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Calculation of the Protein Turnover Rate Using the Number of Incorporated 2H Atoms and Proteomics Analysis of a Single Labeled Sample.

Ilchenko S, Haddad A, Sadana P, Recchia FA, Sadygov RG, Kasumov T.

Anal Chem. 2019 Nov 19;91(22):14340-14351. doi: 10.1021/acs.analchem.9b02757. Epub 2019 Nov 5.


HDL flux is higher in patients with nonalcoholic fatty liver disease.

McCullough A, Previs SF, Dasarathy J, Lee K, Osme A, Kim C, Ilchenko S, Lorkowski SW, Smith JD, Dasarathy S, Kasumov T.

Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E852-E862. doi: 10.1152/ajpendo.00193.2019. Epub 2019 Sep 10.


A novel regulatory role of TRAPPC9 in L-plastin-mediated osteoclast actin ring formation.

Hussein NJ, Mbimba T, Al-Adlaan AA, Ansari MY, Jaber FA, McDermott S, Kasumov T, Safadi FF.

J Cell Biochem. 2020 Jan;121(1):284-298. doi: 10.1002/jcb.29168. Epub 2019 Aug 27.


Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes.

Xu Y, Zhu Y, Jadhav K, Li Y, Sun H, Yin L, Kasumov T, Chen X, Zhang Y.

Hepatol Commun. 2019 Mar 25;3(6):763-775. doi: 10.1002/hep4.1341. eCollection 2019 Jun.


A systematic review: the appraisal of the effects of metformin on lipoprotein modification and function.

Kheniser KG, Kashyap SR, Kasumov T.

Obes Sci Pract. 2019 Jan 7;5(1):36-45. doi: 10.1002/osp4.309. eCollection 2019 Feb. Review.


d2ome, Software for in Vivo Protein Turnover Analysis Using Heavy Water Labeling and LC-MS, Reveals Alterations of Hepatic Proteome Dynamics in a Mouse Model of NAFLD.

Sadygov RG, Avva J, Rahman M, Lee K, Ilchenko S, Kasumov T, Borzou A.

J Proteome Res. 2018 Nov 2;17(11):3740-3748. doi: 10.1021/acs.jproteome.8b00417. Epub 2018 Oct 19.


Hepatic Mitochondrial Defects in a Nonalcoholic Fatty Liver Disease Mouse Model Are Associated with Increased Degradation of Oxidative Phosphorylation Subunits.

Lee K, Haddad A, Osme A, Kim C, Borzou A, Ilchenko S, Allende D, Dasarathy S, McCullough A, Sadygov RG, Kasumov T.

Mol Cell Proteomics. 2018 Dec;17(12):2371-2386. doi: 10.1074/mcp.RA118.000961. Epub 2018 Aug 31.


Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS.

Chen Y, Berejnaia O, Liu J, Wang SP, Daurio NA, Yin W, Mayoral R, Petrov A, Kasumov T, Zhang GF, Previs SF, Kelley DE, McLaren DG.

Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E416-E424. doi: 10.1152/ajpendo.00457.2017. Epub 2018 Mar 6.


Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.

Jadhav K, Xu Y, Xu Y, Li Y, Xu J, Zhu Y, Adorini L, Lee YK, Kasumov T, Yin L, Zhang Y.

Mol Metab. 2018 Mar;9:131-140. doi: 10.1016/j.molmet.2018.01.005. Epub 2018 Jan 11.


Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.

Golizeh M, Lee K, Ilchenko S, Ösme A, Bena J, Sadygov RG, Kashyap SR, Kasumov T.

Free Radic Biol Med. 2017 Dec;113:461-469. doi: 10.1016/j.freeradbiomed.2017.10.373. Epub 2017 Oct 25.


Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes.

Kashyap SR, Osme A, Ilchenko S, Golizeh M, Lee K, Wang S, Bena J, Previs SF, Smith JD, Kasumov T.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):388-396. doi: 10.1210/jc.2017-01551.


Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.

Rachdaoui N, Li L, Willard B, Kasumov T, Previs S, Sarkar D.

