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Items: 1 to 50 of 188

1.

Detection of Nav1.5 Conformational Change in Mammalian Cells Using the Noncanonical Amino Acid ANAP.

Shandell MA, Quejada JR, Yazawa M, Cornish VW, Kass RS.

Biophys J. 2019 Oct 1;117(7):1352-1363. doi: 10.1016/j.bpj.2019.08.028. Epub 2019 Aug 29.

PMID:
31521331
2.

Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase.

Li Y, Hof T, Baldwin TA, Chen L, Kass RS, Dessauer CW.

Cells. 2019 Aug 27;8(9). pii: E981. doi: 10.3390/cells8090981.

3.

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.

Bohnen MS, Ma L, Zhu N, Qi H, McClenaghan C, Gonzaga-Jauregui C, Dewey FE, Overton JD, Reid JG, Shuldiner AR, Baras A, Sampson KJ, Bleda M, Hadinnapola C, Haimel M, Bogaard HJ, Church C, Coghlan G, Corris PA, Eyries M, Gibbs JSR, Girerd B, Houweling AC, Humbert M, Guignabert C, Kiely DG, Lawrie A, MacKenzie Ross RV, Martin JM, Montani D, Peacock AJ, Pepke-Zaba J, Soubrier F, Suntharalingam J, Toshner M, Treacy CM, Trembath RC, Vonk Noordegraaf A, Wharton J, Wilkins MR, Wort SJ, Yates K, Gräf S, Morrell NW, Krishnan U, Rosenzweig EB, Shen Y, Nichols CG, Kass RS, Chung WK.

Circ Genom Precis Med. 2018 Oct;11(10):e002087. doi: 10.1161/CIRCGEN.118.002087.

4.

The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery.

Bohnen MS, Roman-Campos D, Terrenoire C, Jnani J, Sampson KJ, Chung WK, Kass RS.

J Am Heart Assoc. 2017 Sep 9;6(9). pii: e006465. doi: 10.1161/JAHA.117.006465.

5.

KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.

Barro-Soria R, Ramentol R, Liin SI, Perez ME, Kass RS, Larsson HP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7367-E7376. doi: 10.1073/pnas.1710335114. Epub 2017 Aug 14.

6.

Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.

Peng G, Barro-Soria R, Sampson KJ, Larsson HP, Kass RS.

Sci Rep. 2017 Apr 6;7:45911. doi: 10.1038/srep45911.

7.

Molecular Pathophysiology of Congenital Long QT Syndrome.

Bohnen MS, Peng G, Robey SH, Terrenoire C, Iyer V, Sampson KJ, Kass RS.

Physiol Rev. 2017 Jan;97(1):89-134. Review.

8.

Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation.

Lorberbaum T, Sampson KJ, Chang JB, Iyer V, Woosley RL, Kass RS, Tatonetti NP.

J Am Coll Cardiol. 2016 Oct 18;68(16):1756-1764. doi: 10.1016/j.jacc.2016.07.761.

9.

Cardiac Delayed Rectifier Potassium Channels in Health and Disease.

Chen L, Sampson KJ, Kass RS.

Card Electrophysiol Clin. 2016 Jun;8(2):307-22. doi: 10.1016/j.ccep.2016.01.004. Epub 2016 Apr 1. Review.

10.

An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval.

Lorberbaum T, Sampson KJ, Woosley RL, Kass RS, Tatonetti NP.

Drug Saf. 2016 May;39(5):433-41. doi: 10.1007/s40264-016-0393-1.

11.

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes.

Eng G, Lee BW, Protas L, Gagliardi M, Brown K, Kass RS, Keller G, Robinson RB, Vunjak-Novakovic G.

Nat Commun. 2016 Jan 19;7:10312. doi: 10.1038/ncomms10312.

12.

Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3.

Iyer V, Roman-Campos D, Sampson KJ, Kang G, Fishman GI, Kass RS.

Sci Rep. 2015 Aug 20;5:13287. doi: 10.1038/srep13287.

13.

Novel mechanism of transient outward potassium channel current regulation in the heart: implications for cardiac electrophysiology in health and disease.

Bohnen MS, Iyer V, Sampson KJ, Kass RS.

Circ Res. 2015 May 8;116(10):1633-5. doi: 10.1161/CIRCRESAHA.115.306438. No abstract available.

14.

Deranged sodium to sudden death.

Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A.

J Physiol. 2015 Mar 15;593(6):1331-45. doi: 10.1113/jphysiol.2014.281204. Review. Erratum in: J Physiol. 2016 Mar 15;594(6):1791.

15.

Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber.

Iyer V, Sampson KJ, Kass RS.

PLoS One. 2014 Jun 3;9(6):e97720. doi: 10.1371/journal.pone.0097720. eCollection 2014.

