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Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.

Sharma RK, Oliveira AC, Kim S, Rigatto K, Zubcevic J, Rathinasabapathy A, Kumar A, Lebowitz JJ, Khoshbouei H, Lobaton G, Aquino V, Richards EM, Katovich MJ, Shenoy V, Raizada MK.

Hypertension. 2018 Jun;71(6):1156-1163. doi: 10.1161/HYPERTENSIONAHA.118.10934. Epub 2018 Apr 30.


The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.

Rathinasabapathy A, Horowitz A, Horton K, Kumar A, Gladson S, Unger T, Martinez D, Bedse G, West J, Raizada MK, Steckelings UM, Sumners C, Katovich MJ, Shenoy V.

Front Physiol. 2018 Mar 27;9:180. doi: 10.3389/fphys.2018.00180. eCollection 2018.


Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice.

Wang LA, de Kloet AD, Smeltzer MD, Cahill KM, Hiller H, Bruce EB, Pioquinto DJ, Ludin JA, Katovich MJ, Raizada MK, Krause EG.

Neuropharmacology. 2018 May 1;133:85-93. doi: 10.1016/j.neuropharm.2018.01.025.


Beneficial Effects of Angiotensin-(1-7) on CD34+ Cells From Patients With Heart Failure.

Cole-Jeffrey CT, Pepine CJ, Katovich MJ, Grant MB, Raizada MK, Hazra S.

J Cardiovasc Pharmacol. 2018 Mar;71(3):155-159. doi: 10.1097/FJC.0000000000000556.


Therapeutic potential of adipose stem cell-derived conditioned medium against pulmonary hypertension and lung fibrosis.

Rathinasabapathy A, Bruce E, Espejo A, Horowitz A, Sudhan DR, Nair A, Guzzo D, Francis J, Raizada MK, Shenoy V, Katovich MJ.

Br J Pharmacol. 2016 Oct;173(19):2859-79. doi: 10.1111/bph.13562. Epub 2016 Aug 26.


Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.

Wang L, de Kloet AD, Pati D, Hiller H, Smith JA, Pioquinto DJ, Ludin JA, Oh SP, Katovich MJ, Frazier CJ, Raizada MK, Krause EG.

Neuropharmacology. 2016 Jun;105:114-123. doi: 10.1016/j.neuropharm.2015.12.026. Epub 2016 Jan 6.


Angiotensin-(1-7) Decreases Cell Growth and Angiogenesis of Human Nasopharyngeal Carcinoma Xenografts.

Pei N, Wan R, Chen X, Li A, Zhang Y, Li J, Du H, Chen B, Wei W, Qi Y, Zhang Y, Katovich MJ, Sumners C, Zheng H, Li H.

Mol Cancer Ther. 2016 Jan;15(1):37-47. doi: 10.1158/1535-7163.MCT-14-0981. Epub 2015 Dec 15.


Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia.

Qi YF, Zhang J, Wang L, Shenoy V, Krause E, Oh SP, Pepine CJ, Katovich MJ, Raizada MK.

J Mol Med (Berl). 2016 Jan;94(1):37-49.


ACE2 and Microbiota: Emerging Targets for Cardiopulmonary Disease Therapy.

Cole-Jeffrey CT, Liu M, Katovich MJ, Raizada MK, Shenoy V.

J Cardiovasc Pharmacol. 2015 Dec;66(6):540-50. doi: 10.1097/FJC.0000000000000307. Review.



Qi Y, Rathinasabapathy A, Huo T, Zhang J, Shang H, Katz A, Katovich M, Raizada M, Pepine C.

J Hypertens. 2015 Jun;33 Suppl 1:e90. doi: 10.1097/01.hjh.0000467591.88982.2f.


Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.

Bruce E, Shenoy V, Rathinasabapathy A, Espejo A, Horowitz A, Oswalt A, Francis J, Nair A, Unger T, Raizada MK, Steckelings UM, Sumners C, Katovich MJ.

Br J Pharmacol. 2015 May;172(9):2219-31. doi: 10.1111/bph.13044. Epub 2015 Feb 27.


Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.

Shenoy V, Kwon KC, Rathinasabapathy A, Lin S, Jin G, Song C, Shil P, Nair A, Qi Y, Li Q, Francis J, Katovich MJ, Daniell H, Raizada MK.

Hypertension. 2014 Dec;64(6):1248-59. doi: 10.1161/HYPERTENSIONAHA.114.03871. Epub 2014 Sep 15. Erratum in: Hypertension. 2015 Mar;65(3):e8.


Neuroinflammation in pulmonary hypertension: concept, facts, and relevance.

Hilzendeger AM, Shenoy V, Raizada MK, Katovich MJ.

Curr Hypertens Rep. 2014 Sep;16(9):469. doi: 10.1007/s11906-014-0469-1. Review.


Is angiotensin II type 2 receptor a new therapeutic target for cardiovascular disease?

Qi Y, Katovich MJ.

Exp Physiol. 2014 Jul;99(7):933-4. doi: 10.1113/expphysiol.2014.080705. No abstract available.


The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.

Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C.

Neuropharmacology. 2014 Jun;81:134-41. doi: 10.1016/j.neuropharm.2014.01.044. Epub 2014 Feb 6.


Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology.

Qi Y, Zhang J, Cole-Jeffrey CT, Shenoy V, Espejo A, Hanna M, Song C, Pepine CJ, Katovich MJ, Raizada MK.

Hypertension. 2013 Oct;62(4):746-52. doi: 10.1161/HYPERTENSIONAHA.113.01337. Epub 2013 Aug 19.


Diminazene aceturate improves autonomic modulation in pulmonary hypertension.

Rigatto K, Casali KR, Shenoy V, Katovich MJ, Raizada MK.

Eur J Pharmacol. 2013 Aug 5;713(1-3):89-93. doi: 10.1016/j.ejphar.2013.04.017. Epub 2013 May 9.


Angiotensin-converting enzyme 2 activation improves endothelial function.

Fraga-Silva RA, Costa-Fraga FP, Murça TM, Moraes PL, Martins Lima A, Lautner RQ, Castro CH, Soares CM, Borges CL, Nadu AP, Oliveira ML, Shenoy V, Katovich MJ, Santos RA, Raizada MK, Ferreira AJ.

Hypertension. 2013 Jun;61(6):1233-8. doi: 10.1161/HYPERTENSIONAHA.111.00627. Epub 2013 Apr 22.


Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat.

Shan Z, Zubcevic J, Shi P, Jun JY, Dong Y, Murça TM, Lamont GJ, Cuadra A, Yuan W, Qi Y, Li Q, Paton JF, Katovich MJ, Sumners C, Raizada MK.

Hypertension. 2013 Jun;61(6):1328-33. doi: 10.1161/HYPERTENSIONAHA.111.00156. Epub 2013 Apr 1.


Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.

Shenoy V, Gjymishka A, Jarajapu YP, Qi Y, Afzal A, Rigatto K, Ferreira AJ, Fraga-Silva RA, Kearns P, Douglas JY, Agarwal D, Mubarak KK, Bradford C, Kennedy WR, Jun JY, Rathinasabapathy A, Bruce E, Gupta D, Cardounel AJ, Mocco J, Patel JM, Francis J, Grant MB, Katovich MJ, Raizada MK.

Am J Respir Crit Care Med. 2013 Mar 15;187(6):648-57. doi: 10.1164/rccm.201205-0880OC. Epub 2013 Jan 31.


Comparison of the transduction efficiency of tyrosine-mutant adeno-associated virus serotype vectors in kidney.

Qi YF, Li QH, Shenoy V, Zingler M, Jun JY, Verma A, Katovich MJ, Raizada MK.

Clin Exp Pharmacol Physiol. 2013 Jan;40(1):53-5. doi: 10.1111/1440-1681.12037.


Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction.

Murça TM, Moraes PL, Capuruço CA, Santos SH, Melo MB, Santos RA, Shenoy V, Katovich MJ, Raizada MK, Ferreira AJ.

