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Items: 1 to 50 of 214

1.

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease.

Schivo S, Khurana S, Govindaraj K, Scholma J, Kerkhofs J, Zhong L, Huang X, van de Pol J, Langerak R, van Wijnen AJ, Geris L, Karperien M, Post JN.

Cell Signal. 2019 Dec 11;68:109471. doi: 10.1016/j.cellsig.2019.109471. [Epub ahead of print]

2.

Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications.

Jooybar E, Abdekhodaie MJ, Karperien M, Mousavi A, Alvi M, Dijkstra PJ.

Int J Biol Macromol. 2019 Nov 9. pii: S0141-8130(19)36477-3. doi: 10.1016/j.ijbiomac.2019.10.036. [Epub ahead of print]

3.

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs.

Kamperman T, Koerselman M, Kelder C, Hendriks J, Crispim JF, de Peuter X, Dijkstra PJ, Karperien M, Leijten J.

Nat Commun. 2019 Sep 25;10(1):4347. doi: 10.1038/s41467-019-12390-4.

4.

In Vitro Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load.

Spitters TWGM, Stamatialis D, Petit A, Leeuw MGW, Karperien M.

Assay Drug Dev Technol. 2019 May/Jun;17(4):191-200. doi: 10.1089/adt.2018.907.

PMID:
31184960
5.

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials.

Kamperman T, van Loo B, Gurian M, Henke S, Karperien M, Leijten J.

Lab Chip. 2019 Jun 7;19(11):1977-1984. doi: 10.1039/c9lc00054b. Epub 2019 Apr 24.

PMID:
31017163
6.

Mimicking the Articular Joint with In Vitro Models.

Piluso S, Li Y, Abinzano F, Levato R, Moreira Teixeira L, Karperien M, Leijten J, van Weeren R, Malda J.

Trends Biotechnol. 2019 Oct;37(10):1063-1077. doi: 10.1016/j.tibtech.2019.03.003. Epub 2019 Apr 16. Review.

PMID:
31000204
7.

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity.

Huang X, Zhong L, van Helvoort E, Lafeber F, Mastbergen S, Hendriks J, Post JN, Karperien M.

Cartilage. 2019 Apr 4:1947603519841676. doi: 10.1177/1947603519841676. [Epub ahead of print]

PMID:
30947534
8.

Redox-responsive degradable prodrug nanogels for intracellular drug delivery by crosslinking of amine-functionalized poly(N-vinylpyrrolidone) copolymers.

Peng H, Huang X, Melle A, Karperien M, Pich A.

J Colloid Interface Sci. 2019 Mar 22;540:612-622. doi: 10.1016/j.jcis.2019.01.049. Epub 2019 Jan 14.

PMID:
30690386
9.

Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets.

Hadavi E, Leijten J, Engelse M, de Koning E, Jonkheijm P, Karperien M, van Apeldoorn A.

Tissue Eng Part C Methods. 2019 Feb;25(2):71-81. doi: 10.1089/ten.TEC.2018.0336.

PMID:
30632461
10.

Changes in Fluorescence Recovery After Photobleaching (FRAP) as an indicator of SOX9 transcription factor activity.

Govindaraj K, Hendriks J, Lidke DS, Karperien M, Post JN.

Biochim Biophys Acta Gene Regul Mech. 2019 Jan;1862(1):107-117. doi: 10.1016/j.bbagrm.2018.11.001. Epub 2018 Nov 20.

11.

An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes.

Groot Nibbelink M, Skrzypek K, Karbaat L, Both S, Plass J, Klomphaar B, van Lente J, Henke S, Karperien M, Stamatialis D, van Apeldoorn A.

J Mater Sci Mater Med. 2018 Nov 9;29(11):174. doi: 10.1007/s10856-018-6178-6.

12.

An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells.

Jooybar E, Abdekhodaie MJ, Alvi M, Mousavi A, Karperien M, Dijkstra PJ.

Acta Biomater. 2019 Jan 1;83:233-244. doi: 10.1016/j.actbio.2018.10.031. Epub 2018 Oct 24.

PMID:
30366137
13.

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development.

