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Items: 1 to 50 of 342

1.

Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain.

Sharma A, Toy W, Guillen VS, Sharma N, Min J, Carlson KE, Mayne CG, Lin S, Sabio M, Greene G, Katzenellenbogen BS, Chandarlapaty S, Katzenellenbogen JA.

ACS Chem Biol. 2018 Dec 21;13(12):3374-3384. doi: 10.1021/acschembio.8b00877. Epub 2018 Nov 26.

PMID:
30404440
2.

Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.

Selvaraj UM, Zuurbier KR, Whoolery CW, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM.

Endocrinology. 2018 Nov 1;159(11):3848-3859. doi: 10.1210/en.2018-00600.

PMID:
30256928
3.

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.

Katzenellenbogen JA, Mayne CG, Katzenellenbogen BS, Greene GL, Chandarlapaty S.

Nat Rev Cancer. 2018 Oct;18(10):662. doi: 10.1038/s41568-018-0053-0.

PMID:
30185950
4.

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons.

Wang L, Guillen VS, Sharma N, Flessa K, Min J, Carlson KE, Toy W, Braqi S, Katzenellenbogen BS, Katzenellenbogen JA, Chandarlapaty S, Sharma A.

ACS Med Chem Lett. 2018 Jul 5;9(8):803-808. doi: 10.1021/acsmedchemlett.8b00106. eCollection 2018 Aug 9.

PMID:
30128071
5.

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety.

Guivarc'h E, Buscato M, Guihot AL, Favre J, Vessières E, Grimaud L, Wakim J, Melhem NJ, Zahreddine R, Adlanmerini M, Loufrani L, Knauf C, Katzenellenbogen JA, Katzenellenbogen BS, Foidart JM, Gourdy P, Lenfant F, Arnal JF, Henrion D, Fontaine C.

J Am Heart Assoc. 2018 Jun 29;7(13). pii: e008950. doi: 10.1161/JAHA.118.008950.

6.

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.

Katzenellenbogen JA, Mayne CG, Katzenellenbogen BS, Greene GL, Chandarlapaty S.

Nat Rev Cancer. 2018 Jun;18(6):377-388. doi: 10.1038/s41568-018-0001-z. Review. Erratum in: Nat Rev Cancer. 2018 Oct;18(10):662.

7.

Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation.

Vinel A, Coudert AE, Buscato M, Valera MC, Ostertag A, Katzenellenbogen JA, Katzenellenbogen BS, Berdal A, Babajko S, Arnal JF, Fontaine C.

J Bone Miner Res. 2018 Aug;33(8):1520-1531. doi: 10.1002/jbmr.3434. Epub 2018 May 15.

8.

Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice.

Miranda CL, Johnson LA, de Montgolfier O, Elias VD, Ullrich LS, Hay JJ, Paraiso IL, Choi J, Reed RL, Revel JS, Kioussi C, Bobe G, Iwaniec UT, Turner RT, Katzenellenbogen BS, Katzenellenbogen JA, Blakemore PR, Gombart AF, Maier CS, Raber J, Stevens JF.

Sci Rep. 2018 Jan 12;8(1):613. doi: 10.1038/s41598-017-18992-6.

9.

Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors.

Zhao Y, Laws MJ, Guillen VS, Ziegler Y, Min J, Sharma A, Kim SH, Chu D, Park BH, Oesterreich S, Mao C, Shapiro DJ, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS.

Cancer Res. 2017 Oct 15;77(20):5602-5613. doi: 10.1158/0008-5472.CAN-17-1265. Epub 2017 Sep 13.

10.

Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.

Min J, Guillen VS, Sharma A, Zhao Y, Ziegler Y, Gong P, Mayne CG, Srinivasan S, Kim SH, Carlson KE, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA.

J Med Chem. 2017 Jul 27;60(14):6321-6336. doi: 10.1021/acs.jmedchem.7b00585. Epub 2017 Jul 14.

11.

Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer.

Lu W, Katzenellenbogen BS.

