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Items: 1 to 50 of 60

1.

Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics.

Sawant-Basak A, Rodrigues AD, Lech M, Doyonnas R, Kasaian M, Prasad B, Tsamandouras N.

Drug Metab Dispos. 2018 Nov;46(11):1581-1587. doi: 10.1124/dmd.118.082784. Epub 2018 Aug 20.

PMID:
30126862
2.

Proteomic analysis of serum and sputum analytes distinguishes controlled and poorly controlled asthmatics.

Kasaian MT, Lee J, Brennan A, Danto SI, Black KE, Fitz L, Dixon AE.

Clin Exp Allergy. 2018 Jul;48(7):814-824. doi: 10.1111/cea.13151. Epub 2018 May 15.

PMID:
29665127
3.

Modulation of the IL-33/IL-13 Axis in Obesity by IL-13Rα2.

Duffen J, Zhang M, Masek-Hammerman K, Nunez A, Brennan A, Jones JEC, Morin J, Nocka K, Kasaian M.

J Immunol. 2018 Feb 15;200(4):1347-1359. doi: 10.4049/jimmunol.1701256. Epub 2018 Jan 5.

PMID:
29305434
4.

A mechanistic PK/PD model for two anti-IL13 antibodies explains the difference in total IL-13 accumulation observed in clinical studies.

Tiwari A, Kasaian M, Heatherington AC, Jones HM, Hua F.

MAbs. 2016 Jul;8(5):983-90. doi: 10.1080/19420862.2016.1172151. Epub 2016 Apr 6.

5.

Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice.

Kasaian MT, Page KM, Fish S, Brennan A, Cook TA, Moreira K, Zhang M, Jesson M, Marquette K, Agostinelli R, Lee J, Williams CM, Tchistiakova L, Thakker P.

Immunology. 2014 Nov;143(3):416-27. doi: 10.1111/imm.12319.

6.

An IL-4/IL-13 dual antagonist reduces lung inflammation, airway hyperresponsiveness, and IgE production in mice.

Kasaian MT, Marquette K, Fish S, DeClercq C, Agostinelli R, Cook TA, Brennan A, Lee J, Fitz L, Brooks J, Vugmeyster Y, Williams CM, Lofquist A, Tchistiakova L.

Am J Respir Cell Mol Biol. 2013 Jul;49(1):37-46. doi: 10.1165/rcmb.2012-0500OC.

PMID:
23449738
7.

IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2.

Kasaian MT, Raible D, Marquette K, Cook TA, Zhou S, Tan XY, Tchistiakova L.

J Immunol. 2011 Jul 1;187(1):561-9. doi: 10.4049/jimmunol.1100467. Epub 2011 May 27.

8.

Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys.

Nickerson-Nutter C, Tchistiakova L, Seth NP, Kasaian M, Sibley B, Olland S, Zollner R, Brady WA, Mohler KM, Baum P, Wahl A, Herber D, Vugmeyster Y, Wensel D, Wolfman NM, Gill D, Collins M, Dunussi-Joannopoulos K.

Rheumatology (Oxford). 2011 Jun;50(6):1033-44. doi: 10.1093/rheumatology/keq423. Epub 2011 Jan 21.

9.

Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma.

Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM.

Am J Respir Crit Care Med. 2011 Apr 15;183(8):1007-14. doi: 10.1164/rccm.201008-1210OC. Epub 2010 Nov 5.

PMID:
21057005
10.

A human CXCL13-induced actin polymerization assay measured by fluorescence plate reader.

Alley J, Bloom L, Kasaian M, Gao H, Berstein G, Clark JD, Miao W.

Assay Drug Dev Technol. 2010 Feb;8(1):73-84. doi: 10.1089/adt.2008.0187.

PMID:
20085454
11.

IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation.

Silver MR, Margulis A, Wood N, Goldman SJ, Kasaian M, Chaudhary D.

Inflamm Res. 2010 Mar;59(3):207-18. doi: 10.1007/s00011-009-0088-5. Epub 2009 Sep 18.

PMID:
19763788
12.

Analytical validation of a highly sensitive microparticle-based immunoassay for the quantitation of IL-13 in human serum using the Erenna immunoassay system.

St Ledger K, Agee SJ, Kasaian MT, Forlow SB, Durn BL, Minyard J, Lu QA, Todd J, Vesterqvist O, Burczynski ME.

J Immunol Methods. 2009 Oct 31;350(1-2):161-70. doi: 10.1016/j.jim.2009.08.012. Epub 2009 Sep 2.

PMID:
19732777
13.

Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.

Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT.

J Immunol. 2009 Aug 1;183(3):1739-50. doi: 10.4049/jimmunol.0803951. Epub 2009 Jul 10.

14.

Altered regulation of aquaporin gene expression in allergen and IL-13-induced mouse models of asthma.

