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The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells.

Gaud G, Roncagalli R, Chaoui K, Bernard I, Familiades J, Colacios C, Kassem S, Monsarrat B, Burlet-Schiltz O, de Peredo AG, Malissen B, Saoudi A.

Sci Signal. 2018 Jul 10;11(538). pii: eaar3083. doi: 10.1126/scisignal.aar3083.


TIGIT immune checkpoint blockade restores CD8+ T cell immunity against multiple myeloma.

Guillerey C, Harjunpää H, Carrié N, Kassem S, Teo T, Miles K, Krumeich S, Weulersse M, Cuisinier M, Stannard K, Yu Y, Minnie SA, Hill GR, Dougall WC, Avet-Loiseau H, Teng MWL, Nakamura K, Martinet L, Smyth MJ.

Blood. 2018 Jul 9. pii: blood-2018-01-825265. doi: 10.1182/blood-2018-01-825265. [Epub ahead of print]


Late left ventricular rupture as a complication of NeoChord implantation for mitral valve repair.

Kassem S, Ricciardi G, Salvi L, Alimento M.

J Thorac Cardiovasc Surg. 2018 Jul;156(1):e1-e4. doi: 10.1016/j.jtcvs.2018.03.006. Epub 2018 Mar 10. No abstract available.


Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment.

Nakamura K, Kassem S, Cleynen A, Chrétien ML, Guillerey C, Putz EM, Bald T, Förster I, Vuckovic S, Hill GR, Masters SL, Chesi M, Bergsagel PL, Avet-Loiseau H, Martinet L, Smyth MJ.

Cancer Cell. 2018 Apr 9;33(4):634-648.e5. doi: 10.1016/j.ccell.2018.02.007.


An Intervention to Reduce the Time Interval Between Hospital Entry and Emergency Coronary Angiography in Patients with ST-Elevation Myocardial Infarction.

Karkabi B, Jaffe R, Halon DA, Merdler A, Khader N, Rubinshtein R, Goldstein J, Zafrir B, Zissman K, Ben-Dov N, Gabrielly M, Fuks A, Shiran A, Adawi S, Hellman Y, Shahla J, Halabi S, Flugelman MY, Cohen S, Bergman I, Kassem S, Shapira C.

Isr Med Assoc J. 2017 Sep;19(9):547-552.


Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction.

Secher T, Kassem S, Benamar M, Bernard I, Boury M, Barreau F, Oswald E, Saoudi A.

Front Immunol. 2017 Sep 14;8:1096. doi: 10.3389/fimmu.2017.01096. eCollection 2017.


Stereodivergent synthesis with a programmable molecular machine.

Kassem S, Lee ATL, Leigh DA, Marcos V, Palmer LI, Pisano S.

Nature. 2017 Sep 20;549(7672):374-378. doi: 10.1038/nature23677.


Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.

Kassem S, Villanyi Z, Collart MA.

Nucleic Acids Res. 2017 Jul 7;45(12):7539. doi: 10.1093/nar/gkx447. No abstract available.


Single-centre early experience with sutureless valve Perceval: focus onto size gaining.

Zanobini M, Loardi C, Mammana FL, Kassem S, Alamanni F, DI Minno A, Poggio P, Myasaoedova V, Saccocci M.

J Cardiovasc Surg (Torino). 2017 Dec;58(6):951-952. doi: 10.23736/S0021-9509.17.10116-3. Epub 2017 Jul 24. No abstract available.


The 'respect rather than resect' principle in mitral valve repair: the lateral dislocation of the P2 technique.

Zanobini M, Ricciardi G, Mammana FL, Kassem S, Poggio P, Di Minno A, Cavallotti L, Saccocci M.

J Cardiovasc Med (Hagerstown). 2017 Sep;18(9):687-690. doi: 10.2459/JCM.0000000000000541.


Obstetric and perinatal outcomes of singletons after single blastocyst transfer: is there any difference according to blastocyst morphology?

Bouillon C, Celton N, Kassem S, Frapsauce C, Guérif F.

Reprod Biomed Online. 2017 Aug;35(2):197-207. doi: 10.1016/j.rbmo.2017.04.009. Epub 2017 Jun 7.


