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Free heme regulates placenta growth factor through NRF2-antioxidant response signaling.

Kapetanaki MG, Gbotosho OT, Sharma D, Weidert F, Ofori-Acquah SF, Kato GJ.

Free Radic Biol Med. 2019 Aug 10. pii: S0891-5849(19)30791-9. doi: 10.1016/j.freeradbiomed.2019.08.009. [Epub ahead of print]


Cardiac expression of HMOX1 and PGF in sickle cell mice and haem-treated wild type mice dominates organ expression profiles via Nrf2 (Nfe2l2).

Gbotosho OT, Ghosh S, Kapetanaki MG, Lin Y, Weidert F, Bullock GC, Ofori-Acquah SF, Kato GJ.

Br J Haematol. 2019 Aug 6. doi: 10.1111/bjh.16129. [Epub ahead of print]


Sickle cells and sickle trait in thrombosis.

Kato GJ.

Blood. 2019 Jun 6;133(23):2463. doi: 10.1182/blood.2019000694. No abstract available.


Health-related quality of life in sickle cell disease.

Panepinto JA, Kato GJ, Smith WR.

Nat Rev Dis Primers. 2019 Apr 18;5(1):27. doi: 10.1038/s41572-019-0080-5. No abstract available.


Anakinra, What Is Thy Bidding in Pulmonary Hypertension?

Mullin CJ, Kato GJ, Ventetuolo CE.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):267-269. doi: 10.1164/rccm.201811-2192ED. No abstract available.


Brief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers.

Connor JL Jr, Sclafani JA, Kato GJ, Hsieh MM, Minniti CP.

Medicine (Baltimore). 2018 Nov;97(46):e12614. doi: 10.1097/MD.0000000000012614.


Exercise training: a prescription for sickle-cell disease?

Kato GJ.

Lancet Haematol. 2018 Nov;5(11):e502-e503. doi: 10.1016/S2352-3026(18)30178-9. No abstract available.


Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review.

Naik RP, Smith-Whitley K, Hassell KL, Umeh NI, de Montalembert M, Sahota P, Haywood C Jr, Jenkins J, Lloyd-Puryear MA, Joiner CH, Bonham VL, Kato GJ.

Ann Intern Med. 2018 Nov 6;169(9):619-627. doi: 10.7326/M18-1161. Epub 2018 Oct 30.


Sickle related events following cardiac catheterisation: risk implication for other invasive procedures.

Di Maggio R, Conrey A, Taylor TN, Lederman RJ, Rogers T, Nichols J, Bouges S, Minniti CP, Kato GJ, Shet AS, Hsieh MM.

Br J Haematol. 2019 May;185(4):778-780. doi: 10.1111/bjh.15618. Epub 2018 Oct 23. No abstract available.


Simultaneous polymerization and adhesion under hypoxia in sickle cell disease.

Papageorgiou DP, Abidi SZ, Chang HY, Li X, Kato GJ, Karniadakis GE, Suresh S, Dao M.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9473-9478. doi: 10.1073/pnas.1807405115. Epub 2018 Sep 6.


Sleep phenotype in the Townes mouse model of sickle cell disease.

O'Donnell BJ, Guo L, Ghosh S, Shah FA, Strollo PJ Jr, McVerry BJ, Gladwin MT, Ofori-Acquah SF, Kato GJ, O'Donnell CP.

Sleep Breath. 2019 Mar;23(1):333-339. doi: 10.1007/s11325-018-1711-x. Epub 2018 Aug 29.


Abstract Animations for the Communication and Assessment of Pain in Adults: Cross-Sectional Feasibility Study.

Jonassaint CR, Rao N, Sciuto A, Switzer GE, De Castro L, Kato GJ, Jonassaint JC, Hammal Z, Shah N, Wasan A.

J Med Internet Res. 2018 Aug 3;20(8):e10056. doi: 10.2196/10056.


Sickle cell vasculopathy: vascular phenotype on fire!

Kato GJ.

