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Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm.

Jana S, Hu M, Shen M, Kassiri Z.

Exp Mol Med. 2019 Dec 19;51(12):160. doi: 10.1038/s12276-019-0286-3. Review.


Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury.

Masoud AG, Lin J, Azad AK, Farhan MA, Fischer C, Zhu LF, Zhang H, Sis B, Kassiri Z, Moore RB, Kim D, Anderson CC, Vederas JC, Adam BA, Oudit GY, Murray AG.

J Clin Invest. 2020 Jan 2;130(1):94-107. doi: 10.1172/JCI128469.


The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis.

Chute M, Aujla P, Jana S, Kassiri Z.

J Cardiovasc Dev Dis. 2019 Sep 23;6(4). pii: E35. doi: 10.3390/jcdd6040035. Review.


Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.

Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GY.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13006-13015. doi: 10.1073/pnas.1900152116. Epub 2019 Jun 12.


PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.

Patel VB, Zhabyeyev P, Chen X, Wang F, Paul M, Fan D, McLean BA, Basu R, Zhang P, Shah S, Dawson JF, Pyle WG, Hazra M, Kassiri Z, Hazra S, Vanhaesebroeck B, McCulloch CA, Oudit GY.

Nat Commun. 2018 Dec 19;9(1):5390. doi: 10.1038/s41467-018-07812-8.


Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury.

Chen X, Zhabyeyev P, Azad AK, Wang W, Minerath RA, DesAulniers J, Grueter CE, Murray AG, Kassiri Z, Vanhaesebroeck B, Oudit GY.

Cardiovasc Res. 2019 Jul 1;115(8):1343-1356. doi: 10.1093/cvr/cvy298.


Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts.

Jana S, Zhang H, Lopaschuk GD, Freed DH, Sergi C, Kantor PF, Oudit GY, Kassiri Z.

J Am Heart Assoc. 2018 Oct 2;7(19):e010427. doi: 10.1161/JAHA.118.010427.


Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.

Presa N, Clugston RD, Lingrell S, Kelly SE, Merrill AH Jr, Jana S, Kassiri Z, Gómez-Muñoz A, Vance DE, Jacobs RL, van der Veen JN.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):14-25. doi: 10.1016/j.bbadis.2018.10.010. Epub 2018 Oct 6.


Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm.

Shen M, Hu M, Fedak PWM, Oudit GY, Kassiri Z.

Circ Res. 2018 Jul 20;123(3):372-388. doi: 10.1161/CIRCRESAHA.118.313181. Epub 2018 Jun 21.


LOXury of inhibiting fibrosis in volume overload cardiomyopathy.

Jana S, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H629-H631. doi: 10.1152/ajpheart.00315.2018. Epub 2018 Jun 1. No abstract available.


TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.

Zhabyeyev P, Das SK, Basu R, Shen M, Patel VB, Kassiri Z, Oudit GY.

Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H978-H990. doi: 10.1152/ajpheart.00597.2017. Epub 2018 Jan 26.


Guidelines for measuring cardiac physiology in mice.

Lindsey ML, Kassiri Z, Virag JAI, de Castro Brás LE, Scherrer-Crosbie M.

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H733-H752. doi: 10.1152/ajpheart.00339.2017. Epub 2018 Jan 5.


Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy.

Das SK, Zhabyeyev P, Basu R, Patel VB, Dyck JRB, Kassiri Z, Oudit GY.

Biosci Rep. 2018 Jan 10;38(1). pii: BSR20171302. doi: 10.1042/BSR20171302. Print 2018 Feb 28.


Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption.

Sakamuri SSVP, Watts R, Takawale A, Wang X, Hernandez-Anzaldo S, Bahitham W, Fernandez-Patron C, Lehner R, Kassiri Z.

Sci Rep. 2017 Jul 24;7(1):6210. doi: 10.1038/s41598-017-05951-4.


Myocardial overexpression of TIMP3 after myocardial infarction exerts beneficial effects by promoting angiogenesis and suppressing early proteolysis.

Takawale A, Zhang P, Azad A, Wang W, Wang X, Murray AG, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H224-H236. doi: 10.1152/ajpheart.00108.2017. Epub 2017 May 26.


Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63-Integrin β1 Interaction.

Takawale A, Zhang P, Patel VB, Wang X, Oudit G, Kassiri Z.

Hypertension. 2017 Jun;69(6):1092-1103. doi: 10.1161/HYPERTENSIONAHA.117.09045. Epub 2017 Apr 3.


Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase.

van der Veen JN, Lingrell S, Gao X, Takawale A, Kassiri Z, Vance DE, Jacobs RL.

J Lipid Res. 2017 Apr;58(4):656-667. doi: 10.1194/jlr.M070631. Epub 2017 Feb 3.


Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress.

Das SK, Patel VB, Basu R, Wang W, DesAulniers J, Kassiri Z, Oudit GY.