Clin Epigenetics. 2017 Oct 23;9:117. doi: 10.1186/s13148-017-0416-5. eCollection 2017.


Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.

Daurio NA, Wang SP, Chen Y, Zhou H, McLaren DG, Roddy TP, Johns DG, Milot D, Kasumov T, Erion MD, Kelley DE, Previs SF.

J Pharmacol Exp Ther. 2017 Oct;363(1):80-91. doi: 10.1124/jpet.117.241091. Epub 2017 Jul 19. Review.


Stable isotope-based flux studies in nonalcoholic fatty liver disease.

McCullough A, Previs S, Kasumov T.

Pharmacol Ther. 2018 Jan;181:22-33. doi: 10.1016/j.pharmthera.2017.07.008. Epub 2017 Jul 16. Review.


Erratum to: The therapeutic efficacy of intensive medical therapy in ameliorating high-density lipoprotein dysfunction in subjects with type two diabetes.

Kashyap S, Kheniser K, Li L, Bena J, Kasumov T.

Lipids Health Dis. 2016 Nov 9;15(1):191. No abstract available.


Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress.

Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S.

J Physiol. 2016 Dec 15;594(24):7341-7360. doi: 10.1113/JP272796. Epub 2016 Oct 23.


Monitoring the synthesis of biomolecules using mass spectrometry.

Miyagi M, Kasumov T.

Philos Trans A Math Phys Eng Sci. 2016 Oct 28;374(2079). pii: 20150378. doi: 10.1098/rsta.2015.0378.


The therapeutic efficacy of intensive medical therapy in ameliorating high-density lipoprotein dysfunction in subjects with type two diabetes.

Kashyap S, Kheniser K, Li L, Bena J, Kasumov T.

Lipids Health Dis. 2016 Aug 27;15(1):141. doi: 10.1186/s12944-016-0314-4. Erratum in: Lipids Health Dis. 2016 Nov 9;15(1):191.


Proteome Dynamics Reveals Pro-Inflammatory Remodeling of Plasma Proteome in a Mouse Model of NAFLD.

Li L, Bebek G, Previs SF, Smith JD, Sadygov RG, McCullough AJ, Willard B, Kasumov T.

J Proteome Res. 2016 Sep 2;15(9):3388-404. doi: 10.1021/acs.jproteome.6b00601. Epub 2016 Aug 5.


Gaussian Process Modeling of Protein Turnover.

Rahman M, Previs SF, Kasumov T, Sadygov RG.

J Proteome Res. 2016 Jul 1;15(7):2115-22. doi: 10.1021/acs.jproteome.5b00990. Epub 2016 Jun 9.


A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.

Li L, Zhang GF, Lee K, Lopez R, Previs SF, Willard B, McCullough A, Kasumov T.

Free Radic Biol Med. 2016 Jul;96:13-21. doi: 10.1016/j.freeradbiomed.2016.03.032. Epub 2016 Mar 30.


Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.

Li Y, Zalzala M, Jadhav K, Xu Y, Kasumov T, Yin L, Zhang Y.

Hepatology. 2016 Jun;63(6):1860-74. doi: 10.1002/hep.28472. Epub 2016 Mar 15.


Tracer-based estimates of protein flux in cases of incomplete product renewal: evidence and implications of heterogeneity in collagen turnover.

Zhou H, Wang SP, Herath K, Kasumov T, Sadygov RG, Previs SF, Kelley DE.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E115-21. doi: 10.1152/ajpendo.00435.2014. Epub 2015 May 26.


Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis.

Kasumov T, Li L, Li M, Gulshan K, Kirwan JP, Liu X, Previs S, Willard B, Smith JD, McCullough A.

PLoS One. 2015 May 20;10(5):e0126910. doi: 10.1371/journal.pone.0126910. eCollection 2015.


Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes.

Kasumov T, Solomon TP, Hwang C, Huang H, Haus JM, Zhang R, Kirwan JP.

Obesity (Silver Spring). 2015 Jul;23(7):1414-21. doi: 10.1002/oby.21117. Epub 2015 May 12.


HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function.

Berisha SZ, Brubaker G, Kasumov T, Hung KT, DiBello PM, Huang Y, Li L, Willard B, Pollard KA, Nagy LE, Hazen SL, Smith JD.

J Lipid Res. 2015 Mar;56(3):653-64. doi: 10.1194/jlr.M056754. Epub 2015 Jan 5.


Current Bioinformatics Challenges in Proteome Dynamics using Heavy Water-based Metabolic Labeling.

Kasumov T, Willard B, Sadygov RG.

J Data Mining Genomics Proteomics. 2014 Feb;5(1):e112. No abstract available.


Cardiac mitochondrial proteome dynamics with heavy water reveals stable rate of mitochondrial protein synthesis in heart failure despite decline in mitochondrial oxidative capacity.

Shekar KC, Li L, Dabkowski ER, Xu W, Ribeiro RF Jr, Hecker PA, Recchia FA, Sadygov RG, Willard B, Kasumov T, Stanley WC.

J Mol Cell Cardiol. 2014 Oct;75:88-97. doi: 10.1016/j.yjmcc.2014.06.014. Epub 2014 Jul 1.


2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice.

Kasumov T, Willard B, Li L, Li M, Conger H, Buffa JA, Previs S, McCullough A, Hazen SL, Smith JD.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1994-2003. doi: 10.1161/ATVBAHA.113.301700. Epub 2013 Jun 13.


Use of theoretical peptide distributions in phosphoproteome analysis.

Kalita M, Kasumov T, Brasier AR, Sadygov RG.

J Proteome Res. 2013 Jul 5;12(7):3207-14. doi: 10.1021/pr4003382. Epub 2013 Jun 19.


Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria.

Kasumov T, Dabkowski ER, Shekar KC, Li L, Ribeiro RF Jr, Walsh K, Previs SF, Sadygov RG, Willard B, Stanley WC.

Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1201-14. doi: 10.1152/ajpheart.00933.2012. Epub 2013 Mar 1.


Sarcopenia and a physiologically low respiratory quotient in patients with cirrhosis: a prospective controlled study.

Glass C, Hipskind P, Tsien C, Malin SK, Kasumov T, Shah SN, Kirwan JP, Dasarathy S.

J Appl Physiol (1985). 2013 Mar 1;114(5):559-65. doi: 10.1152/japplphysiol.01042.2012. Epub 2013 Jan 3.


An improved measurement of isotopic ratios by high resolution mass spectrometry.

Ilchenko S, Previs SF, Rachdaoui N, Willard B, McCullough AJ, Kasumov T.

J Am Soc Mass Spectrom. 2013 Feb;24(2):309-12. doi: 10.1007/s13361-012-0536-2. Epub 2013 Jan 3.


Role of ceramides in nonalcoholic fatty liver disease.

Pagadala M, Kasumov T, McCullough AJ, Zein NN, Kirwan JP.

Trends Endocrinol Metab. 2012 Aug;23(8):365-71. doi: 10.1016/j.tem.2012.04.005. Epub 2012 May 17.


Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labeling.

Li L, Willard B, Rachdaoui N, Kirwan JP, Sadygov RG, Stanley WC, Previs S, McCullough AJ, Kasumov T.

Mol Cell Proteomics. 2012 Jul;11(7):M111.014209. doi: 10.1074/mcp.M111.014209. Epub 2012 Mar 5.


Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratio.

Heneghan HM, Huang H, Kashyap SR, Gornik HL, McCullough AJ, Schauer PR, Brethauer SA, Kirwan JP, Kasumov T.

Surg Obes Relat Dis. 2013 Jan-Feb;9(1):100-7. doi: 10.1016/j.soard.2011.11.018. Epub 2011 Dec 20.


Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients.

Huang H, Kasumov T, Gatmaitan P, Heneghan HM, Kashyap SR, Schauer PR, Brethauer SA, Kirwan JP.

