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Items: 42


The 1918 influenza pandemic: 100 years of questions answered and unanswered.

Taubenberger JK, Kash JC, Morens DM.

Sci Transl Med. 2019 Jul 24;11(502). pii: eaau5485. doi: 10.1126/scitranslmed.aau5485. Review.


Deep sequencing of 2009 influenza A/H1N1 virus isolated from volunteer human challenge study participants and natural infections.

Xiao Y, Park JK, Williams S, Ramuta M, Cervantes-Medina A, Bristol T, Smith S, Czajkowski L, Han A, Kash JC, Memoli MJ, Taubenberger JK.

Virology. 2019 Aug;534:96-107. doi: 10.1016/j.virol.2019.06.004. Epub 2019 Jun 13.


Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection.

Walters KA, Zhu R, Welge M, Scherler K, Park JK, Rahil Z, Wang H, Auvil L, Bushell C, Lee MY, Baxter D, Bristol T, Rosas LA, Cervantes-Medina A, Czajkowski L, Han A, Memoli MJ, Taubenberger JK, Kash JC.

mBio. 2019 May 14;10(3). pii: e00760-19. doi: 10.1128/mBio.00760-19.


Influenza A Reinfection in Sequential Human Challenge: Implications for Protective Immunity and "Universal" Vaccine Development.

Memoli MJ, Han A, Walters KA, Czajkowski L, Reed S, Athota R, Rosas LA, Cervantes-Medina A, Park JK, Morens DM, Kash JC, Taubenberger JK.

Clin Infect Dis. 2019 Apr 6. pii: ciz281. doi: 10.1093/cid/ciz281. [Epub ahead of print]


Deep Sequencing of H7N9 Influenza A Viruses from 16 Infected Patients from 2013 to 2015 in Shanghai Reveals Genetic Diversity and Antigenic Drift.

Xiao YL, Ren L, Zhang X, Qi L, Kash JC, Xiao Y, Wu F, Wang J, Taubenberger JK.

mSphere. 2018 Sep 19;3(5). pii: e00462-18. doi: 10.1128/mSphereDirect.00462-18.


Differential Ability of Pandemic and Seasonal H1N1 Influenza A Viruses To Alter the Function of Human Neutrophils.

Malachowa N, Freedman B, Sturdevant DE, Kobayashi SD, Nair V, Feldmann F, Starr T, Steele-Mortimer O, Kash JC, Taubenberger JK, Feldmann H, DeLeo FR.

mSphere. 2018 Jan 3;3(1). pii: e00567-17. doi: 10.1128/mSphereDirect.00567-17. eCollection 2018 Jan-Feb.


Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease.

Kash JC, Walters KA, Kindrachuk J, Baxter D, Scherler K, Janosko KB, Adams RD, Herbert AS, James RM, Stonier SW, Memoli MJ, Dye JM, Davey RT Jr, Chertow DS, Taubenberger JK.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaai9321. doi: 10.1126/scitranslmed.aai9321.


Influenza A and methicillin-resistant Staphylococcus aureus co-infection in rhesus macaques - A model of severe pneumonia.

Chertow DS, Kindrachuk J, Sheng ZM, Pujanauski LM, Cooper K, Nogee D, Claire MS, Solomon J, Perry D, Sayre P, Janosko KB, Lackemeyer MG, Bohannon JK, Kash JC, Jahrling PB, Taubenberger JK.

Antiviral Res. 2016 May;129:120-129. doi: 10.1016/j.antiviral.2016.02.013. Epub 2016 Feb 26.


1918 pandemic influenza virus and Streptococcus pneumoniae co-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans.

Walters KA, D'Agnillo F, Sheng ZM, Kindrachuk J, Schwartzman LM, Kuestner RE, Chertow DS, Golding BT, Taubenberger JK, Kash JC.

J Pathol. 2016 Jan;238(1):85-97. doi: 10.1002/path.4638. Epub 2015 Oct 14.


An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus.

Schwartzman LM, Cathcart AL, Pujanauski LM, Qi L, Kash JC, Taubenberger JK.

mBio. 2015 Jul 21;6(4):e01044. doi: 10.1128/mBio.01044-15.


