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Items: 1 to 50 of 134

1.

Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells.

Novohradsky V, Zajac J, Vrana O, Kasparkova J, Brabec V.

Oncotarget. 2018 Jun 19;9(47):28456-28473. doi: 10.18632/oncotarget.25466. eCollection 2018 Jun 19.

2.

Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts.

Chen F, Romero-Canelón I, Soldevila-Barreda JJ, Song JI, Coverdale JPC, Clarkson GJ, Kasparkova J, Habtemariam A, Wills M, Brabec V, Sadler PJ.

Organometallics. 2018 May 29;37(10):1555-1566. doi: 10.1021/acs.organomet.8b00132. Epub 2018 Apr 23.

3.

New (arene)ruthenium(II) complexes of 4‑aryl‑4H‑naphthopyrans with anticancer and anti-vascular activities.

Schmitt F, Kasparkova J, Brabec V, Begemann G, Schobert R, Biersack B.

J Inorg Biochem. 2018 Jul;184:69-78. doi: 10.1016/j.jinorgbio.2018.03.013. Epub 2018 Apr 5.

PMID:
29684697
4.

Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate.

Chen F, Soldevila-Barreda JJ, Romero-Canelón I, Coverdale JPC, Song JI, Clarkson GJ, Kasparkova J, Habtemariam A, Brabec V, Wolny JA, Schünemann V, Sadler PJ.

Dalton Trans. 2018 May 29;47(21):7178-7189. doi: 10.1039/c8dt00438b.

PMID:
29651471
5.

Polynuclear Platinum Complexes. Structural Diversity and DNA Binding.

Brabec V, Kasparkova J, Menon V, Farrell NP.

Met Ions Life Sci. 2018 Feb 5;18. pii: /books/9783110470734/9783110470734-007/9783110470734-008.xml. doi: 10.1515/9783110470734-008. Review.

PMID:
29394021
6.

Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents.

Pracharova J, Vigueras G, Novohradsky V, Cutillas N, Janiak C, Kostrhunova H, Kasparkova J, Ruiz J, Brabec V.

Chemistry. 2018 Mar 26;24(18):4607-4619. doi: 10.1002/chem.201705362. Epub 2018 Feb 27.

PMID:
29369444
7.

Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA.

Lemmerhirt H, Behnisch S, Bodtke A, Lillig CH, Pazderova L, Kasparkova J, Brabec V, Bednarski PJ.

J Inorg Biochem. 2018 Jan;178:94-105. doi: 10.1016/j.jinorgbio.2017.10.011. Epub 2017 Oct 26.

PMID:
29125948
8.

Anticancer kiteplatin pyrophosphate derivatives show unexpected target selectivity for DNA.

Kasparkova J, Kostrhunova H, Novohradsky V, Pracharova J, Curci A, Margiotta N, Natile G, Brabec V.

Dalton Trans. 2017 Oct 24;46(41):14139-14148. doi: 10.1039/c7dt02633a.

PMID:
28972623
9.

Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action.

Novohradsky V, Yellol J, Stuchlikova O, Santana MD, Kostrhunova H, Yellol G, Kasparkova J, Bautista D, Ruiz J, Brabec V.

Chemistry. 2017 Nov 2;23(61):15294-15299. doi: 10.1002/chem.201703581. Epub 2017 Oct 13.

PMID:
28922506
10.

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates.

Novohradsky V, Zanellato I, Marzano C, Pracharova J, Kasparkova J, Gibson D, Gandin V, Osella D, Brabec V.

Sci Rep. 2017 Jun 16;7(1):3751. doi: 10.1038/s41598-017-03864-w.

11.

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex.

Hrabina O, Kasparkova J, Suchankova T, Novohradsky V, Guo Z, Brabec V.

Metallomics. 2017 May 24;9(5):494-500. doi: 10.1039/c7mt00052a.

PMID:
28436510
12.

3-[(E)-(acridin-9'-ylmethylidene)amino]-1-substituted thioureas and their biological activity.

Bečka M, Vilková M, Salem O, Kašpárková J, Brabec V, Kožurková M.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 5;180:234-241. doi: 10.1016/j.saa.2017.03.014. Epub 2017 Mar 8.

PMID:
28315620
13.

Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects.

Intini FP, Zajac J, Novohradsky V, Saltarella T, Pacifico C, Brabec V, Natile G, Kasparkova J.

