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Attenuation of the Hepatoprotective Effects of Ileal Apical Sodium Dependent Bile Acid Transporter (ASBT) Inhibition in Choline-Deficient L-Amino Acid-Defined (CDAA) Diet-Fed Mice.

Rao A, van de Peppel IP, Gumber S, Karpen SJ, Dawson PA.

Front Med (Lausanne). 2020 Feb 25;7:60. doi: 10.3389/fmed.2020.00060. eCollection 2020.


Use of biomarkers to improve immunosuppressive drug development and outcomes in renal organ transplantation: A meeting report.

Mannon RB, Morris RE, Abecassis M, Axelrod D, Bala S, Friedman GS, Heeger PS, Lentine KL, Loupy A, Murphy B, Nickerson P, Sarwal M, O'Doherty I, Spear N, Karpen SR.

Am J Transplant. 2020 Feb 24. doi: 10.1111/ajt.15833. [Epub ahead of print]


A Prospective Trial of Withdrawal and Reinstitution of Ursodeoxycholic Acid in Pediatric Primary Sclerosing Cholangitis.

Black DD, Mack C, Kerkar N, Miloh T, Sundaram SS, Anand R, Gupta A, Alonso E, Arnon R, Bulut P, Karpen S, Lin CH, Rosenthal P, Ryan M, Squires RH, Valentino P, Elsea SH, Shneider BL.

Hepatol Commun. 2019 Aug 29;3(11):1482-1495. doi: 10.1002/hep4.1421. eCollection 2019 Nov.


Neurodevelopmental Outcomes in Preschool and School Aged Children With Biliary Atresia and Their Native Liver.

Squires JE, Ng VL, Hawthorne K, Henn LL, Sorensen LG, Fredericks EM, Alonso EM, Murray KF, Loomes KM, Karpen SJ, Cavallo LA, Molleston JP, Bezerra JA, Rosenthal P, Squires RH, Wang KS, Schwarz KB, Arnon R, Magee JC, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN).

J Pediatr Gastroenterol Nutr. 2020 Jan;70(1):79-86. doi: 10.1097/MPG.0000000000002489.


Response to "Underestimation in Self-Assessment".

Karpen S.

Am J Pharm Educ. 2019 Jun;83(5):7644. doi: 10.5688/ajpe7644. No abstract available.


Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy.

Kim S, Moore J, Alonso E, Bednarek J, Bezerra JA, Goodhue C, Karpen SJ, Loomes KM, Magee JC, Ng VL, Sherker AH, Smith C, Spino C, Venkat V, Wang K, Sokol RJ, Mack CL; Childhood Liver Disease Research Network.

Hepatol Commun. 2019 Mar 25;3(5):685-696. doi: 10.1002/hep4.1332. eCollection 2019 May.


Factors associated with cultures of assessment at US schools and colleges of pharmacy.

Lee KC, Rudolph MJ, Assemi M, Bray BS, Daugherty KK, Karpen SC, Maerten-Rivera JL, Pavuluri N, Sease JM, Vellurattil RP, Weck MA.

Curr Pharm Teach Learn. 2019 Feb;11(2):129-138. doi: 10.1016/j.cptl.2018.11.003. Epub 2018 Nov 23.


Surveying the current landscape of assessment structures and resources in US schools and colleges of pharmacy.

Rudolph MJ, Lee KC, Assemi M, Bray BS, Daugherty KK, Karpen SC, Maerten-Rivera JL, Pavuluri N, Sease JM, Vellurattil RP, Weck MA.

Curr Pharm Teach Learn. 2019 Feb;11(2):117-128. doi: 10.1016/j.cptl.2018.11.002. Epub 2018 Nov 22.


A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia.

Mack CL, Spino C, Alonso EM, Bezerra JA, Moore J, Goodhue C, Ng VL, Karpen SJ, Venkat V, Loomes KM, Wang K, Sherker AH, Magee JC, Sokol RJ; The ChiLDReN Network.

J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):495-501. doi: 10.1097/MPG.0000000000002256.


Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome.

