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Microbiota-targeted maternal antibodies protect neonates from enteric infection.

Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh S, Mekalanos JJ, Kasper DL.

Nature. 2020 Jan 8. doi: 10.1038/s41586-019-1898-4. [Epub ahead of print]


Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis.

Song X, Sun X, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL.

Nature. 2020 Jan;577(7790):410-415. doi: 10.1038/s41586-019-1865-0. Epub 2019 Dec 25.


Symbionts exploit complex signaling to educate the immune system.

Erturk-Hasdemir D, Oh SF, Okan NA, Stefanetti G, Gazzaniga FS, Seeberger PH, Plevy SE, Kasper DL.

Proc Natl Acad Sci U S A. 2019 Dec 6. pii: 201915978. doi: 10.1073/pnas.1915978116. [Epub ahead of print]


The developmentally regulated fetal enterocyte gene, ZP4, mediates anti-inflammation by the symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis.

Gorreja F, Rush ST, Kasper DL, Meng D, Walker WA.

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G398-G407. doi: 10.1152/ajpgi.00046.2019. Epub 2019 Jul 17.


Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.

Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE.

Nat Biomed Eng. 2019 Jul;3(7):583. doi: 10.1038/s41551-019-0428-x.


A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.

Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE.

Nat Biomed Eng. 2019 Jul;3(7):520-531. doi: 10.1038/s41551-019-0397-0. Epub 2019 May 13. Erratum in: Nat Biomed Eng. 2019 Jun 18;:.


Surface Structures of Group B Streptococcus Important in Human Immunity.

Paoletti LC, Kasper DL.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0001-2017. Review.


Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies to Francisella tularensis.

Stefanetti G, Okan N, Fink A, Gardner E, Kasper DL.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7062-7070. doi: 10.1073/pnas.1900144116. Epub 2019 Mar 14.


Polysaccharide structure dictates mechanism of adaptive immune response to glycoconjugate vaccines.

Sun X, Stefanetti G, Berti F, Kasper DL.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):193-198. doi: 10.1073/pnas.1816401115. Epub 2018 Dec 3.


A Phase 2, Randomized, Control Trial of Group B Streptococcus (GBS) Type III Capsular Polysaccharide-tetanus Toxoid (GBS III-TT) Vaccine to Prevent Vaginal Colonization With GBS III.

Hillier SL, Ferrieri P, Edwards MS, Ewell M, Ferris D, Fine P, Carey V, Meyn L, Hoagland D, Kasper DL, Paoletti LC, Hill H, Baker CJ.

Clin Infect Dis. 2019 May 30;68(12):2079-2086. doi: 10.1093/cid/ciy838.


Finding a needle in a haystack: Bacteroides fragilis polysaccharide A as the archetypical symbiosis factor.

Erturk-Hasdemir D, Kasper DL.

Ann N Y Acad Sci. 2018 Apr;1417(1):116-129. doi: 10.1111/nyas.13660. Epub 2018 Mar 12. Review.


Erratum: Moving beyond microbiome-wide associations to causal microbe identification.

Surana NK, Kasper DL.

Nature. 2018 Feb 15;554(7692):392. doi: 10.1038/nature25471. Epub 2018 Jan 17.


Building conventions for unconventional lymphocytes.

Pasman L, Kasper DL.

Immunol Rev. 2017 Sep;279(1):52-62. doi: 10.1111/imr.12576. Review.


Moving beyond microbiome-wide associations to causal microbe identification.

Surana NK, Kasper DL.

Nature. 2017 Dec 14;552(7684):244-247. doi: 10.1038/nature25019. Epub 2017 Dec 6. Erratum in: Nature. 2018 Jan 17;:.


Wild gut microbiota protects from disease.

Gazzaniga FS, Kasper DL.

Cell Res. 2018 Feb;28(2):135-136. doi: 10.1038/cr.2017.150. Epub 2017 Dec 1.


Type I interferon signaling restrains IL-10R+ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis.

Stefan KL, Fink A, Surana NK, Kasper DL, Dasgupta S.

PLoS One. 2017 Nov 30;12(11):e0188600. doi: 10.1371/journal.pone.0188600. eCollection 2017.