Inorg Chem. 2017 Feb 6;56(3):1483-1497. doi: 10.1021/acs.inorgchem.6b02553. Epub 2017 Jan 19.

PMID:
28102676
14.

Effects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and gold.

Schmitt F, Donnelly K, Muenzner JK, Rehm T, Novohradsky V, Brabec V, Kasparkova J, Albrecht M, Schobert R, Mueller T.

J Inorg Biochem. 2016 Oct;163:221-228. doi: 10.1016/j.jinorgbio.2016.07.021. Epub 2016 Jul 27.

PMID:
27491634
15.

Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes.

Brabec V, Kasparkova J, Kostrhunova H, Farrell NP.

Sci Rep. 2016 Aug 30;6:28474. doi: 10.1038/srep28474.

16.

Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity.

Janockova J, Zilecka E, Kasparkova J, Brabec V, Soukup O, Kuca K, Kozurkova M.

Mol Biosyst. 2016 Aug 16;12(9):2910-20. doi: 10.1039/c6mb00332j.

PMID:
27412811
17.

Anticancer potential of a photoactivated transplatin derivative containing the methylazaindole ligand mediated by ROS generation and DNA cleavage.

Pracharova J, Radosova Muchova T, Dvorak Tomastikova E, Intini FP, Pacifico C, Natile G, Kasparkova J, Brabec V.

Dalton Trans. 2016 Aug 16;45(33):13179-86. doi: 10.1039/c6dt01467d.

PMID:
27396365
18.

Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.

Medříková Z, Novohradsky V, Zajac J, Vrána O, Kasparkova J, Bakandritsos A, Petr M, Zbořil R, Brabec V.

Chemistry. 2016 Jul 4;22(28):9750-9. doi: 10.1002/chem.201600949. Epub 2016 Jun 1.

PMID:
27246144
19.

[(η(6)-p-cymene)Ru(H2O)3](2+) binding capability of aminohydroxamates - A solution and solid state study.

Parajdi-Losonczi PL, Bényei AC, Kováts É, Timári I, Muchova TR, Novohradsky V, Kasparkova J, Buglyó P.

J Inorg Biochem. 2016 Jul;160:236-45. doi: 10.1016/j.jinorgbio.2016.02.032. Epub 2016 Feb 27.

PMID:
26971623
20.
21.

New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds.

Salem OM, Vilková M, Janočková J, Jendželovský R, Fedoročko P, Žilecká E, Kašpárková J, Brabec V, Imrich J, Kožurková M.

Int J Biol Macromol. 2016 May;86:690-700. doi: 10.1016/j.ijbiomac.2016.02.018. Epub 2016 Feb 6.

PMID:
26861825
22.

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.

Vrana O, Novohradsky V, Medrikova Z, Burdikova J, Stuchlikova O, Kasparkova J, Brabec V.

Chemistry. 2016 Feb 18;22(8):2728-35. doi: 10.1002/chem.201504671. Epub 2016 Jan 20.

PMID:
26789279
23.

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin.

Zajac J, Kostrhunova H, Novohradsky V, Vrana O, Raveendran R, Gibson D, Kasparkova J, Brabec V.

J Inorg Biochem. 2016 Mar;156:89-97. doi: 10.1016/j.jinorgbio.2015.12.003. Epub 2015 Dec 31.

PMID:
26780576
24.

Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex.

Brabec V, Pracharova J, Stepankova J, Sadler PJ, Kasparkova J.

J Inorg Biochem. 2016 Jul;160:149-55. doi: 10.1016/j.jinorgbio.2015.12.029. Epub 2015 Dec 30.

PMID:
26778426
25.

A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases.

Kasparkova J, Kostrhunova H, Novakova O, Křikavová R, Vančo J, Trávníček Z, Brabec V.

Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14478-82. doi: 10.1002/anie.201506533. Epub 2015 Oct 12.

PMID:
26458068
26.

Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target?

Kasparkova J, Brabec V.

J Inorg Biochem. 2015 Dec;153:206-210. doi: 10.1016/j.jinorgbio.2015.07.014. Epub 2015 Jul 20.

PMID:
26255233
27.

cis-Pt I2(NH3)2: a reappraisal.

Marzo T, Pillozzi S, Hrabina O, Kasparkova J, Brabec V, Arcangeli A, Bartoli G, Severi M, Lunghi A, Totti F, Gabbiani C, Quiroga AG, Messori L.

