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Items: 1 to 50 of 59

1.

Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases.

Holzer T, Probst K, Etich J, Auler M, Georgieva VS, Bluhm B, Frie C, Heilig J, Niehoff A, Nüchel J, Plomann M, Seeger JM, Kashkar H, Baris OR, Wiesner RJ, Brachvogel B.

J Cell Biol. 2019 May 13. pii: jcb.201809056. doi: 10.1083/jcb.201809056. [Epub ahead of print]

PMID:
31085560
2.

The X-linked inhibitor of apoptosis protein (XIAP) is involved in melanoma invasion by regulating cell migration and survival.

Ayachi O, Barlin M, Broxtermann PN, Kashkar H, Mauch C, Zigrino P.

Cell Oncol (Dordr). 2019 Feb 18. doi: 10.1007/s13402-019-00427-1. [Epub ahead of print]

PMID:
30778852
3.

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition.

Gräb J, Suárez I, van Gumpel E, Winter S, Schreiber F, Esser A, Hölscher C, Fritsch M, Herb M, Schramm M, Wachsmuth L, Pallasch C, Pasparakis M, Kashkar H, Rybniker J.

Nat Commun. 2019 Feb 8;10(1):688. doi: 10.1038/s41467-019-08405-9.

4.

Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay.

Habich M, Salscheider SL, Murschall LM, Hoehne MN, Fischer M, Schorn F, Petrungaro C, Ali M, Erdogan AJ, Abou-Eid S, Kashkar H, Dengjel J, Riemer J.

Cell Rep. 2019 Jan 15;26(3):759-774.e5. doi: 10.1016/j.celrep.2018.12.092.

5.

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V.

Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087.

6.

Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer.

Schiffmann LM, Fritsch M, Gebauer F, Günther SD, Stair NR, Seeger JM, Thangarajah F, Dieplinger G, Bludau M, Alakus H, Göbel H, Quaas A, Zander T, Hilberg F, Bruns CJ, Kashkar H, Coutelle O.

Br J Cancer. 2019 Jan;120(1):69-78. doi: 10.1038/s41416-018-0198-3. Epub 2018 Oct 31.

PMID:
30377339
7.

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Hösel M, Quasdorff M, Ringelhan M, Kashkar H, Debey-Pascher S, Sprinzl MF, Bockmann JH, Arzberger S, Webb D, von Olshausen G, Weber A, Schultze JL, Büning H, Heikenwalder M, Protzer U.

Cell Mol Gastroenterol Hepatol. 2017 Jul 19;4(3):339-363. doi: 10.1016/j.jcmgh.2017.07.003. eCollection 2017 Nov.

8.

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T.

Nat Cell Biol. 2017 Apr;19(4):318-328. doi: 10.1038/ncb3488. Epub 2017 Mar 13.

PMID:
28288130
9.

A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition.

Schiffmann LM, Brunold M, Liwschitz M, Goede V, Loges S, Wroblewski M, Quaas A, Alakus H, Stippel D, Bruns CJ, Hallek M, Kashkar H, Hacker UT, Coutelle O.

Br J Cancer. 2017 Feb 28;116(5):600-608. doi: 10.1038/bjc.2017.13. Epub 2017 Jan 31.

10.

Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.

Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T.

Nat Commun. 2016 May 17;7:11593. doi: 10.1038/ncomms11593. No abstract available.

11.

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L; German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project Consortium, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC.

Blood. 2016 Jun 2;127(22):2732-41. doi: 10.1182/blood-2015-11-684183. Epub 2016 Apr 5.

12.

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.

Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T.

Nat Commun. 2016 Feb 4;7:10612. doi: 10.1038/ncomms10612. Erratum in: Nat Commun. 2016 May 17;7:11593.

13.

Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells.

Förster A, Grotha SP, Seeger JM, Rabenhorst A, Gehring M, Raap U, Létard S, Dubreuil P, Kashkar H, Walczak H, Roers A, Hartmann K.

Allergy. 2015 Jul;70(7):764-74. doi: 10.1111/all.12612. Epub 2015 Apr 16.

PMID:
25833810
14.

IAP antagonization promotes inflammatory destruction of vascular endothelium.

Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle PA, Krönke M, Mauch C, Kashkar H.

EMBO Rep. 2015 Jun;16(6):719-27. doi: 10.15252/embr.201439616. Epub 2015 Mar 30.

15.

Regulation of the DNA damage response by ubiquitin conjugation.

Brinkmann K, Schell M, Hoppe T, Kashkar H.

Front Genet. 2015 Mar 10;6:98. doi: 10.3389/fgene.2015.00098. eCollection 2015. Review.

16.

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.

Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H.

Cell Death Dis. 2015 Mar 12;6:e1691. doi: 10.1038/cddis.2015.62.

17.

Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours.

Coutelle O, Schiffmann LM, Liwschitz M, Brunold M, Goede V, Hallek M, Kashkar H, Hacker UT.

Br J Cancer. 2015 Feb 3;112(3):495-503. doi: 10.1038/bjc.2014.629. Epub 2015 Jan 6.

