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Increased von Willebrand Factor Processing in COPD, Reflecting Lung Epithelium Damage, Is Associated with Emphysema, Exacerbations and Elevated Mortality Risk.

Langholm LL, Rønnow SR, Sand JMB, Leeming DJ, Tal-Singer R, Miller BE, Vestbo J, Karsdal MA, Manon-Jensen T.

Int J Chron Obstruct Pulmon Dis. 2020 Mar 9;15:543-552. doi: 10.2147/COPD.S235673. eCollection 2020.


Dose frequency optimization of the dual amylin and calcitonin receptor agonist KBP-088 --long-lasting improvement of food preference and body weight loss.

Larsen AT, Sonne N, Andreassen KV, Karsdal MA, Henriksen K.

J Pharmacol Exp Ther. 2020 Feb 18. pii: jpet.119.263400. doi: 10.1124/jpet.119.263400. [Epub ahead of print]


Correlation between serological biomarkers of extracellular matrix turnover and lung fibrosis and pulmonary artery hypertension in patients with systemic sclerosis.

Kubo S, Siebuhr AS, Bay-Jensen AC, Juhl P, Karsdal MA, Satoh Y, Todoroki Y, Nakano K, Nakayamada S, Tanaka Y.

Int J Rheum Dis. 2020 Feb 5. doi: 10.1111/1756-185X.13804. [Epub ahead of print]


Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome.

Holm Nielsen S, Jonasson L, Kalogeropoulos K, Karsdal MA, Reese-Petersen AL, Auf dem Keller U, Genovese F, Nilsson J, Goncalves I.

J Intern Med. 2020 Feb 3. doi: 10.1111/joim.13034. [Epub ahead of print] Review.


Collagen biology and non-invasive biomarkers of liver fibrosis.

Karsdal MA, Daniels SJ, Holm Nielsen S, Bager C, Rasmussen DGK, Loomba R, Surabattula R, Villesen IF, Luo Y, Shevell D, Gudmann NS, Nielsen MJ, George J, Christian R, Leeming DJ, Schuppan D.

Liver Int. 2020 Jan 29. doi: 10.1111/liv.14390. [Epub ahead of print] Review.


The Dual Amylin and Calcitonin Receptor Agonist, KBP-066, Induces an Equally Potent Weight Loss Across a Broad Dose Range While Higher Doses May Further Improve Insulin Action.

Sonne N, Larsen AT, Andreassen KV, Karsdal MA, Henriksen K.

J Pharmacol Exp Ther. 2020 Apr;373(1):92-102. doi: 10.1124/jpet.119.263723. Epub 2020 Jan 28.


Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition.

Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A, Marrali M, Longato L, Thanapirom K, Vilia MG, Lombardi B, Crowley C, Crawford M, Karsdal MA, Leeming DJ, Marrone G, Bottcher K, Robinson B, Del Rio Hernandez A, Tamburrino D, Spoletini G, Malago M, Hall AR, Godovac-Zimmermann J, Luong TV, De Coppi P, Pinzani M, Rombouts K.

Cells. 2019 Dec 28;9(1). pii: E83. doi: 10.3390/cells9010083.


Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis.

Daniels SJ, Leeming DJ, Detlefsen S, Bruun MF, Hjuler ST, Henriksen K, Hein P, Krag A, Karsdal MA, Nielsen MJ, Brockbank S, Cruwys S.

Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G410-G418. doi: 10.1152/ajpgi.00066.2019. Epub 2020 Jan 6.


Recent advances in understanding the phenotypes of osteoarthritis.

Mobasheri A, Saarakkala S, Finnilä M, Karsdal MA, Bay-Jensen AC, van Spil WE.

F1000Res. 2019 Dec 12;8. pii: F1000 Faculty Rev-2091. doi: 10.12688/f1000research.20575.1. eCollection 2019. Review.


Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer.

Willumsen N, Ali SM, Leitzel K, Drabick JJ, Yee N, Polimera HV, Nagabhairu V, Krecko L, Ali A, Maddukuri A, Moku P, Ali A, Poulose J, Menon H, Pancholy N, Costa L, Karsdal MA, Lipton A.

Sci Rep. 2019 Dec 24;9(1):19761. doi: 10.1038/s41598-019-56268-3.


Blood and urinary collagen markers in osteoarthritis: markers of tissue turnover and disease activity.

Bay-Jensen AC, Engstroem A, Sharma N, Karsdal MA.

Expert Rev Mol Diagn. 2020 Jan;20(1):57-68. doi: 10.1080/14737159.2020.1704257. Epub 2019 Dec 23.


