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Invited Review: Emerging functions of histone H3 mutations in paediatric diffuse high-grade gliomas.

Kasper LH, Baker SJ.

Neuropathol Appl Neurobiol. 2019 Dec 20. doi: 10.1111/nan.12591. [Epub ahead of print] Review.


ChIPseqSpikeInFree: a ChIP-seq normalization approach to reveal global changes in histone modifications without spike-in.

Jin H, Kasper LH, Larson JD, Wu G, Baker SJ, Zhang J, Fan Y.

Bioinformatics. 2020 Feb 15;36(4):1270-1272. doi: 10.1093/bioinformatics/btz720.


Correction to: H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.

Silveira AB, Kasper LH, Fan Y, Jin H, Wu G, Shaw TI, Zhu X, Larson JD, Easton J, Shao Y, Yergeau DA, Rosencrance C, Boggs K, Rusch MC, Ding L, Zhang J, Finkelstein D, Noyes RM, Russell BL, Xu B, Broniscer A, Wetmore C, Pounds SB, Ellison DW, Zhang J, Baker SJ.

Acta Neuropathol. 2019 Jun;137(6):1021. doi: 10.1007/s00401-019-02006-y. Epub 2019 Apr 11.


H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.

Silveira AB, Kasper LH, Fan Y, Jin H, Wu G, Shaw TI, Zhu X, Larson JD, Easton J, Shao Y, Yergeau DA, Rosencrance C, Boggs K, Rusch MC, Ding L, Zhang J, Finkelstein D, Noyes RM, Russell BL, Xu B, Broniscer A, Wetmore C, Pounds SB, Ellison DW, Zhang J, Baker SJ.

Acta Neuropathol. 2019 Apr;137(4):637-655. doi: 10.1007/s00401-019-01975-4. Epub 2019 Feb 15. Erratum in: Acta Neuropathol. 2019 Jun;137(6):1021.


Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression.

Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH, Fan Y, Shaw TI, Silveira AB, Qu C, Xu R, Zhu X, Zhang J, Russell HR, Peters JL, Finkelstein D, Xu B, Lin T, Tinkle CL, Patay Z, Onar-Thomas A, Pounds SB, McKinnon PJ, Ellison DW, Zhang J, Baker SJ.

Cancer Cell. 2019 Jan 14;35(1):140-155.e7. doi: 10.1016/j.ccell.2018.11.015. Epub 2018 Dec 27.


The Microbiome and Neurologic Disease: Past and Future of a 2-Way Interaction.

Ochoa-Repáraz J, Kasper LH.

Neurotherapeutics. 2018 Jan;15(1):1-4. doi: 10.1007/s13311-018-0604-9. No abstract available.


The Gut Microbiome and Multiple Sclerosis.

Ochoa-Repáraz J, Kirby TO, Kasper LH.

Cold Spring Harb Perspect Med. 2018 Jun 1;8(6). pii: a029017. doi: 10.1101/cshperspect.a029017. Review.


CD4+ T cells from multiple sclerosis patients respond to a commensal-derived antigen.

Burgess JN, Pant AB, Kasper LH, Colpitts Brass S.

Ann Clin Transl Neurol. 2017 Sep 27;4(11):825-829. doi: 10.1002/acn3.465. eCollection 2017 Nov.


A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis.

Colpitts SL, Kasper EJ, Keever A, Liljenberg C, Kirby T, Magori K, Kasper LH, Ochoa-Repáraz J.

Gut Microbes. 2017 Nov 2;8(6):561-573. doi: 10.1080/19490976.2017.1353843. Epub 2017 Aug 4.


The chicken or the egg dilemma: intestinal dysbiosis in multiple sclerosis.

Ochoa-Repáraz J, Magori K, Kasper LH.

Ann Transl Med. 2017 Mar;5(6):145. doi: 10.21037/atm.2017.01.18.


Alteration of CD39+Foxp3+ CD4 T cell and cytokine levels in EAE/MS following anti-CD52 treatment.

Pant AB, Wang Y, Mielcarz DW, Kasper EJ, Telesford KM, Mishra M, Haque A, Channon JY, Kasper LH, Begum-Haque S.

J Neuroimmunol. 2017 Feb 15;303:22-30. doi: 10.1016/j.jneuroim.2016.12.010. Epub 2016 Dec 21.


Influence of the Gut Microbiome on Autoimmunity in the Central Nervous System.

Colpitts SL, Kasper LH.

J Immunol. 2017 Jan 15;198(2):596-604. doi: 10.4049/jimmunol.1601438. Review.


Induction of gut regulatory CD39+ T cells by teriflunomide protects against EAE.

Ochoa-Repáraz J, Colpitts SL, Kircher C, Kasper EJ, Telesford KM, Begum-Haque S, Pant A, Kasper LH.

Neurol Neuroimmunol Neuroinflamm. 2016 Oct 12;3(6):e291. eCollection 2016 Dec.