18.

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia.

Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP.

Leukemia. 2015 Apr;29(4):981-4. doi: 10.1038/leu.2014.320. Epub 2014 Nov 7. No abstract available.

PMID:
25376373
19.

The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling.

Bielig H, Lautz K, Braun PR, Menning M, Machuy N, Brügmann C, Barisic S, Eisler SA, Andree M, Zurek B, Kashkar H, Sansonetti PJ, Hausser A, Meyer TF, Kufer TA.

PLoS Pathog. 2014 Sep 4;10(9):e1004351. doi: 10.1371/journal.ppat.1004351. eCollection 2014 Sep.

20.

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H.

EMBO J. 2014 Oct 1;33(19):2171-87. doi: 10.15252/embj.201387244. Epub 2014 Jul 23.

21.

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.

Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H.

EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016.

22.

Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?

Brinkmann K, Kashkar H.

Cell Death Dis. 2014 Mar 6;5:e1098. doi: 10.1038/cddis.2014.61. Review.

23.

S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis.

Fröhlich M, Dejanovic B, Kashkar H, Schwarz G, Nussberger S.

Cell Death Dis. 2014 Feb 13;5:e1057. doi: 10.1038/cddis.2014.17.

24.

Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.

Albert MC, Brinkmann K, Kashkar H.

Mol Cell Oncol. 2014 Jul 28;1(1):e29906. doi: 10.4161/mco.29906. eCollection 2014. Review.

25.

Dimethylfumarate induces apoptosis in human mast cells.

Förster A, Preussner LM, Seeger JM, Rabenhorst A, Kashkar H, Mrowietz U, Hartmann K.

Exp Dermatol. 2013 Nov;22(11):719-24. doi: 10.1111/exd.12247.

PMID:
24112621
26.

Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling.

Gruber S, Straub BK, Ackermann PJ, Wunderlich CM, Mauer J, Seeger JM, Büning H, Heukamp L, Kashkar H, Schirmacher P, Brüning JC, Wunderlich FT.

Cell Rep. 2013 Aug 29;4(4):669-80. doi: 10.1016/j.celrep.2013.07.023. Epub 2013 Aug 15.

27.

Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing.

Brinkmann K, Hombach A, Seeger JM, Wagner-Stippich D, Klubertz D, Krönke M, Abken H, Kashkar H.

Leuk Lymphoma. 2014 Mar;55(3):645-51. doi: 10.3109/10428194.2013.807925. Epub 2013 Jun 26.

PMID:
23697877
28.

TNF-receptor-1 adaptor protein FAN mediates TNF-induced B16 melanoma motility and invasion.

Boecke A, Carstens AC, Neacsu CD, Baschuk N, Haubert D, Kashkar H, Utermöhlen O, Pongratz C, Krönke M.

Br J Cancer. 2013 Jul 23;109(2):422-32. doi: 10.1038/bjc.2013.242. Epub 2013 May 14.

29.

Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.

Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann P, Schüll S, Andree M, Coutelle O, Yazdanpanah B, Seeger JM, Klubertz D, Drebber U, Hacker UT, Krönke M, Mauch C, Hoppe T, Kashkar H.

Cell Rep. 2013 Mar 28;3(3):881-91. doi: 10.1016/j.celrep.2013.02.014. Epub 2013 Mar 14.

30.

Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils.

Förster A, Falcone FH, Gibbs BF, Preussner LM, Fiebig BS, Altunok H, Seeger JM, Cerny-Reiterer S, Rabenhorst A, Papenfuss K, Valent P, Kashkar H, Hartmann K.

Leuk Lymphoma. 2013 Apr;54(4):835-42. doi: 10.3109/10428194.2012.731600. Epub 2012 Oct 9.

PMID:
22989017
31.

TNF-induced target cell killing by CTL activated through cross-presentation.

Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA.

Cell Rep. 2012 Sep 27;2(3):478-87. doi: 10.1016/j.celrep.2012.08.001. Epub 2012 Aug 30.

32.

Factor associated with neutral sphingomyelinase activity mediates navigational capacity of leukocytes responding to wounds and infection: live imaging studies in zebrafish larvae.

Boecke A, Sieger D, Neacsu CD, Kashkar H, Krönke M.

J Immunol. 2012 Aug 15;189(4):1559-66. doi: 10.4049/jimmunol.1102207. Epub 2012 Jul 16.

33.

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC.

Nat Cell Biol. 2011 Apr;13(4):434-46. doi: 10.1038/ncb2211. Epub 2011 Mar 27.

PMID:
21441927
34.

Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis.

Frenzel LP, Patz M, Pallasch CP, Brinker R, Claasen J, Schulz A, Hallek M, Kashkar H, Wendtner CM.

Br J Haematol. 2011 Jan;152(2):191-200. doi: 10.1111/j.1365-2141.2010.08426.x. Epub 2010 Nov 23.

PMID:
21091905
35.

Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA library.