Dalton Trans. 2015 Sep 7;44(33):14896-905. doi: 10.1039/c5dt01196e.

PMID:
26226326
28.

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group.

Muenzner JK, Rehm T, Biersack B, Casini A, de Graaf IA, Worawutputtapong P, Noor A, Kempe R, Brabec V, Kasparkova J, Schobert R.

J Med Chem. 2015 Aug 13;58(15):6283-92. doi: 10.1021/acs.jmedchem.5b00896. Epub 2015 Jul 29.

PMID:
26182125
29.

Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds.

Janočková J, Plšíková J, Kašpárková J, Brabec V, Jendželovský R, Mikeš J, Kovaľ J, Hamuľaková S, Fedoročko P, Kuča K, Kožurková M.

Eur J Pharm Sci. 2015 Aug 30;76:192-202. doi: 10.1016/j.ejps.2015.04.023. Epub 2015 May 8.

PMID:
25960253
30.

New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells.

Novohradsky V, Zerzankova L, Stepankova J, Vrana O, Raveendran R, Gibson D, Kasparkova J, Brabec V.

Biochem Pharmacol. 2015 Jun 1;95(3):133-44. doi: 10.1016/j.bcp.2015.04.003. Epub 2015 Apr 15.

PMID:
25888926
31.

Potentiating effect of UVA irradiation on anticancer activity of Carboplatin derivatives involving 7-azaindoles.

Štarha P, Trávníček Z, Dvořák Z, Radošová-Muchová T, Prachařová J, Vančo J, Kašpárková J.

PLoS One. 2015 Apr 15;10(4):e0123595. doi: 10.1371/journal.pone.0123595. eCollection 2015.

32.

Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors.

Janočková J, Plšíková J, Koval' J, Jendželovský R, Mikeš J, Kašpárková J, Brabec V, Hamuľaková S, Fedoročko P, Kožurková M.

Bioorg Chem. 2015 Apr;59:168-76. doi: 10.1016/j.bioorg.2015.03.002. Epub 2015 Mar 19.

PMID:
25827869
33.

Novel antitumor cisplatin and transplatin derivatives containing 1-methyl-7-azaindole: synthesis, characterization, and cellular responses.

Pracharova J, Saltarella T, Radosova Muchova T, Scintilla S, Novohradsky V, Novakova O, Intini FP, Pacifico C, Natile G, Ilik P, Brabec V, Kasparkova J.

J Med Chem. 2015 Jan 22;58(2):847-59. doi: 10.1021/jm501420k. Epub 2014 Dec 23.

PMID:
25496325
34.

The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions.

Brabec V, Pracharova J, Novakova O, Gibson D, Kasparkova J.

Dalton Trans. 2015 Feb 28;44(8):3573-82. doi: 10.1039/c4dt02603a.

PMID:
25406573
35.

Novel trisubstituted acridines as human telomeric quadruplex binding ligands.

Ungvarsky J, Plsikova J, Janovec L, Koval J, Mikes J, Mikesová L, Harvanova D, Fedorocko P, Kristian P, Kasparkova J, Brabec V, Vojtickova M, Sabolova D, Stramova Z, Rosocha J, Imrich J, Kozurkova M.

Bioorg Chem. 2014 Dec;57:13-29. doi: 10.1016/j.bioorg.2014.07.010. Epub 2014 Aug 10.

PMID:
25171773
36.

Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands.

Novohradsky V, Zerzankova L, Stepankova J, Vrana O, Raveendran R, Gibson D, Kasparkova J, Brabec V.

J Inorg Biochem. 2014 Nov;140:72-9. doi: 10.1016/j.jinorgbio.2014.07.004. Epub 2014 Jul 15.

PMID:
25063910
37.

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex.

Novohradsky V, Zerzankova L, Stepankova J, Kisova A, Kostrhunova H, Liu Z, Sadler PJ, Kasparkova J, Brabec V.

Metallomics. 2014 Aug;6(8):1491-501. doi: 10.1039/c4mt00112e.

PMID:
24828756
38.

Mechanism of cellular accumulation of an iridium(III) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand.

Novohradsky V, Liu Z, Vojtiskova M, Sadler PJ, Brabec V, Kasparkova J.

Metallomics. 2014 Mar;6(3):682-90. doi: 10.1039/c3mt00341h. Epub 2014 Jan 21.

PMID:
24448555
39.

Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer.

