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Items: 25

1.

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors.

Harney AS, Karagiannis GS, Pignatelli J, Smith BD, Kadioglu E, Wise SC, Hood MM, Kaufman MD, Leary CB, Lu WP, Al-Ani G, Chen X, Entenberg D, Oktay MH, Wang Y, Chun L, De Palma M, Jones JG, Flynn DL, Condeelis JS.

Mol Cancer Ther. 2017 Nov;16(11):2486-2501. doi: 10.1158/1535-7163.MCT-17-0241. Epub 2017 Aug 24.

PMID:
28838996
2.

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.

Peng SB, Henry JR, Kaufman MD, Lu WP, Smith BD, Vogeti S, Rutkoski TJ, Wise S, Chun L, Zhang Y, Van Horn RD, Yin T, Zhang X, Yadav V, Chen SH, Gong X, Ma X, Webster Y, Buchanan S, Mochalkin I, Huber L, Kays L, Donoho GP, Walgren J, McCann D, Patel P, Conti I, Plowman GD, Starling JJ, Flynn DL.

Cancer Cell. 2015 Sep 14;28(3):384-98. doi: 10.1016/j.ccell.2015.08.002. Epub 2015 Sep 3.

3.

Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.

Smith BD, Kaufman MD, Leary CB, Turner BA, Wise SC, Ahn YM, Booth RJ, Caldwell TM, Ensinger CL, Hood MM, Lu WP, Patt TW, Patt WC, Rutkoski TJ, Samarakoon T, Telikepalli H, Vogeti L, Vogeti S, Yates KM, Chun L, Stewart LJ, Clare M, Flynn DL.

Mol Cancer Ther. 2015 Sep;14(9):2023-34. doi: 10.1158/1535-7163.MCT-14-1105. Epub 2015 Aug 18.

4.

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL.

J Med Chem. 2015 May 28;58(10):4165-79. doi: 10.1021/acs.jmedchem.5b00067. Epub 2015 May 12.

PMID:
25965804
5.

Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment.

Kwon Y, Smith BD, Zhou Y, Kaufman MD, Godwin AK.

Oncogene. 2015 Jan 8;34(2):144-53. doi: 10.1038/onc.2013.539. Epub 2013 Dec 23.

6.

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Powell NA, Hoffman JK, Ciske FL, Kaufman MD, Kohrt JT, Quin J 3rd, Sheehan DJ, Delaney A, Baxi SM, Catana C, McConnell P, Ohren J, Perrin LA, Edmunds JJ.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1046-50. doi: 10.1016/j.bmcl.2012.12.013. Epub 2012 Dec 20.

PMID:
23312472
7.

Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.

Chan WW, Wise SC, Kaufman MD, Ahn YM, Ensinger CL, Haack T, Hood MM, Jones J, Lord JW, Lu WP, Miller D, Patt WC, Smith BD, Petillo PA, Rutkoski TJ, Telikepalli H, Vogeti L, Yao T, Chun L, Clark R, Evangelista P, Gavrilescu LC, Lazarides K, Zaleskas VM, Stewart LJ, Van Etten RA, Flynn DL.

Cancer Cell. 2011 Apr 12;19(4):556-68. doi: 10.1016/j.ccr.2011.03.003.

8.

Course of relapsing-remitting multiple sclerosis before, during and after natalizumab.

Kaufman MD, Lee R, Norton HJ.

Mult Scler. 2011 Apr;17(4):490-4. doi: 10.1177/1352458510389103. Epub 2010 Dec 6.

PMID:
21135017
9.

Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.

Ahn YM, Clare M, Ensinger CL, Hood MM, Lord JW, Lu WP, Miller DF, Patt WC, Smith BD, Vogeti L, Kaufman MD, Petillo PA, Wise SC, Abendroth J, Chun L, Clark R, Feese M, Kim H, Stewart L, Flynn DL.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5793-8. doi: 10.1016/j.bmcl.2010.07.134. Epub 2010 Aug 3.

PMID:
20800479
10.

Double-lumen tubes: which lumen for the gum elastic bougie?

Stix MS, Ata S, Wolckenhaar M, Kaufman MD.

Anesth Analg. 2010 Jan 1;110(1):258; author reply 258-9. doi: 10.1213/ANE.0b013e3181c293cf. No abstract available.

PMID:
20023188
11.

Update on best practice recommendations for anesthetic perioperative care and pain management in weight loss surgery, 2004-2007.

Schumann R, Jones SB, Cooper B, Kelley SD, Bosch MV, Ortiz VE, Connor KA, Kaufman MD, Harvey AM, Carr DB.

Obesity (Silver Spring). 2009 May;17(5):889-94. doi: 10.1038/oby.2008.569. Epub 2009 Feb 19.

12.

Adherence to therapy: using an evidence-based protocol.

Moore LA, Kaufman MD, Algozzine R, Irish N, Martin M, Posey CR.

Rehabil Nurs. 2007 Nov-Dec;32(6):227-32.

PMID:
18065143
13.

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H.

J Med Chem. 2007 Oct 18;50(21):5090-102. Epub 2007 Sep 19.

PMID:
17880056
14.

Multiple sclerosis: severity and progression rate in African Americans compared with whites.

Kaufman MD, Johnson SK, Moyer D, Bivens J, Norton HJ.

Am J Phys Med Rehabil. 2003 Aug;82(8):582-90.

PMID:
12872014
15.

Gram-Scale Synthesis of (+)-Discodermolide.

Smith III AB, Kaufman MD, Beachamp TJ, LaMarche MJ, Arimoto H.

Org Lett. 2000 Jun 29;2(13):1983. No abstract available.

PMID:
10891208
16.

Gram-scale synthesis of (+)-discodermolide.

Smith AB 3rd, Kaufman MD, Beauchamp TJ, LaMarche MJ, Arimoto H.

Org Lett. 1999 Dec 2;1(11):1823-6. Erratum in: Org Lett 2000 Jun 29;2(13):1983.

PMID:
10836041
17.

Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.

Martello LA, McDaid HM, Regl DL, Yang CP, Meng D, Pettus TR, Kaufman MD, Arimoto H, Danishefsky SJ, Smith AB 3rd, Horwitz SB.

Clin Cancer Res. 2000 May;6(5):1978-87.

19.

Immune-based therapy of multiple sclerosis.

Kaufman MD.

N C Med J. 1995 Aug;56(8):379-84. Review. No abstract available.

PMID:
7566191
20.

Radiation and MS.

Kaufman MD.

Neurology. 1994 Sep;44(9):1769. No abstract available.

PMID:
7936322
21.

Conjugal MS.

Kaufman MD.

Neurology. 1992 Aug;42(8):1644-5. No abstract available.

PMID:
1641177
22.

Paroxysmal unilateral dysosmia: a cured patient.

Kaufman MD, Lassiter KR, Shenoy BV.

Ann Neurol. 1988 Sep;24(3):450-1.

PMID:
3228277
23.

Isolated superior gluteal neuropathy due to intramuscular injection.

Kaufman MD.

N C Med J. 1988 Feb;49(2):85-6. No abstract available.

PMID:
3422711
24.
25.

Masticatory spasm in facial hemiatrophy.

Kaufman MD.

Ann Neurol. 1980 Jun;7(6):585-7.

PMID:
7436363

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