Obesity (Silver Spring). 2011 Nov;19(11):2235-40. doi: 10.1038/oby.2011.107. Epub 2011 May 5.


Measuring protein synthesis using metabolic ²H labeling, high-resolution mass spectrometry, and an algorithm.

Kasumov T, Ilchenko S, Li L, Rachdaoui N, Sadygov RG, Willard B, McCullough AJ, Previs S.

Anal Biochem. 2011 May 1;412(1):47-55. doi: 10.1016/j.ab.2011.01.021. Epub 2011 Jan 20.


Plasma levels of asymmetric dimethylarginine in patients with biopsy-proven nonalcoholic fatty liver disease.

Kasumov T, Edmison JM, Dasarathy S, Bennett C, Lopez R, Kalhan SC.

Metabolism. 2011 Jun;60(6):776-81. doi: 10.1016/j.metabol.2010.07.027. Epub 2010 Sep 23.


Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry.

Kasumov T, Huang H, Chung YM, Zhang R, McCullough AJ, Kirwan JP.

Anal Biochem. 2010 Jun 1;401(1):154-61. doi: 10.1016/j.ab.2010.02.023. Epub 2010 Feb 21.


Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart.

Kasumov T, Sharma N, Huang H, Kombu RS, Cendrowski A, Stanley WC, Brunengraber H.

Cardiovasc Drugs Ther. 2009 Dec;23(6):459-69. doi: 10.1007/s10557-009-6208-1.


Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs.

Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H.

J Biol Chem. 2009 Nov 27;284(48):33521-34. doi: 10.1074/jbc.M109.055665. Epub 2009 Sep 15.


Measuring proteome dynamics in vivo: as easy as adding water?

Rachdaoui N, Austin L, Kramer E, Previs MJ, Anderson VE, Kasumov T, Previs SF.

Mol Cell Proteomics. 2009 Dec;8(12):2653-63. doi: 10.1074/mcp.M900026-MCP200. Epub 2009 Sep 1.


Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver.

Deng S, Zhang GF, Kasumov T, Roe CR, Brunengraber H.

J Biol Chem. 2009 Oct 9;284(41):27799-807. doi: 10.1074/jbc.M109.048744. Epub 2009 Aug 8.


Simultaneous assay of isotopic enrichment and concentration of guanidinoacetate and creatine by gas chromatography-mass spectrometry.

Kasumov T, Gruca LL, Dasarathy S, Kalhan SC.

Anal Biochem. 2009 Dec 1;395(1):91-9. doi: 10.1016/j.ab.2009.07.037. Epub 2009 Jul 29.


Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion.

Dasarathy S, Kasumov T, Edmison JM, Gruca LL, Bennett C, Duenas C, Marczewski S, McCullough AJ, Hanson RW, Kalhan SC.

Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G567-75. doi: 10.1152/ajpgi.00042.2009. Epub 2009 Jul 1.


Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance.

Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, Kirwan JP.

Diabetes. 2009 Feb;58(2):337-43. doi: 10.2337/db08-1228. Epub 2008 Nov 13.


Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle. I. Interrelation between gluconeogenesis and cataplerosis; formation of methoxamates from aminooxyacetate and ketoacids.

Yang L, Kombu RS, Kasumov T, Zhu SH, Cendrowski AV, David F, Anderson VE, Kelleher JK, Brunengraber H.

J Biol Chem. 2008 Aug 8;283(32):21978-87. doi: 10.1074/jbc.M803454200. Epub 2008 Jun 10.


Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern.

Yang L, Kasumov T, Kombu RS, Zhu SH, Cendrowski AV, David F, Anderson VE, Kelleher JK, Brunengraber H.

J Biol Chem. 2008 Aug 8;283(32):21988-96. doi: 10.1074/jbc.M803455200. Epub 2008 Jun 10.


Mass isotopomer study of anaplerosis from propionate in the perfused rat heart.

Kasumov T, Cendrowski AV, David F, Jobbins KA, Anderson VE, Brunengraber H.

Arch Biochem Biophys. 2007 Jul 1;463(1):110-7. Epub 2007 Mar 12.

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