Berauer JP, Mezina AI, Okou DT, Sabo A, Muzny DM, Gibbs RA, Hegde MR, Chopra P, Cutler DJ, Perlmutter DH, Bull LN, Thompson RJ, Loomes KM, Spinner NB, Rajagopalan R, Guthery SL, Moore B, Yandell M, Harpavat S, Magee JC, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Alonso EM, Rosenthal P, Squires RH, Wang KS, Finegold MJ, Russo P, Sherker AH, Sokol RJ, Karpen SJ; Childhood Liver Disease Research Network (ChiLDReN).

Hepatology. 2019 Sep;70(3):899-910. doi: 10.1002/hep.30515. Epub 2019 Mar 21.


Visual biofeedback training reduces quantitative drugs index scores associated with fall risk.

Anson E, Thompson E, Karpen SC, Odle BL, Seier E, Jeka J, Panus PC.

BMC Res Notes. 2018 Oct 22;11(1):750. doi: 10.1186/s13104-018-3859-7.


The Application of Classification Trees to Pharmacy School Admissions.

Karpen SC, Ellis SC.

Am J Pharm Educ. 2018 Sep;82(7):6980. doi: 10.5688/ajpe6980.


Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome.

Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery SL, Thomas D, Sherker AH, Sokol RJ; Childhood Liver Disease Research Network.

Hepatol Commun. 2018 Sep 24;2(10):1184-1198. doi: 10.1002/hep4.1244. eCollection 2018 Oct.


Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial.

Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC; ChiLDReN Network.

J Pediatr. 2018 Nov;202:179-185.e4. doi: 10.1016/j.jpeds.2018.07.002. Epub 2018 Sep 21.


Clinical Consequences of Cardiomyopathy in Children With Biliary Atresia Requiring Liver Transplantation.

Gorgis NM, Kennedy C, Lam F, Thompson K, Coss-Bu J, Akcan Arikan A, Nguyen T, Hosek K, Miloh T, Karpen SJ, Penny DJ, Goss J, Desai MS.

Hepatology. 2019 Mar;69(3):1206-1218. doi: 10.1002/hep.30204. Epub 2019 Feb 17.


TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice.

Eblimit Z, Thevananther S, Karpen SJ, Taegtmeyer H, Moore DD, Adorini L, Penny DJ, Desai MS.

Cardiovasc Ther. 2018 Oct;36(5):e12462. doi: 10.1111/1755-5922.12462. Epub 2018 Aug 22.


Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis.

Loomes KM, Spino C, Goodrich NP, Hangartner TN, Marker AE, Heubi JE, Kamath BM, Shneider BL, Rosenthal P, Hertel PM, Karpen SJ, Molleston JP, Murray KF, Schwarz KB, Squires RH, Teckman J, Turmelle YP, Alonso EM, Sherker AH, Magee JC, Sokol RJ; Childhood Liver Disease Research Network.

Hepatology. 2019 Jan;69(1):245-257. doi: 10.1002/hep.30196. Epub 2018 Dec 27.


The Social Psychology of Biased Self-Assessment.

Karpen SC.

Am J Pharm Educ. 2018 Jun;82(5):6299. doi: 10.5688/ajpe6299. Review.


A randomized, controlled, crossover pilot study of losartan for pediatric nonalcoholic fatty liver disease.

Vos MB, Jin R, Konomi JV, Cleeton R, Cruz J, Karpen S, Rodriguez DS, Frediani JK, McCracken C, Welsh J.

Pilot Feasibility Stud. 2018 Jun 5;4:109. doi: 10.1186/s40814-018-0306-4. eCollection 2018.


Sarcopenia in a mice model of chronic liver disease: role of the ubiquitin-proteasome system and oxidative stress.

Campos F, Abrigo J, Aguirre F, Garcés B, Arrese M, Karpen S, Cabrera D, Andía ME, Simon F, Cabello-Verrugio C.

Pflugers Arch. 2018 Oct;470(10):1503-1519. doi: 10.1007/s00424-018-2167-3. Epub 2018 Jun 20.


Comparing Student Performance on the Old vs New Versions of the NAPLEX.

Welch AC, Karpen SC.

Am J Pharm Educ. 2018 Apr;82(3):6408. doi: 10.5688/ajpe6408.