The role of viral, host, and secondary bacterial factors in influenza pathogenesis.

Kash JC, Taubenberger JK.

Am J Pathol. 2015 Jun;185(6):1528-36. doi: 10.1016/j.ajpath.2014.08.030. Epub 2015 Mar 5. Review.


Contemporary avian influenza A virus subtype H1, H6, H7, H10, and H15 hemagglutinin genes encode a mammalian virulence factor similar to the 1918 pandemic virus H1 hemagglutinin.

Qi L, Pujanauski LM, Davis AS, Schwartzman LM, Chertow DS, Baxter D, Scherler K, Hartshorn KL, Slemons RD, Walters KA, Kash JC, Taubenberger JK.

mBio. 2014 Nov 18;5(6):e02116. doi: 10.1128/mBio.02116-14.


Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.

Kash JC, Xiao Y, Davis AS, Walters KA, Chertow DS, Easterbrook JD, Dunfee RL, Sandouk A, Jagger BW, Schwartzman LM, Kuestner RE, Wehr NB, Huffman K, Rosenthal RA, Ozinsky A, Levine RL, Doctrow SR, Taubenberger JK.

Free Radic Biol Med. 2014 Feb;67:235-47. doi: 10.1016/j.freeradbiomed.2013.10.014. Epub 2013 Oct 17.


Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model.

Kobayashi SD, Olsen RJ, LaCasse RA, Safronetz D, Ashraf M, Porter AR, Braughton KR, Feldmann F, Clifton DR, Kash JC, Bailey JR, Gardner DJ, Otto M, Brining DL, Kreiswirth BN, Taubenberger JK, Parnell MJ, Feldmann H, Musser JM, DeLeo FR.

Virulence. 2013 Nov 15;4(8):707-15. doi: 10.4161/viru.26572. Epub 2013 Oct 8.


High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic.

Xiao YL, Kash JC, Beres SB, Sheng ZM, Musser JM, Taubenberger JK.

J Pathol. 2013 Mar;229(4):535-45. doi: 10.1002/path.4145.


Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain.

Wise HM, Hutchinson EC, Jagger BW, Stuart AD, Kang ZH, Robb N, Schwartzman LM, Kash JC, Fodor E, Firth AE, Gog JR, Taubenberger JK, Digard P.

PLoS Pathog. 2012;8(11):e1002998. doi: 10.1371/journal.ppat.1002998. Epub 2012 Nov 1.


An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.

Jagger BW, Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE, Taubenberger JK, Digard P.

Science. 2012 Jul 13;337(6091):199-204. doi: 10.1126/science.1222213. Epub 2012 Jun 28.


Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice.

Easterbrook JD, Schwartzman LM, Gao J, Kash JC, Morens DM, Couzens L, Wan H, Eichelberger MC, Taubenberger JK.

Virology. 2012 Oct 10;432(1):39-44. doi: 10.1016/j.virol.2012.06.003. Epub 2012 Jun 22.


Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.

Qi L, Davis AS, Jagger BW, Schwartzman LM, Dunham EJ, Kash JC, Taubenberger JK.

J Virol. 2012 Sep;86(17):9211-20. doi: 10.1128/JVI.00887-12. Epub 2012 Jun 20.


Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses.

Kash JC, Walters KA, Davis AS, Sandouk A, Schwartzman LM, Jagger BW, Chertow DS, Li Q, Kuestner RE, Ozinsky A, Taubenberger JK.

mBio. 2011 Sep 20;2(5). pii: e00172-11. doi: 10.1128/mBio.00172-11. Print 2011.


Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak.

Sheng ZM, Chertow DS, Ambroggio X, McCall S, Przygodzki RM, Cunningham RE, Maximova OA, Kash JC, Morens DM, Taubenberger JK.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16416-21. doi: 10.1073/pnas.1111179108. Epub 2011 Sep 19.


Insights on influenza pathogenesis from the grave.

Taubenberger JK, Kash JC.

Virus Res. 2011 Dec;162(1-2):2-7. doi: 10.1016/j.virusres.2011.09.003. Epub 2011 Sep 10. Review.


Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus.