J Physiol. 2019 Feb;597(4):993-994. doi: 10.1113/JP276705. Epub 2018 Aug 3. No abstract available.


Sickle cell disease.

Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF, Vichinsky EP.

Nat Rev Dis Primers. 2018 Mar 15;4:18010. doi: 10.1038/nrdp.2018.10. Review.


Skeletal and myocardial microvascular blood flow in hydroxycarbamide-treated patients with sickle cell disease.

Sachdev V, Sidenko S, Wu MD, Minniti CP, Hannoush H, Brenneman CL, Waclawiw MA, Arai AE, Schechter AN, Kato GJ, Lindner JR.

Br J Haematol. 2017 Nov;179(4):648-656. doi: 10.1111/bjh.14918. Epub 2017 Sep 7.


Haem augments and iron chelation decreases toll-like receptor 4 mediated inflammation in monocytes from sickle cell patients.

Dagur PK, McCoy JP, Nichols J, Mendelsohn L, Seamon C, Kato GJ, van Beers EJ.

Br J Haematol. 2018 May;181(4):552-554. doi: 10.1111/bjh.14663. Epub 2017 Apr 26. No abstract available.


Intravascular hemolysis and the pathophysiology of sickle cell disease.

Kato GJ, Steinberg MH, Gladwin MT.

J Clin Invest. 2017 Mar 1;127(3):750-760. doi: 10.1172/JCI89741. Epub 2017 Mar 1. Review.


Prostacyclin-analog therapy in sickle cell pulmonary hypertension.

Weir NA, Saiyed R, Alam S, Conrey A, Desai HD, George MP, Keeley JH, Klings ES, Mehari A, Taylor JG 6th, Minniti CP, Kato GJ.

Haematologica. 2017 May;102(5):e163-e165. doi: 10.3324/haematol.2015.131227. Epub 2017 Jan 25. No abstract available.


Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli.

Bennewitz MF, Jimenez MA, Vats R, Tutuncuoglu E, Jonassaint J, Kato GJ, Gladwin MT, Sundd P.

JCI Insight. 2017 Jan 12;2(1):e89761. doi: 10.1172/jci.insight.89761.


Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.

Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, Zhang Y, Kato GJ.

Am J Hematol. 2017 Mar;92(3):E31-E34. doi: 10.1002/ajh.24635. Epub 2017 Feb 3. No abstract available.


New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

Oder E, Safo MK, Abdulmalik O, Kato GJ.

Br J Haematol. 2016 Oct;175(1):24-30. doi: 10.1111/bjh.14264. Epub 2016 Sep 8. Review.


Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.

Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9527-32. doi: 10.1073/pnas.1610435113. Epub 2016 Aug 10.


Sickle Cell Imaging Flow Cytometry Assay (SIFCA).

Fertrin KY, Samsel L, van Beers EJ, Mendelsohn L, Kato GJ, McCoy JP Jr.

Methods Mol Biol. 2016;1389:279-92. doi: 10.1007/978-1-4939-3302-0_20.


New insights into sickle cell disease: mechanisms and investigational therapies.

Kato GJ.

Curr Opin Hematol. 2016 May;23(3):224-32. doi: 10.1097/MOH.0000000000000241. Review.


Elevated transpulmonary gradient and cardiac magnetic resonance-derived right ventricular remodeling predict poor outcomes in sickle cell disease.

Nguyen KL, Tian X, Alam S, Mehari A, Leung SW, Seamon C, Allen D, Minniti CP, Sachdev V, Arai AE, Kato GJ.

Haematologica. 2016 Feb;101(2):e40-3. doi: 10.3324/haematol.2015.125229. Epub 2015 Nov 20. No abstract available.


Rapid vs. delayed infrared responses after ischemia reveal recruitment of different vascular beds.

Chang K, Yoon S, Sheth N, Seidel M, Antalek M, Ahad J, Darlington T, Ikeda A, Kato GJ, Ackerman H, Gorbach AM.

