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Items: 1 to 50 of 140

1.

Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated Ir(III) complex conjugated to a far-red emitting coumarin.

Novohradsky V, Rovira A, Hally C, Galindo A, Vigueras G, Gandioso A, Svitelova M, Bresolí-Obach R, Kostrhunova H, Markova L, Kasparkova J, Nonell S, Ruiz J, Brabec V, Marchan V.

Angew Chem Int Ed Engl. 2019 Mar 19. doi: 10.1002/anie.201901268. [Epub ahead of print]

PMID:
30889300
2.

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects.

Kostrhunova H, Petruzzella E, Gibson D, Kasparkova J, Brabec V.

Chemistry. 2019 Feb 10. doi: 10.1002/chem.201805626. [Epub ahead of print]

PMID:
30740808
3.

Synthesis, characterization and biological evaluation of Co(III) complexes with quinolone drugs.

Kozsup M, Farkas E, Bényei AC, Kasparkova J, Crlikova H, Brabec V, Buglyó P.

J Inorg Biochem. 2019 Apr;193:94-105. doi: 10.1016/j.jinorgbio.2019.01.005. Epub 2019 Jan 21.

PMID:
30703748
4.

N,N-Dialkylbenzimidazol-2-ylidene platinum complexes - effects of alkyl residues and ancillary cis-ligands on anticancer activity.

Rehm T, Rothemund M, Bär A, Dietel T, Kempe R, Kostrhunova H, Brabec V, Kasparkova J, Schobert R.

Dalton Trans. 2018 Dec 28;47(48):17367-17381. doi: 10.1039/c8dt03360a. Epub 2018 Nov 27.

PMID:
30480671
5.

Correction: Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells.

Novohradsky V, Zajac J, Vrana O, Kasparkova J, Brabec V.

Oncotarget. 2018 Oct 30;9(85):35599. doi: 10.18632/oncotarget.26304. eCollection 2018 Oct 30.

6.

Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells.

Pracharova J, Novohradsky V, Kostrhunova H, Štarha P, Trávníček Z, Kasparkova J, Brabec V.

Dalton Trans. 2018 Sep 11;47(35):12197-12208. doi: 10.1039/c8dt02236d.

PMID:
30112527
7.

Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells.

Novohradsky V, Zajac J, Vrana O, Kasparkova J, Brabec V.

Oncotarget. 2018 Jun 19;9(47):28456-28473. doi: 10.18632/oncotarget.25466. eCollection 2018 Jun 19. Erratum in: Oncotarget. 2018 Oct 30;9(85):35599.

8.

Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts.

Chen F, Romero-Canelón I, Soldevila-Barreda JJ, Song JI, Coverdale JPC, Clarkson GJ, Kasparkova J, Habtemariam A, Wills M, Brabec V, Sadler PJ.

Organometallics. 2018 May 29;37(10):1555-1566. doi: 10.1021/acs.organomet.8b00132. Epub 2018 Apr 23.

9.

New (arene)ruthenium(II) complexes of 4‑aryl‑4H‑naphthopyrans with anticancer and anti-vascular activities.

Schmitt F, Kasparkova J, Brabec V, Begemann G, Schobert R, Biersack B.

J Inorg Biochem. 2018 Jul;184:69-78. doi: 10.1016/j.jinorgbio.2018.03.013. Epub 2018 Apr 5.

PMID:
29684697
10.

Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate.

Chen F, Soldevila-Barreda JJ, Romero-Canelón I, Coverdale JPC, Song JI, Clarkson GJ, Kasparkova J, Habtemariam A, Brabec V, Wolny JA, Schünemann V, Sadler PJ.

Dalton Trans. 2018 May 29;47(21):7178-7189. doi: 10.1039/c8dt00438b.

PMID:
29651471
11.

Polynuclear Platinum Complexes. Structural Diversity and DNA Binding.

Brabec V, Kasparkova J, Menon V, Farrell NP.

Met Ions Life Sci. 2018 Feb 5;18. pii: /books/9783110470734/9783110470734-007/9783110470734-008.xml. doi: 10.1515/9783110470734-008. Review.

PMID:
29394021
12.

Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents.

Pracharova J, Vigueras G, Novohradsky V, Cutillas N, Janiak C, Kostrhunova H, Kasparkova J, Ruiz J, Brabec V.

Chemistry. 2018 Mar 26;24(18):4607-4619. doi: 10.1002/chem.201705362. Epub 2018 Feb 27.

