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Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions.

Toppala S, Ekblad LL, Lötjönen J, Helin S, Hurme S, Johansson J, Jula A, Karrasch M, Koikkalainen J, Laine H, Parkkola R, Viitanen M, Rinne JO.

J Alzheimers Dis. 2019 Sep 23. doi: 10.3233/JAD-190691. [Epub ahead of print]


Association between Deep Gray Matter Changes and Neurocognitive Function in Mild Cognitive Impairment and Alzheimer's Disease: A Tensor-Based Morphometric MRI Study.

Tuokkola T, Karrasch M, Koikkalainen J, Parkkola R, Lötjönen J, Löyttyniemi E, Hurme S, Rinne JO.

Dement Geriatr Cogn Disord. 2019 Sep 12:1-11. doi: 10.1159/000502476. [Epub ahead of print]


Domain-specific cognitive effects of white matter pathology in old age, mild cognitive impairment and Alzheimer's disease.

Kaskikallio A, Karrasch M, Rinne JO, Tuokkola T, Parkkola R, Grönholm-Nyman P.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2019 Jun 14:1-18. doi: 10.1080/13825585.2019.1628916. [Epub ahead of print]


EBV miRNA expression profiles in different infection stages: A prospective cohort study.

Hartung A, Makarewicz O, Egerer R, Karrasch M, Klink A, Sauerbrei A, Kentouche K, Pletz MW.

PLoS One. 2019 Feb 13;14(2):e0212027. doi: 10.1371/journal.pone.0212027. eCollection 2019.


Identifying brain changes related to cognitive aging using VBM and visual rating scales.

Pergher V, Demaerel P, Soenen O, Saarela C, Tournoy J, Schoenmakers B, Karrasch M, Van Hulle MM.

Neuroimage Clin. 2019;22:101697. doi: 10.1016/j.nicl.2019.101697. Epub 2019 Feb 5.


Cognitive Effects of White Matter Pathology in Normal and Pathological Aging.

Kaskikallio A, Karrasch M, Rinne JO, Tuokkola T, Parkkola R, Grönholm-Nyman P.

J Alzheimers Dis. 2019;67(2):489-493. doi: 10.3233/JAD-180554.


Neurocognition in childhood epilepsy: Impact on mortality and complete seizure remission 50 years later.

Sillanpää M, Saarinen MM, Karrasch M, Schmidt D, Hermann BP.

Epilepsia. 2019 Jan;60(1):131-138. doi: 10.1111/epi.14606. Epub 2018 Nov 22.


Early adjustment of antimicrobial therapy after PCR/electrospray ionization mass spectrometry-based pathogen detection in critically ill patients with suspected sepsis.

Karrasch M, Geraci J, Sachse S, Rödel J, Löffler B, Bauer M, Thomas-Rüddel D, Hagel S, Aschenbach R, Bloos F.

Clin Chem Lab Med. 2018 Jul 26;56(8):e207-e209. doi: 10.1515/cclm-2017-1110. No abstract available.


Value of the eazyplex® CSF direct assay in rapid diagnosis of invasive meningococcal disease - Case report.

Karrasch M, Eisenach S, Vogel U, Zinke J, Witte OW, Günther A, Romeike B, Rödel J.

Acta Microbiol Immunol Hung. 2018 Aug 1;65(3):309-315. doi: 10.1556/030.65.2018.021. Epub 2018 Mar 7.


Rapid acquisition of acyclovir resistance in an immunodeficient patient with herpes simplex encephalitis.

Karrasch M, Liermann K, Betz BB, Wagner S, Scholl S, Dahms C, Sauerbrei A, Kunze A.

J Neurol Sci. 2018 Jan 15;384:89-90. doi: 10.1016/j.jns.2017.11.024. Epub 2017 Nov 21. No abstract available.


Neuroborreliosis and acute encephalopathy: The use of CXCL13 as a biomarker in CNS manifestations of Lyme borreliosis.