Krane CM, Deng B, Mutyam V, McDonald CA, Pazdziorko S, Mason L, Goldman S, Kasaian M, Chaudhary D, Williams C, Ho MW.

Cytokine. 2009 Apr;46(1):111-8. doi: 10.1016/j.cyto.2008.12.018. Epub 2009 Feb 23.

15.

MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice.

Margulis A, Nocka KH, Wood NL, Wolf SF, Goldman SJ, Kasaian MT.

Am J Physiol Lung Cell Mol Physiol. 2009 Feb;296(2):L236-47. doi: 10.1152/ajplung.90462.2008. Epub 2008 Dec 5.

16.

Pharmacokinetic and pharmacodynamic modeling of a humanized anti-IL-13 antibody in naive and Ascaris-challenged cynomolgus monkeys.

Vugmeyster Y, Tian X, Szklut P, Kasaian M, Xu X.

Pharm Res. 2009 Feb;26(2):306-15. doi: 10.1007/s11095-008-9739-4. Epub 2008 Oct 31.

PMID:
18975059
17.

In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2alpha overcomes the asthma-associated response.

Whalen KA, Legault H, Hang C, Hill A, Kasaian M, Donaldson D, Bensch GW, Bensch G, Baker J, Reddy PS, Wood N, Ramarao MK, Ellis DK, Csimma C, McKee C, Clark JD, Ryan J, Dorner AJ, O'Toole M.

Clin Exp Allergy. 2008 Oct;38(10):1590-605. doi: 10.1111/j.1365-2222.2008.03059.x. Epub 2008 Jul 28.

18.

IL-13 as a therapeutic target for respiratory disease.

Kasaian MT, Miller DK.

Biochem Pharmacol. 2008 Jul 15;76(2):147-55. doi: 10.1016/j.bcp.2008.04.002. Epub 2008 Apr 16. Review.

PMID:
18502398
19.

Activation-induced cellular accumulation of histamine in immature but not mature murine mast cells.

Fitz LJ, Brennan A, Wood CR, Goldman SJ, Kasaian MT.

Cell Mol Life Sci. 2008 May;65(10):1585-95. doi: 10.1007/s00018-008-8106-2.

PMID:
18408884
20.

Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys.

Kasaian MT, Tan XY, Jin M, Fitz L, Marquette K, Wood N, Cook TA, Lee J, Widom A, Agostinelli R, Bree A, Schlerman FJ, Olland S, Wadanoli M, Sypek J, Gill D, Goldman SJ, Tchistiakova L.

J Pharmacol Exp Ther. 2008 Jun;325(3):882-92. doi: 10.1124/jpet.108.136515. Epub 2008 Mar 12.

21.

Binding characterization of the interleukin-13 signaling complex and development of a ternary time-resolved fluorescence resonance energy transfer assay.

Yang X, Lee J, Brooks J, Wilhelm J, Myszka D, Kasaian MT, Goldman S, Wolf S, Fitz LJ.

Anal Biochem. 2008 May 15;376(2):206-12. doi: 10.1016/j.ab.2008.02.005. Epub 2008 Feb 13.

PMID:
18328249
22.

A novel and sensitive ELISA reveals that the soluble form of IL-13R-alpha2 is not expressed in plasma of healthy or asthmatic subjects.

O'Toole M, Legault H, Ramsey R, Wynn TA, Kasaian MT.

Clin Exp Allergy. 2008 Apr;38(4):594-601. doi: 10.1111/j.1365-2222.2007.02921.x. Epub 2008 Feb 25.

23.

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of humanized monoclonal anti-IL-13 antibodies with different IL-13 neutralization mechanisms.

Vugmeyster Y, Szklut P, Tchistiakova L, Abraham W, Kasaian M, Xu X.

Int Immunopharmacol. 2008 Mar;8(3):477-83. doi: 10.1016/j.intimp.2007.12.004. Epub 2008 Jan 11.

PMID:
18279802
24.

Natural killer cells from protein kinase C theta-/- mice stimulated with interleukin-12 are deficient in production of interferon-gamma.

Page KM, Chaudhary D, Goldman SJ, Kasaian MT.

J Leukoc Biol. 2008 May;83(5):1267-76. doi: 10.1189/jlb.1107745. Epub 2008 Feb 8.

PMID:
18263766
25.

CAT-2 amplifies the agonist-evoked force of airway smooth muscle by enhancing spermine-mediated phosphatidylinositol-(4)-phosphate-5-kinase-gamma activity.

Chen H, Macleod C, Deng B, Mason L, Kasaian M, Goldman S, Wolf S, Williams C, Bowman MR.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L883-91. Epub 2007 Jul 20.

26.

IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys.

Bree A, Schlerman FJ, Wadanoli M, Tchistiakova L, Marquette K, Tan XY, Jacobson BA, Widom A, Cook TA, Wood N, Vunnum S, Krykbaev R, Xu X, Donaldson DD, Goldman SJ, Sypek J, Kasaian MT.

