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Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction.

Pan Y, Wang Z, Zhang G, Guo J, Zhu X, Zhou J, Zhang Z, Sun Z, Yang J, Kastin AJ, Pan W, Wu X, Zhang J, Wang X, Wang C, He Y.

Curr Mol Med. 2019;19(8):560-569. doi: 10.2174/1566524019666190617172054.


The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.

Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, Hu Q, Lake T, Pan W, Kastin AJ, Kirschner DA, Wood SG, Rockenstein E, Masliah E, Lorimer S, Tanzi RE, Larsen L.

Sci Rep. 2019 Feb 6;9(1):561. doi: 10.1038/s41598-019-38645-0.


Spinal Cord Injury Changes Cytokine Transport.

Pan W, Kastin AJ.

CNS Neurol Disord Drug Targets. 2016;15(9):1139-1150. Review.


Involvement of the Blood-Brain Barrier in Metabolic Regulation.

Kastin AJ, Pan W.

CNS Neurol Disord Drug Targets. 2016;15(9):1118-1128. Review.


Circadian rhythm of autophagy proteins in hippocampus is blunted by sleep fragmentation.

He Y, Cornelissen-Guillaume GG, He J, Kastin AJ, Harrison LM, Pan W.

Chronobiol Int. 2016;33(5):553-60. doi: 10.3109/07420528.2015.1137581. Epub 2016 Apr 14.


The Blood-Brain Barrier: Regulatory Roles in Wakefulness and Sleep.

Pan W, Kastin AJ.

Neuroscientist. 2017 Apr;23(2):124-136. doi: 10.1177/1073858416639005. Epub 2016 Jul 7. Review.


Role of Astrocytes in Leptin Signaling.

Wang Y, Hsuchou H, He Y, Kastin AJ, Pan W.

J Mol Neurosci. 2015 Aug;56(4):829-839. doi: 10.1007/s12031-015-0518-5. Epub 2015 Feb 17.


Leukocyte infiltration across the blood-spinal cord barrier is modulated by sleep fragmentation in mice with experimental autoimmune encephalomyelitis.

He J, Hsuchou H, He Y, Kastin AJ, Mishra PK, Fang J, Pan W.

Fluids Barriers CNS. 2014 Dec 28;11(1):27. doi: 10.1186/2045-8118-11-27. eCollection 2014.


Can sleep apnea cause Alzheimer's disease?

Pan W, Kastin AJ.

Neurosci Biobehav Rev. 2014 Nov;47:656-69. Review.


Sleep restriction impairs blood-brain barrier function.

He J, Hsuchou H, He Y, Kastin AJ, Wang Y, Pan W.

J Neurosci. 2014 Oct 29;34(44):14697-706. doi: 10.1523/JNEUROSCI.2111-14.2014.


Sleep fragmentation has differential effects on obese and lean mice.

He J, Kastin AJ, Wang Y, Pan W.

J Mol Neurosci. 2015 Mar;55(3):644-52. doi: 10.1007/s12031-014-0403-7. Epub 2014 Aug 26.


Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling.

Ouyang S, Hsuchou H, Kastin AJ, Mishra PK, Wang Y, Pan W.

Brain Behav Immun. 2014 Aug;40:61-73. doi: 10.1016/j.bbi.2014.02.003. Epub 2014 Feb 24.


Increased sleep fragmentation in experimental autoimmune encephalomyelitis.

He J, Wang Y, Kastin AJ, Pan W.

Brain Behav Immun. 2014 May;38:53-8. doi: 10.1016/j.bbi.2014.02.005. Epub 2014 Feb 22.


Fibroblast growth factor 19 entry into brain.

Hsuchou H, Pan W, Kastin AJ.

Fluids Barriers CNS. 2013 Nov 1;10(1):32. doi: 10.1186/2045-8118-10-32.


Leptin: a biomarker for sleep disorders?

Pan W, Kastin AJ.

Sleep Med Rev. 2014 Jun;18(3):283-90. doi: 10.1016/j.smrv.2013.07.003. Epub 2013 Sep 27.


Diet-induced obesity suppresses expression of many proteins at the blood-brain barrier.

Ouyang S, Hsuchou H, Kastin AJ, Wang Y, Yu C, Pan W.

J Cereb Blood Flow Metab. 2014 Jan;34(1):43-51. doi: 10.1038/jcbfm.2013.166. Epub 2013 Sep 25.


Hypersomnolence and reduced activity in pan-leptin receptor knockout mice.

Wang Y, He J, Kastin AJ, Hsuchou H, Pan W.

J Mol Neurosci. 2013 Nov;51(3):1038-45. doi: 10.1007/s12031-013-0093-6. Epub 2013 Aug 18.


TNF stimulates nuclear export and secretion of IL-15 by acting on CRM1 and ARF6.

Ouyang S, Hsuchou H, Kastin AJ, Pan W.

