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Items: 23


SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets.

Kasirer-Friede A, Tjahjono W, Eto K, Shattil SJ.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4983-4988. doi: 10.1073/pnas.1819156116. Epub 2019 Feb 25.


Editorial: Molecular Bridges Between Hematology and Inflammation.

Kasirer-Friede A.

Front Med (Lausanne). 2019 Feb 8;6:17. doi: 10.3389/fmed.2019.00017. eCollection 2019. No abstract available.


Optogenetic interrogation of integrin αVβ3 function in endothelial cells.

Liao Z, Kasirer-Friede A, Shattil SJ.

J Cell Sci. 2017 Oct 15;130(20):3532-3541. doi: 10.1242/jcs.205203. Epub 2017 Sep 1.


The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.

van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V.

Cell Host Microbe. 2014 Jun 11;15(6):729-740. doi: 10.1016/j.chom.2014.05.009.


ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.

Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ.

Blood. 2014 May 15;123(20):3156-65. doi: 10.1182/blood-2013-08-520627. Epub 2014 Feb 12.


The mechanism of kindlin-mediated activation of integrin αIIbβ3.

Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH.

Curr Biol. 2013 Nov 18;23(22):2288-2295. doi: 10.1016/j.cub.2013.09.050. Epub 2013 Nov 7.


What is vinculin needed for in platelets?

Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ.

J Thromb Haemost. 2010 Oct;8(10):2294-304. doi: 10.1111/j.1538-7836.2010.03998.x.


Role for ADAP in shear flow-induced platelet mechanotransduction.

Kasirer-Friede A, Ruggeri ZM, Shattil SJ.

Blood. 2010 Mar 18;115(11):2274-82. doi: 10.1182/blood-2009-08-238238. Epub 2009 Dec 7.


Microfluidic devices for studies of shear-dependent platelet adhesion.

Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A.

Lab Chip. 2008 Sep;8(9):1486-95. doi: 10.1039/b804795b. Epub 2008 Jul 23.


Platelet integrins and immunoreceptors.

Kasirer-Friede A, Kahn ML, Shattil SJ.

Immunol Rev. 2007 Aug;218:247-64. Review.


ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.

Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ.

Blood. 2007 Feb 1;109(3):1018-25. Epub 2006 Sep 26.


The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.

Kliche S, Breitling D, Togni M, Pusch R, Heuer K, Wang X, Freund C, Kasirer-Friede A, Menasche G, Koretzky GA, Schraven B.

Mol Cell Biol. 2006 Oct;26(19):7130-44.


PTP-1B is an essential positive regulator of platelet integrin signaling.

Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ.

J Cell Biol. 2005 Aug 29;170(5):837-45. Epub 2005 Aug 22.


Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors.

Kasirer-Friede A, Cozzi MR, Mazzucato M, De Marco L, Ruggeri ZM, Shattil SJ.

Blood. 2004 May 1;103(9):3403-11. Epub 2004 Jan 15.


Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion.

Arya M, López JA, Romo GM, Cruz MA, Kasirer-Friede A, Shattil SJ, Anvari B.

J Thromb Haemost. 2003 Jun;1(6):1150-7.


Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3.

Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ.

J Biol Chem. 2002 Apr 5;277(14):11949-56. Epub 2002 Jan 25.


Role of the gamma chain Ala-Gly-Asp-Val and Aalpha chain Arg-Gly-Asp-Ser sites of fibrinogen in coaggregation of platelets and fibrinogen-coated beads.

Liu Q, Rooney MM, Kasirer-Friede A, Brown E, Lord ST, Frojmovic MM.

Biochim Biophys Acta. 1998 Jun 11;1385(1):33-42.


Limitations and warnings in use of labelled (fibrinogen) ligands to cell receptors.

Frojmovic M, Brown E, Kasirer-Friede A, Liu Q.

Thromb Haemost. 1996 Jul;76(1):124. No abstract available.


Optimally functional fluorescein isothiocyanate-labelled fibrinogen for quantitative studies of binding to activated platelets and platelet aggregation.

Xia Z, Wong T, Liu Q, Kasirer-Friede A, Brown E, Frojmovic MM.

Br J Haematol. 1996 Apr;93(1):204-14.


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