The influence of gut-derived CD39 regulatory T cells in CNS demyelinating disease.

Ochoa-Repáraz J, Kasper LH.

Transl Res. 2017 Jan;179:126-138. doi: 10.1016/j.trsl.2016.07.016. Epub 2016 Jul 28. Review.


The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?

Ochoa-Repáraz J, Kasper LH.

Curr Obes Rep. 2016 Mar;5(1):51-64. doi: 10.1007/s13679-016-0191-1. Review.


Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.

Zheng F, Kasper LH, Bedford DC, Lerach S, Teubner BJ, Brindle PK.

PLoS One. 2016 Jan 5;11(1):e0146366. doi: 10.1371/journal.pone.0146366. eCollection 2016.


Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.

Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R.

Lancet Neurol. 2016 Jan;15(1):35-46. doi: 10.1016/S1474-4422(15)00322-1. Epub 2015 Nov 29.


Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.

Churchman ML, Low J, Qu C, Paietta EM, Kasper LH, Chang Y, Payne-Turner D, Althoff MJ, Song G, Chen SC, Ma J, Rusch M, McGoldrick D, Edmonson M, Gupta P, Wang YD, Caufield W, Freeman B, Li L, Panetta JC, Baker S, Yang YL, Roberts KG, McCastlain K, Iacobucci I, Peters JL, Centonze VE, Notta F, Dobson SM, Zandi S, Dick JE, Janke L, Peng J, Kodali K, Pagala V, Min J, Mayasundari A, Williams RT, Willman CL, Rowe J, Luger S, Dickins RA, Guy RK, Chen T, Mullighan CG.

Cancer Cell. 2015 Sep 14;28(3):343-56. doi: 10.1016/j.ccell.2015.07.016. Epub 2015 Aug 27.


A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.

Telesford KM, Yan W, Ochoa-Reparaz J, Pant A, Kircher C, Christy MA, Begum-Haque S, Kasper DL, Kasper LH.

Gut Microbes. 2015 Jul 4;6(4):234-42. doi: 10.1080/19490976.2015.1056973.


The gut microbiome in multiple sclerosis.

Mielcarz DW, Kasper LH.

Curr Treat Options Neurol. 2015 Apr;17(4):344. doi: 10.1007/s11940-015-0344-7.


Immunomodulatory activity of interferon-beta.

Kasper LH, Reder AT.

Ann Clin Transl Neurol. 2014 Aug;1(8):622-31. doi: 10.1002/acn3.84. Epub 2014 Jul 23. Review.


Gut microbiome and the risk factors in central nervous system autoimmunity.

Ochoa-Repáraz J, Kasper LH.

FEBS Lett. 2014 Nov 17;588(22):4214-22. doi: 10.1016/j.febslet.2014.09.024. Epub 2014 Oct 5. Review.


Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.

Kasper LH, Qu C, Obenauer JC, McGoldrick DJ, Brindle PK.

Nucleic Acids Res. 2014 Oct;42(18):11363-82. doi: 10.1093/nar/gku827. Epub 2014 Sep 23.


The evolving role of the gut microbiome in human disease.

Kasper LH.

FEBS Lett. 2014 Nov 17;588(22):4101. doi: 10.1016/j.febslet.2014.09.015. Epub 2014 Sep 17. No abstract available.


Gut commensalism, cytokines, and central nervous system demyelination.

Telesford K, Ochoa-Repáraz J, Kasper LH.

J Interferon Cytokine Res. 2014 Aug;34(8):605-14. doi: 10.1089/jir.2013.0134. Review.


Digesting the emerging role for the gut microbiome in central nervous system demyelination.

Joscelyn J, Kasper LH.

Mult Scler. 2014 Oct;20(12):1553-9. doi: 10.1177/1352458514541579. Epub 2014 Jul 28. Review.


T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs.

Kasper LH, Fukuyama T, Brindle PK.

PLoS One. 2014 Jul 23;9(7):e102076. doi: 10.1371/journal.pone.0102076. eCollection 2014.


An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling.

Wang Y, Telesford KM, Ochoa-Repáraz J, Haque-Begum S, Christy M, Kasper EJ, Wang L, Wu Y, Robson SC, Kasper DL, Kasper LH.

Nat Commun. 2014 Jul 21;5:4432. doi: 10.1038/ncomms5432.


A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation.

Wang Y, Begum-Haque S, Telesford KM, Ochoa-Repáraz J, Christy M, Kasper EJ, Kasper DL, Robson SC, Kasper LH.

Gut Microbes. 2014 Jul 1;5(4):552-61. doi: 10.4161/gmic.29797. Epub 2014 Jul 9.


The role of microbiome in central nervous system disorders.

Wang Y, Kasper LH.

Brain Behav Immun. 2014 May;38:1-12. doi: 10.1016/j.bbi.2013.12.015. Epub 2013 Dec 25. Review.


Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression.

Kasper LH, Fukuyama T, Lerach S, Chang Y, Xu W, Wu S, Boyd KL, Brindle PK.