Illuminating vital surface molecules of symbionts in health and disease.

Hudak JE, Alvarez D, Skelly A, von Andrian UH, Kasper DL.

Nat Microbiol. 2017 Jun 26;2:17099. doi: 10.1038/nmicrobiol.2017.99.


An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C.

Cell. 2017 Mar 9;168(6):1135-1148.e12. doi: 10.1016/j.cell.2017.02.009. Epub 2017 Mar 2.


Mining the Human Gut Microbiota for Immunomodulatory Organisms.

Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, Benoist C, Kasper DL.

Cell. 2017 Feb 23;168(5):928-943.e11. doi: 10.1016/j.cell.2017.01.022. Epub 2017 Feb 16.


Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice.

Tan TG, Sefik E, Geva-Zatorsky N, Kua L, Naskar D, Teng F, Pasman L, Ortiz-Lopez A, Jupp R, Wu HJ, Kasper DL, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8141-E8150. Epub 2016 Nov 23.


Veggies and Intact Grains a Day Keep the Pathogens Away.

Gazzaniga FS, Kasper DL.

Cell. 2016 Nov 17;167(5):1161-1162. doi: 10.1016/j.cell.2016.10.047.


How colonization by microbiota in early life shapes the immune system.

Gensollen T, Iyer SS, Kasper DL, Blumberg RS.

Science. 2016 Apr 29;352(6285):539-44. doi: 10.1126/science.aad9378. Review.


Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19.

Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL.

mBio. 2016 Mar 15;7(2):e02243. doi: 10.1128/mBio.02243-15.


A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.

Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z.

Nat Med. 2016 Apr;22(4):421-6. doi: 10.1038/nm.4057. Epub 2016 Mar 7.


In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria.

Geva-Zatorsky N, Alvarez D, Hudak JE, Reading NC, Erturk-Hasdemir D, Dasgupta S, von Andrian UH, Kasper DL.

Nat Med. 2015 Sep;21(9):1091-100. doi: 10.1038/nm.3929. Epub 2015 Aug 17.


A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.

Telesford KM, Yan W, Ochoa-Reparaz J, Pant A, Kircher C, Christy MA, Begum-Haque S, Kasper DL, Kasper LH.

Gut Microbes. 2015 Jul 4;6(4):234-42. doi: 10.1080/19490976.2015.1056973.


An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling.

Wang Y, Telesford KM, Ochoa-Repáraz J, Haque-Begum S, Christy M, Kasper EJ, Wang L, Wu Y, Robson SC, Kasper DL, Kasper LH.

Nat Commun. 2014 Jul 21;5:4432. doi: 10.1038/ncomms5432.


Deciphering the tête-à-tête between the microbiota and the immune system.

Surana NK, Kasper DL.

J Clin Invest. 2014 Oct;124(10):4197-203. doi: 10.1172/JCI72332. Epub 2014 Jul 18. Review.


A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation.

Wang Y, Begum-Haque S, Telesford KM, Ochoa-Repáraz J, Christy M, Kasper EJ, Kasper DL, Robson SC, Kasper LH.

Gut Microbes. 2014 Jul 1;5(4):552-61. doi: 10.4161/gmic.29797. Epub 2014 Jul 9.


Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms.

Dasgupta S, Erturk-Hasdemir D, Ochoa-Reparaz J, Reinecker HC, Kasper DL.

Cell Host Microbe. 2014 Apr 9;15(4):413-23. doi: 10.1016/j.chom.2014.03.006.


Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells.

An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL.

Cell. 2014 Jan 16;156(1-2):123-33. doi: 10.1016/j.cell.2013.11.042.


Interactions between the intestinal microbiota and innate lymphoid cells.

Chen VL, Kasper DL.

Gut Microbes. 2014 Jan-Feb;5(1):129-40. doi: 10.4161/gmic.27289. Epub 2013 Dec 16. Review.


Maternal antibody at delivery protects neonates from early onset group B streptococcal disease.

Baker CJ, Carey VJ, Rench MA, Edwards MS, Hillier SL, Kasper DL, Platt R.

J Infect Dis. 2014 Mar 1;209(5):781-8. doi: 10.1093/infdis/jit549. Epub 2013 Oct 16.


