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Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.

McGill JB, Johnson M, Hurst S, Cade WT, Yarasheski KE, Ostlund RE, Schechtman KB, Razani B, Kastan MB, McClain DA, de Las Fuentes L, Davila-Roman VG, Ory DS, Wickline SA, Semenkovich CF.

Diabetol Metab Syndr. 2019 Jul 29;11:61. doi: 10.1186/s13098-019-0456-4. eCollection 2019.


A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers.

Chen J, Kastan MB.

Oncoscience. 2017 Oct 12;4(9-10):122-123. doi: 10.18632/oncoscience.367. eCollection 2017 Sep. No abstract available.


Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells.

Liu X, Li F, Huang Q, Zhang Z, Zhou L, Deng Y, Zhou M, Fleenor DE, Wang H, Kastan MB, Li CY.

Cell Res. 2017 Jun;27(6):764-783. doi: 10.1038/cr.2017.41. Epub 2017 Mar 24.


Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.

Chen J, Crutchley J, Zhang D, Owzar K, Kastan MB.

Cancer Discov. 2017 Jul;7(7):766-781. doi: 10.1158/2159-8290.CD-16-0908. Epub 2017 Mar 13.


Commentary on "Participation of p53 Protein in the Cellular Response to DNA Damage".

Kastan MB.

Cancer Res. 2016 Jul 1;76(13):3663-5. doi: 10.1158/0008-5472.CAN-16-1560. No abstract available.


Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology.

LeBlanc AK, Breen M, Choyke P, Dewhirst M, Fan TM, Gustafson DL, Helman LJ, Kastan MB, Knapp DW, Levin WJ, London C, Mason N, Mazcko C, Olson PN, Page R, Teicher BA, Thamm DH, Trent JM, Vail DM, Khanna C.

Sci Transl Med. 2016 Feb 3;8(324):324ps5. doi: 10.1126/scitranslmed.aaf0746. Review. No abstract available.


Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.

Min J, Guo K, Suryadevara PK, Zhu F, Holbrook G, Chen Y, Feau C, Young BM, Lemoff A, Connelly MC, Kastan MB, Guy RK.

J Med Chem. 2016 Jan 28;59(2):559-77. doi: 10.1021/acs.jmedchem.5b01092. Epub 2016 Jan 12.


Chromatin perturbations during the DNA damage response in higher eukaryotes.

Bakkenist CJ, Kastan MB.

DNA Repair (Amst). 2015 Dec;36:8-12. doi: 10.1016/j.dnarep.2015.09.002. Epub 2015 Sep 9. Review.


ATM functions at the peroxisome to induce pexophagy in response to ROS.

Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL.

Nat Cell Biol. 2015 Oct;17(10):1259-1269. doi: 10.1038/ncb3230. Epub 2015 Sep 7.


HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.

Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG.

Radiat Res. 2015 Jun;183(6):594-609. Epub 2015 May 14.


Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.

Goldstein M, Kastan MB.

Cancer Res. 2015 Jul 1;75(13):2699-707. doi: 10.1158/0008-5472.CAN-15-0400. Epub 2015 May 4.


The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.

Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, Imreh G, Zhivotovsky B, Kastan MB, Helleday T, Farnebo M.

Genes Dev. 2014 Dec 15;28(24):2726-38. doi: 10.1101/gad.246546.114.


The DNA damage response: implications for tumor responses to radiation and chemotherapy.

Goldstein M, Kastan MB.

Annu Rev Med. 2015;66:129-43. doi: 10.1146/annurev-med-081313-121208. Epub 2014 Nov 24. Review.


Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease.

Kennedy EM, Kornepati AV, Goldstein M, Bogerd HP, Poling BC, Whisnant AW, Kastan MB, Cullen BR.

J Virol. 2014 Oct;88(20):11965-72. doi: 10.1128/JVI.01879-14. Epub 2014 Aug 6.


Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.

Wang Q, Goldstein M, Alexander P, Wakeman TP, Sun T, Feng J, Lou Z, Kastan MB, Wang XF.

EMBO J. 2014 Apr 16;33(8):862-77. doi: 10.1002/embj.201386064. Epub 2014 Feb 16.


Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors.

Guo K, Shelat AA, Guy RK, Kastan MB.

J Biomol Screen. 2014 Apr;19(4):538-46. doi: 10.1177/1087057113520325. Epub 2014 Jan 24. Erratum in: J Biomol Screen. 2014 Dec;19(10):1418.


Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.

Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16874-9. doi: 10.1073/pnas.1306160110. Epub 2013 Sep 30.


A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.

Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, Walker CL.

Nat Cell Biol. 2013 Oct;15(10):1186-96. doi: 10.1038/ncb2822. Epub 2013 Aug 18.


Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.

Sandlund JT, Hudson MM, Kennedy W, Onciu M, Kastan MB.

Pediatr Blood Cancer. 2014 Feb;61(2):360-2. doi: 10.1002/pbc.24696. Epub 2013 Jul 30.


Strategies for optimizing the response of cancer and normal tissues to radiation.

Moding EJ, Kastan MB, Kirsch DG.

Nat Rev Drug Discov. 2013 Jul;12(7):526-42. doi: 10.1038/nrd4003. Review.


A message from the Editor-in-Chief.

Kastan MB.

Mol Cancer Res. 2012 Dec;10(12):1513. doi: 10.1158/1541-7786.MCR-12-0644. Epub 2012 Nov 27. No abstract available.


A new role for ATM: regulating mitochondrial function and mitophagy.