Karrasch M, Fingerle V, Boden K, Darr A, Baier M, Straube E, Nenadic I.

Ticks Tick Borne Dis. 2018 Feb;9(2):415-417. doi: 10.1016/j.ttbdis.2017.12.008. Epub 2017 Dec 11.


Longitudinal changes in the brain in mild cognitive impairment: a magnetic resonance imaging study using the visual rating method and tensor-based morphometry.

Tuokkola T, Koikkalainen J, Parkkola R, Karrasch M, Lötjönen J, Rinne JO.

Acta Radiol. 2018 Aug;59(8):973-979. doi: 10.1177/0284185117734418. Epub 2017 Sep 27.


Brain glucose metabolism and its relation to amyloid load in middle-aged adults with childhood-onset epilepsy.

Joutsa J, Rinne JO, Karrasch M, Hermann B, Johansson J, Anttinen A, Eskola O, Helin S, Shinnar S, Sillanpää M; TACOE study group.

Epilepsy Res. 2017 Nov;137:69-72. doi: 10.1016/j.eplepsyres.2017.09.006. Epub 2017 Sep 20.


Physical Activity in Preventing Alzheimer's Disease and Cognitive Decline: A Narrative Review.

Brini S, Sohrabi HR, Peiffer JJ, Karrasch M, Hämäläinen H, Martins RN, Fairchild TJ.

Sports Med. 2018 Jan;48(1):29-44. doi: 10.1007/s40279-017-0787-y. Review.


Regional gray matter correlates of memory for emotion-laden words in middle-aged and older adults: A voxel-based morphometry study.

Saarela C, Joutsa J, Laine M, Parkkola R, Rinne JO, Karrasch M.

PLoS One. 2017 Aug 3;12(8):e0182541. doi: 10.1371/journal.pone.0182541. eCollection 2017.


Brain structure and organization five decades after childhood onset epilepsy.

Garcia-Ramos C, Bobholz S, Dabbs K, Hermann B, Joutsa J, Rinne JO, Karrasch M, Prabhakaran V, Shinnar S, Sillanpää M; TACOE Study Group.

Hum Brain Mapp. 2017 Jun;38(6):3289-3299. doi: 10.1002/hbm.23593. Epub 2017 Apr 3.


Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later.

Joutsa J, Rinne JO, Hermann B, Karrasch M, Anttinen A, Shinnar S, Sillanpää M.

JAMA Neurol. 2017 May 1;74(5):583-590. doi: 10.1001/jamaneurol.2016.6091.


Cognitive Outcome in Childhood-Onset Epilepsy: A Five-Decade Prospective Cohort Study.

Karrasch M, Tiitta P, Hermann B, Joutsa J, Shinnar S, Rinne J, Anttinen A, Sillanpää M.

J Int Neuropsychol Soc. 2017 Apr;23(4):332-340. doi: 10.1017/S1355617716001077. Epub 2017 Jan 10.


Evaluation of loop-mediated isothermal amplification for the rapid identification of bacteria and resistance determinants in positive blood cultures.

Rödel J, Bohnert JA, Stoll S, Wassill L, Edel B, Karrasch M, Löffler B, Pfister W.

Eur J Clin Microbiol Infect Dis. 2017 Jun;36(6):1033-1040. doi: 10.1007/s10096-016-2888-1. Epub 2017 Jan 6.


The relationship between recognition memory for emotion-laden words and white matter microstructure in normal older individuals.

Saarela C, Karrasch M, Ilvesmäki T, Parkkola R, Rinne JO, Laine M.

Neuroreport. 2016 Dec 14;27(18):1345-1349.


A severe pediatric infection with a novel enterovirus A71 strain, Thuringia, Germany.

Karrasch M, Fischer E, Scholten M, Sauerbrei A, Henke A, Renz DM, Mentzel HJ, Böer K, Böttcher S, Diedrich S, Krumbholz A, Zell R.

J Clin Virol. 2016 Nov;84:90-95. doi: 10.1016/j.jcv.2016.09.007. Epub 2016 Oct 19.