PLoS One. 2013 Aug 7;8(8):e69356. doi: 10.1371/journal.pone.0069356. eCollection 2013.


Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis.

Mishra PK, Hsuchou H, Ouyang S, Kastin AJ, Wu X, Pan W.

Brain Behav Immun. 2013 Nov;34:98-107. doi: 10.1016/j.bbi.2013.07.176. Epub 2013 Aug 2.


Diminished leptin signaling can alter circadian rhythm of metabolic activity and feeding.

Hsuchou H, Wang Y, Cornelissen-Guillaume GG, Kastin AJ, Jang E, Halberg F, Pan W.

J Appl Physiol (1985). 2013 Oct 1;115(7):995-1003. doi: 10.1152/japplphysiol.00630.2013. Epub 2013 Jul 18.


Saturable leptin transport across the BBB persists in EAE mice.

Hsuchou H, Mishra PK, Kastin AJ, Wu X, Wang Y, Ouyang S, Pan W.

J Mol Neurosci. 2013 Oct;51(2):364-70. doi: 10.1007/s12031-013-9993-8. Epub 2013 Mar 16.


Endothelial cell leptin receptor mutant mice have hyperleptinemia and reduced tissue uptake.

Hsuchou H, Jayaram B, Kastin AJ, Wang Y, Ouyang S, Pan W.

J Cell Physiol. 2013 Jul;228(7):1610-6. doi: 10.1002/jcp.24325.


Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.

Jayaram B, Pan W, Wang Y, Hsuchou H, Mace A, Cornelissen-Guillaume GG, Mishra PK, Koza RA, Kastin AJ.

J Appl Physiol (1985). 2013 Mar 15;114(6):734-41. doi: 10.1152/japplphysiol.01499.2012. Epub 2013 Jan 17.


Brain interleukin-15 in neuroinflammation and behavior.

Pan W, Wu X, He Y, Hsuchou H, Huang EY, Mishra PK, Kastin AJ.

Neurosci Biobehav Rev. 2013 Feb;37(2):184-92. doi: 10.1016/j.neubiorev.2012.11.009. Epub 2012 Nov 29. Review.


Protective role of astrocytic leptin signaling against excitotoxicity.

Jayaram B, Khan RS, Kastin AJ, Hsuchou H, Wu X, Pan W.

J Mol Neurosci. 2013 Mar;49(3):523-30. doi: 10.1007/s12031-012-9924-0. Epub 2012 Nov 23.


C-reactive protein increases BBB permeability: implications for obesity and neuroinflammation.

Hsuchou H, Kastin AJ, Mishra PK, Pan W.

Cell Physiol Biochem. 2012;30(5):1109-19. doi: 10.1159/000343302. Epub 2012 Sep 27.


Upregulation of astrocytic leptin receptor in mice with experimental autoimmune encephalomyelitis.

Wu X, Hsuchou H, Kastin AJ, Mishra PK, Pan W.

J Mol Neurosci. 2013 Mar;49(3):446-56. doi: 10.1007/s12031-012-9825-2. Epub 2012 Jun 10.


Leptin action on nonneuronal cells in the CNS: potential clinical applications.

Pan W, Hsuchou H, Jayaram B, Khan RS, Huang EY, Wu X, Chen C, Kastin AJ.

Ann N Y Acad Sci. 2012 Aug;1264:64-71. doi: 10.1111/j.1749-6632.2012.06472.x. Epub 2012 Apr 24. Review.


Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis.

Hsuchou H, Kastin AJ, Pan W.

J Mol Neurosci. 2012 Jun;47(2):267-77. doi: 10.1007/s12031-012-9734-4. Epub 2012 Mar 4.


Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity.

Pan W, Hsuchou H, Cornelissen-Guillaume GG, Jayaram B, Wang Y, Tu H, Halberg F, Wu X, Chua SC Jr, Kastin AJ.

J Appl Physiol (1985). 2012 Apr;112(8):1410-8. doi: 10.1152/japplphysiol.00590.2011. Epub 2012 Feb 9.


NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia.

Stone KP, Kastin AJ, Pan W.

Cell Physiol Biochem. 2011;28(1):115-24. doi: 10.1159/000331720. Epub 2011 Aug 16.


Cytokine signaling modulates blood-brain barrier function.

Pan W, Stone KP, Hsuchou H, Manda VK, Zhang Y, Kastin AJ.

Curr Pharm Des. 2011 Nov;17(33):3729-40. Review.


Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB.

Hsuchou H, Kastin AJ, Tu H, Markadakis EN, Stone KP, Wang Y, Heymsfield SB, Chua SS Jr, Obici S, Magrisso IJ, Pan W.

Peptides. 2011 Jul;32(7):1392-9. doi: 10.1016/j.peptides.2011.05.011. Epub 2011 May 17.


Rapid endocytosis of interleukin-15 by cerebral endothelia.