Mutations in the NOT Genes or in the Translation Machinery Similarly Display Increased Resistance to Histidine Starvation.

Collart MA, Kassem S, Villanyi Z.

Front Genet. 2017 May 22;8:61. doi: 10.3389/fgene.2017.00061. eCollection 2017.


Artificial molecular motors.

Kassem S, van Leeuwen T, Lubbe AS, Wilson MR, Feringa BL, Leigh DA.

Chem Soc Rev. 2017 May 9;46(9):2592-2621. doi: 10.1039/c7cs00245a. Review.


Epstein-Barr virus and cytomegalovirus infections and their clinical relevance in Egyptian leukemic pediatric patients.

Loutfy SA, Abo-Shadi MA, Fawzy M, El-Wakil M, Metwally SA, Moneer MM, Fattah NF, Kassem S, Elgebaly A.

Virol J. 2017 Mar 6;14(1):46. doi: 10.1186/s12985-017-0715-7.


Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.

Kassem S, Villanyi Z, Collart MA.

Nucleic Acids Res. 2017 Feb 17;45(3):1186-1199. doi: 10.1093/nar/gkw1059.


Molecular docking based screening of compounds against VP40 from Ebola virus.

M Alam El-Din H, A Loutfy S, Fathy N, H Elberry M, M Mayla A, Kassem S, Naqvi A.

Bioinformation. 2016 Jun 15;12(3):192-196. doi: 10.6026/97320630012192. eCollection 2016.


A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.

Kassem S, Gaud G, Bernard I, Benamar M, Dejean AS, Liblau R, Fournié GJ, Colacios C, Malissen B, Saoudi A.

PLoS Genet. 2016 Jul 20;12(7):e1006185. doi: 10.1371/journal.pgen.1006185. eCollection 2016 Jul.


Low specificity of urinary 3-methoxytyramine in screening of dopamine-secreting pheochromocytomas and paragangliomas.

Patin F, Crinière L, Francia T, Kassem S, Pierre P, Bruno C, Vayne C, Vourc'h P, Benz-de Bretagne I, Andres CR, Blasco H.

Clin Biochem. 2016 Oct;49(15):1205-1208. doi: 10.1016/j.clinbiochem.2016.05.008. Epub 2016 May 18. No abstract available.


Translational Capacity of a Cell Is Determined during Transcription Elongation via the Ccr4-Not Complex.

Gupta I, Villanyi Z, Kassem S, Hughes C, Panasenko OO, Steinmetz LM, Collart MA.

Cell Rep. 2016 May 24;15(8):1782-94. doi: 10.1016/j.celrep.2016.04.055. Epub 2016 May 12.


Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm.

Kassem S, Lee AT, Leigh DA, Markevicius A, Solà J.

Nat Chem. 2016 Feb;8(2):138-43. doi: 10.1038/nchem.2410. Epub 2015 Dec 21.


Vitamin D Deficiency in Patients with Acute Myocardial Infarction: An Italian Single-Center Study.

Aleksova A, Belfiore R, Carriere C, Kassem S, La Carrubba S, Barbati G, Sinagra G.

Int J Vitam Nutr Res. 2015;85(1-2):23-30. doi: 10.1024/0300-9831/a000220.


Entropy in bimolecular simulations: A comprehensive review of atomic fluctuations-based methods.

Kassem S, Ahmed M, El-Sheikh S, Barakat KH.

J Mol Graph Model. 2015 Nov;62:105-117. doi: 10.1016/j.jmgm.2015.09.010. Epub 2015 Sep 15. Review.


Avemar and Echinacea extracts enhance mobilization and homing of CD34(+) stem cells in rats with acute myocardial infarction.

Abdelmonem M, Kassem SH, Gabr H, Shaheen AA, Aboushousha T.

Stem Cell Res Ther. 2015 Sep 14;6:172. doi: 10.1186/s13287-015-0171-5.


An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.

Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, Andréoletti O, Dejean AS, Lesourne R, Fournié GJ, Saoudi A.

J Immunol. 2015 Aug 15;195(4):1608-16. doi: 10.4049/jimmunol.1402562. Epub 2015 Jul 10.


Feasibility of pig and human-derived aortic valve interstitial cells seeding on fixative-free decellularized animal pericardium.