Chronic persistent parvovirus B19 bone marrow infection resulting in transfusion-dependent pure red cell aplasia in multiple myeloma after allogeneic haematopoietic stem cell transplantation and severe graft versus host disease.

Karrasch M, Schmidt V, Hammer A, Hochhaus A, Rosée P, Petersen I, Sauerbrei A, Baier M, Sayer HG, Hermann B.

Hematology. 2017 Mar;22(2):93-98. doi: 10.1080/10245332.2016.1183288. Epub 2016 Jun 16.


Eight Cycles of ABVD Versus Four Cycles of BEACOPPescalated Plus Four Cycles of BEACOPPbaseline in Stage III to IV, International Prognostic Score ≥ 3, High-Risk Hodgkin Lymphoma: First Results of the Phase III EORTC 20012 Intergroup Trial.

Carde P, Karrasch M, Fortpied C, Brice P, Khaled H, Casasnovas O, Caillot D, Gaillard I, Bologna S, Ferme C, Lugtenburg PJ, Morschhauser F, Aurer I, Coiffier B, Meyer R, Seftel M, Wolf M, Glimelius B, Sureda A, Mounier N.

J Clin Oncol. 2016 Jun 10;34(17):2028-36. doi: 10.1200/JCO.2015.64.5648. Epub 2016 Apr 25.


Draft Genome Sequence of the Vaccination Strain Mycobacterium bovis BCG S4-Jena.

Wibberg D, Winkler A, Straube E, Karrasch M, Keller PM, Kalinowski J.

Genome Announc. 2016 Apr 21;4(2). pii: e00296-16. doi: 10.1128/genomeA.00296-16.


Antibiotic treatment algorithm development based on a microarray nucleic acid assay for rapid bacterial identification and resistance determination from positive blood cultures.

Rödel J, Karrasch M, Edel B, Stoll S, Bohnert J, Löffler B, Saupe A, Pfister W.

Diagn Microbiol Infect Dis. 2016 Mar;84(3):252-7. doi: 10.1016/j.diagmicrobio.2015.10.021. Epub 2015 Nov 14.


Childhood-onset epilepsy five decades later. A prospective population-based cohort study.

Sillanpää M, Anttinen A, Rinne JO, Joutsa J, Sonninen P, Erkinjuntti M, Hermann B, Karrasch M, Saarinen M, Tiitta P, Shinnar S.

Epilepsia. 2015 Nov;56(11):1774-83. doi: 10.1111/epi.13187. Epub 2015 Oct 4.


Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.

Sauerbrei A, Bohn-Wippert K, Kaspar M, Krumbholz A, Karrasch M, Zell R.

J Antimicrob Chemother. 2016 Jan;71(1):6-16. doi: 10.1093/jac/dkv285. Epub 2015 Oct 3. Review.


Severe leptospirosis complicated by Epstein-Barr Virus reactivation.

Karrasch M, Herfurth K, Kläver M, Miethke J, Mayer-Scholl A, Luge E, Straube E, Busch M.

Infection. 2015 Dec;43(6):763-9. doi: 10.1007/s15010-015-0786-6. Epub 2015 May 19.


Visual rating method and tensor-based morphometry in the diagnosis of mild cognitive impairment and Alzheimer's disease: a comparative magnetic resonance imaging study.

Tuokkola T, Koikkalainen J, Parkkola R, Karrasch M, Lötjönen J, Rinne JO.

Acta Radiol. 2016 Mar;57(3):348-55. doi: 10.1177/0284185115584656. Epub 2015 May 14.


Ovarian vein thrombosis (OVT) following invasive group A Streptococcus (iGAS) puerperal sepsis associated with expression of streptococcal pyrogenic exotoxin genes speC, speG and speJ.

Karrasch M, Rödel J, Mühler N, Edel B, Sachse S, Schmidt KH, Schneider U, Schlembach D, Mentzel HJ, Pfister W, Schleußner E.

