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Items: 46

1.

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.

Jeay S, Ferretti S, Holzer P, Fuchs J, Chapeau EA, Wartmann M, Sterker D, Romanet V, Murakami M, Kerr G, Durand EY, Gaulis S, Cortes-Cros M, Ruetz S, Stachyra TM, Kallen J, Furet P, Würthner J, Guerreiro N, Halilovic E, Jullion A, Kauffmann A, Kuriakose E, Wiesmann M, Jensen MR, Hofmann F, Sellers WR.

Cancer Res. 2018 Nov 1;78(21):6257-6267. doi: 10.1158/0008-5472.CAN-18-0338. Epub 2018 Aug 22.

PMID:
30135191
2.

Correction of copy number induced false positives in CRISPR screens.

de Weck A, Golji J, Jones MD, Korn JM, Billy E, McDonald ER 3rd, Schmelzle T, Bitter H, Kauffmann A.

PLoS Comput Biol. 2018 Jul 19;14(7):e1006279. doi: 10.1371/journal.pcbi.1006279. eCollection 2018 Jul.

3.

Scar Tissue Formation Following Alveolar Ridge Preservation: A Case Control Study.

Fickl S, Kauffmann F, Stappert CF, Kauffmann A, Schlagenhauf U.

Int J Periodontics Restorative Dent. 2018 Jan/Feb;38(1):e1-e7. doi: 10.11607/prd.3347.

PMID:
29240203
4.

On the relation between economic bubbles and effort gaps between sellers and buyers: An experimental study.

Yechiam E, Kauffmann A, Ashby NJS, Zahavi G.

PLoS One. 2017 Dec 11;12(12):e0189359. doi: 10.1371/journal.pone.0189359. eCollection 2017.

5.

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

McDonald ER 3rd, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T, Sellers WR.

Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005.

6.

Nuclear Magnetic Resonance Structure of an 8 × 8 Nucleotide RNA Internal Loop Flanked on Each Side by Three Watson-Crick Pairs and Comparison to Three-Dimensional Predictions.

Kauffmann AD, Kennedy SD, Zhao J, Turner DH.

Biochemistry. 2017 Jul 25;56(29):3733-3744. doi: 10.1021/acs.biochem.7b00201. Epub 2017 Jul 12.

7.

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.

Chapeau EA, Gembarska A, Durand EY, Mandon E, Estadieu C, Romanet V, Wiesmann M, Tiedt R, Lehar J, de Weck A, Rad R, Barys L, Jeay S, Ferretti S, Kauffmann A, Sutter E, Grevot A, Moulin P, Murakami M, Sellers WR, Hofmann F, Jensen MR.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3151-3156. doi: 10.1073/pnas.1620262114. Epub 2017 Mar 6.

8.

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.

Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, Rakiec D, de Beaumont R, Weber O, Kauffmann A, McDonald ER 3rd, Keen N, Hofmann F, Sellers WR, Schmelzle T, Stegmeier F, Schlabach MR.

Cancer Discov. 2016 Aug;6(8):900-13. doi: 10.1158/2159-8290.CD-16-0178. Epub 2016 Jun 3.

9.

Orientation relationship of eutectoid FeAl and FeAl2.

Scherf A, Kauffmann A, Kauffmann-Weiss S, Scherer T, Li X, Stein F, Heilmaier M.

J Appl Crystallogr. 2016 Feb 24;49(Pt 2):442-449. eCollection 2016 Apr 1.

10.

Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition.

Herkert B, Kauffmann A, Mollé S, Schnell C, Ferrat T, Voshol H, Juengert J, Erasimus H, Marszalek G, Kazic-Legueux M, Billy E, Ruddy D, Stump M, Guthy D, Ristov M, Calkins K, Maira SM, Sellers WR, Hofmann F, Hall MN, Brachmann SM.

Cancer Res. 2016 Jan 15;76(2):390-402. doi: 10.1158/0008-5472.CAN-14-3358. Epub 2015 Nov 17.

11.

Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Burger MT, Nishiguchi G, Han W, Lan J, Simmons R, Atallah G, Ding Y, Tamez V, Zhang Y, Mathur M, Muller K, Bellamacina C, Lindvall MK, Zang R, Huh K, Feucht P, Zavorotinskaya T, Dai Y, Basham S, Chan J, Ginn E, Aycinena A, Holash J, Castillo J, Langowski JL, Wang Y, Chen MY, Lambert A, Fritsch C, Kauffmann A, Pfister E, Vanasse KG, Garcia PD.

J Med Chem. 2015 Nov 12;58(21):8373-86. doi: 10.1021/acs.jmedchem.5b01275. Epub 2015 Oct 27.