A maternal vaccine against group B Streptococcus: past, present, and future.

Chen VL, Avci FY, Kasper DL.

Vaccine. 2013 Aug 28;31 Suppl 4:D13-9. doi: 10.1016/j.vaccine.2012.12.080. Review.


Testosterone: more than having the guts to win the Tour de France.

An D, Kasper DL.

Immunity. 2013 Aug 22;39(2):208-10. doi: 10.1016/j.immuni.2013.08.015.


The atypical lipopolysaccharide of Francisella.

Okan NA, Kasper DL.

Carbohydr Res. 2013 Aug 30;378:79-83. doi: 10.1016/j.carres.2013.06.015. Epub 2013 Jul 2. Review.


Relevance of commensal microbiota in the treatment and prevention of inflammatory bowel disease.

Dasgupta S, Kasper DL.

Inflamm Bowel Dis. 2013 Oct;19(11):2478-89. doi: 10.1097/MIB.0b013e318297d884. Review.


Resident commensals shaping immunity.

Erturk-Hasdemir D, Kasper DL.

Curr Opin Immunol. 2013 Aug;25(4):450-5. doi: 10.1016/j.coi.2013.06.001. Epub 2013 Jul 2. Review.


Carbohydrates and T cells: a sweet twosome.

Avci FY, Li X, Tsuji M, Kasper DL.

Semin Immunol. 2013 Apr;25(2):146-51. doi: 10.1016/j.smim.2013.05.005. Epub 2013 Jun 10. Review.


Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection.

Chen VL, Surana NK, Duan J, Kasper DL.

PLoS One. 2013 Jun 4;8(6):e65405. doi: 10.1371/journal.pone.0065405. Print 2013.


Traffic control at the "Gut-GALT crossroads".

Dasgupta S, Kasper DL.

Cell Res. 2013 May;23(5):590-1. doi: 10.1038/cr.2013.41. Epub 2013 Mar 19.


Kdo hydrolase is required for Francisella tularensis virulence and evasion of TLR2-mediated innate immunity.

Okan NA, Chalabaev S, Kim TH, Fink A, Ross RA, Kasper DL.

mBio. 2013 Feb 12;4(1):e00638-12. doi: 10.1128/mBio.00638-12.


Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons.

Mao YK, Kasper DL, Wang B, Forsythe P, Bienenstock J, Kunze WA.

Nat Commun. 2013;4:1465. doi: 10.1038/ncomms2478.


Isolation of carbohydrate-specific CD4(+) T cell clones from mice after stimulation by two model glycoconjugate vaccines.

Avci FY, Li X, Tsuji M, Kasper DL.

Nat Protoc. 2012 Dec;7(12):2180-92. doi: 10.1038/nprot.2012.138. Epub 2012 Nov 29.


Gut immune maturation depends on colonization with a host-specific microbiota.

Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL.

Cell. 2012 Jun 22;149(7):1578-93. doi: 10.1016/j.cell.2012.04.037.


Microbial exposure during early life has persistent effects on natural killer T cell function.

Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS.

Science. 2012 Apr 27;336(6080):489-93. doi: 10.1126/science.1219328. Epub 2012 Mar 22.


The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA.

Surana NK, Kasper DL.

Immunol Rev. 2012 Jan;245(1):13-26. doi: 10.1111/j.1600-065X.2011.01075.x. Review.


A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design.

Avci FY, Li X, Tsuji M, Kasper DL.

Nat Med. 2011 Nov 20;17(12):1602-9. doi: 10.1038/nm.2535.


Genetic modification of the O-polysaccharide of Francisella tularensis results in an avirulent live attenuated vaccine.

Kim TH, Pinkham JT, Heninger SJ, Chalabaev S, Kasper DL.

J Infect Dis. 2012 Apr 1;205(7):1056-65. doi: 10.1093/infdis/jir620. Epub 2011 Oct 3.


The starting lineup: key microbial players in intestinal immunity and homeostasis.

Reading NC, Kasper DL.

Front Microbiol. 2011 Jul 7;2:148. doi: 10.3389/fmicb.2011.00148. eCollection 2011.

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