Quant Infrared Thermogr J. 2015;12(2):173-183. Epub 2015 Jun 16.


Iron restriction in sickle cell anemia: Time for controlled clinical studies.

Castro O, Kato GJ.

Am J Hematol. 2015 Dec;90(12):E217. doi: 10.1002/ajh.24193. Epub 2015 Nov 17. No abstract available.


Critical Reviews: How we treat sickle cell patients with leg ulcers.

Minniti CP, Kato GJ.

Am J Hematol. 2016 Jan;91(1):22-30. doi: 10.1002/ajh.24134. Epub 2015 Aug 14. Review.


Liver injury is associated with mortality in sickle cell disease.

Feld JJ, Kato GJ, Koh C, Shields T, Hildesheim M, Kleiner DE, Taylor JG 6th, Sandler NG, Douek D, Haynes-Williams V, Nichols JS, Hoofnagle JH, Jake Liang T, Gladwin MT, Heller T.

Aliment Pharmacol Ther. 2015 Oct;42(7):912-21. doi: 10.1111/apt.13347. Epub 2015 Aug 3.


Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial.

Minniti CP, Gorbach AM, Xu D, Hon YY, Delaney KM, Seidel M, Malik N, Peters-Lawrence M, Cantilena C, Nichols JS, Mendelsohn L, Conrey A, Grimes G, Kato GJ.

Lancet Haematol. 2014 Dec 1;1(3):e95-e103.


Gout and sickle cell disease: not all pain is sickle cell pain.

Gupta S, Yui JC, Xu D, Fitzhugh CD, Clark C, Siddiqui S, Conrey AK, Kato GJ, Minniti CP.

Br J Haematol. 2015 Dec;171(5):872-5. doi: 10.1111/bjh.13433. Epub 2015 Apr 20. No abstract available.


Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.

Du E, Diez-Silva M, Kato GJ, Dao M, Suresh S.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1422-7. doi: 10.1073/pnas.1424111112. Epub 2015 Jan 20.


Management of patients with sickle cell disease.

Klings ES, Kato GJ, Gladwin MT.

JAMA. 2015 Jan 6;313(1):91. doi: 10.1001/jama.2014.15898. No abstract available.


Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease.

Novelli EM, Hildesheim M, Rosano C, Vanderpool R, Simon M, Kato GJ, Gladwin MT.

PLoS One. 2014 Dec 5;9(12):e114309. doi: 10.1371/journal.pone.0114309. eCollection 2014.


Prominent role of platelets in the formation of circulating neutrophil-red cell heterocellular aggregates in sickle cell anemia.

Dominical VM, Samsel L, Nichols JS, Costa FF, McCoy JP Jr, Conran N, Kato GJ.

Haematologica. 2014 Nov;99(11):e214-7. doi: 10.3324/haematol.2014.108555. No abstract available.


Defective nitric oxide metabolism in sickle cell disease.

Kato GJ.

Pediatr Blood Cancer. 2015 Mar;62(3):373-4. doi: 10.1002/pbc.25297. Epub 2014 Nov 12. Review. No abstract available.


Iron, inflammation, and early death in adults with sickle cell disease.

van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG 6th, Kato GJ.

Circ Res. 2015 Jan 16;116(2):298-306. doi: 10.1161/CIRCRESAHA.116.304577. Epub 2014 Nov 6.


Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide.

Baird JH, Minniti CP, Lee JM, Tian X, Wu C, Jackson M, Alam S, Taylor JG 6th, Kato GJ.

Br J Haematol. 2015 Mar;168(5):737-46. doi: 10.1111/bjh.13203. Epub 2014 Nov 6.


Imaging flow cytometry documents incomplete resistance of human sickle F-cells to ex vivo hypoxia-induced sickling.

Fertrin KY, van Beers EJ, Samsel L, Mendelsohn LG, Saiyed R, Nichols JS, Hepp DA, Brantner CA, Daniels MP, McCoy JP, Kato GJ.