PMID:
26505898
12.

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR.

Nat Med. 2015 Nov;21(11):1318-25. doi: 10.1038/nm.3954. Epub 2015 Oct 19.

PMID:
26479923
13.

The Influenza A PB1-F2 and N40 Start Codons Are Contained within an RNA Pseudoknot.

Priore SF, Kauffmann AD, Baman JR, Turner DH.

Biochemistry. 2015 Jun 9;54(22):3413-5. doi: 10.1021/bi501564d. Epub 2015 May 27.

14.

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.

Fritsch C, Huang A, Chatenay-Rivauday C, Schnell C, Reddy A, Liu M, Kauffmann A, Guthy D, Erdmann D, De Pover A, Furet P, Gao H, Ferretti S, Wang Y, Trappe J, Brachmann SM, Maira SM, Wilson C, Boehm M, Garcia-Echeverria C, Chene P, Wiesmann M, Cozens R, Lehar J, Schlegel R, Caravatti G, Hofmann F, Sellers WR.

Mol Cancer Ther. 2014 May;13(5):1117-29. doi: 10.1158/1535-7163.MCT-13-0865. Epub 2014 Mar 7.

15.

Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.

Garcia PD, Langowski JL, Wang Y, Chen M, Castillo J, Fanton C, Ison M, Zavorotinskaya T, Dai Y, Lu J, Niu XH, Basham S, Chan J, Yu J, Doyle M, Feucht P, Warne R, Narberes J, Tsang T, Fritsch C, Kauffmann A, Pfister E, Drueckes P, Trappe J, Wilson C, Han W, Lan J, Nishiguchi G, Lindvall M, Bellamacina C, Aycinena JA, Zang R, Holash J, Burger MT.

Clin Cancer Res. 2014 Apr 1;20(7):1834-45. doi: 10.1158/1078-0432.CCR-13-2062. Epub 2014 Jan 28.

16.

Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.

Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B, Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D, Naylor T, Pfister E, Kovats S, Kim S, Dietze K, Dörken B, Steidl C, Tzankov A, Hummel M, Monahan J, Morrissey MP, Fritsch C, Sellers WR, Cooke VG, Gascoyne RD, Lenz G, Stegmeier F.

Nat Med. 2014 Jan;20(1):87-92. doi: 10.1038/nm.3435. Epub 2013 Dec 22.

PMID:
24362935
17.

Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas.

Peille AL, Brouste V, Kauffmann A, Lagarde P, Le Morvan V, Coindre JM, Chibon F, Bresson-Bepoldin L.

PLoS One. 2013 Nov 15;8(11):e80741. doi: 10.1371/journal.pone.0080741. eCollection 2013.

18.

Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors.

Wöhrle S, Weiss A, Ito M, Kauffmann A, Murakami M, Jagani Z, Thuery A, Bauer-Probst B, Reimann F, Stamm C, Pornon A, Romanet V, Guagnano V, Brümmendorf T, Sellers WR, Hofmann F, Roberts CW, Graus Porta D.

PLoS One. 2013 Oct 30;8(10):e77652. doi: 10.1371/journal.pone.0077652. eCollection 2013.

19.

FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

Guagnano V, Kauffmann A, Wöhrle S, Stamm C, Ito M, Barys L, Pornon A, Yao Y, Li F, Zhang Y, Chen Z, Wilson CJ, Bordas V, Le Douget M, Gaither LA, Borawski J, Monahan JE, Venkatesan K, Brümmendorf T, Thomas DM, Garcia-Echeverria C, Hofmann F, Sellers WR, Graus-Porta D.

Cancer Discov. 2012 Dec;2(12):1118-33. doi: 10.1158/2159-8290.CD-12-0210. Epub 2012 Sep 20.

20.

Gene expression signature predicting high-grade prostate cancer responses to oxaliplatin.

Puyo S, Houédé N, Kauffmann A, Richaud P, Robert J, Pourquier P.

Mol Pharmacol. 2012 Dec;82(6):1205-16. doi: 10.1124/mol.112.080333. Epub 2012 Sep 17.

21.

Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations.

Brachmann SM, Kleylein-Sohn J, Gaulis S, Kauffmann A, Blommers MJ, Kazic-Legueux M, Laborde L, Hattenberger M, Stauffer F, Vaxelaire J, Romanet V, Henry C, Murakami M, Guthy DA, Sterker D, Bergling S, Wilson C, Brümmendorf T, Fritsch C, Garcia-Echeverria C, Sellers WR, Hofmann F, Maira SM.

