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Homotaurine Treatment Enhances CD4+ and CD8+ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice.

Tian J, Dang H, O'Laco KA, Song M, Tiu BC, Gilles S, Zakarian C, Kaufman DL.

Immunohorizons. 2019 Oct 21;3(10):498-510. doi: 10.4049/immunohorizons.1900019.


A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA's Ability to Inhibit Inflammatory T Cells.

Tian J, Dang H, Karashchuk N, Xu I, Kaufman DL.

J Diabetes Res. 2019 Feb 26;2019:5783545. doi: 10.1155/2019/5783545. eCollection 2019.


A Capacity Allocation Planning Model for Integrated Care and Access Management.

Deglise-Hawkinson J, Helm JE, Huschka T, Kaufman DL, Van Oyen MP.

Prod Oper Manag. 2018 Dec;27(12):2270-2290. doi: 10.1111/poms.12941. Epub 2018 Sep 6.


Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene.

Yong J, Tian J, Dang H, Wu TT, Atkinson MA, Sun R, Kaufman DL.

Sci Rep. 2019 Mar 12;9(1):4269. doi: 10.1038/s41598-019-38905-z.


Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis.

Tian J, Dang H, Wallner M, Olsen R, Kaufman DL.

Sci Rep. 2018 Nov 8;8(1):16555. doi: 10.1038/s41598-018-32733-3.


Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication.

Tian J, Dang H, Hu A, Xu W, Kaufman DL.

J Diabetes Res. 2017;2017:6403539. doi: 10.1155/2017/6403539. Epub 2017 Sep 5.


Neurological and immunological dysfunction in two patients with Bartonella henselae bacteremia.

Kaufman DL, Kogelnik AM, Mozayeni RB, Cherry NA, Breitschwerdt EB.

Clin Case Rep. 2017 Apr 26;5(6):931-935. doi: 10.1002/ccr3.977. eCollection 2017 Jun.


Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication.

Tian J, Dang H, Middleton B, Kaufman DL.

Sci Rep. 2017 Mar 23;7(1):374. doi: 10.1038/s41598-017-00515-y.


Sientra primary and revision augmentation rupture trending and analysis with magnetic resonance imaging.

Haws MJ, Alizadeh K, Kaufman DL.

Aesthet Surg J. 2015 May;35 Suppl 1:S33-42. doi: 10.1093/asj/sjv021.


Evolving practices in augmentation operative technique with Sientra HSC round implants.

Calobrace MB, Kaufman DL, Gordon AE, Reid DL.

Plast Reconstr Surg. 2014 Jul;134(1 Suppl):57S-67S. doi: 10.1097/PRS.0000000000000354.


γ-Aminobutyric acid regulates both the survival and replication of human β-cells.

Tian J, Dang H, Chen Z, Guan A, Jin Y, Atkinson MA, Kaufman DL.

Diabetes. 2013 Nov;62(11):3760-5. doi: 10.2337/db13-0931. Epub 2013 Aug 30.


Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Laćan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL.

J Neurosci Res. 2013 Oct;91(10):1292-302. doi: 10.1002/jnr.23253. Epub 2013 Aug 1.


Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.

Bilousova T, Dang H, Xu W, Gustafson S, Jin Y, Wickramasinghe L, Won T, Bobarnac G, Middleton B, Tian J, Kaufman DL.

J Neuroimmunol. 2012 Jun 15;247(1-2):1-8. doi: 10.1016/j.jneuroim.2012.03.008. Epub 2012 Apr 12.


Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice.

Tian J, Dang HN, Yong J, Chui WS, Dizon MP, Yaw CK, Kaufman DL.

PLoS One. 2011;6(9):e25338. doi: 10.1371/journal.pone.0025338. Epub 2011 Sep 22.


Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice.

Tian J, Dang H, Kaufman DL.

PLoS One. 2011;6(9):e25337. doi: 10.1371/journal.pone.0025337. Epub 2011 Sep 22.


Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis.

Tian J, Yong J, Dang H, Kaufman DL.

Autoimmunity. 2011 Sep;44(6):465-70. doi: 10.3109/08916934.2011.571223. Epub 2011 May 23.


A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth.

Washburn LR, Zekzer D, Eitan S, Lu Y, Dang H, Middleton B, Evans CJ, Tian J, Kaufman DL.

PLoS One. 2011 Mar 31;6(3):e18439. doi: 10.1371/journal.pone.0018439.


Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes.

Yong J, Rasooly J, Dang H, Lu Y, Middleton B, Zhang Z, Hon L, Namavari M, Stout DB, Atkinson MA, Tian J, Gambhir SS, Kaufman DL.

Diabetes. 2011 May;60(5):1383-92. doi: 10.2337/db10-0907. Epub 2011 Mar 25.


BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.

Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL.

PLoS One. 2011 Jan 31;6(1):e16610. doi: 10.1371/journal.pone.0016610.


Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury.

Joseph MS, Bilousova T, Zdunowski S, Wu ZP, Middleton B, Boudzinskaia M, Wong B, Ali N, Zhong H, Yong J, Washburn L, Escande-Beillard N, Dang H, Edgerton VR, Tillakaratne NJ, Kaufman DL.

