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Items: 1 to 50 of 107

1.

Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1.

Wang C, Hamacher A, Petzsch P, Köhrer K, Niegisch G, Hoffmann MJ, Schulz WA, Kassack MU.

Cancers (Basel). 2020 Feb 3;12(2). pii: E337. doi: 10.3390/cancers12020337.

2.

Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.

Asfaha Y, Schrenk C, Alves Avelar LA, Lange F, Wang C, Bandolik JJ, Hamacher A, Kassack MU, Kurz T.

Bioorg Med Chem. 2020 Jan 1;28(1):115108. doi: 10.1016/j.bmc.2019.115108. Epub 2019 Sep 13.

PMID:
31787463
3.

Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties.

Krieger V, Hamacher A, Cao F, Stenzel K, Gertzen CGW, Schäker-Hübner L, Kurz T, Gohlke H, Dekker FJ, Kassack MU, Hansen FK.

J Med Chem. 2019 Dec 26;62(24):11260-11279. doi: 10.1021/acs.jmedchem.9b01489. Epub 2019 Dec 17.

PMID:
31762274
4.

Recent advances in class IIa histone deacetylases research.

Asfaha Y, Schrenk C, Alves Avelar LA, Hamacher A, Pflieger M, Kassack MU, Kurz T.

Bioorg Med Chem. 2019 Nov 15;27(22):115087. doi: 10.1016/j.bmc.2019.115087. Epub 2019 Sep 6. Review.

PMID:
31561937
5.

The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells.

Wang C, Engelke L, Bickel D, Hamacher A, Frank M, Proksch P, Gohlke H, Kassack MU.

Bioorg Med Chem. 2019 Oct 1;27(19):115044. doi: 10.1016/j.bmc.2019.115044. Epub 2019 Aug 8.

PMID:
31443950
6.

Novel α,β-unsaturated hydroxamic acid derivatives overcome cisplatin resistance.

Pflieger M, Hamacher A, Öz T, Horstick-Muche N, Boesen B, Schrenk C, Kassack MU, Kurz T.

Bioorg Med Chem. 2019 Oct 1;27(19):115036. doi: 10.1016/j.bmc.2019.07.052. Epub 2019 Aug 7.

PMID:
31431326
7.

Brominated Azaphilones from the Sponge-Associated Fungus Penicillium canescens Strain 4.14.6a.

Frank M, Hartmann R, Plenker M, Mándi A, Kurtán T, Özkaya FC, Müller WEG, Kassack MU, Hamacher A, Lin W, Liu Z, Proksch P.

J Nat Prod. 2019 Aug 23;82(8):2159-2166. doi: 10.1021/acs.jnatprod.9b00151. Epub 2019 Jul 30.

PMID:
31359750
8.

Cyclic heptapeptides from the soil-derived fungus Clonostachys rosea.

Abdel-Wahab NM, Harwoko H, Müller WEG, Hamacher A, Kassack MU, Fouad MA, Kamel MS, Lin W, Ebrahim W, Liu Z, Proksch P.

Bioorg Med Chem. 2019 Sep 1;27(17):3954-3959. doi: 10.1016/j.bmc.2019.07.025. Epub 2019 Jul 12.

PMID:
31324567
9.

Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y2 receptor antagonist.

Brockmann N, Sureechatchaiyan P, Müller D, Hennicke T, Hausmann R, Fritz G, Hamacher A, Kassack MU.

Purinergic Signal. 2019 Sep;15(3):287-298. doi: 10.1007/s11302-019-09663-4. Epub 2019 Jul 3.

10.

Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae.

Yu H, Sperlich J, Höfert SP, Janiak C, Teusch N, Stuhldreier F, Wesselborg S, Wang C, Kassack MU, Dai H, Liu Z, Proksch P.

Fitoterapia. 2019 Sep;137:104249. doi: 10.1016/j.fitote.2019.104249. Epub 2019 Jun 25.

PMID:
31247219
11.

Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High Grade Serous Ovarian Cancer Cell Lines.

Bandolik JJ, Hamacher A, Schrenk C, Weishaupt R, Kassack MU.

Int J Mol Sci. 2019 Jun 22;20(12). pii: E3052. doi: 10.3390/ijms20123052.

12.

3-O-Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis.

Rehberg N, Omeje E, Ebada SS, van Geelen L, Liu Z, Sureechatchayan P, Kassack MU, Ioerger TR, Proksch P, Kalscheuer R.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00136-19. doi: 10.1128/AAC.00136-19. Print 2019 Sep.

PMID:
31209015
13.

Indole Diterpenoids from an Endophytic Penicillium sp.