J Allergy Clin Immunol. 2007 May;119(5):1251-7. Epub 2007 Mar 26.

PMID:
17379289
27.

Efficacy of IL-13 neutralization in a sheep model of experimental asthma.

Kasaian MT, Donaldson DD, Tchistiakova L, Marquette K, Tan XY, Ahmed A, Jacobson BA, Widom A, Cook TA, Xu X, Barry AB, Goldman SJ, Abraham WM.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):368-76. Epub 2006 Oct 5.

PMID:
17023688
28.

PKCtheta: A potential therapeutic target for T-cell-mediated diseases.

Chaudhary D, Kasaian M.

Curr Opin Investig Drugs. 2006 May;7(5):432-7. Review.

PMID:
16729719
29.

IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13.

Fish SC, Donaldson DD, Goldman SJ, Williams CM, Kasaian MT.

J Immunol. 2005 Jun 15;174(12):7716-24.

30.

IL-21 effects on human IgE production in response to IL-4 or IL-13.

Wood N, Bourque K, Donaldson DD, Collins M, Vercelli D, Goldman SJ, Kasaian MT.

Cell Immunol. 2004 Sep-Oct;231(1-2):133-45. Epub 2005 Feb 9.

PMID:
15919378
31.

Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand.

Madrenas J, Chau LA, Teft WA, Wu PW, Jussif J, Kasaian M, Carreno BM, Ling V.

J Immunol. 2004 May 15;172(10):5948-56.

32.

Beneficial effects of estrogen treatment in the HLA-B27 transgenic rat model of inflammatory bowel disease.

Harnish DC, Albert LM, Leathurby Y, Eckert AM, Ciarletta A, Kasaian M, Keith JC Jr.

Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G118-25. Epub 2003 Sep 4.

33.

Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.

Wood N, Whitters MJ, Jacobson BA, Witek J, Sypek JP, Kasaian M, Eppihimer MJ, Unger M, Tanaka T, Goldman SJ, Collins M, Donaldson DD, Grusby MJ.

J Exp Med. 2003 Mar 17;197(6):703-9.

34.

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.

Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ.

Immunity. 2002 Apr;16(4):559-69.

35.
37.

The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms.

Konieczny A, Morgenstern JP, Bizinkauskas CB, Lilley CH, Brauer AW, Bond JF, Aalberse RC, Wallner BP, Kasaian MT.

Immunology. 1997 Dec;92(4):577-86.

38.

VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection.

Schettino EW, Chai SK, Kasaian MT, Schroeder HW Jr, Casali P.

J Immunol. 1997 Mar 1;158(5):2477-89.

39.

Cytokine priming of human basophils: description of allergen 'nonreleasers'.

Black KM, Lussier AM, Gion WR, Kasaian MT.

Int Arch Allergy Immunol. 1996 Oct;111(2):142-51.

PMID:
8859222
40.

IL-4 production by allergen-stimulated primary cultures: identification of basophils as the major IL-4-producing cell type.

Kasaian MT, Clay MJ, Happ MP, Garman RD, Hirani S, Luqman M.

Int Immunol. 1996 Aug;8(8):1287-97.

PMID:
8918698
41.

B-1 cellular origin and VH segment structure of IgG, IgA, and IgM anti-DNA autoantibodies in patients with systemic lupus erythematosus.

Kasaian MT, Casali P.

Ann N Y Acad Sci. 1995 Sep 29;764:410-23. Review. No abstract available.

PMID:
7486556
42.

An increased frequency of IgE-producing B cell precursors contributes to the elevated levels of plasma IgE in atopic subjects.

Kasaian MT, Meyer CH, Nault AK, Bond JF.

Clin Exp Allergy. 1995 Aug;25(8):749-55.

PMID:
7584687
43.
44.
45.

Flow cytometric analysis of fluorescein-labeled nerve growth factor binding to A875 human melanoma cells.

Kasaian MT, Jacobberger JW, Neet KE.

Exp Cell Res. 1994 Jan;210(1):77-85.

PMID:
8270000
46.

Natural autoantibodies.

Chai SK, Mantovani L, Kasaian MT, Casali P.

Adv Exp Med Biol. 1994;347:147-59. Review. No abstract available.

PMID:
7526635
47.

Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.

Ikematsu H, Kasaian MT, Schettino EW, Casali P.

J Immunol. 1993 Oct 1;151(7):3604-16.

48.

Autoimmunity-prone B-1 (CD5 B) cells, natural antibodies and self recognition.

Kasaian MT, Casali P.

Autoimmunity. 1993;15(4):315-29. Review.

PMID:
7511005
49.

Analysis of the human CD5- CD45RAlow B-cell subset.

Kasaian MT, Casali P.

Ann N Y Acad Sci. 1992 May 4;651:59-69. No abstract available.

PMID:
1376086
50.

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