Pongratz C, Yazdanpanah B, Kashkar H, Lehmann MJ, Kräusslich HG, Krönke M.

PLoS One. 2010 Oct 8;5(10):e13172. doi: 10.1371/journal.pone.0013172.

36.

Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy.

Goede V, Coutelle O, Neuneier J, Reinacher-Schick A, Schnell R, Koslowsky TC, Weihrauch MR, Cremer B, Kashkar H, Odenthal M, Augustin HG, Schmiegel W, Hallek M, Hacker UT.

Br J Cancer. 2010 Oct 26;103(9):1407-14. doi: 10.1038/sj.bjc.6605925. Epub 2010 Oct 5.

37.

Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis.

Hörnle M, Peters N, Thayaparasingham B, Vörsmann H, Kashkar H, Kulms D.

Oncogene. 2011 Feb 3;30(5):575-87. doi: 10.1038/onc.2010.434. Epub 2010 Sep 20.

PMID:
20856198
38.

X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promise.

Kashkar H.

Clin Cancer Res. 2010 Sep 15;16(18):4496-502. doi: 10.1158/1078-0432.CCR-10-1664. Epub 2010 Aug 3. Review.

39.

Elevated XIAP expression alone does not confer chemoresistance.

Seeger JM, Brinkmann K, Yazdanpanah B, Haubert D, Pongratz C, Coutelle O, Krönke M, Kashkar H.

Br J Cancer. 2010 Jun 8;102(12):1717-23. doi: 10.1038/sj.bjc.6605704. Epub 2010 May 18.

40.

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib.

Lecis D, Drago C, Manzoni L, Seneci P, Scolastico C, Mastrangelo E, Bolognesi M, Anichini A, Kashkar H, Walczak H, Delia D.

Br J Cancer. 2010 Jun 8;102(12):1707-16. doi: 10.1038/sj.bjc.6605687. Epub 2010 May 11.

41.

The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack.

Seeger JM, Schmidt P, Brinkmann K, Hombach AA, Coutelle O, Zigrino P, Wagner-Stippich D, Mauch C, Abken H, Krönke M, Kashkar H.

Cancer Res. 2010 Mar 1;70(5):1825-34. doi: 10.1158/0008-5472.CAN-09-3175. Epub 2010 Feb 23.

42.

Role of LIF/STAT3 signaling in the regulation of major histocompatibility complex class I molecules in murine embryonic stem cells.

Gupta MK, Yazdanpanah B, Fatima A, Daglidu E, Kashkar H, Krönke M, Hescheler J, Sarić T.

J Stem Cells Regen Med. 2010 Oct 23;6(2):68. eCollection 2010. No abstract available.

PMID:
24693087
43.

Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation.

Meemboor S, Mertens J, Flenner E, Groneck L, Zingarelli A, Gamstätter T, Bessler M, Seeger JM, Kashkar H, Odenthal M, Kalka-Moll WM.

Innate Immun. 2010 Oct;16(5):310-21. doi: 10.1177/1753425909346974. Epub 2009 Nov 6.

PMID:
19897529
44.

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.

Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18351-6. doi: 10.1073/pnas.0907325106. Epub 2009 Oct 5.

45.

Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8CD28 regulatory T lymphocytes by TCR crosslinking.

Mertens J, Fabri M, Zingarelli A, Kubacki T, Meemboor S, Groneck L, Seeger J, Bessler M, Hafke H, Odenthal M, Bieler JG, Kalka C, Schneck JP, Kashkar H, Kalka-Moll WM.

PLoS Pathog. 2009 Sep;5(9):e1000596. doi: 10.1371/journal.ppat.1000596. Epub 2009 Sep 25.

46.

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M.

Nature. 2009 Aug 27;460(7259):1159-63. doi: 10.1038/nature08206. Epub 2009 Jul 29.

PMID:
19641494
47.

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.

Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, Bos E, Wiegmann K, Wallich R, Peters PJ, Herzig S, Schmelzer E, Krönke M, Simon MM, Utermöhlen O.

Nat Immunol. 2009 Jul;10(7):761-8. doi: 10.1038/ni.1757. Epub 2009 Jun 14.

PMID:
19525969
48.

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR.

Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK.

Cancer Res. 2009 Apr 15;69(8):3256-61. doi: 10.1158/0008-5472.CAN-08-4055. Epub 2009 Apr 7. Erratum in: Cancer Res. 2015 May 1;75(9):1922.

49.

Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease.

Pallasch CP, Schulz A, Kutsch N, Schwamb J, Hagist S, Kashkar H, Ultsch A, Wickenhauser C, Hallek M, Wendtner CM.

Blood. 2008 Nov 15;112(10):4213-9. doi: 10.1182/blood-2008-05-157255. Epub 2008 Aug 15. Erratum in: Blood. 2018 May 17;131(20):2272.

50.

PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganization.

Haubert D, Gharib N, Rivero F, Wiegmann K, Hösel M, Krönke M, Kashkar H.

EMBO J. 2007 Jul 25;26(14):3308-21. Epub 2007 Jun 28.

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