Santoro R, Consolo F, Spiccia M, Piola M, Kassem S, Prandi F, Vinci MC, Forti E, Polvani G, Fiore GB, Soncini M, Pesce M.

J Biomed Mater Res B Appl Biomater. 2016 Feb;104(2):345-56. doi: 10.1002/jbm.b.33404. Epub 2015 Mar 23.


The Not5 subunit of the ccr4-not complex connects transcription and translation.

Villanyi Z, Ribaud V, Kassem S, Panasenko OO, Pahi Z, Gupta I, Steinmetz L, Boros I, Collart MA.

PLoS Genet. 2014 Oct 23;10(10):e1004569. doi: 10.1371/journal.pgen.1004569. eCollection 2014 Oct.


Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M.

J Exp Med. 2014 Aug 25;211(9):1779-92. doi: 10.1084/jem.20131276. Epub 2014 Jul 29.


Rho-GTPases as key regulators of T lymphocyte biology.

Saoudi A, Kassem S, Dejean A, Gaud G.

Small GTPases. 2014;5. pii: e28208. doi: 10.4161/sgtp.28208. Epub 2014 May 8. Review.


Coronary artery disease associated with severe mitral and tricuspid valve regurgitation after left pneumonectomy: report of a successful hybrid procedure.

Gennari M, Kassem S, Teruzzi G, Agrifoglio M.

Interact Cardiovasc Thorac Surg. 2014 Aug;19(2):318-20. doi: 10.1093/icvts/ivu120. Epub 2014 Apr 25.


Acute aortic insufficiency due to rupture of an aortic valve commissure.

Kassem S, Polvani G, Al Jaber E, Gennari M.

J Card Surg. 2014 Jul;29(4):497-8. doi: 10.1111/jocs.12276. Epub 2014 Jan 12.


Paradoxical stitches aim to discipline the anterior leaflet to avoid postplasty systolic anterior motion.

Kassem S.

J Thorac Cardiovasc Surg. 2013 Mar;145(3):893-5. doi: 10.1016/j.jtcvs.2012.11.088. No abstract available.


Saphenous vein cannulation in re-redo cardiac surgery.

Agrifoglio M, Gennari M, Kassem S, Polvani G.

J Card Surg. 2012 Nov;27(6):676-7. doi: 10.1111/jocs.12004. Epub 2012 Oct 15.


Face-to-face single patch: a new technique to repair the commissures of the mitral valve.

Kassem S, Al-Faraidy K, Elkady Y, Takriti A.

J Thorac Cardiovasc Surg. 2012 Dec;144(6):1523-7. doi: 10.1016/j.jtcvs.2012.07.079. Epub 2012 Aug 29. No abstract available.


Partial anomalous pulmonary vein connection.

Generali T, Daprati A, Kassem S, Alamanni F.

J Card Surg. 2012 Mar;27(2):245. doi: 10.1111/j.1540-8191.2011.01380.x. Epub 2012 Jan 11. No abstract available.


Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46.

Gur C, Enk J, Kassem SA, Suissa Y, Magenheim J, Stolovich-Rain M, Nir T, Achdout H, Glaser B, Shapiro J, Naparstek Y, Porgador A, Dor Y, Mandelboim O.

J Immunol. 2011 Sep 15;187(6):3096-103. doi: 10.4049/jimmunol.1101269. Epub 2011 Aug 17.


Hemoglobin drop after anesthesia in craniosynstosis: Dilemma of operate or not to operate.

El-Ghandour N, Kassem S, Al Sabbagh AJ, Al-Banyan A, Shubbak FA, Hassib A, Zaki H.

Anesth Essays Res. 2011 Jul-Dec;5(2):233-5. doi: 10.4103/0259-1162.94792.


Papillary muscle-to-anterior annulus stitches: another technique to prevent systolic anterior motion after mitral valve repair.

Kassem S, Jamil H.

J Thorac Cardiovasc Surg. 2011 Nov;142(5):1278-81. doi: 10.1016/j.jtcvs.2011.03.025. Epub 2011 Apr 29. No abstract available.


Annulus-edge-papillary stitch to repair P2 of the mitral valve posterior leaflet.

Kassem S, Othman M.