Regul Pept. 2012 Aug 20;177(1-3):107-15. doi: 10.1016/j.regpep.2012.05.093. Epub 2012 May 14.


Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury.

Qi Y, Li H, Shenoy V, Li Q, Wong F, Zhang L, Raizada MK, Sumners C, Katovich MJ.

Exp Physiol. 2012 Jan;97(1):89-101. doi: 10.1113/expphysiol.2011.060673. Epub 2011 Oct 3.


Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology.

Qi Y, Shenoy V, Wong F, Li H, Afzal A, Mocco J, Sumners C, Raizada MK, Katovich MJ.

Exp Physiol. 2011 Sep;96(9):863-74. doi: 10.1113/expphysiol.2011.056994. Epub 2011 Jun 17.


Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke.

Mecca AP, Regenhardt RW, O'Connor TE, Joseph JP, Raizada MK, Katovich MJ, Sumners C.

Exp Physiol. 2011 Oct;96(10):1084-96. doi: 10.1113/expphysiol.2011.058578. Epub 2011 Jun 17.


ACE2, a promising therapeutic target for pulmonary hypertension.

Shenoy V, Qi Y, Katovich MJ, Raizada MK.

Curr Opin Pharmacol. 2011 Apr;11(2):150-5. doi: 10.1016/j.coph.2010.12.002. Epub 2011 Jan 5. Review.


Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases.

Ferreira AJ, Shenoy V, Qi Y, Fraga-Silva RA, Santos RA, Katovich MJ, Raizada MK.

Exp Physiol. 2011 Mar;96(3):287-94. doi: 10.1113/expphysiol.2010.055277. Epub 2010 Dec 10.


Involvement of the brain (pro)renin receptor in cardiovascular homeostasis.

Shan Z, Shi P, Cuadra AE, Dong Y, Lamont GJ, Li Q, Seth DM, Navar LG, Katovich MJ, Sumners C, Raizada MK.

Circ Res. 2010 Oct 1;107(7):934-8. doi: 10.1161/CIRCRESAHA.110.226977. Epub 2010 Aug 5.


The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.

Shenoy V, Ferreira AJ, Qi Y, Fraga-Silva RA, Díez-Freire C, Dooies A, Jun JY, Sriramula S, Mariappan N, Pourang D, Venugopal CS, Francis J, Reudelhuber T, Santos RA, Patel JM, Raizada MK, Katovich MJ.

Am J Respir Crit Care Med. 2010 Oct 15;182(8):1065-72. doi: 10.1164/rccm.200912-1840OC. Epub 2010 Jun 25.


Brain microglial cytokines in neurogenic hypertension.

Shi P, Diez-Freire C, Jun JY, Qi Y, Katovich MJ, Li Q, Sriramula S, Francis J, Sumners C, Raizada MK.

Hypertension. 2010 Aug;56(2):297-303. doi: 10.1161/HYPERTENSIONAHA.110.150409. Epub 2010 Jun 14.


ACE2 activation promotes antithrombotic activity.

Fraga-Silva RA, Sorg BS, Wankhede M, Dedeugd C, Jun JY, Baker MB, Li Y, Castellano RK, Katovich MJ, Raizada MK, Ferreira AJ.

Mol Med. 2010 May-Jun;16(5-6):210-5. doi: 10.2119/molmed.2009.00160. Epub 2010 Jan 22.


Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases.

Ferreira AJ, Santos RA, Bradford CN, Mecca AP, Sumners C, Katovich MJ, Raizada MK.

Hypertension. 2010 Feb;55(2):207-13. doi: 10.1161/HYPERTENSIONAHA.109.140145. Epub 2009 Dec 28. Review. No abstract available.


Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells.

Li H, Qi Y, Li C, Braseth LN, Gao Y, Shabashvili AE, Katovich MJ, Sumners C.

Mol Cancer Ther. 2009 Dec;8(12):3255-65. doi: 10.1158/1535-7163.MCT-09-0237.


NT79: A novel neurotensin analog with selective behavioral effects.