PMID:
29369444
13.

Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA.

Lemmerhirt H, Behnisch S, Bodtke A, Lillig CH, Pazderova L, Kasparkova J, Brabec V, Bednarski PJ.

J Inorg Biochem. 2018 Jan;178:94-105. doi: 10.1016/j.jinorgbio.2017.10.011. Epub 2017 Oct 26.

PMID:
29125948
14.

Anticancer kiteplatin pyrophosphate derivatives show unexpected target selectivity for DNA.

Kasparkova J, Kostrhunova H, Novohradsky V, Pracharova J, Curci A, Margiotta N, Natile G, Brabec V.

Dalton Trans. 2017 Oct 24;46(41):14139-14148. doi: 10.1039/c7dt02633a.

PMID:
28972623
15.

Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action.

Novohradsky V, Yellol J, Stuchlikova O, Santana MD, Kostrhunova H, Yellol G, Kasparkova J, Bautista D, Ruiz J, Brabec V.

Chemistry. 2017 Nov 2;23(61):15294-15299. doi: 10.1002/chem.201703581. Epub 2017 Oct 13.

PMID:
28922506
16.

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates.

Novohradsky V, Zanellato I, Marzano C, Pracharova J, Kasparkova J, Gibson D, Gandin V, Osella D, Brabec V.

Sci Rep. 2017 Jun 16;7(1):3751. doi: 10.1038/s41598-017-03864-w.

17.

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex.

Hrabina O, Kasparkova J, Suchankova T, Novohradsky V, Guo Z, Brabec V.

Metallomics. 2017 May 24;9(5):494-500. doi: 10.1039/c7mt00052a.

PMID:
28436510
18.

3-[(E)-(acridin-9'-ylmethylidene)amino]-1-substituted thioureas and their biological activity.

Bečka M, Vilková M, Salem O, Kašpárková J, Brabec V, Kožurková M.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 5;180:234-241. doi: 10.1016/j.saa.2017.03.014. Epub 2017 Mar 8.

PMID:
28315620
19.

Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects.

Intini FP, Zajac J, Novohradsky V, Saltarella T, Pacifico C, Brabec V, Natile G, Kasparkova J.

Inorg Chem. 2017 Feb 6;56(3):1483-1497. doi: 10.1021/acs.inorgchem.6b02553. Epub 2017 Jan 19.

PMID:
28102676
20.

Effects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and gold.

Schmitt F, Donnelly K, Muenzner JK, Rehm T, Novohradsky V, Brabec V, Kasparkova J, Albrecht M, Schobert R, Mueller T.

J Inorg Biochem. 2016 Oct;163:221-228. doi: 10.1016/j.jinorgbio.2016.07.021. Epub 2016 Jul 27.

PMID:
27491634
21.

Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes.

Brabec V, Kasparkova J, Kostrhunova H, Farrell NP.

Sci Rep. 2016 Aug 30;6:28474. doi: 10.1038/srep28474.

22.

Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity.

Janockova J, Zilecka E, Kasparkova J, Brabec V, Soukup O, Kuca K, Kozurkova M.

Mol Biosyst. 2016 Aug 16;12(9):2910-20. doi: 10.1039/c6mb00332j.

PMID:
27412811
23.

Anticancer potential of a photoactivated transplatin derivative containing the methylazaindole ligand mediated by ROS generation and DNA cleavage.

Pracharova J, Radosova Muchova T, Dvorak Tomastikova E, Intini FP, Pacifico C, Natile G, Kasparkova J, Brabec V.

Dalton Trans. 2016 Aug 16;45(33):13179-86. doi: 10.1039/c6dt01467d.

PMID:
27396365
24.

Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.

Medříková Z, Novohradsky V, Zajac J, Vrána O, Kasparkova J, Bakandritsos A, Petr M, Zbořil R, Brabec V.

Chemistry. 2016 Jul 4;22(28):9750-9. doi: 10.1002/chem.201600949. Epub 2016 Jun 1.

PMID:
27246144
25.

[(η(6)-p-cymene)Ru(H2O)3](2+) binding capability of aminohydroxamates - A solution and solid state study.

Parajdi-Losonczi PL, Bényei AC, Kováts É, Timári I, Muchova TR, Novohradsky V, Kasparkova J, Buglyó P.

