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Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA.

Brem R, Guven M, Karran P.

Free Radic Biol Med. 2017 Jun;107:101-109. doi: 10.1016/j.freeradbiomed.2016.10.488. Epub 2016 Oct 27. Review.


Photosensitized UVA-Induced Cross-Linking between Human DNA Repair and Replication Proteins and DNA Revealed by Proteomic Analysis.

Guven M, Barnouin K, Snijders AP, Karran P.

J Proteome Res. 2016 Dec 2;15(12):4612-4623. Epub 2016 Oct 5.


Protein oxidation, UVA and human DNA repair.

Karran P, Brem R.

DNA Repair (Amst). 2016 Aug;44:178-185. doi: 10.1016/j.dnarep.2016.05.024. Epub 2016 May 20. Review.


Oxidative Stress-Induced Protein Damage Inhibits DNA Repair and Determines Mutation Risk and Therapeutic Efficacy.

McAdam E, Brem R, Karran P.

Mol Cancer Res. 2016 Jul;14(7):612-22. doi: 10.1158/1541-7786.MCR-16-0053. Epub 2016 Apr 22.


Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells.

Guven M, Brem R, Macpherson P, Peacock M, Karran P.

J Invest Dermatol. 2015 Nov;135(11):2834-2841. doi: 10.1038/jid.2015.255. Epub 2015 Jul 2.


UVA photoactivation of DNA containing halogenated thiopyrimidines induces cytotoxic DNA lesions.

Brem R, Zhang X, Xu YZ, Karran P.

J Photochem Photobiol B. 2015 Apr;145:1-10. doi: 10.1016/j.jphotobiol.2015.02.012. Epub 2015 Feb 20.


MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation.

Grasso F, Ruggieri V, De Luca G, Leopardi P, Mancuso MT, Casorelli I, Pichierri P, Karran P, Bignami M.

Oncotarget. 2015 Apr 10;6(10):7481-92.


DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib.

Peacock M, Brem R, Macpherson P, Karran P.

Nucleic Acids Res. 2014 Dec 16;42(22):13714-22. doi: 10.1093/nar/gku1213. Epub 2014 Nov 20.


Response to Emanuele.

Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P.

J Invest Dermatol. 2014 Jul;134(7):2053-2055. doi: 10.1038/jid.2014.67. Epub 2014 Feb 3. No abstract available.


Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation.

Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P.

J Invest Dermatol. 2014 May;134(5):1408-1417. doi: 10.1038/jid.2013.509. Epub 2013 Nov 27.


Efficient long DNA gap-filling in a mammalian cell-free system: a potential new in vitro DNA replication assay.

Nakao S, Zhang S, Vaara M, Syväoja JE, Lee MY, Tsurimoto T, Karran P, Oda S.

Biochimie. 2013 Feb;95(2):320-8. doi: 10.1016/j.biochi.2012.09.031. Epub 2012 Oct 10.


Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells.

Brem R, Karran P.

Cancer Res. 2012 Sep 15;72(18):4787-95. doi: 10.1158/0008-5472.CAN-12-1278. Epub 2012 Jul 20.


Multiple forms of DNA damage caused by UVA photoactivation of DNA 6-thioguanine.

Brem R, Karran P.

Photochem Photobiol. 2012 Jan-Feb;88(1):5-13. doi: 10.1111/j.1751-1097.2011.01043.x. Epub 2011 Dec 16. Review.


6-Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cells.

Daehn I, Brem R, Barkauskaite E, Karran P.

FEBS Lett. 2011 Dec 15;585(24):3941-6. doi: 10.1016/j.febslet.2011.10.040. Epub 2011 Nov 2.


4-Thiothymidine sensitization of DNA to UVA offers potential for a novel photochemotherapy.

Reelfs O, Karran P, Young AR.

Photochem Photobiol Sci. 2012 Jan;11(1):148-54. doi: 10.1039/c1pp05188a. Epub 2011 Nov 2.


Reversal of UVA skin photosensitivity and DNA damage in kidney transplant recipients by replacing azathioprine.