Camilleri ET, Dudakovic A, Riester SM, Galeano-Garces C, Paradise CR, Bradley EW, McGee-Lawrence ME, Im HJ, Karperien M, Krych AJ, Westendorf JJ, Larson AN, van Wijnen AJ.

J Biol Chem. 2018 Dec 7;293(49):19001-19011. doi: 10.1074/jbc.RA118.003909. Epub 2018 Oct 16.

14.

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells.

Hadavi E, Leijten J, Brinkmann J, Jonkheijm P, Karperien M, van Apeldoorn A.

Tissue Eng Part C Methods. 2018 Nov;24(11):628-636. doi: 10.1089/ten.TEC.2018.0151. Epub 2018 Nov 7.

PMID:
30306836
15.

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension.

Huang X, Zhong L, Hendriks J, Post JN, Karperien M.

J Orthop Res. 2019 Jan;37(1):84-93. doi: 10.1002/jor.24142. Epub 2018 Oct 1.

16.

Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6.

Cabanas-Danés J, Landman E, Huskens J, Karperien M, Jonkheijm P.

Langmuir. 2018 Aug 7;34(31):9298-9306. doi: 10.1021/acs.langmuir.8b00853. Epub 2018 Jul 26.

17.
18.

Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics.

Kamperman T, Trikalitis VD, Karperien M, Visser CW, Leijten J.

ACS Appl Mater Interfaces. 2018 Jul 18;10(28):23433-23438. doi: 10.1021/acsami.8b05227. Epub 2018 Jul 2.

19.

An important step towards a prevascularized islet macroencapsulation device-effect of micropatterned membranes on development of endothelial cell network.

Skrzypek K, Nibbelink MG, Karbaat LP, Karperien M, van Apeldoorn A, Stamatialis D.

J Mater Sci Mater Med. 2018 Jun 25;29(7):91. doi: 10.1007/s10856-018-6102-0.

20.

Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice.

Dudakovic A, Camilleri ET, Paradise CR, Samsonraj RM, Gluscevic M, Paggi CA, Begun DL, Khani F, Pichurin O, Ahmed FS, Elsayed R, Elsalanty M, McGee-Lawrence ME, Karperien M, Riester SM, Thaler R, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2018 Aug 17;293(33):12894-12907. doi: 10.1074/jbc.RA118.002983. Epub 2018 Jun 13.

21.

Molecular characterization of physis tissue by RNA sequencing.

Paradise CR, Galeano-Garces C, Galeano-Garces D, Dudakovic A, Milbrandt TA, Saris DBF, Krych AJ, Karperien M, Ferguson GB, Evseenko D, Riester SM, van Wijnen AJ, Larson AN.

Gene. 2018 Aug 20;668:87-96. doi: 10.1016/j.gene.2018.05.034. Epub 2018 May 25.

22.

Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging.

Hendriks J, Stojanovic I, Schasfoort RBM, Saris DBF, Karperien M.

Anal Chem. 2018 Jun 5;90(11):6563-6571. doi: 10.1021/acs.analchem.8b00260. Epub 2018 May 15.

23.

Single-Cell Microgels: Technology, Challenges, and Applications.

Kamperman T, Karperien M, Le Gac S, Leijten J.

Trends Biotechnol. 2018 Aug;36(8):850-865. doi: 10.1016/j.tibtech.2018.03.001. Epub 2018 Apr 12. Review.

PMID:
29656795
24.

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis.

Huang X, Post JN, Zhong L, Leijten J, Larsson S, Karperien M, Struglics A.

Osteoarthritis Cartilage. 2018 Jun;26(6):834-843. doi: 10.1016/j.joca.2018.02.904. Epub 2018 Mar 8.

25.

Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture.

Pleumeekers MM, Nimeskern L, Koevoet JLM, Karperien M, Stok KS, van Osch GJVM.

PLoS One. 2018 Feb 28;13(2):e0190744. doi: 10.1371/journal.pone.0190744. eCollection 2018.

26.

The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells.

Huang X, Zhong L, Hendriks J, Post JN, Karperien M.

Int J Mol Sci. 2018 Feb 13;19(2). pii: E561. doi: 10.3390/ijms19020561.

27.

In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials.

Visser CW, Kamperman T, Karbaat LP, Lohse D, Karperien M.