J Inorg Biochem. 2016 Jul;160:236-45. doi: 10.1016/j.jinorgbio.2016.02.032. Epub 2016 Feb 27.

PMID:
26971623
26.
27.

New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds.

Salem OM, Vilková M, Janočková J, Jendželovský R, Fedoročko P, Žilecká E, Kašpárková J, Brabec V, Imrich J, Kožurková M.

Int J Biol Macromol. 2016 May;86:690-700. doi: 10.1016/j.ijbiomac.2016.02.018. Epub 2016 Feb 6.

PMID:
26861825
28.

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.

Vrana O, Novohradsky V, Medrikova Z, Burdikova J, Stuchlikova O, Kasparkova J, Brabec V.

Chemistry. 2016 Feb 18;22(8):2728-35. doi: 10.1002/chem.201504671. Epub 2016 Jan 20.

PMID:
26789279
29.

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin.

Zajac J, Kostrhunova H, Novohradsky V, Vrana O, Raveendran R, Gibson D, Kasparkova J, Brabec V.

J Inorg Biochem. 2016 Mar;156:89-97. doi: 10.1016/j.jinorgbio.2015.12.003. Epub 2015 Dec 31.

PMID:
26780576
30.

Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex.

Brabec V, Pracharova J, Stepankova J, Sadler PJ, Kasparkova J.

J Inorg Biochem. 2016 Jul;160:149-55. doi: 10.1016/j.jinorgbio.2015.12.029. Epub 2015 Dec 30.

PMID:
26778426
31.

A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases.

Kasparkova J, Kostrhunova H, Novakova O, Křikavová R, Vančo J, Trávníček Z, Brabec V.

Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14478-82. doi: 10.1002/anie.201506533. Epub 2015 Oct 12.

PMID:
26458068
32.

Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target?

Kasparkova J, Brabec V.

J Inorg Biochem. 2015 Dec;153:206-210. doi: 10.1016/j.jinorgbio.2015.07.014. Epub 2015 Jul 20.

PMID:
26255233
33.

cis-Pt I2(NH3)2: a reappraisal.

Marzo T, Pillozzi S, Hrabina O, Kasparkova J, Brabec V, Arcangeli A, Bartoli G, Severi M, Lunghi A, Totti F, Gabbiani C, Quiroga AG, Messori L.

Dalton Trans. 2015 Sep 7;44(33):14896-905. doi: 10.1039/c5dt01196e.

PMID:
26226326
34.

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group.

Muenzner JK, Rehm T, Biersack B, Casini A, de Graaf IA, Worawutputtapong P, Noor A, Kempe R, Brabec V, Kasparkova J, Schobert R.

J Med Chem. 2015 Aug 13;58(15):6283-92. doi: 10.1021/acs.jmedchem.5b00896. Epub 2015 Jul 29.

PMID:
26182125
35.

Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds.

Janočková J, Plšíková J, Kašpárková J, Brabec V, Jendželovský R, Mikeš J, Kovaľ J, Hamuľaková S, Fedoročko P, Kuča K, Kožurková M.

Eur J Pharm Sci. 2015 Aug 30;76:192-202. doi: 10.1016/j.ejps.2015.04.023. Epub 2015 May 8.

PMID:
25960253
36.

New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells.

Novohradsky V, Zerzankova L, Stepankova J, Vrana O, Raveendran R, Gibson D, Kasparkova J, Brabec V.

Biochem Pharmacol. 2015 Jun 1;95(3):133-44. doi: 10.1016/j.bcp.2015.04.003. Epub 2015 Apr 15.

PMID:
25888926
37.

Potentiating effect of UVA irradiation on anticancer activity of Carboplatin derivatives involving 7-azaindoles.

Štarha P, Trávníček Z, Dvořák Z, Radošová-Muchová T, Prachařová J, Vančo J, Kašpárková J.

PLoS One. 2015 Apr 15;10(4):e0123595. doi: 10.1371/journal.pone.0123595. eCollection 2015.

38.

Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors.

Janočková J, Plšíková J, Koval' J, Jendželovský R, Mikeš J, Kašpárková J, Brabec V, Hamuľaková S, Fedoročko P, Kožurková M.

Bioorg Chem. 2015 Apr;59:168-76. doi: 10.1016/j.bioorg.2015.03.002. Epub 2015 Mar 19.

PMID:
25827869
39.

Novel antitumor cisplatin and transplatin derivatives containing 1-methyl-7-azaindole: synthesis, characterization, and cellular responses.

