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Items: 1 to 50 of 66

1.

Engineered occluded apo-intermediate of LacY.

Smirnova I, Kasho V, Kaback HR.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12716-12721. doi: 10.1073/pnas.1816267115. Epub 2018 Nov 26.

2.

Crystal Structure of a ligand-bound LacY-Nanobody Complex.

Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8769-8774. doi: 10.1073/pnas.1801774115. Epub 2018 Aug 14.

3.

Oversized galactosides as a probe for conformational dynamics in LacY.

Smirnova I, Kasho V, Jiang X, Chen HM, Withers SG, Kaback HR.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4146-4151. doi: 10.1073/pnas.1800706115. Epub 2018 Mar 30.

4.

An Asymmetric Conformational Change in LacY.

Smirnova I, Kasho V, Jiang X, Kaback HR.

Biochemistry. 2017 Apr 4;56(13):1943-1950. doi: 10.1021/acs.biochem.7b00134. Epub 2017 Mar 23.

5.

Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.

Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback HR.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12420-12425. Epub 2016 Oct 19.

6.

Transient conformers of LacY are trapped by nanobodies.

Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13839-44. doi: 10.1073/pnas.1519485112. Epub 2015 Oct 28. Erratum in: Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E101.

7.

Outward-facing conformers of LacY stabilized by nanobodies.

Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18548-53. doi: 10.1073/pnas.1422265112. Epub 2014 Dec 15.

8.

Real-time conformational changes in LacY.

Smirnova I, Kasho V, Kaback HR.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8440-5. doi: 10.1073/pnas.1408374111. Epub 2014 May 28.

9.

Structure of sugar-bound LacY.

Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1784-8. doi: 10.1073/pnas.1324141111. Epub 2014 Jan 22.

10.

Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation.

Smirnova I, Kasho V, Sugihara J, Kaback HR.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8876-81. doi: 10.1073/pnas.1306849110. Epub 2013 May 13.

11.

Role of protons in sugar binding to LacY.

Smirnova I, Kasho V, Sugihara J, Vázquez-Ibar JL, Kaback HR.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16835-40. doi: 10.1073/pnas.1214890109. Epub 2012 Oct 2.

12.

Sugar recognition by CscB and LacY.

Sugihara J, Smirnova I, Kasho V, Kaback HR.

Biochemistry. 2011 Dec 27;50(51):11009-14. doi: 10.1021/bi201592y. Epub 2011 Dec 1.

13.

Lactose permease and the alternating access mechanism.

Smirnova I, Kasho V, Kaback HR.

Biochemistry. 2011 Nov 15;50(45):9684-93. doi: 10.1021/bi2014294. Epub 2011 Oct 19.

14.

Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding.

Smirnova I, Kasho V, Sugihara J, Kaback HR.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15147-51. doi: 10.1073/pnas.1112157108. Epub 2011 Sep 6.

15.

The alternating access transport mechanism in LacY.

Kaback HR, Smirnova I, Kasho V, Nie Y, Zhou Y.

J Membr Biol. 2011 Jan;239(1-2):85-93. doi: 10.1007/s00232-010-9327-5. Epub 2010 Dec 16. Review.

16.

Probing of the rates of alternating access in LacY with Trp fluorescence.

Smirnova I, Kasho V, Sugihara J, Kaback HR.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21561-6. doi: 10.1073/pnas.0911434106. Epub 2009 Dec 3.

17.

Residues in the H+ translocation site define the pKa for sugar binding to LacY.

Smirnova I, Kasho V, Sugihara J, Choe JY, Kaback HR.

Biochemistry. 2009 Sep 22;48(37):8852-60. doi: 10.1021/bi9011918.

18.

Protonation and sugar binding to LacY.

Smirnova IN, Kasho V, Kaback HR.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8896-901. doi: 10.1073/pnas.0803577105. Epub 2008 Jun 20.

19.

Sugar binding induces an outward facing conformation of LacY.

Smirnova I, Kasho V, Choe JY, Altenbach C, Hubbell WL, Kaback HR.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16504-9. Epub 2007 Oct 9.

20.

Single-molecule FRET reveals sugar-induced conformational dynamics in LacY.

Majumdar DS, Smirnova I, Kasho V, Nir E, Kong X, Weiss S, Kaback HR.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12640-5. Epub 2007 May 14.

21.

Direct sugar binding to LacY measured by resonance energy transfer.

Smirnova IN, Kasho VN, Kaback HR.

Biochemistry. 2006 Dec 26;45(51):15279-87. Epub 2006 Nov 29.

22.

Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli.

Nie Y, Smirnova I, Kasho V, Kaback HR.

J Biol Chem. 2006 Nov 24;281(47):35779-84. Epub 2006 Sep 26.

23.

Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease.

Kasho VN, Smirnova IN, Kaback HR.

J Mol Biol. 2006 May 12;358(4):1060-70. Epub 2006 Mar 9.

24.

Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease.

Vadyvaloo V, Smirnova IN, Kasho VN, Kaback HR.

J Mol Biol. 2006 May 12;358(4):1051-9. Epub 2006 Mar 9.

25.

Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli.

Ermolova NV, Smirnova IN, Kasho VN, Kaback HR.

Biochemistry. 2005 May 31;44(21):7669-77.

PMID:
15909981
26.

The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport.

Abramson J, Smirnova I, Kasho V, Verner G, Iwata S, Kaback HR.

FEBS Lett. 2003 Nov 27;555(1):96-101. Review.

27.

Structure and mechanism of the lactose permease of Escherichia coli.

Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S.

Science. 2003 Aug 1;301(5633):610-5.

28.

Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats.

Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ.

Gastroenterology. 2002 Jan;122(1):106-18.

PMID:
11781286
29.

18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding.

