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Items: 1 to 50 of 465

1.

Selective Non-nuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.

Selvaraj UM, Zuurbier K, Whoolery C, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM.

Endocrinology. 2018 Sep 25. doi: 10.1210/en.2018-00600. [Epub ahead of print]

PMID:
30256928
2.

Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer.

Zhou D, Xu J, Mpoy C, Chu W, Kim SH, Li H, Rogers BE, Katzenellenbogen JA.

Nucl Med Biol. 2018 Aug 24;66:26-31. doi: 10.1016/j.nucmedbio.2018.08.003. [Epub ahead of print]

PMID:
30195072
3.

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.

Katzenellenbogen JA, Mayne CG, Katzenellenbogen BS, Greene GL, Chandarlapaty S.

Nat Rev Cancer. 2018 Oct;18(10):662. doi: 10.1038/s41568-018-0053-0.

PMID:
30185950
4.

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.

Bononi G, Granchi C, Lapillo M, Giannotti M, Nieri D, Fortunato S, Boustani ME, Caligiuri I, Poli G, Carlson KE, Kim SH, Macchia M, Martinelli A, Rizzolio F, Chicca A, Katzenellenbogen JA, Minutolo F, Tuccinardi T.

Eur J Med Chem. 2018 Sep 5;157:817-836. doi: 10.1016/j.ejmech.2018.08.038. Epub 2018 Aug 16.

PMID:
30144699
5.

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons.

Wang L, Guillen VS, Sharma N, Flessa K, Min J, Carlson KE, Toy W, Braqi S, Katzenellenbogen BS, Katzenellenbogen JA, Chandarlapaty S, Sharma A.

ACS Med Chem Lett. 2018 Jul 5;9(8):803-808. doi: 10.1021/acsmedchemlett.8b00106. eCollection 2018 Aug 9.

PMID:
30128071
6.

Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure-Activity Relationships Governing Pan- and Selective Signaling Inhibitors.

Pollock JA, Sharma N, Ippagunta SK, Redecke V, Häcker H, Katzenellenbogen JA.

ChemMedChem. 2018 Aug 16. doi: 10.1002/cmdc.201800417. [Epub ahead of print]

PMID:
30117269
7.

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.

Ippagunta SK, Pollock JA, Sharma N, Lin W, Chen T, Tawaratsumida K, High AA, Min J, Chen Y, Guy RK, Redecke V, Katzenellenbogen JA, Häcker H.

Sci Signal. 2018 Aug 14;11(543). pii: eaaq1077. doi: 10.1126/scisignal.aaq1077.

PMID:
30108181
8.

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety.

Guivarc'h E, Buscato M, Guihot AL, Favre J, Vessières E, Grimaud L, Wakim J, Melhem NJ, Zahreddine R, Adlanmerini M, Loufrani L, Knauf C, Katzenellenbogen JA, Katzenellenbogen BS, Foidart JM, Gourdy P, Lenfant F, Arnal JF, Henrion D, Fontaine C.

J Am Heart Assoc. 2018 Jun 29;7(13). pii: e008950. doi: 10.1161/JAHA.118.008950.

9.

Increase in chemokine CXCL1 by ERβ ligand treatment is a key mediator in promoting axon myelination.

Karim H, Kim SH, Lapato AS, Yasui N, Katzenellenbogen JA, Tiwari-Woodruff SK.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6291-6296. doi: 10.1073/pnas.1721732115. Epub 2018 May 29.

10.

Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community.

Chen KLA, Liu X, Zhao YC, Hieronymi K, Rossi G, Auvil LS, Welge M, Bushell C, Smith RL, Carlson KE, Kim SH, Katzenellenbogen JA, Miller MJ, Madak-Erdogan Z.

Sci Rep. 2018 May 25;8(1):8166. doi: 10.1038/s41598-018-26506-1.

11.

Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells.

Amzaleg Y, Ji J, Kittivanichkul D, E Törnqvist A, Windahl S, Sabag E, Khalid AB, Sternberg H, West M, Katzenellenbogen JA, Krum SA, Chimge NO, Schones DE, Gabet Y, Ohlsson C, Frenkel B.

J Steroid Biochem Mol Biol. 2018 Oct;183:10-17. doi: 10.1016/j.jsbmb.2018.05.002. Epub 2018 May 8.