Eur J Obstet Gynecol Reprod Biol. 2015 Jan;184:127-30. doi: 10.1016/j.ejogrb.2014.11.019. Epub 2014 Nov 24. No abstract available.


Detection of pneumonia associated pathogens using a prototype multiplexed pneumonia test in hospitalized patients with severe pneumonia.

Schulte B, Eickmeyer H, Heininger A, Juretzek S, Karrasch M, Denis O, Roisin S, Pletz MW, Klein M, Barth S, Lüdke GH, Thews A, Torres A, Cillóniz C, Straube E, Autenrieth IB, Keller PM.

PLoS One. 2014 Nov 14;9(11):e110566. doi: 10.1371/journal.pone.0110566. eCollection 2014.


Education-corrected CERAD identifies MCI and dementia in Parkinson's disease.

Karrasch M, Laatu S, Ellfolk U, Marttila R, Martikainen K.

Acta Neurol Scand. 2015 Apr;131(4):219-24. doi: 10.1111/ane.12310. Epub 2014 Oct 2.


Primary Epstein-Barr virus infection and probable parvovirus B19 reactivation resulting in fulminant hepatitis and fulfilling five of eight criteria for hemophagocytic lymphohistiocytosis.

Karrasch M, Felber J, Keller PM, Kletta C, Egerer R, Bohnert J, Hermann B, Pfister W, Theis B, Petersen I, Stallmach A, Baier M.

Int J Infect Dis. 2014 Nov;28:143-6. doi: 10.1016/j.ijid.2014.08.003. Epub 2014 Sep 19.


A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses.

Markert JM, Razdan SN, Kuo HC, Cantor A, Knoll A, Karrasch M, Nabors LB, Markiewicz M, Agee BS, Coleman JM, Lakeman AD, Palmer CA, Parker JN, Whitley RJ, Weichselbaum RR, Fiveash JB, Gillespie GY.

Mol Ther. 2014 May;22(5):1048-55. doi: 10.1038/mt.2014.22. Epub 2014 Feb 27.


Epstein-Barr Virus MicroRNAs in plasma as potential biomarkers for chronic infections: (response to: Kawano et al; The Journal of Infectious Diseases; 2013; 208:771-9).

Malkewitz A, Makarewicz O, Kentouche K, Keller P, Karrasch M, Pletz MW.

J Infect Dis. 2014 Apr 15;209(8):1297-8. doi: 10.1093/infdis/jit675. Epub 2013 Dec 5. No abstract available.


Brain volumetric correlates of memory in early Parkinson's disease.

Ellfolk U, Joutsa J, Rinne JO, Parkkola R, Jokinen P, Karrasch M.

J Parkinsons Dis. 2013;3(4):593-601. doi: 10.3233/JPD-130276.


Sequential combination of gemtuzumab ozogamicin and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia: results of a randomized phase III trial by the EORTC and GIMEMA consortium (AML-17).

Amadori S, Suciu S, Stasi R, Salih HR, Selleslag D, Muus P, De Fabritiis P, Venditti A, Ho AD, Lübbert M, Thomas X, Latagliata R, Halkes CJ, Falzetti F, Magro D, Guimaraes JE, Berneman Z, Specchia G, Karrasch M, Fazi P, Vignetti M, Willemze R, de Witte T, Marie JP.

J Clin Oncol. 2013 Dec 10;31(35):4424-30. doi: 10.1200/JCO.2013.49.0771. Epub 2013 Oct 14.


Five-year follow-up of 11C-PIB uptake in Alzheimer's disease and MCI.

Kemppainen NM, Scheinin NM, Koivunen J, Johansson J, Toivonen JT, Någren K, Rokka J, Karrasch M, Parkkola R, Rinne JO.

Eur J Nucl Med Mol Imaging. 2014 Feb;41(2):283-9. doi: 10.1007/s00259-013-2562-0. Epub 2013 Sep 27.