Farley RA, Elquza E, Müller-Ehmsen J, Kane DJ, Nagy AK, Kasho VN, Faller LD.

Biochemistry. 2001 May 29;40(21):6361-70.

PMID:
11371198
30.

The electrophilic and leaving group phosphates in the catalytic mechanism of yeast pyrophosphatase.

Zyryanov AB, Pohjanjoki P, Kasho VN, Shestakov AS, Goldman A, Lahti R, Baykov AA.

J Biol Chem. 2001 May 25;276(21):17629-34. Epub 2001 Feb 20.

31.

Catalytically important ionizations along the reaction pathway of yeast pyrophosphatase.

Belogurov GA, Fabrichniy IP, Pohjanjoki P, Kasho VN, Lehtihuhta E, Turkina MV, Cooperman BS, Goldman A, Baykov AA, Lahti R.

Biochemistry. 2000 Nov 14;39(45):13931-8.

PMID:
11076535
32.

Probing essential water in yeast pyrophosphatase by directed mutagenesis and fluoride inhibition measurements.

Pohjanjoki P, Fabrichniy IP, Kasho VN, Cooperman BS, Goldman A, Baykov AA, Lahti R.

J Biol Chem. 2001 Jan 5;276(1):434-41.

33.

Functional characterization of Escherichia coli inorganic pyrophosphatase in zwitterionic buffers.

Baykov AA, Hyytiä T, Turkina MV, Efimova IS, Kasho VN, Goldman A, Cooperman BS, Lahti R.

Eur J Biochem. 1999 Mar;260(2):308-17.

34.
35.

Trimeric inorganic pyrophosphatase of Escherichia coli obtained by directed mutagenesis.

Velichko IS, Mikalahti K, Kasho VN, Dudarenkov VY, Hyytiä T, Goldman A, Cooperman BS, Lahti R, Baykov AA.

Biochemistry. 1998 Jan 13;37(2):734-40.

PMID:
9425097
36.

Eosin, energy transfer, and RH421 report the same conformational change in sodium pump as fluorescein.

Lin SH, Smirnova IN, Kasho VN, Faller LD.

Ann N Y Acad Sci. 1997 Nov 3;834:442-4. No abstract available.

PMID:
9432920
37.

A proposal for the Mg2+ binding site of P-type ion motive ATPases and the mechanism of phosphoryl group transfer.

Kasho VN, Stengelin M, Smirnova IN, Faller LD.

Biochemistry. 1997 Jul 1;36(26):8045-52.

PMID:
9201952
38.

Structural and functional consequences of substitutions at the tyrosine 55-lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphatase.

Fabrichniy IP, Kasho VN, Hyytiä T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, Baykov AA.

Biochemistry. 1997 Jun 24;36(25):7746-53.

PMID:
9201916
39.

Site-directed mutagenesis of the sodium pump: analysis of mutations to amino acids in the proposed nucleotide binding site by stable oxygen isotope exchange.

Farley RA, Heart E, Kabalin M, Putnam D, Wang K, Kasho VN, Faller LD.

Biochemistry. 1997 Jan 28;36(4):941-51.

PMID:
9020794
40.

Feasibility of analysing [13C]urea breath tests for Helicobacter pylori by gas chromatography-mass spectrometry in the selected ion monitoring mode.

Kasho VN, Cheng S, Jensen DM, Ajie H, Lee WN, Faller LD.

Aliment Pharmacol Ther. 1996 Dec;10(6):985-95.

PMID:
8971299
41.

Effect of E20D substitution in the active site of Escherichia coli inorganic pyrophosphatase on its quaternary structure and catalytic properties.

Volk SE, Dudarenkov VY, Käpylä J, Kasho VN, Voloshina OA, Salminen T, Goldman A, Lahti R, Baykov AA, Cooperman BS.

Biochemistry. 1996 Apr 16;35(15):4662-9.

PMID:
8664255
42.

Catalysis by Escherichia coli inorganic pyrophosphatase: pH and Mg2+ dependence.

Baykov AA, Hyytia T, Volk SE, Kasho VN, Vener AV, Goldman A, Lahti R, Cooperman BS.

Biochemistry. 1996 Apr 16;35(15):4655-61.

PMID:
8664254
43.

Dissociation of hexameric Escherichia coli inorganic pyrophosphatase into trimers on His-136-->Gln or His-140-->Gln substitution and its effect on enzyme catalytic properties.

Baykov AA, Dudarenkov VY, Käpylä J, Salminen T, Hyytiä T, Kasho VN, Husgafvel S, Cooperman BS, Goldman A, Lahti R.

J Biol Chem. 1995 Dec 22;270(51):30804-12.

44.

Rates of elementary steps catalyzed by rat liver cytosolic and mitochondrial inorganic pyrophosphatases in both directions.

Smirnova IN, Kasho VN, Volk SE, Ivanov AH, Baykov AA.

Arch Biochem Biophys. 1995 Apr 20;318(2):340-8.

PMID:
7733662
47.

[Superoxide dismutase in liver ischemia].

Nagler LG, Makarova OV, Zamchuk LA, Vartanian LS, Rashba IuA, Kasho VN, Evtushenko OA.

Biokhimiia. 1991 Apr;56(4):674-80. Russian.

PMID:
1912070
48.

Kinetics and thermodynamics of catalysis by the inorganic pyrophosphatase of Escherichia coli in both directions.

Baykov AA, Shestakov AS, Kasho VN, Vener AV, Ivanov AH.

Eur J Biochem. 1990 Dec 27;194(3):879-87.

50.

Allosteric regulation of yeast inorganic pyrophosphatase by substrate.

Baykov AA, Pavlov AR, Kasho VN, Avaeva SM.

Arch Biochem Biophys. 1989 Sep;273(2):301-8.

PMID:
2549872

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