Sci Adv. 2018 Jan 31;4(1):eaao1175. doi: 10.1126/sciadv.aao1175. eCollection 2018 Jan.

28.

Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds.

Huang X, Hou Y, Zhong L, Huang D, Qian H, Karperien M, Chen W.

Biomacromolecules. 2018 Jan 8;19(1):94-102. doi: 10.1021/acs.biomac.7b01271. Epub 2017 Dec 18.

PMID:
29211452
29.

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression.

Zhong L, Schivo S, Huang X, Leijten J, Karperien M, Post JN.

Int J Mol Sci. 2017 Nov 22;18(11). pii: E2491. doi: 10.3390/ijms18112491.

30.

Pancreatic islet macroencapsulation using microwell porous membranes.

Skrzypek K, Groot Nibbelink M, van Lente J, Buitinga M, Engelse MA, de Koning EJP, Karperien M, van Apeldoorn A, Stamatialis D.

Sci Rep. 2017 Aug 23;7(1):9186. doi: 10.1038/s41598-017-09647-7.

31.

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI.

Bakker B, Eijkel GB, Heeren RMA, Karperien M, Post JN, Cillero-Pastor B.

Anal Chem. 2017 Sep 5;89(17):9438-9444. doi: 10.1021/acs.analchem.7b02265. Epub 2017 Aug 14.

32.

Arthroscopic Airbrush-Assisted Cell Spraying for Cartilage Repair: Design, Development, and Characterization of Custom-Made Arthroscopic Spray Nozzles.

Dijkstra K, Hendriks J, Karperien M, Vonk LA, Saris DBF.

Tissue Eng Part C Methods. 2017 Sep;23(9):505-515. doi: 10.1089/ten.TEC.2017.0228. Epub 2017 Aug 8.

PMID:
28683651
33.

Molecular Validation of Chondrogenic Differentiation and Hypoxia Responsiveness of Platelet-Lysate Expanded Adipose Tissue-Derived Human Mesenchymal Stromal Cells.

Galeano-Garces C, Camilleri ET, Riester SM, Dudakovic A, Larson DR, Qu W, Smith J, Dietz AB, Im HJ, Krych AJ, Larson AN, Karperien M, van Wijnen AJ.

Cartilage. 2017 Jul;8(3):283-299. doi: 10.1177/1947603516659344. Epub 2016 Jul 21.

34.

Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration.

Fu Y, Karbaat L, Wu L, Leijten J, Both SK, Karperien M.

Tissue Eng Part B Rev. 2017 Dec;23(6):515-528. doi: 10.1089/ten.TEB.2016.0365. Review.

PMID:
28490258
35.

Micro-fabricated scaffolds lead to efficient remission of diabetes in mice.

Buitinga M, Assen F, Hanegraaf M, Wieringa P, Hilderink J, Moroni L, Truckenmüller R, van Blitterswijk C, Römer GW, Carlotti F, de Koning E, Karperien M, van Apeldoorn A.

Biomaterials. 2017 Aug;135:10-22. doi: 10.1016/j.biomaterials.2017.03.031. Epub 2017 Mar 27.

PMID:
28478326
36.

Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape.

Kamperman T, Henke S, Visser CW, Karperien M, Leijten J.

Small. 2017 Jun;13(22). doi: 10.1002/smll.201603711. Epub 2017 Apr 28.

PMID:
28452168
37.

Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macroenvironments.

Kamperman T, Henke S, van den Berg A, Shin SR, Tamayol A, Khademhosseini A, Karperien M, Leijten J.

Adv Healthc Mater. 2017 Feb;6(3). doi: 10.1002/adhm.201600913. Epub 2016 Dec 14.

PMID:
27973710
38.

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells.

Zhong L, Huang X, Rodrigues ED, Leijten JC, Verrips T, El Khattabi M, Karperien M, Post JN.

Stem Cells Dev. 2016 Dec 1;25(23):1808-1817. Epub 2016 Oct 27.

39.

A Protocol to Enhance INS1E and MIN6 Functionality-The Use of Theophylline.

Groot Nibbelink M, Marchioli G, Moroni L, Karperien M, Van Apeldoorn A.

Int J Mol Sci. 2016 Sep 12;17(9). pii: E1532. doi: 10.3390/ijms17091532.

