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Items: 1 to 50 of 74

1.

Oligoarginine Peptides, a New Family of nAChR Inhibitors.

Lebedev D, Kryukova E, Ivanov I, Egorova N, Timofeev N, Spirova E, Tufanova E, Siniavin A, Kudryavtsev D, Kasheverov I, Zouridakis M, Katsarava R, Zavradashvili N, Iagorshvili I, Tzartos S, Tsetlin V.

Mol Pharmacol. 2019 Sep 6. pii: mol.119.117713. doi: 10.1124/mol.119.117713. [Epub ahead of print]

2.

Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity.

Barykin EP, Garifulina AI, Kruykova EV, Spirova EN, Anashkina AA, Adzhubei AA, Shelukhina IV, Kasheverov IE, Mitkevich VA, Kozin SA, Hollmann M, Tsetlin VI, Makarov AA.

Cells. 2019 Jul 25;8(8). pii: E771. doi: 10.3390/cells8080771.

3.

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs.

Kryukova EV, Egorova NS, Kudryavtsev DS, Lebedev DS, Spirova EN, Zhmak MN, Garifulina AI, Kasheverov IE, Utkin YN, Tsetlin VI.

Front Pharmacol. 2019 Jul 3;10:748. doi: 10.3389/fphar.2019.00748. eCollection 2019.

4.

Scorpion toxins interact with nicotinic acetylcholine receptors.

Kasheverov IE, Oparin PB, Zhmak MN, Egorova NS, Ivanov IA, Gigolaev AM, Nekrasova OV, Serebryakova MV, Kudryavtsev DS, Prokopev NA, Hoang AN, Tsetlin VI, Vassilevski AA, Utkin YN.

FEBS Lett. 2019 Jul 5. doi: 10.1002/1873-3468.13530. [Epub ahead of print]

PMID:
31276191
5.

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors.

Zouridakis M, Papakyriakou A, Ivanov IA, Kasheverov IE, Tsetlin V, Tzartos S, Giastas P.

Front Pharmacol. 2019 May 1;10:474. doi: 10.3389/fphar.2019.00474. eCollection 2019.

6.

Novel long-chain neurotoxins from Bungarus candidus distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors.

Utkin YN, Kuch U, Kasheverov IE, Lebedev DS, Cederlund E, Molles BE, Polyak I, Ivanov IA, Prokopev NA, Ziganshin RH, Jornvall H, Alvelius G, Chanhome L, Warrell DA, Mebs D, Bergman T, Tsetlin VI.

Biochem J. 2019 Apr 26;476(8):1285-1302. doi: 10.1042/BCJ20180909.

PMID:
30944155
7.

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors.

Spirova EN, Ivanov IA, Kasheverov IE, Kudryavtsev DS, Shelukhina IV, Garifulina AI, Son LV, Lummis SCR, Malca-Garcia GR, Bussmann RW, Hennig L, Giannis A, Tsetlin VI.

PLoS One. 2019 Jan 4;14(1):e0210182. doi: 10.1371/journal.pone.0210182. eCollection 2019.

8.

Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors.

Kryukova EV, Ivanov IA, Lebedev DS, Spirova EN, Senko DA, Egorova NS, Kasheverov IE, Tsetlin VI.

Dokl Biochem Biophys. 2018 Nov;483(1):313-315. doi: 10.1134/S1607672918060017. Epub 2019 Jan 3.

PMID:
30607728
9.

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models.

Kryukova EV, Ivanov IA, Lebedev DS, Spirova EN, Egorova NS, Zouridakis M, Kasheverov IE, Tzartos SJ, Tsetlin VI.

Mar Drugs. 2018 Nov 22;16(12). pii: E460. doi: 10.3390/md16120460.

10.

Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists.

Yu J, Zhu X, Zhang L, Kudryavtsev D, Kasheverov I, Lei Y, Zhangsun D, Tsetlin V, Luo S.