Pracharova J, Saltarella T, Radosova Muchova T, Scintilla S, Novohradsky V, Novakova O, Intini FP, Pacifico C, Natile G, Ilik P, Brabec V, Kasparkova J.

J Med Chem. 2015 Jan 22;58(2):847-59. doi: 10.1021/jm501420k. Epub 2014 Dec 23.

PMID:
25496325
40.

The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions.

Brabec V, Pracharova J, Novakova O, Gibson D, Kasparkova J.

Dalton Trans. 2015 Feb 28;44(8):3573-82. doi: 10.1039/c4dt02603a.

PMID:
25406573
41.

Novel trisubstituted acridines as human telomeric quadruplex binding ligands.

Ungvarsky J, Plsikova J, Janovec L, Koval J, Mikes J, Mikesová L, Harvanova D, Fedorocko P, Kristian P, Kasparkova J, Brabec V, Vojtickova M, Sabolova D, Stramova Z, Rosocha J, Imrich J, Kozurkova M.

Bioorg Chem. 2014 Dec;57:13-29. doi: 10.1016/j.bioorg.2014.07.010. Epub 2014 Aug 10.

PMID:
25171773
42.

Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands.

Novohradsky V, Zerzankova L, Stepankova J, Vrana O, Raveendran R, Gibson D, Kasparkova J, Brabec V.

J Inorg Biochem. 2014 Nov;140:72-9. doi: 10.1016/j.jinorgbio.2014.07.004. Epub 2014 Jul 15.

PMID:
25063910
43.

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex.

Novohradsky V, Zerzankova L, Stepankova J, Kisova A, Kostrhunova H, Liu Z, Sadler PJ, Kasparkova J, Brabec V.

Metallomics. 2014 Aug;6(8):1491-501. doi: 10.1039/c4mt00112e.

PMID:
24828756
44.

Mechanism of cellular accumulation of an iridium(III) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand.

Novohradsky V, Liu Z, Vojtiskova M, Sadler PJ, Brabec V, Kasparkova J.

Metallomics. 2014 Mar;6(3):682-90. doi: 10.1039/c3mt00341h. Epub 2014 Jan 21.

PMID:
24448555
45.

Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer.

Kasparkova J, Thibault T, Kostrhunova H, Stepankova J, Vojtiskova M, Muchova T, Midoux P, Malinge JM, Brabec V.

FEBS J. 2014 Mar;281(5):1393-408. doi: 10.1111/febs.12711. Epub 2014 Jan 23.

46.

Lichen secondary metabolites as DNA-interacting agents.

Plsíkova J, Stepankova J, Kasparkova J, Brabec V, Backor M, Kozurkova M.

Toxicol In Vitro. 2014 Mar;28(2):182-6. doi: 10.1016/j.tiv.2013.11.003. Epub 2013 Nov 20.

PMID:
24269500
47.

Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand.

Frybortova M, Novakova O, Stepankova J, Novohradsky V, Gibson D, Kasparkova J, Brabec V.

J Inorg Biochem. 2013 Sep;126:46-54. doi: 10.1016/j.jinorgbio.2013.05.009. Epub 2013 May 28.

PMID:
23770803
48.

Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts.

Zhao Y, Woods JA, Farrer NJ, Robinson KS, Pracharova J, Kasparkova J, Novakova O, Li H, Salassa L, Pizarro AM, Clarkson GJ, Song L, Brabec V, Sadler PJ.

Chemistry. 2013 Jul 15;19(29):9578-91. doi: 10.1002/chem.201300374. Epub 2013 Jun 3.

49.

Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells.

Muchova T, Pracharova J, Starha P, Olivova R, Vrana O, Benesova B, Kasparkova J, Travnicek Z, Brabec V.

J Biol Inorg Chem. 2013 Jun;18(5):579-89. doi: 10.1007/s00775-013-1003-7. Epub 2013 May 15.

PMID:
23674329
50.

3,6-bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents.

Plsikova J, Janovec L, Koval J, Ungvarsky J, Mikes J, Jendzelovsky R, Fedorocko P, Imrich J, Kristian P, Kasparkova J, Brabec V, Kozurkova M.

Eur J Med Chem. 2012 Nov;57:283-95. doi: 10.1016/j.ejmech.2012.09.020. Epub 2012 Sep 23.

PMID:
23072739

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