PMID:
29751107
12.

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.

Katzenellenbogen JA, Mayne CG, Katzenellenbogen BS, Greene GL, Chandarlapaty S.

Nat Rev Cancer. 2018 Jun;18(6):377-388. doi: 10.1038/s41568-018-0001-z. Review. Erratum in: Nat Rev Cancer. 2018 Oct;18(10):662.

PMID:
29662238
13.

Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation.

Vinel A, Coudert AE, Buscato M, Valera MC, Ostertag A, Katzenellenbogen JA, Katzenellenbogen BS, Berdal A, Babajko S, Arnal JF, Fontaine C.

J Bone Miner Res. 2018 Aug;33(8):1520-1531. doi: 10.1002/jbmr.3434. Epub 2018 May 15.

PMID:
29624728
14.

Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice.

Miranda CL, Johnson LA, de Montgolfier O, Elias VD, Ullrich LS, Hay JJ, Paraiso IL, Choi J, Reed RL, Revel JS, Kioussi C, Bobe G, Iwaniec UT, Turner RT, Katzenellenbogen BS, Katzenellenbogen JA, Blakemore PR, Gombart AF, Maier CS, Raber J, Stevens JF.

Sci Rep. 2018 Jan 12;8(1):613. doi: 10.1038/s41598-017-18992-6.

15.

Effects of Exposure to the Endocrine-Disrupting Chemical Bisphenol A During Critical Windows of Murine Pituitary Development.

Eckstrum KS, Edwards W, Banerjee A, Wang W, Flaws JA, Katzenellenbogen JA, Kim SH, Raetzman LT.

Endocrinology. 2018 Jan 1;159(1):119-131. doi: 10.1210/en.2017-00565.

PMID:
29092056
16.

Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors.

Zhao Y, Laws MJ, Guillen VS, Ziegler Y, Min J, Sharma A, Kim SH, Chu D, Park BH, Oesterreich S, Mao C, Shapiro DJ, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS.

Cancer Res. 2017 Oct 15;77(20):5602-5613. doi: 10.1158/0008-5472.CAN-17-1265. Epub 2017 Sep 13.

17.

17β-Estradiol Dysregulates Innate Immune Responses to Pseudomonas aeruginosa Respiratory Infection and Is Modulated by Estrogen Receptor Antagonism.

Abid S, Xie S, Bose M, Shaul PW, Terada LS, Brody SL, Thomas PJ, Katzenellenbogen JA, Kim SH, Greenberg DE, Jain R.

Infect Immun. 2017 Sep 20;85(10). pii: e00422-17. doi: 10.1128/IAI.00422-17. Print 2017 Oct.

18.

Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.

Min J, Guillen VS, Sharma A, Zhao Y, Ziegler Y, Gong P, Mayne CG, Srinivasan S, Kim SH, Carlson KE, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA.

J Med Chem. 2017 Jul 27;60(14):6321-6336. doi: 10.1021/acs.jmedchem.7b00585. Epub 2017 Jul 14.

19.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691c. No abstract available.

PMID:
28514424
20.

Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691b. No abstract available.

PMID:
28514419
21.

Evaluation of aromatic radiobromination by nucleophilic substitution using diaryliodonium salt precursors.

Zhou D, Kim SH, Chu W, Voller T, Katzenellenbogen JA.

J Labelled Comp Radiopharm. 2017 Jul;60(9):450-456. doi: 10.1002/jlcr.3519. Epub 2017 Jun 14.

22.

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.

Menazza S, Sun J, Appachi S, Chambliss KL, Kim SH, Aponte A, Khan S, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW, Murphy E.

J Mol Cell Cardiol. 2017 Jun;107:41-51. doi: 10.1016/j.yjmcc.2017.04.004. Epub 2017 Apr 27.

23.

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.

Madak-Erdogan Z, Charn TH, Jiang Y, Liu ET, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Syst Biol. 2017 Apr 25;13(4):929. doi: 10.15252/msb.20177595. No abstract available.

24.

Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

Stender JD, Nwachukwu JC, Kastrati I, Kim Y, Strid T, Yakir M, Srinivasan S, Nowak J, Izard T, Rangarajan ES, Carlson KE, Katzenellenbogen JA, Yao XQ, Grant BJ, Leong HS, Lin CY, Frasor J, Nettles KW, Glass CK.

