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Items: 1 to 50 of 100

1.

Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor.

Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V.

Nature. 2019 May;569(7756):E6. doi: 10.1038/s41586-019-1209-0.

PMID:
31048811
2.

Structural basis of ligand recognition at the human MT1 melatonin receptor.

Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V.

Nature. 2019 May;569(7755):284-288. doi: 10.1038/s41586-019-1141-3. Epub 2019 Apr 24. Erratum in: Nature. 2019 May 3;:.

PMID:
31019306
3.

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity.

Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V.

Nature. 2019 May;569(7755):289-292. doi: 10.1038/s41586-019-1144-0. Epub 2019 Apr 24.

PMID:
31019305
4.

Computational design for thermostabilization of GPCRs.

Popov P, Kozlovskii I, Katritch V.

Curr Opin Struct Biol. 2019 Mar 22;55:25-33. doi: 10.1016/j.sbi.2019.02.010. [Epub ahead of print] Review.

PMID:
30909106
5.

Crystal Structure of the Human Cannabinoid Receptor CB2.

Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.

Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10.

PMID:
30639103
6.

Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC.

Nat Chem Biol. 2019 Feb;15(2):206. doi: 10.1038/s41589-018-0214-1.

PMID:
30573766
7.

Exploring Pairwise Chemical Crosslinking To Study Peptide-Receptor Interactions.

Seidel L, Zarzycka B, Katritch V, Coin I.

Chembiochem. 2019 Mar 1;20(5):683-692. doi: 10.1002/cbic.201800582. Epub 2019 Jan 25.

PMID:
30565820
8.

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC.

Nat Chem Biol. 2019 Jan;15(1):11-17. doi: 10.1038/s41589-018-0160-y. Epub 2018 Dec 3. Erratum in: Nat Chem Biol. 2019 Feb;15(2):206.

9.

Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers.

Ye W, Tu YH, Cooper AJ, Zhang Z, Katritch V, Liman ER.

Sci Rep. 2018 Nov 20;8(1):17104. doi: 10.1038/s41598-018-35435-y.

10.

Crystal structure of the Frizzled 4 receptor in a ligand-free state.

Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F.

Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22.

PMID:
30135577
11.

An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction.

Tian C, Kay Y, Sadybekov A, Rao S, Katritch V, Herring BE.

Front Mol Neurosci. 2018 Jul 6;11:223. doi: 10.3389/fnmol.2018.00223. eCollection 2018.

12.

Computational design of thermostabilizing point mutations for G protein-coupled receptors.

Popov P, Peng Y, Shen L, Stevens RC, Cherezov V, Liu ZJ, Katritch V.

Elife. 2018 Jun 21;7. pii: e34729. doi: 10.7554/eLife.34729.

13.

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor.

Eddy MT, Gao ZG, Mannes P, Patel N, Jacobson KA, Katritch V, Stevens RC, Wüthrich K.

J Am Chem Soc. 2018 Jul 5;140(26):8228-8235. doi: 10.1021/jacs.8b03805. Epub 2018 Jun 20.

14.

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ.

Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1.

15.

Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.

White KL, Eddy MT, Gao ZG, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC.

Structure. 2018 Feb 6;26(2):259-269.e5. doi: 10.1016/j.str.2017.12.013. Epub 2018 Jan 27.

16.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL.

Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4.

17.

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist.

Roach JJ, Sasano Y, Schmid CL, Zaidi S, Katritch V, Stevens RC, Bohn LM, Shenvi RA.

ACS Cent Sci. 2017 Dec 27;3(12):1329-1336. doi: 10.1021/acscentsci.7b00488. Epub 2017 Dec 13.

18.

Intracellular Transfer of Na+ in an Active-State G-Protein-Coupled Receptor.

Vickery ON, Carvalheda CA, Zaidi SA, Pisliakov AV, Katritch V, Zachariae U.

Structure. 2018 Jan 2;26(1):171-180.e2. doi: 10.1016/j.str.2017.11.013. Epub 2017 Dec 14.

19.

Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Westphal MV, Schafroth MA, Sarott RC, Imhof MA, Bold CP, Leippe P, Dhopeshwarkar A, Grandner JM, Katritch V, Mackie K, Trauner D, Carreira EM, Frank JA.

J Am Chem Soc. 2017 Dec 20;139(50):18206-18212. doi: 10.1021/jacs.7b06456. Epub 2017 Dec 12.

PMID:
29161035
20.

An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio.

Sadybekov A, Tian C, Arnesano C, Katritch V, Herring BE.

Nat Commun. 2017 Sep 19;8(1):601. doi: 10.1038/s41467-017-00472-0.

21.

Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells.

Seidel L, Zarzycka B, Zaidi SA, Katritch V, Coin I.

Elife. 2017 Aug 3;6. pii: e27711. doi: 10.7554/eLife.27711.

22.

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.

Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8223-8228. doi: 10.1073/pnas.1700891114. Epub 2017 Jul 17.

23.

Structural basis for selectivity and diversity in angiotensin II receptors.

Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V.

Nature. 2017 Apr 20;544(7650):327-332. doi: 10.1038/nature22035. Epub 2017 Apr 5.

24.

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor.

Zheng Z, Huang XP, Mangano TJ, Zou R, Chen X, Zaidi SA, Roth BL, Stevens RC, Katritch V.

J Med Chem. 2017 Apr 13;60(7):3070-3081. doi: 10.1021/acs.jmedchem.7b00109. Epub 2017 Apr 3.

25.

Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.

Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V.

Sci Adv. 2016 Sep 23;2(9):e1600292. eCollection 2016 Sep.

26.

Expression and purification of an engineered human endothelin receptor B in a monomeric form.

Mishin AV, Luginina AP, Potapenko AP, Borshchevskiy VI, Katritch V, Edelweiss E, Okhrimenko IS, Gordeliy VI, Cherezov VG.

Dokl Biochem Biophys. 2016 Mar;467(1):157-61. doi: 10.1134/S1607672916020216. Epub 2016 May 20.

PMID:
27193723
27.

In vitro expression and analysis of the 826 human G protein-coupled receptors.

Lv X, Liu J, Shi Q, Tan Q, Wu D, Skinner JJ, Walker AL, Zhao L, Gu X, Chen N, Xue L, Si P, Zhang L, Wang Z, Katritch V, Liu ZJ, Stevens RC.

Protein Cell. 2016 May;7(5):325-37. doi: 10.1007/s13238-016-0263-8. Epub 2016 Apr 16.

28.

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.

Lamichhane R, Liu JJ, Pljevaljcic G, White KL, van der Schans E, Katritch V, Stevens RC, Wüthrich K, Millar DP.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14254-9. doi: 10.1073/pnas.1519626112. Epub 2015 Nov 2.

29.

The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor.

Miller RL, Thompson AA, Trapella C, Guerrini R, Malfacini D, Patel N, Han GW, Cherezov V, Caló G, Katritch V, Stevens RC.

Structure. 2015 Dec 1;23(12):2291-2299. doi: 10.1016/j.str.2015.07.024. Epub 2015 Oct 29.

30.

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.

Zhang H, Unal H, Desnoyer R, Han GW, Patel N, Katritch V, Karnik SS, Cherezov V, Stevens RC.

J Biol Chem. 2015 Dec 4;290(49):29127-39. doi: 10.1074/jbc.M115.689000. Epub 2015 Sep 29.

31.

Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y₁₄ receptor.

Kiselev E, Balasubramanian R, Uliassi E, Brown KA, Trujillo K, Katritch V, Hammes E, Stevens RC, Harden TK, Jacobson KA.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4733-4739. doi: 10.1016/j.bmcl.2015.08.021. Epub 2015 Aug 10.

32.

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE.

Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22.

33.

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information.

Paoletta S, Sabbadin D, von Kügelgen I, Hinz S, Katritch V, Hoffmann K, Abdelrahman A, Straßburger J, Baqi Y, Zhao Q, Stevens RC, Moro S, Müller CE, Jacobson KA.

J Comput Aided Mol Des. 2015 Aug;29(8):737-56. doi: 10.1007/s10822-015-9858-z. Epub 2015 Jul 21.

