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Items: 33

1.

Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2.

Hill SE, Kauffman KJ, Krout M, Richmond JE, Melia TJ, Colón-Ramos DA.

Dev Cell. 2019 Apr 22;49(2):251-266.e8. doi: 10.1016/j.devcel.2019.02.013. Epub 2019 Mar 14.

PMID:
30880001
2.

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes.

Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A.

Nat Cell Biol. 2019 Mar;21(3):372-383. doi: 10.1038/s41556-019-0274-9. Epub 2019 Feb 18.

PMID:
30778222
3.

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium.

Patel AK, Kaczmarek JC, Bose S, Kauffman KJ, Mir F, Heartlein MW, DeRosa F, Langer R, Anderson DG.

Adv Mater. 2019 Feb;31(8):e1805116. doi: 10.1002/adma.201805116. Epub 2019 Jan 4.

PMID:
30609147
4.

Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.

Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M.

Circulation. 2019 Jan 2;139(1):78-96. doi: 10.1161/CIRCULATIONAHA.118.034588.

PMID:
30586693
5.

Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells.

Kaczmarek JC, Kauffman KJ, Fenton OS, Sadtler K, Patel AK, Heartlein MW, DeRosa F, Anderson DG.

Nano Lett. 2018 Oct 10;18(10):6449-6454. doi: 10.1021/acs.nanolett.8b02917. Epub 2018 Sep 20.

PMID:
30211557
6.

Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs.

Fenton OS, Kauffman KJ, McClellan RL, Kaczmarek JC, Zeng MD, Andresen JL, Rhym LH, Heartlein MW, DeRosa F, Anderson DG.

Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13582-13586. doi: 10.1002/anie.201809056. Epub 2018 Sep 14.

PMID:
30112821
7.

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse.

Kauffman KJ, Oberli MA, Dorkin JR, Hurtado JE, Kaczmarek JC, Bhadani S, Wyckoff J, Langer R, Jaklenec A, Anderson DG.

Mol Ther Nucleic Acids. 2018 Mar 2;10:55-63. doi: 10.1016/j.omtn.2017.11.005. Epub 2017 Nov 21.

8.

Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.

Kauffman KJ, Yu S, Jin J, Mugo B, Nguyen N, O'Brien A, Nag S, Lystad AH, Melia TJ.

Autophagy. 2018;14(6):992-1010. doi: 10.1080/15548627.2018.1437341. Epub 2018 Apr 10.

9.

Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes.

Fenton OS, Kauffman KJ, Kaczmarek JC, McClellan RL, Jhunjhunwala S, Tibbitt MW, Zeng MD, Appel EA, Dorkin JR, Mir FF, Yang JH, Oberli MA, Heartlein MW, DeRosa F, Langer R, Anderson DG.

Adv Mater. 2017 Sep;29(33). doi: 10.1002/adma.201606944. Epub 2017 Jul 6.

PMID:
28681930
10.

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing.

Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC.

Mol Ther Nucleic Acids. 2017 Jun 16;7:314-323. doi: 10.1016/j.omtn.2017.04.014. Epub 2017 Apr 20.

11.

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.

Hydbring P, Wang Y, Fassl A, Li X, Matia V, Otto T, Choi YJ, Sweeney KE, Suski JM, Yin H, Bogorad RL, Goel S, Yuzugullu H, Kauffman KJ, Yang J, Jin C, Li Y, Floris D, Swanson R, Ng K, Sicinska E, Anders L, Zhao JJ, Polyak K, Anderson DG, Li C, Sicinski P.

Cancer Cell. 2017 Apr 10;31(4):576-590.e8. doi: 10.1016/j.ccell.2017.03.004.

12.

Delivery technologies for genome editing.

Yin H, Kauffman KJ, Anderson DG.

Nat Rev Drug Discov. 2017 Jun;16(6):387-399. doi: 10.1038/nrd.2016.280. Epub 2017 Mar 24. Review.

PMID:
28337020
13.

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics.

Dahlman JE, Kauffman KJ, Xing Y, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2060-2065. doi: 10.1073/pnas.1620874114. Epub 2017 Feb 6.

14.

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs.

Kaczmarek JC, Patel AK, Kauffman KJ, Fenton OS, Webber MJ, Heartlein MW, DeRosa F, Anderson DG.

Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13808-13812. doi: 10.1002/anie.201608450. Epub 2016 Sep 30.

15.

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo.

Kauffman KJ, Mir FF, Jhunjhunwala S, Kaczmarek JC, Hurtado JE, Yang JH, Webber MJ, Kowalski PS, Heartlein MW, DeRosa F, Anderson DG.

Biomaterials. 2016 Dec;109:78-87. doi: 10.1016/j.biomaterials.2016.09.006. Epub 2016 Sep 25.

16.

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system.

DeRosa F, Guild B, Karve S, Smith L, Love K, Dorkin JR, Kauffman KJ, Zhang J, Yahalom B, Anderson DG, Heartlein MW.