Horm Cancer. 2017 Aug;8(4):230-242. doi: 10.1007/s12672-017-0298-1. Epub 2017 Jun 2.

12.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691c. No abstract available.

PMID:
28514424
13.

Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691b. No abstract available.

PMID:
28514419
14.

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.

Menazza S, Sun J, Appachi S, Chambliss KL, Kim SH, Aponte A, Khan S, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW, Murphy E.

J Mol Cell Cardiol. 2017 Jun;107:41-51. doi: 10.1016/j.yjmcc.2017.04.004. Epub 2017 Apr 27.

15.

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.

Madak-Erdogan Z, Charn TH, Jiang Y, Liu ET, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Syst Biol. 2017 Apr 25;13(4):929. doi: 10.15252/msb.20177595. No abstract available.

16.

MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.

Christenson JL, Butterfield KT, Spoelstra NS, Norris JD, Josan JS, Pollock JA, McDonnell DP, Katzenellenbogen BS, Katzenellenbogen JA, Richer JK.

Horm Cancer. 2017 Apr;8(2):69-77. doi: 10.1007/s12672-017-0285-6. Epub 2017 Feb 13.

17.

Corrigendum to "Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity" [Mol. Cell Endocrinol. 440 (2016) 138-150].

Nelson AW, Groen AJ, Miller JL, Warren AY, Holmes KA, Tarulli GA, Tilley WD, Katzenellenbogen BS, Hawse JR, Gnanapragasam VJ, Carroll JS.

Mol Cell Endocrinol. 2017 Mar 5;443:175. doi: 10.1016/j.mce.2017.01.048. No abstract available.

PMID:
28183459
18.

Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity.

Nelson AW, Groen AJ, Miller JL, Warren AY, Holmes KA, Tarulli GA, Tilley WD, Katzenellenbogen BS, Hawse JR, Gnanapragasam VJ, Carroll JS.

Mol Cell Endocrinol. 2017 Jan 15;440:138-150. doi: 10.1016/j.mce.2016.11.016. Epub 2016 Nov 23. Erratum in: Mol Cell Endocrinol. 2017 Mar 5;443:175.

19.

Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 Jan;13(1):111-118. doi: 10.1038/nchembio.2236. Epub 2016 Nov 21. Erratum in: Nat Chem Biol. 2017 May 17;13(6):691. Nat Chem Biol. 2017 May 17;13(6):691.

20.

OCT-4: a novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells.

Bhatt S, Stender JD, Joshi S, Wu G, Katzenellenbogen BS.

Oncogene. 2016 Nov 3;35(44):5722-5734. doi: 10.1038/onc.2016.105. Epub 2016 Apr 11.

PMID:
27065334
21.

Endocrine treatment in breast cancer: Cure, resistance and beyond.

Tryfonidis K, Zardavas D, Katzenellenbogen BS, Piccart M.

Cancer Treat Rev. 2016 Nov;50:68-81. doi: 10.1016/j.ctrv.2016.08.008. Epub 2016 Sep 7. Review.

PMID:
27643748
22.

Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.

Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW.

Endocrinology. 2016 Oct;157(10):3731-3741. Epub 2016 Aug 23.

23.

Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells.

Gong P, Madak-Erdogan Z, Flaws JA, Shapiro DJ, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Cell Endocrinol. 2016 Dec 5;437:190-200. doi: 10.1016/j.mce.2016.08.025. Epub 2016 Aug 16.

24.

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.

Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS.

Sci Signal. 2016 May 24;9(429):ra53. doi: 10.1126/scisignal.aad8170.

25.

Science Signaling podcast for 24 May 2016: Designer estrogens.

Katzenellenbogen BS, Katzenellenbogen JA, Madak-Erdogan Z, VanHook AM.

Sci Signal. 2016 May 24;9(429):pc12. doi: 10.1126/scisignal.aag1040.

PMID:
27221709
26.

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL.

Elife. 2016 Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792.

27.