Neuropharmacology. 2018 Sep 1;139:226-237. doi: 10.1016/j.neuropharm.2018.07.019. Epub 2018 Jul 17.

PMID:
30025921
11.

Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites.

Kudryavtsev DS, Spirova EN, Shelukhina IV, Son LV, Makarova YV, Utkina NK, Kasheverov IE, Tsetlin VI.

Mar Drugs. 2018 Mar 28;16(4). pii: E109. doi: 10.3390/md16040109.

12.

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.

Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI.

Sci Rep. 2017 Nov 30;7(1):16606. doi: 10.1038/s41598-017-16809-0.

13.

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors.

Vulfius CA, Kasheverov IE, Kryukova EV, Spirova EN, Shelukhina IV, Starkov VG, Andreeva TV, Faure G, Zouridakis M, Tsetlin VI, Utkin YN.

PLoS One. 2017 Oct 12;12(10):e0186206. doi: 10.1371/journal.pone.0186206. eCollection 2017.

14.

[Possible involvement of neuronal nicotinic acetylcholine receptors in compensatory brain mechanisms at early stages of Parkinson's disease].

Kryukova EV, Shelukhina IV, Kolacheva AA, Alieva AK, Shadrina MI, Slominsky PA, Kasheverov IE, Utkin YN, Ugrumov MV, Tsetlin VI.

Biomed Khim. 2017 May;63(3):241-247. doi: 10.18097/PBMC20176303241. Russian.

PMID:
28781257
15.

High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method.

Kasheverov IE, Chugunov AO, Kudryavtsev DS, Ivanov IA, Zhmak MN, Shelukhina IV, Spirova EN, Tabakmakher VM, Zelepuga EA, Efremov RG, Tsetlin VI.

Sci Rep. 2016 Nov 14;6:36848. doi: 10.1038/srep36848.

16.

Analysis of binding centers in nicotinic receptors with the aid of synthetic peptides.

Kasheverov IE, Kryukova EV, Kudryavtsev DS, Ivanov IA, Egorova NV, Zhmak MN, Spirova EN, Shelukhina IV, Odinokov AV, Alfimov MV, Tsetlin VI.

Dokl Biochem Biophys. 2016 Sep;470(1):338-341. Epub 2016 Nov 6.

PMID:
27817023
17.

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer.

Dyshlovoy SA, Otte K, Alsdorf WH, Hauschild J, Lange T, Venz S, Bauer CK, Bähring R, Amann K, Mandanchi R, Schumacher U, Schröder-Schwarz J, Makarieva TN, Guzii AG, Tabakmakher KM, Fedorov SN, Shubina LK, Kasheverov IE, Ehmke H, Steuber T, Stonik VA, Bokemeyer C, Honecker F, von Amsberg G.

Oncotarget. 2016 Oct 25;7(43):69703-69717. doi: 10.18632/oncotarget.11941.

18.

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models.

Faure G, Shelukhina IV, Porowinska D, Shulepko MA, Lyukmanova EN, Dolgikh DA, Spirova EN, Kasheverov IE, Utkin YN, Corringer JP, Tsetlin VI.

Dokl Biochem Biophys. 2016 May;468(1):193-6. doi: 10.1134/S1607672916030091. Epub 2016 Jul 15.

PMID:
27417718
19.

Central loop of non-conventional toxin WTX from Naja kaouthia is important for interaction with nicotinic acetylcholine receptors.

Lyukmanova EN, Shulepko MA, Shenkarev ZO, Kasheverov IE, Chugunov AO, Kulbatskii DS, Myshkin MY, Utkin YN, Efremov RG, Tsetlin VI, Arseniev AS, Kirpichnikov MP, Dolgikh DA.

Toxicon. 2016 Sep 1;119:274-9. doi: 10.1016/j.toxicon.2016.06.012. Epub 2016 Jun 23.

PMID:
27343701
20.

Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs.