Mol Cell. 2017 Mar 16;65(6):1122-1135.e5. doi: 10.1016/j.molcel.2017.02.008.

25.

Estrogens and androgens inhibit association of RANKL with the pre-osteoblast membrane through post-translational mechanisms.

Martin A, Yu J, Xiong J, Khalid AB, Katzenellenbogen B, Kim SH, Katzenellenbogen JA, Malaivijitnond S, Gabet Y, Krum SA, Frenkel B.

J Cell Physiol. 2017 Dec;232(12):3798-3807. doi: 10.1002/jcp.25862. Epub 2017 May 11.

26.

MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.

Christenson JL, Butterfield KT, Spoelstra NS, Norris JD, Josan JS, Pollock JA, McDonnell DP, Katzenellenbogen BS, Katzenellenbogen JA, Richer JK.

Horm Cancer. 2017 Apr;8(2):69-77. doi: 10.1007/s12672-017-0285-6. Epub 2017 Feb 13.

27.

Extra-nuclear effects of estrogen on cortical bone in males require ERαAF-1.

Farman HH, Wu J, Gustafsson KL, Windahl SH, Kim SH, Katzenellenbogen JA, Ohlsson C, Lagerquist MK.

J Mol Endocrinol. 2017 Feb;58(2):105-111. doi: 10.1530/JME-16-0209. Epub 2017 Jan 5.

28.

Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

Nwachukwu JC, Srinivasan S, Bruno NE, Nowak J, Wright NJ, Minutolo F, Rangarajan ES, Izard T, Yao XQ, Grant BJ, Kojetin DJ, Elemento O, Katzenellenbogen JA, Nettles KW.

Cell Chem Biol. 2017 Jan 19;24(1):35-45. doi: 10.1016/j.chembiol.2016.11.014. Epub 2016 Dec 29.

29.

Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands.

Sharma N, Carlson KE, Nwachukwu JC, Srinivasan S, Sharma A, Nettles KW, Katzenellenbogen JA.

ACS Chem Biol. 2017 Feb 17;12(2):494-503. doi: 10.1021/acschembio.6b00918. Epub 2016 Dec 29.

30.

Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists.

Toy W, Weir H, Razavi P, Lawson M, Goeppert AU, Mazzola AM, Smith A, Wilson J, Morrow C, Wong WL, De Stanchina E, Carlson KE, Martin TS, Uddin S, Li Z, Fanning S, Katzenellenbogen JA, Greene G, Baselga J, Chandarlapaty S.

Cancer Discov. 2017 Mar;7(3):277-287. doi: 10.1158/2159-8290.CD-15-1523. Epub 2016 Dec 16.

31.

Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands.

Zhang S, Wang Z, Hu Z, Li C, Tang C, Carlson KE, Luo J, Dong C, Katzenellenbogen JA, Huang J, Zhou HB.

ChemMedChem. 2017 Feb 3;12(3):235-249. doi: 10.1002/cmdc.201600593. Epub 2017 Jan 9.

32.

Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 Jan;13(1):111-118. doi: 10.1038/nchembio.2236. Epub 2016 Nov 21. Erratum in: Nat Chem Biol. 2017 May 17;13(6):691. Nat Chem Biol. 2017 May 17;13(6):691.

33.

Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.

Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW.

Endocrinology. 2016 Oct;157(10):3731-3741. Epub 2016 Aug 23.

34.

Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells.

Gong P, Madak-Erdogan Z, Flaws JA, Shapiro DJ, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Cell Endocrinol. 2016 Dec 5;437:190-200. doi: 10.1016/j.mce.2016.08.025. Epub 2016 Aug 16.

35.

Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.

Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD.

Nat Chem Biol. 2016 Oct;12(10):795-801. doi: 10.1038/nchembio.2131. Epub 2016 Aug 8.

36.

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.

Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS.

Sci Signal. 2016 May 24;9(429):ra53. doi: 10.1126/scisignal.aad8170.

37.

Science Signaling podcast for 24 May 2016: Designer estrogens.

Katzenellenbogen BS, Katzenellenbogen JA, Madak-Erdogan Z, VanHook AM.