Differential utilization of nuclear and extranuclear receptor signaling pathways in the actions of estrogens, SERMs, and a tissue-selective estrogen complex (TSEC).

Madak-Erdogan Z, Gong P, Katzenellenbogen BS.

J Steroid Biochem Mol Biol. 2016 Apr;158:198-206. doi: 10.1016/j.jsbmb.2015.12.008. Epub 2015 Dec 12.

PMID:
26689478
28.

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.

Aumsuwan P, Khan SI, Khan IA, Ali Z, Avula B, Walker LA, Shariat-Madar Z, Helferich WG, Katzenellenbogen BS, Dasmahapatra AK.

Arch Biochem Biophys. 2016 Feb 1;591:98-110. doi: 10.1016/j.abb.2015.12.001. Epub 2015 Dec 10.

PMID:
26682631
29.

Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis.

Zhao Y, Chen Y, Kuang Y, Bagchi MK, Taylor RN, Katzenellenbogen JA, Katzenellenbogen BS.

Endocrinology. 2016 Feb;157(2):900-12. doi: 10.1210/en.2015-1324. Epub 2015 Dec 14.

30.

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.

Boonmuen N, Gong P, Ali Z, Chittiboyina AG, Khan I, Doerge DR, Helferich WG, Carlson KE, Martin T, Piyachaturawat P, Katzenellenbogen JA, Katzenellenbogen BS.

Steroids. 2016 Jan;105:42-9. doi: 10.1016/j.steroids.2015.11.006. Epub 2015 Nov 26.

31.

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland.

Madak-Erdogan Z, Gong P, Zhao YC, Xu L, Wrobel KU, Hartman JA, Wang M, Cam A, Iwaniec UT, Turner RT, Twaddle NC, Doerge DR, Khan IA, Katzenellenbogen JA, Katzenellenbogen BS, Helferich WG.

Mol Nutr Food Res. 2016 Feb;60(2):369-80. doi: 10.1002/mnfr.201500445. Epub 2015 Nov 10.

32.

Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination.

Poitelon Y, Bogni S, Matafora V, Della-Flora Nunes G, Hurley E, Ghidinelli M, Katzenellenbogen BS, Taveggia C, Silvestri N, Bachi A, Sannino A, Wrabetz L, Feltri ML.

Nat Commun. 2015 Sep 18;6:8303. doi: 10.1038/ncomms9303.

33.

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.

Smirnova NF, Fontaine C, Buscato M, Lupieri A, Vinel A, Valera MC, Guillaume M, Malet N, Foidart JM, Raymond-Letron I, Lenfant F, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Laffargue M, Arnal JF.

Circ Res. 2015 Oct 9;117(9):770-8. doi: 10.1161/CIRCRESAHA.115.306416. Epub 2015 Aug 27.

34.

Protective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor α.

Valéra MC, Fontaine C, Lenfant F, Cabou C, Guillaume M, Smirnova N, Kim SH, Chambon P, Katzenellenbogen JA, Katzenellenbogen BS, Payrastre B, Arnal JF.

Endocrinology. 2015 Nov;156(11):4293-301. doi: 10.1210/en.2015-1522. Epub 2015 Aug 17.

35.

Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History.

Kim SH, Madak-Erdogan Z, Bae SC, Carlson KE, Mayne CG, Granick S, Katzenellenbogen BS, Katzenellenbogen JA.

J Am Chem Soc. 2015 Aug 19;137(32):10326-35. doi: 10.1021/jacs.5b05952. Epub 2015 Aug 10.

36.

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.

Zhao Y, Gong P, Chen Y, Nwachukwu JC, Srinivasan S, Ko C, Bagchi MK, Taylor RN, Korach KS, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS.

Sci Transl Med. 2015 Jan 21;7(271):271ra9. doi: 10.1126/scitranslmed.3010626. Erratum in: Sci Transl Med. 2015 Feb 11;7(274):274er1.

37.

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model.