Stepanov A, Belyy A, Kasheverov I, Rybinets A, Dronina M, Dyachenko I, Murashev A, Knorre V, Sakharov D, Ponomarenko N, Tsetlin V, Tonevitsky A, Deyev S, Belogurov A Jr, Gabibov A.

Biotechnol Lett. 2016 Jul;38(7):1173-80. doi: 10.1007/s10529-016-2092-5. Epub 2016 Apr 21.

PMID:
27099070
21.

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR.

Lin B, Xu M, Zhu X, Wu Y, Liu X, Zhangsun D, Hu Y, Xiang SH, Kasheverov IE, Tsetlin VI, Wang X, Luo S.

Sci Rep. 2016 Mar 1;6:22349. doi: 10.1038/srep22349.

22.

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.

Lyukmanova EN, Shulepko MA, Kudryavtsev D, Bychkov ML, Kulbatskii DS, Kasheverov IE, Astapova MV, Feofanov AV, Thomsen MS, Mikkelsen JD, Shenkarev ZO, Tsetlin VI, Dolgikh DA, Kirpichnikov MP.

PLoS One. 2016 Feb 23;11(2):e0149733. doi: 10.1371/journal.pone.0149733. eCollection 2016.

23.

Nonconventional three-finger toxin BMLCL from krait Bungarus multicinctus venom with high affinity interacts with nicotinic acetylcholine receptors.

Utkin YN, Kasheverov IE, Kudryavtsev DS, Andreeva TV, Starkov VG, Ziganshin RH, Kuznetsov DV, Anh HN, Thao NT, Khoa NC, Tsetlin VI.

Dokl Biochem Biophys. 2015;464:294-7. doi: 10.1134/S1607672915050099. Epub 2015 Oct 31.

PMID:
26518551
24.

Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.

Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, Starkov VG, Ramerstorfer J, Sieghart W, Tsetlin VI, Utkin YN.

J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.

25.

Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins.

Kudryavtsev D, Shelukhina I, Vulfius C, Makarieva T, Stonik V, Zhmak M, Ivanov I, Kasheverov I, Utkin Y, Tsetlin V.

Toxins (Basel). 2015 May 14;7(5):1683-701. doi: 10.3390/toxins7051683. Review.

26.

Rational design of new ligands for nicotinic receptors on the basis of α-conotoxin PnIA.

Kasheverov IE, Kudryavtsev DS, Ivanov IA, Zhmak MN, Chugunov AO, Tabakmakher VM, Zelepuga EA, Efremov RG, Tsetlin VI.

Dokl Biochem Biophys. 2015;461:106-9. doi: 10.1134/S1607672915020118. Epub 2015 May 5. No abstract available.

PMID:
25937226
27.

6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.

Kasheverov IE, Shelukhina IV, Kudryavtsev DS, Makarieva TN, Spirova EN, Guzii AG, Stonik VA, Tsetlin VI.

Mar Drugs. 2015 Mar 12;13(3):1255-66. doi: 10.3390/md13031255.

28.

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

Vulfius CA, Kasheverov IE, Starkov VG, Osipov AV, Andreeva TV, Filkin SY, Gorbacheva EV, Astashev ME, Tsetlin VI, Utkin YN.

PLoS One. 2014 Dec 18;9(12):e115428. doi: 10.1371/journal.pone.0115428. eCollection 2014.

29.

Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology.

Kudryavtsev D, Makarieva T, Utkina N, Santalova E, Kryukova E, Methfessel C, Tsetlin V, Stonik V, Kasheverov I.

Mar Drugs. 2014 Mar 28;12(4):1859-75. doi: 10.3390/md12041859.

30.

Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.

Lyukmanova EN, Shulepko MA, Buldakova SL, Kasheverov IE, Shenkarev ZO, Reshetnikov RV, Filkin SY, Kudryavtsev DS, Ojomoko LO, Kryukova EV, Dolgikh DA, Kirpichnikov MP, Bregestovski PD, Tsetlin VI.