Mol Cancer Ther. 2012 Aug;11(8):1747-57. doi: 10.1158/1535-7163.MCT-11-1021. Epub 2012 May 31.

22.

Absence of transcriptomic signature of response to chemotherapy in metastatic colorectal carcinoma patients.

Laroche-Clary A, Kauffmann A, Smith D, Laurand-Quancard A, Evrard S, Brunet R, Le Morvan V, Robert J.

Pharmacogenomics. 2012 Mar;13(4):497-504. doi: 10.2217/pgs.11.174. Epub 2012 Feb 13.

PMID:
22329722
23.

Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors.

Lagarde P, Pérot G, Kauffmann A, Brulard C, Dapremont V, Hostein I, Neuville A, Wozniak A, Sciot R, Schöffski P, Aurias A, Coindre JM, Debiec-Rychter M, Chibon F.

Clin Cancer Res. 2012 Feb 1;18(3):826-38. doi: 10.1158/1078-0432.CCR-11-1610. Epub 2011 Dec 13.

24.

Critical current scaling and anisotropy in oxypnictide superconductors.

Kidszun M, Haindl S, Thersleff T, Hänisch J, Kauffmann A, Iida K, Freudenberger J, Schultz L, Holzapfel B.

Phys Rev Lett. 2011 Apr 1;106(13):137001. Epub 2011 Mar 29.

PMID:
21517413
25.

Contributions of the EMERALD project to assessing and improving microarray data quality.

Beisvåg V, Kauffmann A, Malone J, Foy C, Salit M, Schimmel H, Bongcam-Rudloff E, Landegren U, Parkinson H, Huber W, Brazma A, Sandvik AK, Kuiper M.

Biotechniques. 2011 Jan;50(1):27-31. doi: 10.2144/000113591.

PMID:
21231919
26.

Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity.

Chibon F, Lagarde P, Salas S, Pérot G, Brouste V, Tirode F, Lucchesi C, de Reynies A, Kauffmann A, Bui B, Terrier P, Bonvalot S, Le Cesne A, Vince-Ranchère D, Blay JY, Collin F, Guillou L, Leroux A, Coindre JM, Aurias A.

Nat Med. 2010 Jul;16(7):781-7. doi: 10.1038/nm.2174. Epub 2010 Jun 27.

PMID:
20581836
27.

On: transference.

Duarte AL, Lewkowicz AB, Kauffmann AL, Iankilevich E, Brodacz G, Soares GA, Cabral Pellanda LE, Mondrzak VS.

Int J Psychoanal. 2010 Apr;91(2):403-5. doi: 10.1111/j.1745-8315.2010.00240.x. No abstract available.

PMID:
20536868
28.

High upper critical fields and evidence of weak-link behavior in superconducting LaFeAsO1-xFx thin films.

Haindl S, Kidszun M, Kauffmann A, Nenkov K, Kozlova N, Freudenberger J, Thersleff T, Hänisch J, Werner J, Reich E, Schultz L, Holzapfel B.

Phys Rev Lett. 2010 Feb 19;104(7):077001. Epub 2010 Feb 18.

PMID:
20366908
29.

Microarray data quality control improves the detection of differentially expressed genes.

Kauffmann A, Huber W.

Genomics. 2010 Mar;95(3):138-42. doi: 10.1016/j.ygeno.2010.01.003. Epub 2010 Jan 14. Review.

30.

Improvement of RNA secondary structure prediction using RNase H cleavage and randomized oligonucleotides.

Kauffmann AD, Campagna RJ, Bartels CB, Childs-Disney JL.

Nucleic Acids Res. 2009 Oct;37(18):e121. doi: 10.1093/nar/gkp587. Epub 2009 Jul 13.

31.

Importing ArrayExpress datasets into R/Bioconductor.

Kauffmann A, Rayner TF, Parkinson H, Kapushesky M, Lukk M, Brazma A, Huber W.

Bioinformatics. 2009 Aug 15;25(16):2092-4. doi: 10.1093/bioinformatics/btp354. Epub 2009 Jun 8.

32.

MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: a molecular portrait of stage 4S.

Bénard J, Raguénez G, Kauffmann A, Valent A, Ripoche H, Joulin V, Job B, Danglot G, Cantais S, Robert T, Terrier-Lacombe MJ, Chassevent A, Koscielny S, Fischer M, Berthold F, Lipinski M, Tursz T, Dessen P, Lazar V, Valteau-Couanet D.

Mol Oncol. 2008 Oct;2(3):261-71. doi: 10.1016/j.molonc.2008.07.002. Epub 2008 Jul 23.

33.

Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas.