End-product of fibrinogen is elevated in emphysematous chronic obstructive pulmonary disease and is predictive of mortality in the ECLIPSE cohort.

Manon-Jensen T, Langholm LL, Rønnow SR, Karsdal MA, Tal-Singer R, Vestbo J, Leeming DJ, Miller BE, Bülow Sand JM.

Respir Med. 2019 Nov - Dec;160:105814. doi: 10.1016/j.rmed.2019.105814. Epub 2019 Nov 6.


An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants.

Thudium CS, Engstrom A, Groen SS, Karsdal MA, Bay-Jensen AC.

J Vis Exp. 2019 Nov 3;(153). doi: 10.3791/59467.


Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors.

Sharma N, Drobinski P, Kayed A, Chen Z, Kjelgaard-Petersen CF, Gantzel T, Karsdal MA, Michaelis M, Ladel C, Bay-Jensen AC, Lindemann S, Thudium CS.

Osteoarthritis Cartilage. 2019 Nov 14. pii: S1063-4584(19)31266-X. doi: 10.1016/j.joca.2019.11.002. [Epub ahead of print]


Collagen turnover profiles in chronic kidney disease.

Rasmussen DGK, Boesby L, Nielsen SH, Tepel M, Birot S, Karsdal MA, Kamper AL, Genovese F.

Sci Rep. 2019 Nov 5;9(1):16062. doi: 10.1038/s41598-019-51905-3.


Biochemical markers in osteoarthritis with lessons learned from osteoporosis.

Karsdal MA, Henriksen K, Bay-Jensen AC.

Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):73-87. Epub 2019 Oct 15. Review.


Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients.

Nielsen MJ, Villesen IF, Gudmann NS, Leeming DJ, Krag A, Karsdal MA, Zimmermann T, Schuppan D.

Sci Rep. 2019 Oct 16;9(1):14857. doi: 10.1038/s41598-019-51394-4.


The intestinal tissue homeostasis - the role of extracellular matrix remodeling in inflammatory bowel disease.

Mortensen JH, Lindholm M, Langholm LL, Kjeldsen J, Bay-Jensen AC, Karsdal MA, Manon-Jensen T.

Expert Rev Gastroenterol Hepatol. 2019 Oct;13(10):977-993. doi: 10.1080/17474124.2019.1673729. Epub 2019 Oct 22.


Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?

Karsdal MA, Detlefsen S, Daniels SJ, Nielsen MJ, Krag A, Schuppan D.

Hepatology. 2020 Jan;71(1):346-351. doi: 10.1002/hep.30969. Epub 2019 Dec 18. Review. No abstract available.


Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis.

Bihlet AR, Byrjalsen I, Bay-Jensen AC, Andersen JR, Christiansen C, Riis BJ, Karsdal MA.

Arthritis Res Ther. 2019 Sep 3;21(1):203. doi: 10.1186/s13075-019-1987-7.


Clinical Relevance of Collagen Protein Degradation Markers C3M and C4M in the Serum of Breast Cancer Patients Treated with Neoadjuvant Therapy in the GeparQuinto Trial.

Banys-Paluchowski M, Loibl S, Witzel I, Mundhenke C, Lederer B, Solbach C, Karn T, Marmé F, Nekljudova V, Schem C, Stickeler E, Willumsen N, Karsdal MA, Untch M, Müller V.

Cancers (Basel). 2019 Aug 15;11(8). pii: E1186. doi: 10.3390/cancers11081186.


Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program.

Huber Y, Pfirrmann D, Gebhardt I, Labenz C, Gehrke N, Straub BK, Ruckes C, Bantel H, Belda E, Clément K, Leeming DJ, Karsdal MA, Galle PR, Simon P, Schattenberg JM.

Aliment Pharmacol Ther. 2019 Oct;50(8):930-939. doi: 10.1111/apt.15427. Epub 2019 Jul 25.


Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice.

Cooke EJ, Wyseure T, Zhou JY, Gopal S, Nasamran CA, Fisch KM, Manon-Jensen T, Karsdal MA, Mosnier LO, von Drygalski A.

J Thromb Haemost. 2019 Nov;17(11):1815-1826. doi: 10.1111/jth.14567. Epub 2019 Aug 9.


Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort.

Organ LA, Duggan AR, Oballa E, Taggart SC, Simpson JK, Kang'ombe AR, Braybrooke R, Molyneaux PL, North B, Karkera Y, Leeming DJ, Karsdal MA, Nanthakumar CB, Fahy WA, Marshall RP, Jenkins RG, Maher TM.

Respir Res. 2019 Jul 12;20(1):148. doi: 10.1186/s12931-019-1118-7.


Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART.