34.

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.

Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL.

Chem Biol. 2015 Jun 18;22(6):764-75. doi: 10.1016/j.chembiol.2015.05.012.

35.

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.

Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U, Sawaya MR, Xu Q, Messerschmidt M, Williams GJ, Boutet S, Yefanov OM, White TA, Wang C, Ishchenko A, Tirupula KC, Desnoyer R, Coe J, Conrad CE, Fromme P, Stevens RC, Katritch V, Karnik SS, Cherezov V.

Cell. 2015 May 7;161(4):833-44. doi: 10.1016/j.cell.2015.04.011. Epub 2015 Apr 23.

36.

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function.

Jacobson KA, Paoletta S, Katritch V, Wu B, Gao ZG, Zhao Q, Stevens RC, Kiselev E.

Mol Pharmacol. 2015 Aug;88(2):220-30. doi: 10.1124/mol.114.095711. Epub 2015 Apr 2. Review.

37.

Two disparate ligand-binding sites in the human P2Y1 receptor.

Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B.

Nature. 2015 Apr 16;520(7547):317-21. doi: 10.1038/nature14287. Epub 2015 Mar 30.

38.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V.

Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb 16.

39.

Generic GPCR residue numbers - aligning topology maps while minding the gaps.

Isberg V, de Graaf C, Bortolato A, Cherezov V, Katritch V, Marshall FH, Mordalski S, Pin JP, Stevens RC, Vriend G, Gloriam DE.

Trends Pharmacol Sci. 2015 Jan;36(1):22-31. doi: 10.1016/j.tips.2014.11.001. Epub 2014 Dec 22. Review.

40.

Sodium ion binding pocket mutations and adenosine A2A receptor function.

Massink A, Gutiérrez-de-Terán H, Lenselink EB, Ortiz Zacarías NV, Xia L, Heitman LH, Katritch V, Stevens RC, IJzerman AP.

Mol Pharmacol. 2015 Feb;87(2):305-13. doi: 10.1124/mol.114.095737. Epub 2014 Dec 3. Erratum in: Mol Pharmacol. 2019 Apr;95(4):462.

41.

Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes.

Kiselev E, Barrett MO, Katritch V, Paoletta S, Weitzer CD, Brown KA, Hammes E, Yin AL, Zhao Q, Stevens RC, Harden TK, Jacobson KA.

ACS Chem Biol. 2014 Dec 19;9(12):2833-42. doi: 10.1021/cb500614p. Epub 2014 Oct 20.

42.

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges.

Kufareva I, Katritch V; Participants of GPCR Dock 2013, Stevens RC, Abagyan R.

Structure. 2014 Aug 5;22(8):1120-1139. doi: 10.1016/j.str.2014.06.012. Epub 2014 Jul 24.

43.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC.

Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355.

44.

Agonist-bound structure of the human P2Y12 receptor.

Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q.

Nature. 2014 May 1;509(7498):119-22. doi: 10.1038/nature13288.

45.

Allosteric sodium in class A GPCR signaling.

Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC.

Trends Biochem Sci. 2014 May;39(5):233-44. doi: 10.1016/j.tibs.2014.03.002. Epub 2014 Apr 21.

46.

Structure of the human P2Y12 receptor in complex with an antithrombotic drug.

Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W, Fenalti G, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q.

Nature. 2014 May 1;509(7498):115-8. doi: 10.1038/nature13083. Epub 2014 Mar 23.

47.

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.

Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC.

Science. 2014 Apr 4;344(6179):58-64. doi: 10.1126/science.1249489. Epub 2014 Mar 6.

48.

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.

Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V.

Nat Commun. 2014;5:3309. doi: 10.1038/ncomms4309.

49.

Molecular control of δ-opioid receptor signalling.

Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC.

Nature. 2014 Feb 13;506(7487):191-6. doi: 10.1038/nature12944. Epub 2014 Jan 12.

50.

Serial femtosecond crystallography of G protein-coupled receptors.

Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah ST, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JC, Stevens RC, Cherezov V.

Science. 2013 Dec 20;342(6165):1521-4. doi: 10.1126/science.1244142.

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