Stone KP, Kastin AJ, Hsuchou H, Yu C, Pan W.

J Neurochem. 2011 Feb;116(4):544-53. doi: 10.1111/j.1471-4159.2010.07142.x. Epub 2011 Jan 19.


Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice.

Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ.

J Mol Neurosci. 2011 Mar;43(3):478-84. doi: 10.1007/s12031-010-9470-6. Epub 2010 Nov 18.


Potential protective role of IL15Rα during inflammation.

Pan W, Wu X, Kastin AJ, Zhang Y, Hsuchou H, Halberg F, Chatu F, Khan RS, Robert B, Cornelissen-Guillaume GG.

J Mol Neurosci. 2011 Mar;43(3):412-23. doi: 10.1007/s12031-010-9459-1. Epub 2010 Oct 28.


Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells.

Hsuchou H, Kastin AJ, Tu H, Joan Abbott N, Couraud PO, Pan W.

J Neurochem. 2010 Dec;115(5):1288-98. doi: 10.1111/j.1471-4159.2010.07028.x. Epub 2010 Oct 26.


Concepts for biologically active peptides.

Kastin AJ, Pan W.

Curr Pharm Des. 2010 Oct;16(30):3390-400. Review.


Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor.

Wu X, Hsuchou H, Kastin AJ, He Y, Khan RS, Stone KP, Cash MS, Pan W.

Psychoneuroendocrinology. 2011 Feb;36(2):266-78. doi: 10.1016/j.psyneuen.2010.07.017. Epub 2010 Aug 17.


Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1).

Khan RS, Yu C, Kastin AJ, He Y, Ehrensing RH, Hsuchou H, Stone KP, Pan W.

Int J Pept. 2010;2010. pii: 537639. doi: 10.1155/2010/537639. Epub 2010 Mar 28.


Essential role of interleukin-15 receptor in normal anxiety behavior.

Wu X, He Y, Hsuchou H, Kastin AJ, Rood JC, Pan W.

Brain Behav Immun. 2010 Nov;24(8):1340-6. doi: 10.1016/j.bbi.2010.06.012. Epub 2010 Jul 1.


The role of cerebral vascular NFkappaB in LPS-induced inflammation: differential regulation of efflux transporter and transporting cytokine receptors.

Pan W, Yu C, Hsuchou H, Kastin AJ.

Cell Physiol Biochem. 2010;25(6):623-30. doi: 10.1159/000315081. Epub 2010 May 18.


The effects of IL2Rgamma knockout on depression and contextual memory.

Wu X, Kastin AJ, Hsuchou H, Pan W.

Behav Brain Res. 2010 Dec 1;213(2):319-22. doi: 10.1016/j.bbr.2010.04.046. Epub 2010 May 12.


Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis.

Wu X, Pan W, He Y, Hsuchou H, Kastin AJ.

J Neuroimmunol. 2010 Jun;223(1-2):65-72. doi: 10.1016/j.jneuroim.2010.04.001. Epub 2010 Apr 28.


Expression and signaling of novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier.

Wu X, Pan W, Stone KP, Zhang Y, Hsuchou H, Kastin AJ.

J Neurochem. 2010 Jul;114(1):122-9. doi: 10.1111/j.1471-4159.2010.06729.x. Epub 2010 Apr 2.


Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory.

He Y, Hsuchou H, Wu X, Kastin AJ, Khan RS, Pistell PJ, Wang WH, Feng J, Li Z, Guo X, Pan W.

J Neurosci. 2010 Mar 31;30(13):4725-34. doi: 10.1523/JNEUROSCI.6160-09.2010.


Unique leptin trafficking by a tailless receptor.

Tu H, Hsuchou H, Kastin AJ, Wu X, Pan W.

FASEB J. 2010 Jul;24(7):2281-91. doi: 10.1096/fj.09-143487. Epub 2010 Mar 11.


Corticotropin-releasing hormone receptor-1 in cerebral microvessels changes during development and influences urocortin transport across the blood-brain barrier.

Hsuchou H, Kastin AJ, Wu X, Tu H, Pan W.

Endocrinology. 2010 Mar;151(3):1221-7. doi: 10.1210/en.2009-1039. Epub 2009 Dec 23.


IL-15 receptor deletion results in circadian changes of locomotor and metabolic activity.

He Y, Wu X, Khan RS, Kastin AJ, Cornelissen-Guillaume GG, Hsuchou H, Robert B, Halberg F, Pan W.

J Mol Neurosci. 2010 Jun;41(2):315-21. doi: 10.1007/s12031-009-9319-z. Epub 2009 Dec 10.


Leptin receptor mRNA in rat brain astrocytes.

Hsuchou H, Pan W, Barnes MJ, Kastin AJ.

Peptides. 2009 Dec;30(12):2275-80. doi: 10.1016/j.peptides.2009.08.023. Epub 2009 Sep 9.

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