J Neurosci Res. 2011 Mar;89(3):365-72. doi: 10.1002/jnr.22557. Epub 2010 Dec 22.


Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves.

Wu ZP, Bilousova T, Escande-Beillard N, Dang H, Hsieh T, Tian J, Kaufman DL.

Immunol Lett. 2011 Mar 30;135(1-2):118-23. doi: 10.1016/j.imlet.2010.10.011. Epub 2010 Oct 23.


Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair.

Wu ZP, Washburn L, Bilousova TV, Boudzinskaia M, Escande-Beillard N, Querubin J, Dang H, Xie CW, Tian J, Kaufman DL.

J Neuroimmunol. 2011 Mar;232(1-2):8-16. doi: 10.1016/j.jneuroim.2010.09.009. Epub 2010 Oct 14.


Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented.

Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, Joyce S, Tian J, Kaufman DL.

J Immunol. 2010 Jan 15;184(2):816-23. doi: 10.4049/jimmunol.0902159. Epub 2009 Dec 16.


Antigen-based therapy for the treatment of type 1 diabetes.

Tian J, Kaufman DL.

Diabetes. 2009 Sep;58(9):1939-46. doi: 10.2337/db09-0451. No abstract available.


Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid.

Chen L, Zhang Y, Kong X, Lan E, Huang Z, Peng S, Kaufman DL, Tian J.

J Med Chem. 2008 Aug 14;51(15):4834-8. doi: 10.1021/jm800167u. Epub 2008 Jul 4.


The postnatal maternal environment influences diabetes development in nonobese diabetic mice.

Washburn LR, Dang H, Tian J, Kaufman DL.

J Autoimmun. 2007 Feb;28(1):19-23. Epub 2007 Jan 4.


Long-term monitoring of transplanted islets using positron emission tomography.

Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL.

Mol Ther. 2006 Dec;14(6):851-6. Epub 2006 Sep 18.


Noninvasive imaging of islet grafts using positron-emission tomography.

Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11294-9.


Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice.

Olcott AP, Tian J, Walker V, Dang H, Middleton B, Adorini L, Washburn L, Kaufman DL.

J Immunol. 2005 Aug 1;175(3):1991-9.


Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model.

Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL.

J Immunol. 2004 Oct 15;173(8):5298-304.


A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.

Olcott AP, Tocco G, Tian J, Zekzer D, Fukuto J, Ignarro L, Kaufman DL.

Diabetes. 2004 Oct;53(10):2574-80.


Bioluminescent monitoring of islet graft survival after transplantation.

Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL.

Mol Ther. 2004 Mar;9(3):428-35.


Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens.

Tian J, Lu Y, Hanssen L, Dang H, Kaufman DL.

Cell Immunol. 2003 Aug;224(2):74-85.


Somatic instability of the NF2 gene in schwannomatosis.

Kaufman DL, Heinrich BS, Willett C, Perry A, Finseth F, Sobel RA, MacCollin M.

Arch Neurol. 2003 Sep;60(9):1317-20.


Murder mysteries in type 1 diabetes.

Kaufman DL.

Nat Med. 2003 Feb;9(2):161-2. No abstract available.


Antigen-based immunotherapy drives the precocious development of autoimmunity.

Tian J, Olcott AP, Kaufman DL.

J Immunol. 2002 Dec 1;169(11):6564-9.


Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop.

Kaufman DL, Tisch R, Sarvetnick N, Chatenoud L, Harrison LC, Haskins K, Quinn A, Sercarz E, Singh B, von Herrath M, Wegmann D, Wen L, Zekzer D.

Diabetes. 2001 Nov;50(11):2459-63. Review.


Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice.

Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL.

J Immunol. 2001 Jul 15;167(2):1081-9.


The frequency of high avidity T cells determines the hierarchy of determinant spreading.

Tian J, Gregori S, Adorini L, Kaufman DL.

J Immunol. 2001 Jun 15;166(12):7144-50.


GABA(A) receptors mediate inhibition of T cell responses.

Tian J, Chau C, Hales TG, Kaufman DL.

J Neuroimmunol. 1999 Apr 1;96(1):21-8.


Antigen-based immunotherapy for autoimmune disease: from animal models to humans?

Tian J, Olcott A, Hanssen L, Zekzer D, Kaufman DL.

Immunol Today. 1999 Apr;20(4):190-5. Review.


Attenuation of inducible Th2 immunity with autoimmune disease progression.

Tian J, Kaufman DL.

J Immunol. 1998 Nov 15;161(10):5399-403.


Infectious Th1 and Th2 autoimmunity in diabetes-prone mice.

Tian J, Olcott AP, Hanssen LR, Zekzer D, Middleton B, Kaufman DL.

Immunol Rev. 1998 Aug;164:119-27. Review.


In vivo administration of c-Fos antisense oligonucleotides accelerates amygdala kindling.

Rocha L, Kaufman DL.

Neurosci Lett. 1998 Jan 30;241(2-3):111-4.


Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens.

Tian J, Lehmann PV, Kaufman DL.

J Exp Med. 1997 Dec 15;186(12):2039-43.

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