J Thorac Cardiovasc Surg. 2011 Jun;141(6):e45-7. doi: 10.1016/j.jtcvs.2011.02.016. Epub 2011 Mar 21. No abstract available.


Do statins improve outcomes and delay the progression of non-rheumatic calcific aortic stenosis?

Parolari A, Tremoli E, Cavallotti L, Trezzi M, Kassem S, Loardi C, Veglia F, Ferrari G, Pacini D, Alamanni F.

Heart. 2011 Apr;97(7):523-9. doi: 10.1136/hrt.2010.215046. Epub 2011 Jan 26. Review.


Biology of mitral valve prolapse: the harvest is big, but the workers are few.

Loardi C, Alamanni F, Trezzi M, Kassem S, Cavallotti L, Tremoli E, Pacini D, Parolari A.

Int J Cardiol. 2011 Sep 1;151(2):129-35. doi: 10.1016/j.ijcard.2010.11.004. Epub 2010 Dec 17. Review.


Regulatory T-cells in Graves' orbitopathy: baseline findings and immunomodulation by anti-T lymphocyte globulin.

Kahaly GJ, Shimony O, Gellman YN, Lytton SD, Eshkar-Sebban L, Rosenblum N, Refaeli E, Kassem S, Ilany J, Naor D.

J Clin Endocrinol Metab. 2011 Feb;96(2):422-9. doi: 10.1210/jc.2010-1424. Epub 2010 Dec 8.


Tent-shape technique: another procedure to repair P2 of posterior leaflet of mitral valve.

Kassem S, Moasis GA, Biglioli P.

Eur J Cardiothorac Surg. 2011 Jun;39(6):1064-6. doi: 10.1016/j.ejcts.2010.10.013. Epub 2010 Dec 15.


Mycotic ascending aortic pseudoaneurysm following reduction aortoplasty.

Zoli S, Kassem S, Tessitore G, Annoni A, Alamanni F, Agrifoglio M.

J Card Surg. 2011 Jan;26(1):100-1. doi: 10.1111/j.1540-8191.2010.01153.x. Epub 2010 Nov 14. No abstract available.


Eagle-shaped patch to restore mitral-aortic continuity.

Kassem S, Alamanni F, Moasis GA.

J Thorac Cardiovasc Surg. 2011 May;141(5):1321-3. doi: 10.1016/j.jtcvs.2010.08.041. Epub 2010 Oct 8. No abstract available.


In situ right internal thoracic artery is usually long enough for grafting the circumflex artery through the transverse sinus.

Agrifoglio M, Kassem S, Alamanni F.

J Thorac Cardiovasc Surg. 2010 Sep;140(3):731-2. doi: 10.1016/j.jtcvs.2010.02.054. No abstract available.


A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolism.

Wells PS, Majeed H, Kassem S, Langlois N, Gin B, Clermont J, Taljaard M.

Thromb Res. 2010 Jun;125(6):e259-64. doi: 10.1016/j.thromres.2009.11.020. Epub 2010 Apr 24.


Large islets, beta-cell proliferation, and a glucokinase mutation.

Kassem S, Bhandari S, Rodríguez-Bada P, Motaghedi R, Heyman M, García-Gimeno MA, Cobo-Vuilleumier N, Sanz P, Maclaren NK, Rahier J, Glaser B, Cuesta-Muñoz AL.

N Engl J Med. 2010 Apr 8;362(14):1348-50. doi: 10.1056/NEJMc0909845. No abstract available. Erratum in: N Engl J Med. 2010 Nov 25;363(22):2178.


EuroSCORE performance in valve surgery: a meta-analysis.

Parolari A, Pesce LL, Trezzi M, Cavallotti L, Kassem S, Loardi C, Pacini D, Tremoli E, Alamanni F.

Ann Thorac Surg. 2010 Mar;89(3):787-93, 793.e1-2. doi: 10.1016/j.athoracsur.2009.11.032.


Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity or mortality? No.

Kassem SA, Raz I.

Diabetes Care. 2009 Nov;32 Suppl 2:S337-41. doi: 10.2337/dc09-S335. Review. No abstract available.


Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results.

Eldor R, Kassem S, Raz I.

Diabetes Metab Res Rev. 2009 May;25(4):316-20. doi: 10.1002/dmrr.942. Review.


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