Easterbrook JD, Dunfee RL, Schwartzman LM, Jagger BW, Sandouk A, Kash JC, Memoli MJ, Taubenberger JK.

Influenza Other Respir Viruses. 2011 Nov;5(6):418-25. doi: 10.1111/j.1750-2659.2011.00254.x. Epub 2011 Apr 18.


Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection.

Easterbrook JD, Kash JC, Sheng ZM, Qi L, Gao J, Kilbourne ED, Eichelberger MC, Taubenberger JK.

Influenza Other Respir Viruses. 2011 May;5(3):198-205. doi: 10.1111/j.1750-2659.2010.00191.x. Epub 2011 Jan 25.


The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding.

Qi L, Kash JC, Dugan VG, Jagger BW, Lau YF, Sheng ZM, Crouch EC, Hartshorn KL, Taubenberger JK.

Virology. 2011 Apr 10;412(2):426-34. doi: 10.1016/j.virol.2011.01.029. Epub 2011 Feb 18.


The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase.

Jagger BW, Memoli MJ, Sheng ZM, Qi L, Hrabal RJ, Allen GL, Dugan VG, Wang R, Digard P, Kash JC, Taubenberger JK.

mBio. 2010 May 18;1(1). pii: e00067-10. doi: 10.1128/mBio.00067-10.


Influenza virus evolution, host adaptation, and pandemic formation.

Taubenberger JK, Kash JC.

Cell Host Microbe. 2010 Jun 25;7(6):440-51. doi: 10.1016/j.chom.2010.05.009. Review.


Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus.

Kash JC, Qi L, Dugan VG, Jagger BW, Hrabal RJ, Memoli MJ, Morens DM, Taubenberger JK.

Influenza Other Respir Viruses. 2010 May 1;4(3):121-7. doi: 10.1111/j.1750-2659.2010.00132.x.


An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice.

Memoli MJ, Tumpey TM, Jagger BW, Dugan VG, Sheng ZM, Qi L, Kash JC, Taubenberger JK.

Virology. 2009 Oct 25;393(2):338-45. doi: 10.1016/j.virol.2009.08.021. Epub 2009 Sep 5.


Role of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis for mice.

Qi L, Kash JC, Dugan VG, Wang R, Jin G, Cunningham RE, Taubenberger JK.

J Virol. 2009 Apr;83(8):3754-61. doi: 10.1128/JVI.02596-08. Epub 2009 Feb 11.


Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.

Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M, Feldmann F, Alimonti JB, Fernando L, Li Y, Katze MG, Feldmann H, Kawaoka Y.

Nature. 2007 Jan 18;445(7125):319-23.


Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus.

Kash JC, Tumpey TM, Proll SC, Carter V, Perwitasari O, Thomas MJ, Basler CF, Palese P, Taubenberger JK, García-Sastre A, Swayne DE, Katze MG.

Nature. 2006 Oct 5;443(7111):578-81. Epub 2006 Sep 27.


Hijacking of the host-cell response and translational control during influenza virus infection.

Kash JC, Goodman AG, Korth MJ, Katze MG.

Virus Res. 2006 Jul;119(1):111-20. Epub 2006 Apr 19. Review.


Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence.

Kash JC, Mühlberger E, Carter V, Grosch M, Perwitasari O, Proll SC, Thomas MJ, Weber F, Klenk HD, Katze MG.

J Virol. 2006 Mar;80(6):3009-20.


Virus infection and the interferon response: a global view through functional genomics.

Korth MJ, Kash JC, Furlong JC, Katze MG.

Methods Mol Med. 2005;116:37-55. Review.


Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus.

Kash JC, Basler CF, García-Sastre A, Carter V, Billharz R, Swayne DE, Przygodzki RM, Taubenberger JK, Katze MG, Tumpey TM.

J Virol. 2004 Sep;78(17):9499-511.


Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis.

Kash JC, Cunningham DM, Smit MW, Park Y, Fritz D, Wilusz J, Katze MG.

J Virol. 2002 Oct;76(20):10417-26.


Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein.

Nair AK, Kash JC, Peegel H, Menon KM.

J Biol Chem. 2002 Jun 14;277(24):21468-73. Epub 2002 Apr 8.

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