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Items: 14


The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance.

Venetsanakos E, Brameld KA, Phan VT, Verner E, Owens TD, Xing Y, Tam D, LaStant J, Leung K, Karr DE, Hill RJ, Gerritsen ME, Goldstein DM, Funk JO, Bradshaw JM.

Mol Cancer Ther. 2017 Dec;16(12):2668-2676. doi: 10.1158/1535-7163.MCT-17-0309. Epub 2017 Oct 4.


Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

Brameld KA, Owens TD, Verner E, Venetsanakos E, Bradshaw JM, Phan VT, Tam D, Leung K, Shu J, LaStant J, Loughhead DG, Ton T, Karr DE, Gerritsen ME, Goldstein DM, Funk JO.

J Med Chem. 2017 Aug 10;60(15):6516-6527. doi: 10.1021/acs.jmedchem.7b00360. Epub 2017 Jul 25.


Prolonged and tunable residence time using reversible covalent kinase inhibitors.

Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, Gerritsen ME, Funk JO, Owens TD, Verner E, Brameld KA, Hill RJ, Goldstein DM, Taunton J.

Nat Chem Biol. 2015 Jul;11(7):525-31. doi: 10.1038/nchembio.1817. Epub 2015 May 25.


Determination of equilibrium constant of amino carbamate adduct formation in sisomicin by a high pH based high performance liquid chromatography.

Wlasichuk KB, Tan L, Guo Y, Hildebrandt DJ, Zhang H, Karr DE, Schmidt DE Jr.

J Pharm Biomed Anal. 2015;111:126-30. doi: 10.1016/j.jpba.2015.03.033. Epub 2015 Apr 3.


A high pH based reversed-phase high performance liquid chromatographic method for the analysis of aminoglycoside plazomicin and its impurities.

Tan L, Wlasichuk KB, Schmidt DE Jr, Campbell RL, Hirtzer P, Cheng L, Karr DE.

J Pharm Biomed Anal. 2012 Jul;66:75-84. doi: 10.1016/j.jpba.2012.03.003. Epub 2012 Mar 10.


Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus.

Higgins DL, Chang R, Debabov DV, Leung J, Wu T, Krause KM, Sandvik E, Hubbard JM, Kaniga K, Schmidt DE Jr, Gao Q, Cass RT, Karr DE, Benton BM, Humphrey PP.

Antimicrob Agents Chemother. 2005 Mar;49(3):1127-34.


Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).

Leadbetter MR, Adams SM, Bazzini B, Fatheree PR, Karr DE, Krause KM, Lam BM, Linsell MS, Nodwell MB, Pace JL, Quast K, Shaw JP, Soriano E, Trapp SG, Villena JD, Wu TX, Christensen BG, Judice JK.

J Antibiot (Tokyo). 2004 May;57(5):326-36.


Increasing the efficiency of pharmacokinetic sample procurement, preparation and analysis by liquid chromatography/tandem mass spectrometry.

Villa JS, Cass RT, Karr DE, Adams SM, Shaw JP, Schmidt DE Jr.

Rapid Commun Mass Spectrom. 2004;18(10):1066-72.


Cellular fatty acid composition and ubiquinone content of Legionella feeleii sp. nov.

Moss CW, Bibb WF, Karr DE, Guerrant GO, Lambert MA.

J Clin Microbiol. 1983 Oct;18(4):917-9.


Cellular fatty acids of Capnocytophaga species.

Dees SB, Karr DE, Hollis D, Moss CW.

J Clin Microbiol. 1982 Nov;16(5):779-83.


Isoprenoid quinones of the genus Legionella.

Karr DE, Bibb WF, Moss CW.

J Clin Microbiol. 1982 Jun;15(6):1044-8.


Cellular fatty acid composition of Legionella longbeachae sp. nov.

Moss CW, Karr DE, Dees SB.

J Clin Microbiol. 1981 Dec;14(6):692-4.


[Influence of high-voltage ignition systems on the function of implanted pacemaker. Part 1 (author's transl)].

Neu H, Thull R, Karr DE.

Biomed Tech (Berl). 1980 May;25(5):116-22. German. No abstract available.


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