Hofbauer GF, Attard NR, Harwood CA, McGregor JM, Dziunycz P, Iotzova-Weiss G, Straub G, Meyer R, Kamenisch Y, Berneburg M, French LE, Wüthrich RP, Karran P, Serra AL.

Am J Transplant. 2012 Jan;12(1):218-25. doi: 10.1111/j.1600-6143.2011.03751.x. Epub 2011 Sep 22.


Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells.

Reelfs O, Macpherson P, Ren X, Xu YZ, Karran P, Young AR.

Nucleic Acids Res. 2011 Dec;39(22):9620-32. doi: 10.1093/nar/gkr674. Epub 2011 Sep 2.


UVA photosensitization of thiopurines and skin cancer in organ transplant recipients.

Attard NR, Karran P.

Photochem Photobiol Sci. 2012 Jan;11(1):62-8. doi: 10.1039/c1pp05194f. Epub 2011 Aug 23. Review.


Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation.

Brem R, Daehn I, Karran P.

DNA Repair (Amst). 2011 Aug 15;10(8):869-76. doi: 10.1016/j.dnarep.2011.05.010. Epub 2011 Jun 30.


Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.

Pridgeon SW, Heer R, Taylor GA, Newell DR, O'Toole K, Robinson M, Xu YZ, Karran P, Boddy AV.

Br J Cancer. 2011 Jun 7;104(12):1869-76. doi: 10.1038/bjc.2011.180. Epub 2011 May 24.


Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA.

Gueranger Q, Kia A, Frith D, Karran P.

Nucleic Acids Res. 2011 Jul;39(12):5057-66. doi: 10.1093/nar/gkr112. Epub 2011 Mar 11.


Photo-oxidation of 6-thioguanine by UVA: the formation of addition products with low molecular weight thiol compounds.

Ren X, Xu YZ, Karran P.

Photochem Photobiol. 2010 Sep-Oct;86(5):1038-45. doi: 10.1111/j.1751-1097.2010.00771.x.


DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation.

Brem R, Li F, Montaner B, Reelfs O, Karran P.

Oncogene. 2010 Jul 8;29(27):3953-63. doi: 10.1038/onc.2010.140. Epub 2010 May 3.


Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation.

Ren X, Li F, Jeffs G, Zhang X, Xu YZ, Karran P.

Nucleic Acids Res. 2010 Apr;38(6):1832-40. doi: 10.1093/nar/gkp1165. Epub 2009 Dec 21.


Expression of DNA mismatch repair proteins and MSH2 polymorphisms in nonmelanoma skin cancers of organ transplant recipients.

Perrett CM, Harwood CA, McGregor JM, Warwick J, Cerio R, Karran P.

Br J Dermatol. 2010 Apr;162(4):732-42. doi: 10.1111/j.1365-2133.2009.09550.x. Epub 2009 Oct 10.


Carcinogenic mechanisms related to immunosuppressive therapy.

Perrett CM, Harwood CA, McGregor JM, Karran P.

Cancer Treat Res. 2009;146:123-32. doi: 10.1007/978-0-387-78574-5_11. Review. No abstract available.


Immune effector cells produce lethal DNA damage in cells treated with a thiopurine.

Daehn I, Karran P.

Cancer Res. 2009 Mar 15;69(6):2393-9. doi: 10.1158/0008-5472.CAN-08-4264. Epub 2009 Feb 24.


Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions.

Brem R, Li F, Karran P.

Nucleic Acids Res. 2009 Apr;37(6):1951-61. doi: 10.1093/nar/gkp070. Epub 2009 Feb 10.


PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients.

Harwood CA, Attard NR, O'Donovan P, Chambers P, Perrett CM, Proby CM, McGregor JM, Karran P.

Br J Cancer. 2008 Oct 21;99(8):1276-84. doi: 10.1038/sj.bjc.6604665.


Azathioprine treatment photosensitizes human skin to ultraviolet A radiation.

Perrett CM, Walker SL, O'Donovan P, Warwick J, Harwood CA, Karran P, McGregor JM.

Br J Dermatol. 2008 Jul;159(1):198-204. doi: 10.1111/j.1365-2133.2008.08610.x. Epub 2008 May 16.


Reactive oxygen-mediated damage to a human DNA replication and repair protein.