Dold L, Nielsen MJ, Praktiknjo M, Schwarze-Zander C, Boesecke C, Schierwagen R, Mohr R, Wasmuth JC, Jansen C, Bischoff J, Rockstroh JK, Karsdal MA, Spengler U, Trebicka J, Leeming DJ.

PLoS One. 2019 Jul 11;14(7):e0219526. doi: 10.1371/journal.pone.0219526. eCollection 2019.


Markers of Collagen Formation and Degradation Reflect Renal Function and Predict Adverse Outcomes in Patients With Type 1 Diabetes.

Pilemann-Lyberg S, Rasmussen DGK, Hansen TW, Tofte N, Winther SA, Holm Nielsen S, Theilade S, Karsdal MA, Genovese F, Rossing P.

Diabetes Care. 2019 Sep;42(9):1760-1768. doi: 10.2337/dc18-2599. Epub 2019 Jul 1.


Use of Plasma Fragments of Propeptides of Type III, V, and VI Procollagen for the Detection of Liver Fibrosis in Type 2 Diabetes.

Bril F, Leeming DJ, Karsdal MA, Kalavalapalli S, Barb D, Lai J, Rabe M, Cusi K.

Diabetes Care. 2019 Jul;42(7):1348-1351. doi: 10.2337/dc18-2578. Epub 2019 May 21.


Serological Assessment of the Quality of Wound Healing Processes in Crohn's Disease.

Sun S, Karsdal MA, Mortensen JH, Luo Y, Kjeldsen J, Krag A, Jensen MD, Bay-Jensen AC, Manon-Jensen T.

J Gastrointestin Liver Dis. 2019 Jun 1;28:175-182. doi: 10.15403/jgld-178.


A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model.

Katri A, Dąbrowska A, Löfvall H, Karsdal MA, Andreassen KV, Thudium CS, Henriksen K.

Osteoarthritis Cartilage. 2019 Sep;27(9):1339-1346. doi: 10.1016/j.joca.2019.05.016. Epub 2019 Jun 5.


Extracellular Matrix Fragments of the Basement Membrane and the Interstitial Matrix Are Serological Markers of Intestinal Tissue Remodeling and Disease Activity in Dextran Sulfate Sodium Colitis.

Lindholm M, Manon-Jensen T, Madsen GI, Krag A, Karsdal MA, Kjeldsen J, Mortensen JH.

Dig Dis Sci. 2019 Nov;64(11):3134-3142. doi: 10.1007/s10620-019-05676-6. Epub 2019 May 24.


Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass.

Huang G, Rocha GV, Pencina KM, Cox K, Krishnan V, Henriksen K, Mitchell P, Sissons SE, Li Z, Nedergaard AF, Karsdal MA, Sun S, Storer TW, Basaria S, Bhasin S.

J Clin Endocrinol Metab. 2019 May 23. pii: jc.2019-00505. doi: 10.1210/jc.2019-00505. [Epub ahead of print]


The Dual Amylin and Calcitonin Receptor Agonist KBP-088 Induces Weight Loss and Improves Insulin Sensitivity Superior to Chronic Amylin Therapy.

Larsen AT, Sonne N, Andreassen KV, Gehring K, Karsdal MA, Henriksen K.

J Pharmacol Exp Ther. 2019 Jul;370(1):35-43. doi: 10.1124/jpet.119.257576. Epub 2019 Apr 26.


Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest.

Grand J, Kjaergaard J, Nielsen N, Friberg H, Cronberg T, Bro-Jeppesen J, Karsdal MA, Nielsen HB, Frydland M, Henriksen K, Mattsson N, Zetterberg H, Hassager C.

Biomarkers. 2019 Sep;24(6):584-591. doi: 10.1080/1354750X.2019.1609580. Epub 2019 May 31.


The message from the matrix-should we listen more closely?

Burgess JK, Weckmann M, Karsdal MA.

J Thorac Dis. 2019 Mar;11(Suppl 3):S230-S233. doi: 10.21037/jtd.2019.01.68. No abstract available.


Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort.

Rønnow SR, Sand JMB, Langholm LL, Manon-Jensen T, Karsdal MA, Tal-Singer R, Miller BE, Vestbo J, Leeming DJ.

Respir Res. 2019 Apr 1;20(1):63. doi: 10.1186/s12931-019-1026-x.


Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis.

Bay-Jensen AC, Platt A, Jenkins MA, Weinblatt ME, Byrjalsen I, Musa K, Genovese MC, Karsdal MA.

BMC Rheumatol. 2019 Jan 31;3:3. doi: 10.1186/s41927-019-0052-0. eCollection 2019.


Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography.

Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen CH, Sirlin CB, Loomba R.

Hepatology. 2019 Jul;70(1):127-141. doi: 10.1002/hep.30610. Epub 2019 Apr 29.


Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort.

Rønnow SR, Langholm LL, Sand JMB, Thorlacius-Ussing J, Leeming DJ, Manon-Jensen T, Tal-Singer R, Miller BE, Karsdal MA, Vestbo J.

Sci Rep. 2019 Mar 11;9(1):4064. doi: 10.1038/s41598-019-40785-2.


Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study.

Willumsen N, Bager C, Karsdal MA.

Transl Oncol. 2019 May;12(5):693-698. doi: 10.1016/j.tranon.2019.02.004. Epub 2019 Mar 9.


A marker of type VI collagen formation (PRO-C6) is associated with higher arterial stiffness in type 1 diabetes.

Frimodt-Møller M, Hansen TW, Rasmussen DGK, Theilade S, Nielsen SH, Karsdal MA, Genovese F, Rossing P.

Acta Diabetol. 2019 Jun;56(6):711-712. doi: 10.1007/s00592-019-01306-9. Epub 2019 Mar 9. No abstract available.


Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis - Effects of a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist and a glucagon-like peptide-1 analogue.

Daniels SJ, Leeming DJ, Detlefsen S, Bruun MF, Hjuler ST, Henriksen K, Hein P, Karsdal MA, Brockbank S, Cruwys S.

Biomed Pharmacother. 2019 Mar;111:926-933. doi: 10.1016/j.biopha.2018.12.130. Epub 2019 Jan 7.


GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro.

Löfvall H, Katri A, Dąbrowska A, Karsdal MA, Luo Y, He Y, Manon-Jensen T, Dziegiel MH, Bay-Jensen AC, Thudium CS, Henriksen K.

Sci Rep. 2019 Feb 28;9(1):3050. doi: 10.1038/s41598-019-39803-0.


Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model.

Katri A, Dąbrowska A, Löfvall H, Ding M, Karsdal MA, Andreassen KV, Thudium CS, Henriksen K.

Arthritis Res Ther. 2019 Feb 22;21(1):68. doi: 10.1186/s13075-019-1819-9.


Enhanced processing of von Willebrand factor reflects disease severity and discriminates severe portal hypertension in cirrhosis.

Langholm LL, Manon-Jensen T, Karsdal MA, Bendtsen F, Leeming DJ, Møller S.

Eur J Gastroenterol Hepatol. 2019 Aug;31(8):1040-1048. doi: 10.1097/MEG.0000000000001380.


Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis.

Lehmann J, Praktiknjo M, Nielsen MJ, Schierwagen R, Meyer C, Thomas D, Violi F, Strassburg CP, Bendtsen F, Møller S, Krag A, Karsdal MA, Leeming DJ, Trebicka J.

Liver Int. 2019 May;39(5):885-893. doi: 10.1111/liv.14070. Epub 2019 Mar 7.


Potential diagnostic value of a type X collagen neo-epitope biomarker for knee osteoarthritis.

He Y, Manon-Jensen T, Arendt-Nielsen L, Petersen KK, Christiansen T, Samuels J, Abramson S, Karsdal MA, Attur M, Bay-Jensen AC.

Osteoarthritis Cartilage. 2019 Apr;27(4):611-620. doi: 10.1016/j.joca.2019.01.001. Epub 2019 Jan 14.


Vastatin (the NC1 domain of human type VIII collagen a1 chain) is linked to stromal reactivity and elevated in serum from patients with colorectal cancer.

Willumsen N, Jorgensen LN, Karsdal MA.

Cancer Biol Ther. 2019;20(5):692-699. doi: 10.1080/15384047.2018.1550571. Epub 2019 Jan 9.


Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients.

Karsdal MA, Verburg KM, West CR, Bay-Jensen AC, Keller DS, Arends RHGP.

Osteoarthritis Cartilage. 2019 Mar;27(3):484-492. doi: 10.1016/j.joca.2018.12.001. Epub 2018 Dec 18.


Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients.

Jensen C, Madsen DH, Hansen M, Schmidt H, Svane IM, Karsdal MA, Willumsen N.

J Immunother Cancer. 2018 Dec 19;6(1):152. doi: 10.1186/s40425-018-0474-z.


A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis.

Leeming DJ, Willumsen N, Sand JMB, Holm Nielsen S, Dasgupta B, Brodmerkel C, Curran M, Bager CL, Karsdal MA.

Biochem Biophys Rep. 2018 Nov 30;17:38-43. doi: 10.1016/j.bbrep.2018.11.002. eCollection 2019 Mar.

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