Puget S, Grill J, Valent A, Bieche I, Dantas-Barbosa C, Kauffmann A, Dessen P, Lacroix L, Geoerger B, Job B, Dirven C, Varlet P, Peyre M, Dirks PB, Sainte-Rose C, Vassal G.

J Clin Oncol. 2009 Apr 10;27(11):1884-92. doi: 10.1200/JCO.2007.15.4195. Epub 2009 Mar 16.

PMID:
19289631
34.

arrayQualityMetrics--a bioconductor package for quality assessment of microarray data.

Kauffmann A, Gentleman R, Huber W.

Bioinformatics. 2009 Feb 1;25(3):415-6. doi: 10.1093/bioinformatics/btn647. Epub 2008 Dec 23.

35.

Overexpression of DNA repair genes is associated with metastasis: a new hypothesis.

Sarasin A, Kauffmann A.

Mutat Res. 2008 Jul-Aug;659(1-2):49-55. doi: 10.1016/j.mrrev.2007.12.002. Epub 2008 Jan 16. Review.

PMID:
18308619
36.

High expression of DNA repair pathways is associated with metastasis in melanoma patients.

Kauffmann A, Rosselli F, Lazar V, Winnepenninckx V, Mansuet-Lupo A, Dessen P, van den Oord JJ, Spatz A, Sarasin A.

Oncogene. 2008 Jan 24;27(5):565-73. Epub 2007 Sep 24.

PMID:
17891185
37.

Trauma, causality and time: some reflections: Epistemology Study Group, Porto Alegre Psychoanalytical Society.

Mondrzak VS, Duarte AL, Lewkowicz AB, Kauffmann AL, Iankilevich E, Brodacz G, Soares GP, Pellanda LE; Epistemology Study Group, Porto Alegre Psychoanalytical Society.

Int J Psychoanal. 2007 Apr;88(Pt 2):463-74.

PMID:
17392060
38.

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach.

Raslova H, Kauffmann A, Sekkaï D, Ripoche H, Larbret F, Robert T, Tronik Le Roux D, Kroemer G, Debili N, Dessen P, Lazar V, Vainchenker W.

Blood. 2007 Apr 15;109(8):3225-34. Epub 2006 Dec 14.

39.

Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: Relationship to Bcl-2 family and caspase activation.

Hamaï A, Richon C, Meslin F, Faure F, Kauffmann A, Lecluse Y, Jalil A, Larue L, Avril MF, Chouaib S, Mehrpour M.

Oncogene. 2006 Dec 7;25(58):7618-34. Epub 2006 Sep 18. Erratum in: Oncogene. 2007 Feb 22;26(8):1256.

PMID:
16983347
40.

Apoptosis regulation in tetraploid cancer cells.

Castedo M, Coquelle A, Vivet S, Vitale I, Kauffmann A, Dessen P, Pequignot MO, Casares N, Valent A, Mouhamad S, Schmitt E, Modjtahedi N, Vainchenker W, Zitvogel L, Lazar V, Garrido C, Kroemer G.

EMBO J. 2006 Jun 7;25(11):2584-95. Epub 2006 May 4.

41.

Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure.

Abouzahr S, Bismuth G, Gaudin C, Caroll O, Van Endert P, Jalil A, Dausset J, Vergnon I, Richon C, Kauffmann A, Galon J, Raposo G, Mami-Chouaib F, Chouaib S.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1428-33. Epub 2006 Jan 23.

42.

Excitability of the Clay model for squid giant axon.

Pakdaman K, Kauffmann A, Mestivier D.

Biosystems. 2003 Sep;71(1-2):157-67.

PMID:
14568216
43.

Toxicokinetics of isoprene in rodents and humans.

Filser JG, Csanády GA, Denk B, Hartmann M, Kauffmann A, Kessler W, Kreuzer PE, Pütz C, Shen JH, Stei P.

Toxicology. 1996 Oct 28;113(1-3):278-87.

PMID:
8901909
44.

[On radioisotope examinations of the lymphatic system].

Micluţia M, Holan T, Kauffmann A, Spermezan R, Crişan M.

Chirurgia (Bucur). 1974 Feb;23(2):145-54. Romanian. No abstract available.

PMID:
4822422
45.

Carcinoma of the ampulla of Vater: survival for more than 5 years after pancreatoduodenectomy.

KAUFFMANN A.

Tex State J Med. 1959 Aug;55:698-701. No abstract available.

PMID:
14404846
46.

The problem of the silent gallstone.

MOORE RM, KAUFFMANN AF, McNEILL JP.

South Med J. 1951 Nov;44(11):1027-33. No abstract available.

PMID:
14876530

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