Ariantari NP, Ancheeva E, Wang C, Mándi A, Knedel TO, Kurtán T, Chaidir C, Müller WEG, Kassack MU, Janiak C, Daletos G, Proksch P.

J Nat Prod. 2019 Jun 28;82(6):1412-1423. doi: 10.1021/acs.jnatprod.8b00723. Epub 2019 May 22.

PMID:
31117519
14.

Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension.

Choi SY, Kee HJ, Sun S, Seok YM, Ryu Y, Kim GR, Kee SJ, Pflieger M, Kurz T, Kassack MU, Jeong MH.

J Cell Mol Med. 2019 Apr;23(4):2801-2812. doi: 10.1111/jcmm.14188. Epub 2019 Feb 7.

15.

Cryptic Secondary Metabolites from the Sponge-Associated Fungus Aspergillus ochraceus.

Frank M, Özkaya FC, Müller WEG, Hamacher A, Kassack MU, Lin W, Liu Z, Proksch P.

Mar Drugs. 2019 Feb 3;17(2). pii: E99. doi: 10.3390/md17020099.

16.

Adenosine enhances cisplatin sensitivity in human ovarian cancer cells.

Sureechatchaiyan P, Hamacher A, Brockmann N, Stork B, Kassack MU.

Purinergic Signal. 2018 Dec;14(4):395-408. doi: 10.1007/s11302-018-9622-7. Epub 2018 Aug 4.

17.

Effects of novel HDAC inhibitors on urothelial carcinoma cells.

Kaletsch A, Pinkerneil M, Hoffmann MJ, Jaguva Vasudevan AA, Wang C, Hansen FK, Wiek C, Hanenberg H, Gertzen C, Gohlke H, Kassack MU, Kurz T, Schulz WA, Niegisch G.

Clin Epigenetics. 2018 Jul 31;10(1):100. doi: 10.1186/s13148-018-0531-y.

18.

Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors.

Mackwitz MKW, Hamacher A, Osko JD, Held J, Schöler A, Christianson DW, Kassack MU, Hansen FK.

Org Lett. 2018 Jun 1;20(11):3255-3258. doi: 10.1021/acs.orglett.8b01118. Epub 2018 May 23.

19.

Metabolites from the endophytic fungus Cylindrocarpon sp. isolated from tropical plant Sapium ellipticum.

Kamdem RST, Pascal W, Rehberg N, van Geelen L, Höfert SP, Knedel TO, Janiak C, Sureechatchaiyan P, Kassack MU, Lin W, Kalscheuer R, Liu Z, Proksch P.

Fitoterapia. 2018 Jul;128:175-179. doi: 10.1016/j.fitote.2018.05.020. Epub 2018 May 17.

PMID:
29778573
20.

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.

Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A, Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J.

Blood. 2018 Jul 19;132(3):307-320. doi: 10.1182/blood-2017-10-810986. Epub 2018 May 3.

21.

Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells.

Buß I, Hamacher A, Sarin N, Kassack MU, Kalayda GV.

Metallomics. 2018 Mar 1;10(3):414-425. doi: 10.1039/c7mt00334j. Epub 2018 Feb 8.

PMID:
29417972
22.

Isolation of circulating tumor cells from pancreatic cancer by automated filtration.

Brychta N, Drosch M, Driemel C, Fischer JC, Neves RP, Esposito I, Knoefel W, Möhlendick B, Hille C, Stresemann A, Krahn T, Kassack MU, Stoecklein NH, von Ahsen O.

Oncotarget. 2017 Sep 16;8(49):86143-86156. doi: 10.18632/oncotarget.21026. eCollection 2017 Oct 17.

23.

Induction of new metabolites from the endophytic fungus Bionectria sp. through bacterial co-culture.

Kamdem RST, Wang H, Wafo P, Ebrahim W, Özkaya FC, Makhloufi G, Janiak C, Sureechatchaiyan P, Kassack MU, Lin W, Liu Z, Proksch P.

Fitoterapia. 2018 Jan;124:132-136. doi: 10.1016/j.fitote.2017.10.021. Epub 2017 Oct 26.

PMID:
29106994
24.

Inhibition of PI3K/Akt/mTOR overcomes cisplatin resistance in the triple negative breast cancer cell line HCC38.

Gohr K, Hamacher A, Engelke LH, Kassack MU.

BMC Cancer. 2017 Nov 3;17(1):711. doi: 10.1186/s12885-017-3695-5.

25.

Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.

Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P.

J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2.

PMID:
29094598
26.

Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity.

Stenzel K, Chua MJ, Duffy S, Antonova-Koch Y, Meister S, Hamacher A, Kassack MU, Winzeler E, Avery VM, Kurz T, Andrews KT, Hansen FK.