Gene Ther. 2016 Oct;23(10):699-707. doi: 10.1038/gt.2016.46. Epub 2016 Jun 30.

17.

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.

Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M.

Sci Transl Med. 2016 Jun 8;8(342):342ra80. doi: 10.1126/scitranslmed.aaf1435.

18.

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery.

Fenton OS, Kauffman KJ, McClellan RL, Appel EA, Dorkin JR, Tibbitt MW, Heartlein MW, DeRosa F, Langer R, Anderson DG.

Adv Mater. 2016 Apr 20;28(15):2939-43. doi: 10.1002/adma.201505822. Epub 2016 Feb 18.

19.

Materials for non-viral intracellular delivery of messenger RNA therapeutics.

Kauffman KJ, Webber MJ, Anderson DG.

J Control Release. 2016 Oct 28;240:227-234. doi: 10.1016/j.jconrel.2015.12.032. Epub 2015 Dec 21. Review.

PMID:
26718856
20.

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.

Kauffman KJ, Dorkin JR, Yang JH, Heartlein MW, DeRosa F, Mir FF, Fenton OS, Anderson DG.

Nano Lett. 2015 Nov 11;15(11):7300-6. doi: 10.1021/acs.nanolett.5b02497. Epub 2015 Oct 20.

PMID:
26469188
21.

The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs.

Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia TJ, Reinisch KM.

Dev Cell. 2015 Sep 14;34(5):569-76. doi: 10.1016/j.devcel.2015.08.010. Epub 2015 Sep 3.

22.

Cancer nanotherapeutics in clinical trials.

Lytton-Jean AK, Kauffman KJ, Kaczmarek JC, Langer R.

Cancer Treat Res. 2015;166:293-322. doi: 10.1007/978-3-319-16555-4_13. Review.

PMID:
25895874
23.

Nanotechnology for in vivo targeted siRNA delivery.

Dahlman JE, Kauffman KJ, Langer R, Anderson DG.

Adv Genet. 2014;88:37-69. doi: 10.1016/B978-0-12-800148-6.00003-1. Review.

PMID:
25409603
24.

The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin.

Burke KA, Kauffman KJ, Umbaugh CS, Frey SL, Legleiter J.

J Biol Chem. 2013 May 24;288(21):14993-5005. doi: 10.1074/jbc.M112.446237. Epub 2013 Apr 9.

25.

Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product.

Kauffman KJ, Do C, Sharma S, Gallovic MD, Bachelder EM, Ainslie KM.

ACS Appl Mater Interfaces. 2012 Aug;4(8):4149-55. doi: 10.1021/am3008888. Epub 2012 Aug 2.

PMID:
22833690
26.

Synthesis, optimization, and characterization of camptothecin-loaded acetalated dextran porous microparticles for pulmonary delivery.

Meenach SA, Kim YJ, Kauffman KJ, Kanthamneni N, Bachelder EM, Ainslie KM.

Mol Pharm. 2012 Feb 6;9(2):290-8. doi: 10.1021/mp2003785. Epub 2012 Jan 13.

PMID:
22149217
27.

Optimization of rapamycin-loaded acetalated dextran microparticles for immunosuppression.

Kauffman KJ, Kanthamneni N, Meenach SA, Pierson BC, Bachelder EM, Ainslie KM.

Int J Pharm. 2012 Jan 17;422(1-2):356-63. doi: 10.1016/j.ijpharm.2011.10.034. Epub 2011 Oct 21.

PMID:
22037446
28.

A stripe-to-droplet transition driven by conformational transitions in a binary lipid-lipopolymer mixture at the air-water interface.

El-Khouri RJ, Frey SL, Szmodis AW, Hall E, Kauffman KJ, Patten TE, Lee KY, Parikh AN.

Langmuir. 2011 Mar 1;27(5):1900-6. doi: 10.1021/la104175f. Epub 2011 Jan 18.

PMID:
21244080
29.

Designing experiments that aid in the identification of regulatory networks.

Kauffman KJ, Ogunnaike BA, Edwards JS.

Brief Funct Genomic Proteomic. 2006 Feb;4(4):331-42. Epub 2006 Feb 10.

PMID:
17202124
30.

Advances in flux balance analysis.

Kauffman KJ, Prakash P, Edwards JS.

Curr Opin Biotechnol. 2003 Oct;14(5):491-6.

PMID:
14580578
31.
32.

Decreased protein expression and intermittent recoveries in BiP levels result from cellular stress during heterologous protein expression in Saccharomyces cerevisiae.

Kauffman KJ, Pridgen EM, Doyle FJ 3rd, Dhurjati PS, Robinson AS.

Biotechnol Prog. 2002 Sep-Oct;18(5):942-50.

PMID:
12363344
33.

Description and analysis of metabolic connectivity and dynamics in the human red blood cell.

Kauffman KJ, Pajerowski JD, Jamshidi N, Palsson BO, Edwards JS.

Biophys J. 2002 Aug;83(2):646-62.

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