16.

KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps.

Barro-Soria R, Rebolledo S, Liin SI, Perez ME, Sampson KJ, Kass RS, Larsson HP.

Nat Commun. 2014 Apr 28;5:3750. doi: 10.1038/ncomms4750.

17.

A novel channelopathy in pulmonary arterial hypertension.

Chung WK, Sampson KS, Kass RS.

N Engl J Med. 2013 Nov 28;369(22):2162. doi: 10.1056/NEJMc1311060. No abstract available.

PMID:
24283236
18.

Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.

Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE.

Circ Res. 2013 Sep 13;113(7):e50-e61. doi: 10.1161/CIRCRESAHA.113.301971. Epub 2013 Jul 29.

19.

A novel channelopathy in pulmonary arterial hypertension.

Ma L, Roman-Campos D, Austin ED, Eyries M, Sampson KS, Soubrier F, Germain M, Trégouët DA, Borczuk A, Rosenzweig EB, Girerd B, Montani D, Humbert M, Loyd JE, Kass RS, Chung WK.

N Engl J Med. 2013 Jul 25;369(4):351-361. doi: 10.1056/NEJMoa1211097.

20.

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.

Yu H, Lin Z, Mattmann ME, Zou B, Terrenoire C, Zhang H, Wu M, McManus OB, Kass RS, Lindsley CW, Hopkins CR, Li M.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8732-7. doi: 10.1073/pnas.1300684110. Epub 2013 May 6.

21.

Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.

Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJ, Mamarbachi MA, Varro A, Jordaens L, Res J, Kass RS, Wilde AA, Bezzina CR, Nattel S.

Circ Res. 2013 May 10;112(10):1310-22. doi: 10.1161/CIRCRESAHA.112.300227. Epub 2013 Mar 26.

22.

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.

Terrenoire C, Wang K, Tung KW, Chung WK, Pass RH, Lu JT, Jean JC, Omari A, Sampson KJ, Kotton DN, Keller G, Kass RS.

J Gen Physiol. 2013 Jan;141(1):61-72. doi: 10.1085/jgp.201210899.

23.

The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.

Li Y, Chen L, Kass RS, Dessauer CW.

J Biol Chem. 2012 Aug 24;287(35):29815-24. doi: 10.1074/jbc.M112.380568. Epub 2012 Jul 9.

24.

Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.

Osteen JD, Barro-Soria R, Robey S, Sampson KJ, Kass RS, Larsson HP.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7103-8. doi: 10.1073/pnas.1201582109. Epub 2012 Apr 16.

25.

Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation.

Glaaser IW, Osteen JD, Puckerin A, Sampson KJ, Jin X, Kass RS.

Nat Commun. 2012 Feb 28;3:706. doi: 10.1038/ncomms1717.

26.

Stoichiometry of the slow I(ks) potassium channel in human embryonic stem cell-derived myocytes.

Wang M, Kass RS.

Pediatr Cardiol. 2012 Aug;33(6):938-42. doi: 10.1007/s00246-012-0255-2. Epub 2012 Mar 16.

PMID:
22421958
27.

Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.

Chan PJ, Osteen JD, Xiong D, Bohnen MS, Doshi D, Sampson KJ, Marx SO, Karlin A, Kass RS.

J Gen Physiol. 2012 Feb;139(2):135-44. doi: 10.1085/jgp.201110672. Epub 2012 Jan 16.

28.

Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry.

Wang K, Terrenoire C, Sampson KJ, Iyer V, Osteen JD, Lu J, Keller G, Kotton DN, Kass RS.

J Physiol. 2011 Dec 15;589(Pt 24):6093-104. doi: 10.1113/jphysiol.2011.220863. Epub 2011 Oct 24.

29.

A-kinase anchoring protein 9 and IKs channel regulation.

Chen L, Kass RS.

J Cardiovasc Pharmacol. 2011 Nov;58(5):459-13. doi: 10.1097/FJC.0b013e318232c80c. Review.

30.

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms.

Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE.

Sci Transl Med. 2011 Aug 31;3(98):98ra83. doi: 10.1126/scitranslmed.3002588.

31.

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P.

Prog Biophys Mol Biol. 2011 Oct;107(1):4-10. doi: 10.1016/j.pbiomolbio.2011.07.001. Epub 2011 Jul 6.

32.

O-glycosylation of the cardiac I(Ks) complex.

Chandrasekhar KD, Lvov A, Terrenoire C, Gao GY, Kass RS, Kobertz WR.

J Physiol. 2011 Aug 1;589(Pt 15):3721-30. doi: 10.1113/jphysiol.2011.211284. Epub 2011 Jun 13.

33.

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.

Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22710-5. doi: 10.1073/pnas.1016300108. Epub 2010 Dec 13.

34.

The cardiac IKs channel, complex indeed.

Osteen JD, Sampson KJ, Kass RS.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18751-2. doi: 10.1073/pnas.1014150107. Epub 2010 Oct 25. No abstract available.

35.

Location, location, regulation: a novel role for β-spectrin in the heart.

Sampson KJ, Kass RS.

J Clin Invest. 2010 Oct;120(10):3434-7. doi: 10.1172/JCI44810. Epub 2010 Sep 27.

36.

A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.

Sampson KJ, Iyer V, Marks AR, Kass RS.

J Physiol. 2010 Jul 15;588(Pt 14):2643-55. doi: 10.1113/jphysiol.2010.187328. Epub 2010 May 24.

37.

Recent progress in congenital long QT syndrome.

Lu JT, Kass RS.

Curr Opin Cardiol. 2010 May;25(3):216-21. doi: 10.1097/HCO.0b013e32833846b3. Review.

38.

Molecular mechanisms of adrenergic stimulation in the heart.

Sampson KJ, Kass RS.

Heart Rhythm. 2010 Aug;7(8):1151-3. doi: 10.1016/j.hrthm.2010.02.013. Epub 2010 Feb 13. Review.

39.

Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3.

Bankston JR, Kass RS.

J Mol Cell Cardiol. 2010 Jan;48(1):246-53. doi: 10.1016/j.yjmcc.2009.05.012. Epub 2009 May 28.

40.

Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine.

Lindegger N, Hagen BM, Marks AR, Lederer WJ, Kass RS.

J Mol Cell Cardiol. 2009 Aug;47(2):326-34. doi: 10.1016/j.yjmcc.2009.04.003. Epub 2009 Apr 14.

41.

The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.

Terrenoire C, Houslay MD, Baillie GS, Kass RS.

J Biol Chem. 2009 Apr 3;284(14):9140-6. doi: 10.1074/jbc.M805366200. Epub 2009 Feb 13.

42.

Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines.

Chung DY, Chan PJ, Bankston JR, Yang L, Liu G, Marx SO, Karlin A, Kass RS.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):743-8. doi: 10.1073/pnas.0811897106. Epub 2009 Jan 8.

43.

KCNE variants reveal a critical role of the beta subunit carboxyl terminus in PKA-dependent regulation of the IKs potassium channel.

Kurokawa J, Bankston JR, Kaihara A, Chen L, Furukawa T, Kass RS.

Channels (Austin). 2009 Jan-Feb;3(1):16-24. Epub 2009 Jan 7.

44.

Ion channels: The voltage-sensor quartet.

Bankston JR, Kass RS.

Nature. 2008 Nov 13;456(7219):183-5. doi: 10.1038/456183a. No abstract available.

45.

A novel LQT-3 mutation disrupts an inactivation gate complex with distinct rate-dependent phenotypic consequences.

Bankston JR, Sampson KJ, Kateriya S, Glaaser IW, Malito DL, Chung WK, Kass RS.

Channels (Austin). 2007 Jul-Aug;1(4):273-80. Epub 2007 Aug 31.

PMID:
18708744
46.

Another calcium paradox in heart failure.

Kass RS, Lindegger N, Hagen B, Lederer WJ.

J Mol Cell Cardiol. 2008 Jul;45(1):28-31. doi: 10.1016/j.yjmcc.2008.04.001. Epub 2008 Apr 16. No abstract available.

PMID:
18504047
47.

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

Lehnart SE, Mongillo M, Bellinger A, Lindegger N, Chen BX, Hsueh W, Reiken S, Wronska A, Drew LJ, Ward CW, Lederer WJ, Kass RS, Morley G, Marks AR.

J Clin Invest. 2008 Jun;118(6):2230-45. doi: 10.1172/JCI35346.

48.

IKs response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules.

Nicolas CS, Park KH, El Harchi A, Camonis J, Kass RS, Escande D, Mérot J, Loussouarn G, Le Bouffant F, Baró I.

Cardiovasc Res. 2008 Aug 1;79(3):427-35. doi: 10.1093/cvr/cvn085. Epub 2008 Apr 5.

49.

Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy.

Holland KD, Kearney JA, Glauser TA, Buck G, Keddache M, Blankston JR, Glaaser IW, Kass RS, Meisler MH.

Neurosci Lett. 2008 Mar 5;433(1):65-70. doi: 10.1016/j.neulet.2007.12.064. Epub 2008 Jan 11.

50.

Mutation of an A-kinase-anchoring protein causes long-QT syndrome.

Chen L, Marquardt ML, Tester DJ, Sampson KJ, Ackerman MJ, Kass RS.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20990-5. Epub 2007 Dec 19.

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