J Biol Chem. 2013 May 31;288(22):15888-99. doi: 10.1074/jbc.M112.436576. Epub 2013 Apr 12.

31.

Human neuromodulator SLURP-1: bacterial expression, binding to muscle-type nicotinic acetylcholine receptor, secondary structure, and conformational heterogeneity in solution.

Shulepko MA, Lyukmanova EN, Paramonov AS, Lobas AA, Shenkarev ZO, Kasheverov IE, Dolgikh DA, Tsetlin VI, Arseniev AS, Kirpichnikov MP.

Biochemistry (Mosc). 2013 Feb;78(2):204-11. doi: 10.1134/S0006297913020090.

PMID:
23581991
32.

[Effect of alpha-conotoxin MII and its N-terminal derivatives on Ca2+ and Na+ signals induced by nicotine in neuroblastoma cell line SH-SY5Y].

Surin AM, Kriukova EV, Strukov AS, Zhmak MN, Talka R, Tuominen R, Salminen O, Khiroug L, Kasheverov IE, Tsetlin VI.

Bioorg Khim. 2012 Mar-Apr;38(2):214-22. Russian.

PMID:
22792725
33.

Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor.

Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kryukova EV, Zhmak MN, Starkov VG, Hoang NA, Bertrand D, Ramerstorfer J, Sieghart W, Thompson AJ, Lummis SC, Tsetlin VI.

J Biol Chem. 2012 Aug 3;287(32):27079-86. doi: 10.1074/jbc.M112.363051. Epub 2012 May 21.

34.

The new peptide from the Fea's viper Azemiops feae venom interacts with nicotinic acetylcholine receptors.

Utkin YN, Weise Ch, Hoang NA, Kasheverov IE, Starkov VG, Tsetlin VI.

Dokl Biochem Biophys. 2012 Jan-Feb;442:33-5. doi: 10.1134/S1607672912010103. Epub 2012 Mar 15. No abstract available. Erratum in: Dokl Biochem Biophys. 2012 May-Jun;444:182.

PMID:
22419091
35.

[Bacterial expression of water-soluble domain of Lynx1, endogenic neuromodulator of human nicotinic acetylcholine receptors].

Shulepko MA, Liukmanova EN, Kasheverov IE, Dolgikh DA, Tsetlin VI, Kirpichnikov MP.

Bioorg Khim. 2011 Sep-Oct;37(5):609-15. Russian.

PMID:
22332355
36.

Dimeric α-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors.

Osipov AV, Rucktooa P, Kasheverov IE, Filkin SY, Starkov VG, Andreeva TV, Sixma TK, Bertrand D, Utkin YN, Tsetlin VI.

J Biol Chem. 2012 Feb 24;287(9):6725-34. doi: 10.1074/jbc.M111.322313. Epub 2012 Jan 5.

37.

Design of new α-conotoxins: from computer modeling to synthesis of potent cholinergic compounds.

Kasheverov IE, Zhmak MN, Khruschov AY, Tsetlin VI.

Mar Drugs. 2011;9(10):1698-714. doi: 10.3390/md9101698. Epub 2011 Sep 28.

38.

An unusual phospholipase A₂ from puff adder Bitis arietans venom--a novel blocker of nicotinic acetylcholine receptors.

Vulfius CA, Gorbacheva EV, Starkov VG, Osipov AV, Kasheverov IE, Andreeva TV, Astashev ME, Tsetlin VI, Utkin YN.

Toxicon. 2011 Apr;57(5):787-93. doi: 10.1016/j.toxicon.2011.02.013. Epub 2011 Feb 17.

PMID:
21333664
39.

NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.

Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP.

J Biol Chem. 2011 Mar 25;286(12):10618-27. doi: 10.1074/jbc.M110.189100. Epub 2011 Jan 20.

40.

Assembly of nicotinic and other Cys-loop receptors.

