Split-Run: an improved bioinformatics pipeline for identification of genome-wide non-canonical spliced regions using RNA-Seq data.

Bai Y, Kinne J, Donham B, Jiang F, Ding L, Hassler JR, Kaufman RJ.

BMC Genomics. 2016 Aug 22;17 Suppl 7:503. doi: 10.1186/s12864-016-2896-7.

20.

The unfolded protein response in immunity and inflammation.

Grootjans J, Kaser A, Kaufman RJ, Blumberg RS.

Nat Rev Immunol. 2016 Aug;16(8):469-84. doi: 10.1038/nri.2016.62. Epub 2016 Jun 27. Review.

21.

Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.

Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH 3rd, Ferguson TA, Chen DF, Kaufman RJ, Hu Y.

J Neurosci. 2016 May 25;36(21):5891-903. doi: 10.1523/JNEUROSCI.3709-15.2016.

22.

The role of ER stress in lipid metabolism and lipotoxicity.

Han J, Kaufman RJ.

J Lipid Res. 2016 Aug;57(8):1329-38. doi: 10.1194/jlr.R067595. Epub 2016 May 4. Review.

23.

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.

Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B.

Nature. 2016 Mar 24;531(7595):523-527. doi: 10.1038/nature17186. Epub 2016 Mar 16.

24.

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink DM, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C.

Brain Res. 2016 Oct 1;1648(Pt B):603-616. doi: 10.1016/j.brainres.2016.02.033. Epub 2016 Mar 2. Review.

25.

Protein misfolding in the endoplasmic reticulum as a conduit to human disease.

Wang M, Kaufman RJ.

Nature. 2016 Jan 21;529(7586):326-35. doi: 10.1038/nature17041. Review.

PMID:
26791723
26.

When Less Is Better: ER Stress and Beta Cell Proliferation.

Yong J, Itkin-Ansari P, Kaufman RJ.

Dev Cell. 2016 Jan 11;36(1):4-6. doi: 10.1016/j.devcel.2015.12.030.

27.

Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.

Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, Tamayo-Castillo G, Sherman DH, Kaufman RJ, Fribley AM.

ACS Med Chem Lett. 2015 Sep 8;6(11):1122-7. doi: 10.1021/acsmedchemlett.5b00133. eCollection 2015 Nov 12.

28.

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.

Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR III, Itkin-Ansari P, Volkmann N, Kaufman RJ.

PLoS Biol. 2015 Oct 15;13(10):e1002277. doi: 10.1371/journal.pbio.1002277. eCollection 2015 Oct.

29.

Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts.

Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH.

ACS Med Chem Lett. 2015 Jul 6;6(8):877-81. doi: 10.1021/acsmedchemlett.5b00127. eCollection 2015 Aug 13.

30.

eIF2α Confers Cellular Tolerance to S. aureus α-Toxin.

von Hoven G, Neukirch C, Meyenburg M, Füser S, Petrivna MB, Rivas AJ, Ryazanov A, Kaufman RJ, Aroian RV, Husmann M.

Front Immunol. 2015 Jul 27;6:383. doi: 10.3389/fimmu.2015.00383. eCollection 2015.

31.

Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.

D'Osualdo A, Anania VG, Yu K, Lill JR, Kaufman RJ, Matsuzawa S, Reed JC.

PLoS One. 2015 Jun 18;10(6):e0130635. doi: 10.1371/journal.pone.0130635. eCollection 2015.

32.

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.

Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH.

Nat Genet. 2015 Jul;47(7):757-65. doi: 10.1038/ng.3319. Epub 2015 Jun 1.

33.

C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions.

Zhou AX, Wang X, Lin CS, Han J, Yong J, Nadolski MJ, Borén J, Kaufman RJ, Tabas I.

Circ Res. 2015 May 22;116(11):1736-43. doi: 10.1161/CIRCRESAHA.116.305602. Epub 2015 Apr 14.

34.

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis.

Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, Katze MG, Kaufman RJ.