ChemMedChem. 2017 Oct 9;12(19):1627-1636. doi: 10.1002/cmdc.201700360. Epub 2017 Sep 13.

PMID:
28812327
27.

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.

Stenzel K, Hamacher A, Hansen FK, Gertzen CGW, Senger J, Marquardt V, Marek L, Marek M, Romier C, Remke M, Jung M, Gohlke H, Kassack MU, Kurz T.

J Med Chem. 2017 Jul 13;60(13):5334-5348. doi: 10.1021/acs.jmedchem.6b01538. Epub 2017 Jun 19.

PMID:
28581289
28.

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

Krieger V, Hamacher A, Gertzen CGW, Senger J, Zwinderman MRH, Marek M, Romier C, Dekker FJ, Kurz T, Jung M, Gohlke H, Kassack MU, Hansen FK.

J Med Chem. 2017 Jul 13;60(13):5493-5506. doi: 10.1021/acs.jmedchem.7b00197. Epub 2017 Jun 16.

PMID:
28574690
29.

Design and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit.

Alves Avelar LA, Held J, Engel JA, Sureechatchaiyan P, Hansen FK, Hamacher A, Kassack MU, Mordmüller B, Andrews KT, Kurz T.

Arch Pharm (Weinheim). 2017 Apr;350(3-4). doi: 10.1002/ardp.201600347. Epub 2017 Mar 20.

PMID:
28317157
30.

OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum.

Hemphill CFP, Sureechatchaiyan P, Kassack MU, Orfali RS, Lin W, Daletos G, Proksch P.

J Antibiot (Tokyo). 2017 Jun;70(6):726-732. doi: 10.1038/ja.2017.21. Epub 2017 Mar 8.

PMID:
28270687
31.

Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501.

Li HL, Li XM, Li X, Wang CY, Liu H, Kassack MU, Meng LH, Wang BG.

J Nat Prod. 2017 Jan 27;80(1):162-168. doi: 10.1021/acs.jnatprod.6b00797. Epub 2016 Dec 19.

PMID:
27992187
32.

Three Diketopiperazine Alkaloids with Spirocyclic Skeletons and One Bisthiodiketopiperazine Derivative from the Mangrove-Derived Endophytic Fungus Penicillium brocae MA-231.

Meng LH, Wang CY, Mándi A, Li XM, Hu XY, Kassack MU, Kurtán T, Wang BG.

Org Lett. 2016 Oct 21;18(20):5304-5307. doi: 10.1021/acs.orglett.6b02620. Epub 2016 Oct 10.

PMID:
27723361
33.

α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers.

Diedrich D, Moita AJ, Rüther A, Frieg B, Reiss GJ, Hoeppner A, Kurz T, Gohlke H, Lüdeke S, Kassack MU, Hansen FK.

Chemistry. 2016 Dec 5;22(49):17600-17611. doi: 10.1002/chem.201602521. Epub 2016 Aug 30.

PMID:
27573537
34.

Cytotoxic 14-Membered Macrolides from a Mangrove-Derived Endophytic Fungus, Pestalotiopsis microspora.

Liu S, Dai H, Makhloufi G, Heering C, Janiak C, Hartmann R, Mándi A, Kurtán T, Müller WE, Kassack MU, Lin W, Liu Z, Proksch P.

J Nat Prod. 2016 Sep 23;79(9):2332-40. doi: 10.1021/acs.jnatprod.6b00473. Epub 2016 Aug 24.

PMID:
27556865
35.

Synthesis of oxime-based CO-releasing molecules, CORMs and their immobilization on maghemite nanoparticles for magnetic-field induced CO release.

Meyer H, Brenner M, Höfert SP, Knedel TO, Kunz PC, Schmidt AM, Hamacher A, Kassack MU, Janiak C.

Dalton Trans. 2016 May 4;45(18):7605-15. doi: 10.1039/c5dt04888e.

PMID:
27048982
36.

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.

Hansen SV, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME, Wargent ET, Shimpukade B, Almeida R, Ejsing CS, Cawthorne MA, Kassack MU, Milligan G, Ulven T.

J Med Chem. 2016 Mar 24;59(6):2841-6. doi: 10.1021/acs.jmedchem.5b01962. Epub 2016 Mar 15.

PMID:
26928019
37.

Bispidin-9,9-diol Analogues of Cisplatin, Carboplatin, and Oxaliplatin: Synthesis, Structures, and Cytotoxicity.

Cui H, Goddard R, Pörschke KR, Hamacher A, Kassack MU.

Inorg Chem. 2016 Mar 21;55(6):2986-97. doi: 10.1021/acs.inorgchem.5b02855. Epub 2016 Feb 26.

PMID:
26918619
38.