Tsetlin V, Kuzmin D, Kasheverov I.

J Neurochem. 2011 Mar;116(5):734-41. doi: 10.1111/j.1471-4159.2010.07060.x. Epub 2011 Jan 13. Review.

41.

Bacterial production and refolding from inclusion bodies of a "weak" toxin, a disulfide rich protein.

Lyukmanova EN, Shulepko MA, Tikhonov RV, Shenkarev ZO, Paramonov AS, Wulfson AN, Kasheverov IE, Ustich TL, Utkin YN, Arseniev AS, Tsetlin VI, Dolgikh DA, Kirpichnikov MP.

Biochemistry (Mosc). 2009 Oct;74(10):1142-9.

PMID:
19916927
42.

Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor.

Kasheverov IE, Zhmak MN, Fish A, Rucktooa P, Khruschov AY, Osipov AV, Ziganshin RH, D'hoedt D, Bertrand D, Sixma TK, Smit AB, Tsetlin VI.

J Neurochem. 2009 Nov;111(4):934-44. doi: 10.1111/j.1471-4159.2009.06359.x. Epub 2009 Aug 27.

43.

Naturally occurring and synthetic peptides acting on nicotinic acetylcholine receptors.

Kasheverov IE, Utkin YN, Tsetlin VI.

Curr Pharm Des. 2009;15(21):2430-52. Review.

PMID:
19601841
44.

Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors.

Tsetlin V, Utkin Y, Kasheverov I.

Biochem Pharmacol. 2009 Oct 1;78(7):720-31. doi: 10.1016/j.bcp.2009.05.032. Epub 2009 Jun 6. Review.

PMID:
19501053
45.

Naturally occurring disulfide-bound dimers of three-fingered toxins: a paradigm for biological activity diversification.

Osipov AV, Kasheverov IE, Makarova YV, Starkov VG, Vorontsova OV, Ziganshin RKh, Andreeva TV, Serebryakova MV, Benoit A, Hogg RC, Bertrand D, Tsetlin VI, Utkin YN.

J Biol Chem. 2008 May 23;283(21):14571-80. doi: 10.1074/jbc.M802085200. Epub 2008 Apr 1.

46.

Alpha-conotoxin analogs with enhanced affinity for nicotinic receptors and acetylcholine-binding proteins.

Tsetlin VI, Kasheverov IE, Zhmak MN, Utkin YN, Vulfius CA, Smit AB, Bertrand D.

J Mol Neurosci. 2006;30(1-2):77-8.

PMID:
17192636
47.

A model for short alpha-neurotoxin bound to nicotinic acetylcholine receptor from Torpedo californica.

Mordvintsev DY, Polyak YL, Kuzmine DA, Levtsova OV, Tourleigh YV, Kasheverov IE.

J Mol Neurosci. 2006;30(1-2):71-2.

PMID:
17192633
48.

Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors.

Smit AB, Celie PH, Kasheverov IE, Mordvintsev DY, van Nierop P, Bertrand D, Tsetlin V, Sixma TK.

J Mol Neurosci. 2006;30(1-2):9-10.

PMID:
17192605
49.

Alpha-conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californica and some neuronal subtypes of nicotinic acetylcholine receptors.

Kasheverov IE, Zhmak MN, Vulfius CA, Gorbacheva EV, Mordvintsev DY, Utkin YN, van Elk R, Smit AB, Tsetlin VI.

FEBS J. 2006 Oct;273(19):4470-81. Epub 2006 Sep 5.

50.

Analysis of specificity of antibodies against synthetic fragments of different neuronal nicotinic acetylcholine receptor subunits.

Shelukhina IV, Kryukova EV, Skok MV, Lykhmus EY, Zhmak MN, Mordvintsev DY, Kasheverov IE, Tsetlin VI.

Biochemistry (Mosc). 2006 Jul;71(7):749-58.

PMID:
16903829

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