Montaner B, O'Donovan P, Reelfs O, Perrett CM, Zhang X, Xu YZ, Ren X, Macpherson P, Frith D, Karran P.

EMBO Rep. 2007 Nov;8(11):1074-9. Epub 2007 Oct 12.


Thiopurines, DNA damage, DNA repair and therapy-related cancer.

Karran P.

Br Med Bull. 2006;79-80:153-70. Epub 2007 Feb 2. Review.


Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy.

Perrett CM, McGregor JM, Warwick J, Karran P, Leigh IM, Proby CM, Harwood CA.

Br J Dermatol. 2007 Feb;156(2):320-8.


Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha.

Barone F, McCulloch SD, Macpherson P, Maga G, Yamada M, Nohmi T, Minoprio A, Mazzei F, Kunkel TA, Karran P, Bignami M.

DNA Repair (Amst). 2007 Mar 1;6(3):355-66. Epub 2006 Dec 26.


Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light.

Zhang X, Jeffs G, Ren X, O'Donovan P, Montaner B, Perrett CM, Karran P, Xu YZ.

DNA Repair (Amst). 2007 Mar 1;6(3):344-54. Epub 2006 Dec 22.


Involvement of mismatch repair in transcription-coupled nucleotide excision repair.

Kobayashi K, Karran P, Oda S, Yanaga K.

Hum Cell. 2005 Sep;18(3):103-15. Review.


Topical photodynamic therapy with methyl aminolevulinate to treat sebaceous hyperplasia in an organ transplant recipient.

Perrett CM, McGregor J, Barlow RJ, Karran P, Proby C, Harwood CA.

Arch Dermatol. 2006 Jun;142(6):781-2. No abstract available.


8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.

Macpherson P, Barone F, Maga G, Mazzei F, Karran P, Bignami M.

Nucleic Acids Res. 2005 Sep 20;33(16):5094-105. Print 2005. Erratum in: Nucleic Acids Res. 2005;33(18):6081.


Azathioprine and UVA light generate mutagenic oxidative DNA damage.

O'Donovan P, Perrett CM, Zhang X, Montaner B, Xu YZ, Harwood CA, McGregor JM, Walker SL, Hanaoka F, Karran P.

Science. 2005 Sep 16;309(5742):1871-4.


Structural and dynamic effects of single 7-hydro-8-oxoguanine bases located in a frameshift target DNA sequence.

Barone F, Lankas F, Spackova N, Sponer J, Karran P, Bignami M, Mazzei F.

Biophys Chem. 2005 Oct 22;118(1):31-41.


Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome.

Offman J, Gascoigne K, Bristow F, Macpherson P, Bignami M, Casorelli I, Leone G, Pagano L, Sica S, Halil O, Cummins D, Banner NR, Karran P.

Mol Cancer Res. 2005 May;3(5):251-60.


Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.

Oda S, Maehara Y, Ikeda Y, Oki E, Egashira A, Okamura Y, Takahashi I, Kakeji Y, Sumiyoshi Y, Miyashita K, Yamada Y, Zhao Y, Hattori H, Taguchi K, Ikeuchi T, Tsuzuki T, Sekiguchi M, Karran P, Yoshida MA.

Nucleic Acids Res. 2005 Mar 18;33(5):1628-36. Print 2005.


Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation.

Offman J, Opelz G, Doehler B, Cummins D, Halil O, Banner NR, Burke MM, Sullivan D, Macpherson P, Karran P.

Blood. 2004 Aug 1;104(3):822-8. Epub 2004 Apr 15.


4-Thio-5-bromo-2'-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damage.

Xu YZ, Zhang X, Wu HC, Massey A, Karran P.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):995-7.


Human mismatch repair, drug-induced DNA damage, and secondary cancer.

Karran P, Offman J, Bignami M.

Biochimie. 2003 Nov;85(11):1149-60. Review.


The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells.

Russo MT, Blasi MF, Chiera F, Fortini P, Degan P, Macpherson P, Furuichi M, Nakabeppu Y, Karran P, Aquilina G, Bignami M.

Mol Cell Biol. 2004 Jan;24(1):465-74.

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