Sci Signal. 2016 May 24;9(429):pc12. doi: 10.1126/scisignal.aag1040.

PMID:
27221709
38.

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.

Granchi C, Lapillo M, Spena CR, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F.

ChemMedChem. 2016 Aug 19;11(16):1752-61. doi: 10.1002/cmdc.201600140. Epub 2016 May 2.

39.

Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.

Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F.

Cell Metab. 2016 May 10;23(5):837-51. doi: 10.1016/j.cmet.2016.03.015. Epub 2016 Apr 28.

40.

Predictive features of ligand-specific signaling through the estrogen receptor.

Nwachukwu JC, Srinivasan S, Zheng Y, Wang S, Min J, Dong C, Liao Z, Nowak J, Wright NJ, Houtman R, Carlson KE, Josan JS, Elemento O, Katzenellenbogen JA, Zhou HB, Nettles KW.

Mol Syst Biol. 2016 Apr 22;12(4):864. doi: 10.15252/msb.20156701.

41.

Facile purification and click labeling with 2-[18F]fluoroethyl azide using solid phase extraction cartridges.

Zhou D, Chu W, Peng X, McConathy J, Mach RH, Katzenellenbogen JA.

Tetrahedron Lett. 2015 Feb 7;56(7):952-954. Epub 2014 Nov 4.

42.

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL.

Elife. 2016 Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792.

43.

Imaging Diagnostic and Therapeutic Targets: Steroid Receptors in Breast Cancer.

Fowler AM, Clark AS, Katzenellenbogen JA, Linden HM, Dehdashti F.

J Nucl Med. 2016 Feb;57 Suppl 1:75S-80S. doi: 10.2967/jnumed.115.157933. Review.

44.

Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.

Xiong R, Patel HK, Gutgesell LM, Zhao J, Delgado-Rivera L, Pham TND, Zhao H, Carlson K, Martin T, Katzenellenbogen JA, Moore TW, Tonetti DA, Thatcher GRJ.

J Med Chem. 2016 Jan 14;59(1):219-237. doi: 10.1021/acs.jmedchem.5b01276. Epub 2015 Dec 30.

45.

Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis.

Zhao Y, Chen Y, Kuang Y, Bagchi MK, Taylor RN, Katzenellenbogen JA, Katzenellenbogen BS.

Endocrinology. 2016 Feb;157(2):900-12. doi: 10.1210/en.2015-1324. Epub 2015 Dec 14.

46.

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.

Boonmuen N, Gong P, Ali Z, Chittiboyina AG, Khan I, Doerge DR, Helferich WG, Carlson KE, Martin T, Piyachaturawat P, Katzenellenbogen JA, Katzenellenbogen BS.

Steroids. 2016 Jan;105:42-9. doi: 10.1016/j.steroids.2015.11.006. Epub 2015 Nov 26.

47.

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland.

Madak-Erdogan Z, Gong P, Zhao YC, Xu L, Wrobel KU, Hartman JA, Wang M, Cam A, Iwaniec UT, Turner RT, Twaddle NC, Doerge DR, Khan IA, Katzenellenbogen JA, Katzenellenbogen BS, Helferich WG.

Mol Nutr Food Res. 2016 Feb;60(2):369-80. doi: 10.1002/mnfr.201500445. Epub 2015 Nov 10.

48.

Preparation of o-Fluorophenols from Nonaromatic Precursors: Mechanistic Considerations for Adaptation to Fluorine-18 Radiolabeling.

Yasui N, Mayne CG, Katzenellenbogen JA.

Org Lett. 2015 Nov 20;17(22):5540-3. doi: 10.1021/acs.orglett.5b02640. Epub 2015 Nov 4.

49.

Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles.

Pollock JA, Kim SH, Katzenellenbogen JA.

Tetrahedron Lett. 2015 Oct 28;56(44):6097-6099.

50.

Estrogen Receptor-Selective Agonists Modulate Learning in Female Rats in a Dose- and Task-Specific Manner.

Pisani SL, Neese SL, Katzenellenbogen JA, Schantz SL, Korol DL.

Endocrinology. 2016 Jan;157(1):292-303. doi: 10.1210/en.2015-1616. Epub 2015 Oct 14.

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