Valentin-Vega YA, Kastan MB.

Autophagy. 2012 May 1;8(5):840-1. doi: 10.4161/auto.19693. Epub 2012 May 1.


Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation.

Lim Y, Hedayati M, Merchant AA, Zhang Y, Yu HH, Kastan MB, Matsui W, Deweese TL.

Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):800-6. doi: 10.1016/j.ijrobp.2012.01.026. Epub 2012 Mar 22.


Autophagy links inflammasomes to atherosclerotic progression.

Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF.

Cell Metab. 2012 Apr 4;15(4):534-44. doi: 10.1016/j.cmet.2012.02.011. Epub 2012 Mar 20.


Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.

Chen J, Guo K, Kastan MB.

J Biol Chem. 2012 May 11;287(20):16467-76. doi: 10.1074/jbc.M112.349274. Epub 2012 Mar 20.


Mitochondrial dysfunction in ataxia-telangiectasia.

Valentin-Vega YA, Maclean KH, Tait-Mulder J, Milasta S, Steeves M, Dorsey FC, Cleveland JL, Green DR, Kastan MB.

Blood. 2012 Feb 9;119(6):1490-500. doi: 10.1182/blood-2011-08-373639. Epub 2011 Dec 5.


5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage.

Chen J, Kastan MB.

Genes Dev. 2010 Oct 1;24(19):2146-56. doi: 10.1101/gad.1968910. Epub 2010 Sep 13.


Multiple roles of ATM in monitoring and maintaining DNA integrity.

Derheimer FA, Kastan MB.

FEBS Lett. 2010 Sep 10;584(17):3675-81. doi: 10.1016/j.febslet.2010.05.031. Epub 2010 May 24. Review.


Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia.

Leung W, Neale G, Behm F, Iyengar R, Finkelstein D, Kastan MB, Pui CH.

Cancer Epidemiol. 2010 Jun;34(3):303-8. doi: 10.1016/j.canep.2010.03.008. Epub 2010 Apr 22.


The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.

Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD.

Immunity. 2010 Mar 26;32(3):379-91. doi: 10.1016/j.immuni.2010.03.003. Epub 2010 Mar 18.


ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4153-8. doi: 10.1073/pnas.0913860107. Epub 2010 Feb 16. Erratum in: Proc Natl Acad Sci U S A. 2012 May 22;109(21):8352.


Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.

Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M.

Mol Cell. 2008 Oct 24;32(2):180-9. doi: 10.1016/j.molcel.2008.08.031.


Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation.

Rainey MD, Charlton ME, Stanton RV, Kastan MB.

Cancer Res. 2008 Sep 15;68(18):7466-74. doi: 10.1158/0008-5472.CAN-08-0763.


Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites.

Berkovich E, Monnat RJ Jr, Kastan MB.

Nat Protoc. 2008;3(5):915-22. doi: 10.1038/nprot.2008.54.


Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.

Chandhasin C, Ducu RI, Berkovich E, Kastan MB, Marriott SJ.

J Virol. 2008 Jul;82(14):6952-61. doi: 10.1128/JVI.02331-07. Epub 2008 Apr 23.


DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture.

Kastan MB.

Mol Cancer Res. 2008 Apr;6(4):517-24. doi: 10.1158/1541-7786.MCR-08-0020.


A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.

Tang X, Hui ZG, Cui XL, Garg R, Kastan MB, Xu B.

Mol Cell Biol. 2008 Apr;28(8):2559-66. doi: 10.1128/MCB.01711-07. Epub 2008 Feb 4.


Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.

Maclean KH, Dorsey FC, Cleveland JL, Kastan MB.

J Clin Invest. 2008 Jan;118(1):79-88. Erratum in: J Clin Invest. 2008 Apr;118(4):1584.


Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.

Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O'Malley BW.

Cancer Res. 2007 Dec 15;67(24):12026-33.


Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.

Maclean KH, Kastan MB, Cleveland JL.

Mol Cancer Res. 2007 Jul;5(7):705-11.


Our cells get stressed too! Implications for human disease.

Kastan MB.

Blood Cells Mol Dis. 2007 Sep-Oct;39(2):148-50. Epub 2007 May 29.


Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.

Berkovich E, Monnat RJ Jr, Kastan MB.

Nat Cell Biol. 2007 Jun;9(6):683-90. Epub 2007 May 7.


p53: a two-faced cancer gene.

Kastan MB, Berkovich E.

Nat Cell Biol. 2007 May;9(5):489-91. No abstract available.


Wild-type p53: tumors can't stand it.

Kastan MB.

Cell. 2007 Mar 9;128(5):837-40. Review.


Cellular survival pathways and resistance to cancer therapy.

Dennis PA, Kastan MB.

Drug Resist Updat. 1998;1(5):301-9.


ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.

Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, Bernal-Mizrachi C, Muslin AJ, Kastan MB, Semenkovich CF.

Cell Metab. 2006 Nov;4(5):377-89.


The ATM-dependent DNA damage signaling pathway.

Kitagawa R, Kastan MB.

Cold Spring Harb Symp Quant Biol. 2005;70:99-109. Review.


A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia.

Sandlund JT, Kastan MB, Kennedy W, Behm F, Entrekin E, Pui CH, Kalwinsky DT, Raimondi SC.

Cancer Genet Cytogenet. 2006 Jul 1;168(1):69-72.


Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.

Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J.

J Cell Biol. 2006 Apr 24;173(2):195-206. Epub 2006 Apr 17.


The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.

Genes Dev. 2005 Dec 15;19(24):3043-54.

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