Valence and arousal ratings for 420 Finnish nouns by age and gender.

Söderholm C, Häyry E, Laine M, Karrasch M.

PLoS One. 2013 Aug 30;8(8):e72859. doi: 10.1371/journal.pone.0072859. eCollection 2013.


Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson's disease.

Ellfolk U, Joutsa J, Rinne JO, Parkkola R, Jokinen P, Karrasch M.

J Neural Transm (Vienna). 2014 Jan;121(1):33-40. doi: 10.1007/s00702-013-1073-2. Epub 2013 Aug 3.


CERAD test performance and cognitive impairment in Parkinson's disease.

Karrasch M, Laatu S, Martikainen K, Marttila R.

Acta Neurol Scand. 2013 Dec;128(6):409-13. doi: 10.1111/ane.12138. Epub 2013 May 14.


Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction.

Jokinen P, Karrasch M, Brück A, Johansson J, Bergman J, Rinne JO.

J Neurol Sci. 2013 Jun 15;329(1-2):23-8. doi: 10.1016/j.jns.2013.03.006. Epub 2013 Apr 3.


Apathy is associated with activities of daily living ability in Parkinson's disease.

Laatu S, Karrasch M, Martikainen K, Marttila R.

Dement Geriatr Cogn Disord. 2013;35(5-6):249-55. doi: 10.1159/000347129. Epub 2013 Mar 7.


Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results.

Dastugue N, Suciu S, Plat G, Speleman F, Cavé H, Girard S, Bakkus M, Pagès MP, Yakouben K, Nelken B, Uyttebroeck A, Gervais C, Lutz P, Teixeira MR, Heimann P, Ferster A, Rohrlich P, Collonge MA, Munzer M, Luquet I, Boutard P, Sirvent N, Karrasch M, Bertrand Y, Benoit Y.

Blood. 2013 Mar 28;121(13):2415-23. doi: 10.1182/blood-2012-06-437681. Epub 2013 Jan 15.


Prospective international multicenter phase II trial of intravenous pegylated liposomal doxorubicin monochemotherapy in patients with stage IIB, IVA, or IVB advanced mycosis fungoides: final results from EORTC 21012.

Dummer R, Quaglino P, Becker JC, Hasan B, Karrasch M, Whittaker S, Morris S, Weichenthal M, Stadler R, Bagot M, Cozzio A, Bernengo MG, Knobler R.

J Clin Oncol. 2012 Nov 20;30(33):4091-7. doi: 10.1200/JCO.2011.39.8065. Epub 2012 Oct 8.


A European multicentre PET study of fibrillar amyloid in Alzheimer's disease.

Nordberg A, Carter SF, Rinne J, Drzezga A, Brooks DJ, Vandenberghe R, Perani D, Forsberg A, Långström B, Scheinin N, Karrasch M, Någren K, Grimmer T, Miederer I, Edison P, Okello A, Van Laere K, Nelissen N, Vandenbulcke M, Garibotto V, Almkvist O, Kalbe E, Hinz R, Herholz K.

Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):104-14. doi: 10.1007/s00259-012-2237-2. Epub 2012 Sep 8.


Efficacy and safety of bexarotene combined with psoralen-ultraviolet A (PUVA) compared with PUVA treatment alone in stage IB-IIA mycosis fungoides: final results from the EORTC Cutaneous Lymphoma Task Force phase III randomized clinical trial (NCT00056056).

Whittaker S, Ortiz P, Dummer R, Ranki A, Hasan B, Meulemans B, Gellrich S, Knobler R, Stadler R, Karrasch M.

Br J Dermatol. 2012 Sep;167(3):678-87. doi: 10.1111/j.1365-2133.2012.11156.x.


Applicability of the CANTAB-PAL computerized memory test in identifying amnestic mild cognitive impairment and Alzheimer's disease.

Junkkila J, Oja S, Laine M, Karrasch M.

Dement Geriatr Cogn Disord. 2012;34(2):83-9. Epub 2012 Aug 27.


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