40.

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.

Camilleri ET, Gustafson MP, Dudakovic A, Riester SM, Garces CG, Paradise CR, Takai H, Karperien M, Cool S, Sampen HJ, Larson AN, Qu W, Smith J, Dietz AB, van Wijnen AJ.

Stem Cell Res Ther. 2016 Aug 11;7(1):107. doi: 10.1186/s13287-016-0370-8.

41.

Modelling with ANIMO: between fuzzy logic and differential equations.

Schivo S, Scholma J, van der Vet PE, Karperien M, Post JN, van de Pol J, Langerak R.

BMC Syst Biol. 2016 Jul 27;10(1):56. doi: 10.1186/s12918-016-0286-z.

42.

Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels.

Henke S, Leijten J, Kemna E, Neubauer M, Fery A, van den Berg A, van Apeldoorn A, Karperien M.

Macromol Biosci. 2016 Oct;16(10):1524-1532. doi: 10.1002/mabi.201600174. Epub 2016 Jul 21.

PMID:
27440382
43.

Correlation between Gene Expression and Osteoarthritis Progression in Human.

Zhong L, Huang X, Karperien M, Post JN.

Int J Mol Sci. 2016 Jul 14;17(7). pii: E1126. doi: 10.3390/ijms17071126.

44.

The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes.

Lewallen EA, Bonin CA, Li X, Smith J, Karperien M, Larson AN, Lewallen DG, Cool SM, Westendorf JJ, Krych AJ, Leontovich AA, Im HJ, van Wijnen AJ.

Gene. 2016 Oct 15;591(2):456-64. doi: 10.1016/j.gene.2016.06.063. Epub 2016 Jul 1.

45.

Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans.

Marchioli G, Luca AD, de Koning E, Engelse M, Van Blitterswijk CA, Karperien M, Van Apeldoorn AA, Moroni L.

Adv Healthc Mater. 2016 Jul;5(13):1606-16. doi: 10.1002/adhm.201600058. Epub 2016 Apr 26.

PMID:
27113576
46.

Opening the "White Box" in Tissue Engineering: Visualization of Cell Aggregates in Optically Scattering Scaffolds.

Groot Nibbelink M, Daoudi K, Slegers S, Grootendorst D, Dantuma M, Steenbergen W, Karperien M, Manohar S, van Apeldoorn A.

Tissue Eng Part C Methods. 2016 Jun;22(6):534-42. doi: 10.1089/ten.TEC.2015.0462. Epub 2016 May 19.

PMID:
27056242
47.

Cell-transfecting multilayered surfaces from poly(amido amine)s.

Hujaya SD, Marchioli G, van Apeldoorn AA, Paulusse JM, Karperien M, Engbersen JF.

J Control Release. 2015 Sep 10;213:e58-9. doi: 10.1016/j.jconrel.2015.05.096. Epub 2015 Aug 19. No abstract available.

PMID:
27005195
48.

RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes.

Lin Y, Lewallen EA, Camilleri ET, Bonin CA, Jones DL, Dudakovic A, Galeano-Garces C, Wang W, Karperien MJ, Larson AN, Dahm DL, Stuart MJ, Levy BA, Smith J, Ryssman DB, Westendorf JJ, Im HJ, van Wijnen AJ, Riester SM, Krych AJ.

J Orthop Res. 2016 Nov;34(11):1950-1959. doi: 10.1002/jor.23209. Epub 2016 Mar 3.

49.

Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site.

Buitinga M, Janeczek Portalska K, Cornelissen DJ, Plass J, Hanegraaf M, Carlotti F, de Koning E, Engelse M, van Blitterswijk C, Karperien M, van Apeldoorn A, de Boer J.

Tissue Eng Part A. 2016 Feb;22(3-4):375-85. doi: 10.1089/ten.tea.2015.0317. Epub 2016 Jan 27.

50.

Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells.

Wu L, Prins HJ, Leijten J, Helder MN, Evseenko D, Moroni L, van Blitterswijk CA, Lin Y, Karperien M.

Tissue Eng Part A. 2016 Feb;22(3-4):336-48. doi: 10.1089/ten.TEA.2015.0269. Epub 2016 Feb 1.

PMID:
26732248

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