PLoS One. 2013 Dec 10;8(12):e82684. doi: 10.1371/journal.pone.0082684. eCollection 2013.


Mast cells modulate acute toxoplasmosis in murine models.

Huang B, Huang S, Chen Y, Zheng H, Shen J, Lun ZR, Wang Y, Kasper LH, Lu F.

PLoS One. 2013 Oct 16;8(10):e77327. doi: 10.1371/journal.pone.0077327. eCollection 2013.


Evaluation of the adjuvant effect of pidotimod on the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models.

Zhao Y, Huang B, Huang S, Zheng H, Li YQ, Lun ZR, Shen J, Wang Y, Kasper LH, Lu F.

Parasitol Res. 2013 Sep;112(9):3151-60. doi: 10.1007/s00436-013-3491-3. Epub 2013 Jun 20.


Upregulated expression of Tim-3 involved in the process of toxoplasmic encephalitis in mouse model.

Wu B, Huang B, Chen Y, Li S, Yan J, Zheng H, Huang S, Shen J, Lun ZR, Wang Y, Kasper LH, Lu F.

Parasitol Res. 2013 Jul;112(7):2511-21. doi: 10.1007/s00436-013-3416-1. Epub 2013 Apr 18.


Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORγt responses and by increasing IL-10 production in experimental allergic encephalomyelitis.

Begum-Haque S, Christy M, Wang Y, Kasper E, Ochoa-Reparaz J, Smith JY, Haque A, Kasper LH.

J Neuroimmunol. 2013 Jan 15;254(1-2):117-24. doi: 10.1016/j.jneuroim.2012.10.003. Epub 2012 Nov 7.


Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK.

Nat Genet. 2012 Oct;44(10):1104-10. doi: 10.1038/ng.2396. Epub 2012 Sep 2.


Cryopreservation of Toxoplasma gondii in infected murine tissues.

Zheng H, Chen Y, Lu F, Liu M, Yang X, Fu X, Zhao Y, Huang B, Huang S, Kasper LH.

Parasitol Res. 2012 Dec;111(6):2449-53. doi: 10.1007/s00436-012-2991-x. Epub 2012 Jun 16.


Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

Bedford DC, Kasper LH, Wang R, Chang Y, Green DR, Brindle PK.

Cell Metab. 2011 Aug 3;14(2):219-30. doi: 10.1016/j.cmet.2011.06.010.


CREBBP mutations in relapsed acute lymphoblastic leukaemia.

Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK, Downing JR.

Nature. 2011 Mar 10;471(7337):235-9. doi: 10.1038/nature09727.


Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R.

Nature. 2011 Mar 10;471(7337):189-95. doi: 10.1038/nature09730.


Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease.

Ochoa-Repáraz J, Mielcarz DW, Begum-Haque S, Kasper LH.

Ann Neurol. 2011 Feb;69(2):240-7. doi: 10.1002/ana.22344. Review.


Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora.

Ochoa-Repáraz J, Mielcarz DW, Haque-Begum S, Kasper LH.

Gut Microbes. 2010 Mar;1(2):103-108. Epub 2010 Feb 15.


Interferon therapy in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of the comparative trials.

Oliver BJ, Kohli E, Kasper LH.

J Neurol Sci. 2011 Mar 15;302(1-2):96-105. doi: 10.1016/j.jns.2010.11.003. Epub 2010 Dec 16. Review.


Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K.

EMBO J. 2011 Jan 19;30(2):249-62. doi: 10.1038/emboj.2010.318. Epub 2010 Dec 3.


Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate.

Begum-Haque S, Christy M, Ochoa-Reparaz J, Nowak EC, Mielcarz D, Haque A, Kasper LH.

J Neuroimmunol. 2011 Mar;232(1-2):136-44. doi: 10.1016/j.jneuroim.2010.10.031. Epub 2010 Nov 26.


CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation.

Kasper LH, Lerach S, Wang J, Wu S, Jeevan T, Brindle PK.

EMBO J. 2010 Nov 3;29(21):3660-72. doi: 10.1038/emboj.2010.235. Epub 2010 Sep 21.


Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.

Ochoa-Repáraz J, Mielcarz DW, Ditrio LE, Burroughs AR, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH.

J Immunol. 2010 Oct 1;185(7):4101-8. doi: 10.4049/jimmunol.1001443. Epub 2010 Sep 3.


A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease.

Ochoa-Repáraz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH.

Mucosal Immunol. 2010 Sep;3(5):487-95. doi: 10.1038/mi.2010.29. Epub 2010 Jun 9.


TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii.

Foureau DM, Mielcarz DW, Menard LC, Schulthess J, Werts C, Vasseur V, Ryffel B, Kasper LH, Buzoni-Gatel D.

J Immunol. 2010 Jun 15;184(12):7022-9. doi: 10.4049/jimmunol.0901642. Epub 2010 May 19.

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