Boules M, Liang Y, Briody S, Miura T, Fauq I, Oliveros A, Wilson M, Khaniyev S, Williams K, Li Z, Qi Y, Katovich M, Richelson E.

Brain Res. 2010 Jan 13;1308:35-46. doi: 10.1016/j.brainres.2009.10.050. Epub 2009 Oct 27.


Selective tropism of the recombinant adeno-associated virus 9 serotype for rat cardiac tissue.

Qi Y, Liu X, Li H, Shenoy V, Li Q, Hauswirth WW, Sumners C, Katovich MJ.

J Gene Med. 2010 Jan;12(1):22-34. doi: 10.1002/jgm.1404.


17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats.

Shenoy V, Grobe JL, Qi Y, Ferreira AJ, Fraga-Silva RA, Collamat G, Bruce E, Katovich MJ.

Peptides. 2009 Dec;30(12):2309-15. doi: 10.1016/j.peptides.2009.09.005. Epub 2009 Sep 9.


Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.

Yamazato Y, Ferreira AJ, Hong KH, Sriramula S, Francis J, Yamazato M, Yuan L, Bradford CN, Shenoy V, Oh SP, Katovich MJ, Raizada MK.

Hypertension. 2009 Aug;54(2):365-71. doi: 10.1161/HYPERTENSIONAHA.108.125468. Epub 2009 Jun 29.


Candesartan pretreatment is cerebroprotective in a rat model of endothelin-1-induced middle cerebral artery occlusion.

Mecca AP, O'Connor TE, Katovich MJ, Sumners C.

Exp Physiol. 2009 Aug;94(8):937-46. doi: 10.1113/expphysiol.2009.047936. Epub 2009 May 8.


Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.

Ferreira AJ, Shenoy V, Yamazato Y, Sriramula S, Francis J, Yuan L, Castellano RK, Ostrov DA, Oh SP, Katovich MJ, Raizada MK.

Am J Respir Crit Care Med. 2009 Jun 1;179(11):1048-54. doi: 10.1164/rccm.200811-1678OC. Epub 2009 Feb 26.


Angiotensin-(1-7) as an antihypertensive, antifibrotic target.

Katovich MJ, Grobe JL, Raizada MK.

Curr Hypertens Rep. 2008 Jun;10(3):227-32. Review.


Macrophage migration inhibitory factor in hypothalamic paraventricular nucleus neurons decreases blood pressure in spontaneously hypertensive rats.

Li H, Gao Y, Qi Y, Katovich MJ, Jiang N, Braseth LN, Scheuer DA, Shi P, Sumners C.

FASEB J. 2008 Sep;22(9):3175-85. doi: 10.1096/fj.08-108662. Epub 2008 Jun 5.


Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.

Hernández Prada JA, Ferreira AJ, Katovich MJ, Shenoy V, Qi Y, Santos RA, Castellano RK, Lampkins AJ, Gubala V, Ostrov DA, Raizada MK.

Hypertension. 2008 May;51(5):1312-7. doi: 10.1161/HYPERTENSIONAHA.107.108944. Epub 2008 Apr 7.


Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology.

Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK.

Hypertension. 2008 Mar;51(3):712-8. doi: 10.1161/HYPERTENSIONAHA.107.100693. Epub 2008 Feb 4.


ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts.

Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ.

Clin Sci (Lond). 2007 Oct;113(8):357-64.


Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7).

Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ.

Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H736-42. Epub 2006 Nov 10.


Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor.

Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C.

Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H727-35. Epub 2006 Nov 3.


Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats.

Mitra A, Katovich MJ, Mecca A, Rowland NE.

Physiol Behav. 2006 Sep 30;89(2):221-5. Epub 2006 Jul 12.


Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension.

Grobe JL, Mecca AP, Mao H, Katovich MJ.

Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2417-23. Epub 2006 Jan 13.


Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats.

Grobe JL, Katovich MJ.

Regul Pept. 2006 Jan 15;133(1-3):62-7. Epub 2005 Oct 10.


Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats.

Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK.

Exp Physiol. 2005 Sep;90(5):783-90. Epub 2005 Jul 27.

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