Ellagic Acid and Resveratrol Prevent the Development of Cisplatin Resistance in the Epithelial Ovarian Cancer Cell Line A2780.

Engelke LH, Hamacher A, Proksch P, Kassack MU.

J Cancer. 2016 Jan 10;7(4):353-63. doi: 10.7150/jca.13754. eCollection 2016.

39.

Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors.

Diedrich D, Hamacher A, Gertzen CG, Alves Avelar LA, Reiss GJ, Kurz T, Gohlke H, Kassack MU, Hansen FK.

Chem Commun (Camb). 2016 Feb 21;52(15):3219-22. doi: 10.1039/c5cc10301k.

PMID:
26810607
40.

Stabilizing Alginate Confinement and Polymer Coating of CO-Releasing Molecules Supported on Iron Oxide Nanoparticles To Trigger the CO Release by Magnetic Heating.

Meyer H, Winkler F, Kunz P, Schmidt AM, Hamacher A, Kassack MU, Janiak C.

Inorg Chem. 2015 Dec 7;54(23):11236-46. doi: 10.1021/acs.inorgchem.5b01675. Epub 2015 Nov 23.

PMID:
26595858
41.

mESC-based in vitro differentiation models to study vascular response and functionality following genotoxic insults.

Hennicke T, Nieweg K, Brockmann N, Kassack MU, Gottmann K, Fritz G.

Toxicol Sci. 2015 Mar;144(1):138-50. doi: 10.1093/toxsci/kfu264. Epub 2014 Dec 15.

PMID:
25516496
42.

Stability of murine bradykinin type 2 receptor despite treatment with NO, bradykinin, icatibant, or C1-INH.

Khosravani F, Suvorava T, Dao VT, Brockmann N, Kocgirli O, Herbst FF, Valcaccia S, Kassack MU, Bas M, Kojda G.

Allergy. 2015 Mar;70(3):285-94. doi: 10.1111/all.12556. Epub 2014 Dec 24.

PMID:
25477154
43.

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages.

Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, Mordmüller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT, Kurz T.

Eur J Med Chem. 2014 Jul 23;82:204-13. doi: 10.1016/j.ejmech.2014.05.050. Epub 2014 May 22.

44.

Bispidine analogues of cisplatin, carboplatin, and oxaliplatin. synthesis, structures, and cytotoxicity.

Cui H, Goddard R, Pörschke KR, Hamacher A, Kassack MU.

Inorg Chem. 2014 Apr 7;53(7):3371-84. doi: 10.1021/ic402737f. Epub 2014 Mar 25.

PMID:
24665859
45.

A new cytotoxic steroid from co-fermentation of two marine alga-derived micro-organisms.

Ebada SS, Fischer T, Klaßen S, Hamacher A, Roth YO, Kassack MU, Roth EH.

Nat Prod Res. 2014;28(16):1241-5. doi: 10.1080/14786419.2014.895730. Epub 2014 Mar 13.

PMID:
24620785
46.

Psychrophilin E, a new cyclotripeptide, from co-fermentation of two marine alga-derived fungi of the genus Aspergillus.

Ebada SS, Fischer T, Hamacher A, Du FY, Roth YO, Kassack MU, Wang BG, Roth EH.

Nat Prod Res. 2014;28(11):776-81. doi: 10.1080/14786419.2014.880911. Epub 2014 Jan 31.

PMID:
24483240
47.

Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla.

Rönsberg D, Debbab A, Mándi A, Vasylyeva V, Böhler P, Stork B, Engelke L, Hamacher A, Sawadogo R, Diederich M, Wray V, Lin W, Kassack MU, Janiak C, Scheu S, Wesselborg S, Kurtán T, Aly AH, Proksch P.

J Org Chem. 2013 Dec 20;78(24):12409-25. doi: 10.1021/jo402066b. Epub 2013 Dec 11.

PMID:
24295452
48.

The diadenosine homodinucleotide P18 improves in vitro myelination in experimental Charcot-Marie-Tooth type 1A.

Nobbio L, Visigalli D, Mannino E, Fiorese F, Kassack MU, Sturla L, Prada V, De Flora A, Zocchi E, Bruzzone S, Schenone A.

J Cell Biochem. 2014 Jan;115(1):161-7. doi: 10.1002/jcb.24644.

49.

In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469.

Urban C, Hamacher A, Partke HJ, Roden M, Schinner S, Christiansen E, Due-Hansen ME, Ulven T, Gohlke H, Kassack MU.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1021-30. doi: 10.1007/s00210-013-0899-3. Epub 2013 Jul 17.

PMID:
23861168
50.

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.

Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T.

ACS Med Chem Lett. 2013 May 9;4(5):441-445. Epub 2013 Apr 8.

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