J Am Heart Assoc. 2017 Jan 23;6(1). pii: e003456. doi: 10.1161/JAHA.116.003456.


Genetic deletion of soluble epoxide hydrolase provides cardioprotective responses following myocardial infarction in aged mice.

Jamieson KL, Samokhvalov V, Akhnokh MK, Lee K, Cho WJ, Takawale A, Wang X, Kassiri Z, Seubert JM.

Prostaglandins Other Lipid Mediat. 2017 Sep;132:47-58. doi: 10.1016/j.prostaglandins.2017.01.001. Epub 2017 Jan 16. Review.


Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage.

Shen M, Morton J, Davidge ST, Kassiri Z.

J Mol Cell Cardiol. 2017 Feb;103:11-21. doi: 10.1016/j.yjmcc.2016.12.001. Epub 2016 Dec 16.


Crossing Into the Next Frontier of Cardiac Extracellular Matrix Research.

Spinale FG, Frangogiannis NG, Hinz B, Holmes JW, Kassiri Z, Lindsey ML.

Circ Res. 2016 Oct 28;119(10):1040-1045. No abstract available.


Modulation of Systemic Metabolism by MMP-2: From MMP-2 Deficiency in Mice to MMP-2 Deficiency in Patients.

Fernandez-Patron C, Kassiri Z, Leung D.

Compr Physiol. 2016 Sep 15;6(4):1935-1949. doi: 10.1002/cphy.c160010. Review.


Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism.

Hernandez-Anzaldo S, Brglez V, Hemmeryckx B, Leung D, Filep JG, Vance JE, Vance DE, Kassiri Z, Lijnen RH, Lambeau G, Fernandez-Patron C.

J Am Heart Assoc. 2016 Sep 30;5(10). pii: e004228.


A Disintegrin and Metalloprotease-17 Regulates Pressure Overload-Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1.

Fan D, Takawale A, Shen M, Samokhvalov V, Basu R, Patel V, Wang X, Fernandez-Patron C, Seubert JM, Oudit GY, Kassiri Z.

Hypertension. 2016 Oct;68(4):937-48. doi: 10.1161/HYPERTENSIONAHA.116.07566. Epub 2016 Aug 22.


Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.

Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z, Seubert JM.

Front Pharmacol. 2016 Jun 7;7:133. doi: 10.3389/fphar.2016.00133. eCollection 2016.


Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure.

Sakamuri SS, Takawale A, Basu R, Fedak PW, Freed D, Sergi C, Oudit GY, Kassiri Z.

Transl Res. 2016 Jun;172:30-44. doi: 10.1016/j.trsl.2016.02.006. Epub 2016 Feb 23.


Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.

van der Veen JN, Lingrell S, Gao X, Quiroga AD, Takawale A, Armstrong EA, Yager JY, Kassiri Z, Lehner R, Vance DE, Jacobs RL.

Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G526-38. doi: 10.1152/ajpgi.00243.2015. Epub 2016 Jan 21.


Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy.

Das SK, Wang W, Zhabyeyev P, Basu R, McLean B, Fan D, Parajuli N, DesAulniers J, Patel VB, Hajjar RJ, Dyck JR, Kassiri Z, Oudit GY.

Sci Rep. 2015 Dec 7;5:18132. doi: 10.1038/srep18132.


Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.

Hernandez-Anzaldo S, Berry E, Brglez V, Leung D, Yun TJ, Lee JS, Filep JG, Kassiri Z, Cheong C, Lambeau G, Lehner R, Fernandez-Patron C.

J Am Heart Assoc. 2015 Nov 13;4(11). pii: e002553. doi: 10.1161/JAHA.115.002553.


ADAMs family and relatives in cardiovascular physiology and pathology.

Zhang P, Shen M, Fernandez-Patron C, Kassiri Z.

J Mol Cell Cardiol. 2016 Apr;93:186-99. doi: 10.1016/j.yjmcc.2015.10.031. Epub 2015 Oct 29. Review.


Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis.

Fan D, Takawale A, Shen M, Wang W, Wang X, Basu R, Oudit GY, Kassiri Z.

Circ Heart Fail. 2015 Sep;8(5):970-9. doi: 10.1161/CIRCHEARTFAILURE.114.002029. Epub 2015 Jul 1.


Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload.

Das SK, DesAulniers J, Dyck JR, Kassiri Z, Oudit GY.

Liver Int. 2016 Feb;36(2):246-57. doi: 10.1111/liv.12893. Epub 2015 Jul 3.


Extracellular matrix communication and turnover in cardiac physiology and pathology.

Takawale A, Sakamuri SS, Kassiri Z.

Compr Physiol. 2015 Apr;5(2):687-719. doi: 10.1002/cphy.c140045. Review.


Antagonism of angiotensin 1-7 prevents the therapeutic effects of recombinant human ACE2.