Kasparkova J, Thibault T, Kostrhunova H, Stepankova J, Vojtiskova M, Muchova T, Midoux P, Malinge JM, Brabec V.

FEBS J. 2014 Mar;281(5):1393-408. doi: 10.1111/febs.12711. Epub 2014 Jan 23.

40.

Lichen secondary metabolites as DNA-interacting agents.

Plsíkova J, Stepankova J, Kasparkova J, Brabec V, Backor M, Kozurkova M.

Toxicol In Vitro. 2014 Mar;28(2):182-6. doi: 10.1016/j.tiv.2013.11.003. Epub 2013 Nov 20.

PMID:
24269500
41.

Activation of trans geometry in bifunctional mononuclear platinum complexes by a non-bulky methylamine ligand.

Frybortova M, Novakova O, Stepankova J, Novohradsky V, Gibson D, Kasparkova J, Brabec V.

J Inorg Biochem. 2013 Sep;126:46-54. doi: 10.1016/j.jinorgbio.2013.05.009. Epub 2013 May 28.

PMID:
23770803
42.

Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts.

Zhao Y, Woods JA, Farrer NJ, Robinson KS, Pracharova J, Kasparkova J, Novakova O, Li H, Salassa L, Pizarro AM, Clarkson GJ, Song L, Brabec V, Sadler PJ.

Chemistry. 2013 Jul 15;19(29):9578-91. doi: 10.1002/chem.201300374. Epub 2013 Jun 3.

43.

Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells.

Muchova T, Pracharova J, Starha P, Olivova R, Vrana O, Benesova B, Kasparkova J, Travnicek Z, Brabec V.

J Biol Inorg Chem. 2013 Jun;18(5):579-89. doi: 10.1007/s00775-013-1003-7. Epub 2013 May 15.

PMID:
23674329
44.

3,6-bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents.

Plsikova J, Janovec L, Koval J, Ungvarsky J, Mikes J, Jendzelovsky R, Fedorocko P, Imrich J, Kristian P, Kasparkova J, Brabec V, Kozurkova M.

Eur J Med Chem. 2012 Nov;57:283-95. doi: 10.1016/j.ejmech.2012.09.020. Epub 2012 Sep 23.

PMID:
23072739
45.

Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug.

Brabec V, Malina J, Margiotta N, Natile G, Kasparkova J.

Chemistry. 2012 Nov 26;18(48):15439-48. doi: 10.1002/chem.201202117. Epub 2012 Oct 12.

PMID:
23065963
46.

DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear Pt(II) complex.

Mlcouskova J, Kasparkova J, Suchankova T, Komeda S, Brabec V.

J Inorg Biochem. 2012 Sep;114:15-23. doi: 10.1016/j.jinorgbio.2012.04.015. Epub 2012 May 4.

PMID:
22687561
47.

Energetics, conformation, and recognition of DNA duplexes containing a major adduct of an anticancer azolato-bridged dinuclear Pt(II) complex.

Mlcouskova J, Malina J, Novohradsky V, Kasparkova J, Komeda S, Brabec V.

Biochim Biophys Acta. 2012 Oct;1820(10):1502-11. doi: 10.1016/j.bbagen.2012.05.014. Epub 2012 Jun 7.

PMID:
22683702
48.

Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2].

Tai HC, Brodbeck R, Kasparkova J, Farrer NJ, Brabec V, Sadler PJ, Deeth RJ.

Inorg Chem. 2012 Jun 18;51(12):6830-41. doi: 10.1021/ic3005745. Epub 2012 Jun 5.

PMID:
22668523
49.

Valuable insight into the anticancer activity of the platinum-histone deacetylase inhibitor conjugate, cis-[Pt(NH3)2malSAHA-2H)].

Brabec V, Griffith DM, Kisova A, Kostrhunova H, Zerzankova L, Marmion CJ, Kasparkova J.

Mol Pharm. 2012 Jul 2;9(7):1990-9. doi: 10.1021/mp300038f. Epub 2012 May 25.

PMID:
22591133
50.

Interactions of DNA with a new platinum(IV) azide dipyridine complex activated by UVA and visible light: relationship to toxicity in tumor cells.

Pracharova J, Zerzankova L, Stepankova J, Novakova O, Farrer NJ, Sadler PJ, Brabec V, Kasparkova J.

Chem Res Toxicol. 2012 May 21;25(5):1099-111. doi: 10.1021/tx300057y. Epub 2012 Mar 28.

PMID:
22420335

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