Blood. 2014 Jul 24;124(4):658-60. doi: 10.1182/blood-2014-03-559054. No abstract available.


Sleep disturbance, depression and pain in adults with sickle cell disease.

Wallen GR, Minniti CP, Krumlauf M, Eckes E, Allen D, Oguhebe A, Seamon C, Darbari DS, Hildesheim M, Yang L, Schulden JD, Kato GJ, Taylor JG 6th.

BMC Psychiatry. 2014 Jul 21;14:207. doi: 10.1186/1471-244X-14-207.


Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption.

Klings ES, Machado RF, Morris CR, Gordeuk VR, Kato GJ, Ataga KI, Castro O, Hsu L, Telen MJ, Krishnamurti L, Steinberg MH, Gladwin MT; ATS Clinical Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease Committee.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):238-40. doi: 10.1164/rccm.201404-0733LE. No abstract available.


Computed tomography correlates with cardiopulmonary hemodynamics in pulmonary hypertension in adults with sickle cell disease.

Linguraru MG, Pura JA, Gladwin MT, Koroulakis AI, Minniti C, Machado RF, Kato GJ, Wood BJ.

Pulm Circ. 2014 Jun;4(2):319-29. doi: 10.1086/675997.


Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.

Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Goldsmith JC, Kato GJ, Gordeuk VR, Machado RF; walk-PHaSST Investigators and Patients.

PLoS One. 2014 Jul 2;9(7):e99489. doi: 10.1371/journal.pone.0099489. eCollection 2014.


Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.

Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG 6th, Noguchi CT, Kato GJ.

Blood. 2014 Aug 7;124(6):946-54. doi: 10.1182/blood-2013-11-539718. Epub 2014 Jun 10.


Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.

Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, Zhang J, Kato GJ, Abdulmalik OY, Zhang W, Dowhan W, Kellems RE, Zhang P, Jin J, Safo M, Tsai AL, Juneja HS, Xia Y.

J Clin Invest. 2014 Jun;124(6):2750-61. doi: 10.1172/JCI74604. Epub 2014 May 16.


Microvascular oxygen consumption during sickle cell pain crisis.

Rowley CA, Ikeda AK, Seidel M, Anaebere TC, Antalek MD, Seamon C, Conrey AK, Mendelsohn L, Nichols J, Gorbach AM, Kato GJ, Ackerman H.

Blood. 2014 May 15;123(20):3101-4. doi: 10.1182/blood-2013-11-533406. Epub 2014 Mar 24.


No NO means yes to sickle red cell adhesion.

Kato GJ.

Blood. 2014 Mar 20;123(12):1780-2. doi: 10.1182/blood-2014-02-551218. No abstract available.


An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease.

Klings ES, Machado RF, Barst RJ, Morris CR, Mubarak KK, Gordeuk VR, Kato GJ, Ataga KI, Gibbs JS, Castro O, Rosenzweig EB, Sood N, Hsu L, Wilson KC, Telen MJ, Decastro LM, Krishnamurti L, Steinberg MH, Badesch DB, Gladwin MT; American Thoracic Society Ad Hoc Committee on Pulmonary Hypertension of Sickle Cell Disease.

Am J Respir Crit Care Med. 2014 Mar 15;189(6):727-40. doi: 10.1164/rccm.201401-0065ST.


Therapeutic strategies to alter the oxygen affinity of sickle hemoglobin.

Safo MK, Kato GJ.

Hematol Oncol Clin North Am. 2014 Apr;28(2):217-31. doi: 10.1016/j.hoc.2013.11.001. Epub 2014 Jan 21. Review.


Imaging flow cytometry for automated detection of hypoxia-induced erythrocyte shape change in sickle cell disease.

van Beers EJ, Samsel L, Mendelsohn L, Saiyed R, Fertrin KY, Brantner CA, Daniels MP, Nichols J, McCoy JP, Kato GJ.

Am J Hematol. 2014 Jun;89(6):598-603. doi: 10.1002/ajh.23699. Epub 2014 Apr 12.

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