Patel VB, Takawale A, Ramprasath T, Das SK, Basu R, Grant MB, Hall DA, Kassiri Z, Oudit GY.

J Mol Med (Berl). 2015 Sep;93(9):1003-13. doi: 10.1007/s00109-015-1285-z. Epub 2015 Apr 15.


Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.

Berry E, Hernandez-Anzaldo S, Ghomashchi F, Lehner R, Murakami M, Gelb MH, Kassiri Z, Wang X, Fernandez-Patron C.

J Am Heart Assoc. 2015 Mar 27;4(4). pii: e001868. doi: 10.1161/JAHA.115.001868.


Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm.

Shen M, Lee J, Basu R, Sakamuri SS, Wang X, Fan D, Kassiri Z.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):888-98. doi: 10.1161/ATVBAHA.114.305115. Epub 2015 Feb 5.


Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart.

Wang X, Berry E, Hernandez-Anzaldo S, Takawale A, Kassiri Z, Fernandez-Patron C.

Hypertension. 2015 Apr;65(4):882-8. doi: 10.1161/HYPERTENSIONAHA.114.04989. Epub 2015 Feb 2.


PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.

McLean BA, Zhabyeyev P, Patel VB, Basu R, Parajuli N, DesAulniers J, Murray AG, Kassiri Z, Vanhaesebroeck B, Oudit GY.

Cardiovasc Res. 2015 Mar 1;105(3):292-303. doi: 10.1093/cvr/cvv016. Epub 2015 Jan 24.


Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy.

Haddad G, Zhabyeyev P, Farhan M, Zhu LF, Kassiri Z, Rayner DC, Vanhaesebroeck B, Oudit GY, Murray AG.

Blood. 2014 Sep 25;124(13):2142-9. doi: 10.1182/blood-2014-02-557975. Epub 2014 Aug 18.


The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.

Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.

BMC Cardiovasc Disord. 2014 Jul 25;14:91. doi: 10.1186/1471-2261-14-91.


Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology.

Putko BN, Wang Z, Lo J, Anderson T, Becher H, Dyck JR, Kassiri Z, Oudit GY; Alberta HEART Investigators.

PLoS One. 2014 Jun 12;9(6):e99495. doi: 10.1371/journal.pone.0099495. eCollection 2014.


Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm.

Lee J, Shen M, Parajuli N, Oudit GY, McMurtry MS, Kassiri Z.

J Mol Med (Berl). 2014 Sep;92(9):939-49. doi: 10.1007/s00109-014-1178-6. Epub 2014 Jun 5.


Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4.

Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY, Kassiri Z.

Circ Heart Fail. 2014 Jul;7(4):652-62. doi: 10.1161/CIRCHEARTFAILURE.114.001113. Epub 2014 May 19.


Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling.

Patel VB, Zhong JC, Fan D, Basu R, Morton JS, Parajuli N, McMurtry MS, Davidge ST, Kassiri Z, Oudit GY.

Hypertension. 2014 Jul;64(1):157-64. doi: 10.1161/HYPERTENSIONAHA.114.03388. Epub 2014 May 5.


Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease.

Wang W, Patel VB, Parajuli N, Fan D, Basu R, Wang Z, Ramprasath T, Kassiri Z, Penninger JM, Oudit GY.

J Mol Med (Berl). 2014 Aug;92(8):847-58. doi: 10.1007/s00109-014-1149-y. Epub 2014 Apr 15.


Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction.

Fan D, Takawale A, Basu R, Patel V, Lee J, Kandalam V, Wang X, Oudit GY, Kassiri Z.

Cardiovasc Res. 2014 Jul 15;103(2):268-80. doi: 10.1093/cvr/cvu072. Epub 2014 Apr 1.


Matrix as an interstitial transport system.

Fan D, Creemers EE, Kassiri Z.

Circ Res. 2014 Feb 28;114(5):889-902. doi: 10.1161/CIRCRESAHA.114.302335. Review.


Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation.

Mori J, Patel VB, Abo Alrob O, Basu R, Altamimi T, Desaulniers J, Wagg CS, Kassiri Z, Lopaschuk GD, Oudit GY.

Circ Heart Fail. 2014 Mar 1;7(2):327-39. doi: 10.1161/CIRCHEARTFAILURE.113.000672. Epub 2014 Jan 3.


Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.

Patel VB, Clarke N, Wang Z, Fan D, Parajuli N, Basu R, Putko B, Kassiri Z, Turner AJ, Oudit GY.

J Mol Cell Cardiol. 2014 Jan;66:167-76. doi: 10.1016/j.yjmcc.2013.11.017. Epub 2013 Dec 9.


Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.

Song B, Zhang ZZ, Zhong JC, Yu XY, Oudit GY, Jin HY, Lu L, Xu YL, Kassiri Z, Shen WF, Gao PJ, Zhu DL.

Circ J. 2013;77(12):2997-3006. Epub 2013 Oct 26.

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