Paterni I, Bertini S, Granchi C, Tuccinardi T, Macchia M, Martinelli A, Caligiuri I, Toffoli G, Rizzolio F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Minutolo F.

J Med Chem. 2015 Feb 12;58(3):1184-94. doi: 10.1021/jm501829f. Epub 2015 Jan 14.

38.

Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens.

Gong P, Madak-Erdogan Z, Li J, Cheng J, Greenlief CM, Helferich W, Katzenellenbogen JA, Katzenellenbogen BS.

Nucl Recept Signal. 2014 Sep 12;12:e001. doi: 10.1621/nrs.12001. eCollection 2014.

39.

Estrogen-induced CCN1 is critical for establishment of endometriosis-like lesions in mice.

Zhao Y, Li Q, Katzenellenbogen BS, Lau LF, Taylor RN, Bagchi IC, Bagchi MK.

Mol Endocrinol. 2014 Dec;28(12):1934-47. doi: 10.1210/me.2014-1080.

40.

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.

Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF.

EMBO Mol Med. 2014 Oct;6(10):1328-46. doi: 10.15252/emmm.201404112.

41.

The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells.

Bergamaschi A, Madak-Erdogan Z, Kim YJ, Choi YL, Lu H, Katzenellenbogen BS.

Breast Cancer Res. 2014 Sep 12;16(5):436. doi: 10.1186/s13058-014-0436-4.

42.

Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells.

Aumsuwan P, Khan SI, Khan IA, Avula B, Walker LA, Helferich WG, Katzenellenbogen BS, Dasmahapatra AK.

In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):59-71. doi: 10.1007/s11626-014-9807-5. Epub 2014 Aug 23.

PMID:
25148825
43.

Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer.

Holton SE, Bergamaschi A, Katzenellenbogen BS, Bhargava R.

PLoS One. 2014 May 9;9(5):e96878. doi: 10.1371/journal.pone.0096878. eCollection 2014.

44.

Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response.

Mir M, Bergamaschi A, Katzenellenbogen BS, Popescu G.

PLoS One. 2014 Feb 18;9(2):e89000. doi: 10.1371/journal.pone.0089000. eCollection 2014.

45.

Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer.

Madak-Erdogan Z, Ventrella R, Petry L, Katzenellenbogen BS.

Mol Cancer Res. 2014 May;12(5):714-27. doi: 10.1158/1541-7786.MCR-13-0588. Epub 2014 Feb 6.

46.

Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells.

Clark S, Rainville J, Zhao X, Katzenellenbogen BS, Pfaff D, Vasudevan N.

J Steroid Biochem Mol Biol. 2014 Jan;139:45-53. doi: 10.1016/j.jsbmb.2013.09.010. Epub 2013 Oct 10.

PMID:
24121066
47.

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens.

Jiang Y, Gong P, Madak-Erdogan Z, Martin T, Jeyakumar M, Carlson K, Khan I, Smillie TJ, Chittiboyina AG, Rotte SC, Helferich WG, Katzenellenbogen JA, Katzenellenbogen BS.

FASEB J. 2013 Nov;27(11):4406-18. doi: 10.1096/fj.13-234617. Epub 2013 Jul 23.

48.

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.

Madak-Erdogan Z, Charn TH, Jiang Y, Liu ET, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Syst Biol. 2013 Jun 18;9:676. doi: 10.1038/msb.2013.28. Erratum in: Mol Syst Biol. 2017 Apr 25;13(4):929.

49.

Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.

Bartell SM, Han L, Kim HN, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Chambliss KL, Shaul PW, Roberson PK, Weinstein RS, Jilka RL, Almeida M, Manolagas SC.

Mol Endocrinol. 2013 Apr;27(4):649-56. doi: 10.1210/me.2012-1368. Epub 2013 Feb 26.

50.

The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization.

Zhao Y, Park S, Bagchi MK, Taylor RN, Katzenellenbogen BS.

Endocrinology. 2013 Mar;154(3):1349-60. doi: 10.1210/en.2012-2026. Epub 2013 Feb 7.

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