Diabetes. 2015 Aug;64(8):2892-904. doi: 10.2337/db14-1357. Epub 2015 Mar 20.

35.

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.

Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, Callaghan MU, Golden JE, Fribley AM, Kaufman RJ.

ACS Med Chem Lett. 2014 Oct 29;5(12):1278-1283. eCollection 2014 Dec 11.

36.

Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100.

Wang S, Park S, Kodali VK, Han J, Yip T, Chen Z, Davidson NO, Kaufman RJ.

Mol Biol Cell. 2015 Feb 15;26(4):594-604. doi: 10.1091/mbc.E14-08-1274. Epub 2014 Dec 17.

37.

Cantharidins induce ER stress and a terminal unfolded protein response in OSCC.

Xi Y, Garshott DM, Brownell AL, Yoo GH, Lin HS, Freeburg TL, Yoo NG, Kaufman RJ, Callaghan MU, Fribley AM.

J Dent Res. 2015 Feb;94(2):320-9. doi: 10.1177/0022034514559376. Epub 2014 Nov 25.

38.

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL.

EMBO J. 2015 Jan 2;34(1):4-19. doi: 10.15252/embj.201488896. Epub 2014 Oct 31.

39.

Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic β-cell Dysfunction.

Javeed N, Sagar G, Dutta SK, Smyrk TC, Lau JS, Bhattacharya S, Truty M, Petersen GM, Kaufman RJ, Chari ST, Mukhopadhyay D.

Clin Cancer Res. 2015 Apr 1;21(7):1722-33. doi: 10.1158/1078-0432.CCR-14-2022. Epub 2014 Oct 29. Erratum in: Clin Cancer Res. 2015 Oct 1;21(19):4495.

40.

The impact of the endoplasmic reticulum protein-folding environment on cancer development.

Wang M, Kaufman RJ.

Nat Rev Cancer. 2014 Sep;14(9):581-97. doi: 10.1038/nrc3800. Review.

PMID:
25145482
41.

Celastrol induces unfolded protein response-dependent cell death in head and neck cancer.

Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ.

Exp Cell Res. 2015 Jan 15;330(2):412-22. doi: 10.1016/j.yexcr.2014.08.014. Epub 2014 Aug 17.

42.

ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.

Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M.

Cancer Cell. 2014 Sep 8;26(3):331-343. doi: 10.1016/j.ccr.2014.07.001. Epub 2014 Aug 14.

43.

Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling.

Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, Péterfy M.

J Biol Chem. 2014 Aug 29;289(35):24417-27. doi: 10.1074/jbc.M114.588764. Epub 2014 Jul 17.

44.

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R.

PLoS One. 2014 Jul 3;9(7):e101643. doi: 10.1371/journal.pone.0101643. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110914.

45.

Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-Seq data.

Bai Y, Hassler J, Ziyar A, Li P, Wright Z, Menon R, Omenn GS, Cavalcoli JD, Kaufman RJ, Sartor MA.

PLoS One. 2014 Jul 3;9(7):e100864. doi: 10.1371/journal.pone.0100864. eCollection 2014.

46.

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.

Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjević K, Kaufman RJ, Walter P, Costa-Mattioli M.

Nat Neurosci. 2014 Aug;17(8):1073-82. doi: 10.1038/nn.3754. Epub 2014 Jun 29.

47.

Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.

Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M.

Sci Signal. 2014 Jun 10;7(329):ra54. doi: 10.1126/scisignal.2004983.

48.

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA.

PLoS Genet. 2014 May 8;10(5):e1004348. doi: 10.1371/journal.pgen.1004348. eCollection 2014 May.

49.

Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease.

Cao SS, Kaufman RJ.

Antioxid Redox Signal. 2014 Jul 20;21(3):396-413. doi: 10.1089/ars.2014.5851. Epub 2014 Jun 12. Review.

50.

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics.

Kaufman RJ, Malhotra JD.

Biochim Biophys Acta. 2014 Oct;1843(10):2233-9. doi: 10.1016/j.bbamcr.2014.03.022. Epub 2014 Mar 30. Review.

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