Novel Bile Acid Therapies for Liver Disease.

Karpen SJ.

Gastroenterol Hepatol (N Y). 2018 Feb;14(2):117-119. No abstract available.


Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century.

Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ.

Hepatology. 2018 Sep;68(3):1163-1173. doi: 10.1002/hep.29905. Review.


Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study.

Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN).

J Pediatr. 2018 May;196:139-147.e3. doi: 10.1016/j.jpeds.2017.12.048. Epub 2018 Mar 5.


P Value Problems.

Karpen SC.

Am J Pharm Educ. 2017 Nov;81(9):6570. doi: 10.5688/ajpe6570. No abstract available.


Misuses of Regression and ANCOVA in Educational Research.

Karpen SC.

Am J Pharm Educ. 2017 Oct;81(8):6501. doi: 10.5688/ajpe6501. No abstract available.


Organic solute transporter-β (SLC51B) deficiency in two brothers with congenital diarrhea and features of cholestasis.

Sultan M, Rao A, Elpeleg O, Vaz FM, Abu-Libdeh B, Karpen SJ, Dawson PA.

Hepatology. 2018 Aug;68(2):590-598. doi: 10.1002/hep.29516. Epub 2018 May 11.


Centruroides sculpturatus envenomation in three adult patients requiring treatment with antivenom.

Hurst NB, Lipe DN, Karpen SR, Patanwala AE, Taylor AM, Boesen KJ, Shirazi FM.

Clin Toxicol (Phila). 2018 Apr;56(4):294-296. doi: 10.1080/15563650.2017.1371310. Epub 2017 Sep 5.


Assessing Faculty and Student Interpretations of AACP Survey Items with Cognitive Interviewing.

Karpen SC, Hagemeier NE.

Am J Pharm Educ. 2017 Jun;81(5):88. doi: 10.5688/ajpe81588.


Initial assessment of the infant with neonatal cholestasis-Is this biliary atresia?

Shneider BL, Moore J, Kerkar N, Magee JC, Ye W, Karpen SJ, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Whitington PF, Rosenthal P, Squires RH, Guthery SL, Arnon R, Schwarz KB, Turmelle YP, Sherker AH, Sokol RJ; Childhood Liver Disease Research Network.

PLoS One. 2017 May 11;12(5):e0176275. doi: 10.1371/journal.pone.0176275. eCollection 2017.


Development and evaluation of the medication-based index of physical function (MedIP).

Hall CD, Karpen SC, Odle B, Panus PC, Walls ZF.

Age Ageing. 2017 Sep 1;46(5):761-766. doi: 10.1093/ageing/afx056.


Level of γ-glutamyltransferase in 2-Year-old Children With Biliary Atresia Associates With Progression of Portal Hypertension.

Freeman AJ, Ng VL, Harpavat S, Hrycko A, Apted Z, Bulut P, Leong T, Karpen SJ.

Clin Gastroenterol Hepatol. 2017 Jul;15(7):1133-1135. doi: 10.1016/j.cgh.2017.02.025. Epub 2017 Mar 1. No abstract available.


Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis.

Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL; Childhood Liver Disease Research Network (ChiLDReN).

Hepatology. 2017 May;65(5):1645-1654. doi: 10.1002/hep.29019. Epub 2017 Mar 22.


In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores.

Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E; NASH CRN.

Gastroenterology. 2016 Dec;151(6):1141-1154.e9. doi: 10.1053/j.gastro.2016.08.027. Epub 2016 Aug 26.


Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart.

Desai MS, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen SJ, Penny DJ, Moore DD, Anakk S.

Hepatology. 2017 Jan;65(1):189-201. doi: 10.1002/hep.28890. Epub 2016 Nov 29.


Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.

Rao A, Kosters A, Mells JE, Zhang W, Setchell KD, Amanso AM, Wynn GM, Xu T, Keller BT, Yin H, Banton S, Jones DP, Wu H, Dawson PA, Karpen SJ.

Sci Transl Med. 2016 Sep 21;8(357):357ra122. doi: 10.1126/scitranslmed.aaf4823.


Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ.

J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):154-168. doi: 10.1097/MPG.0000000000001334.


Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives.

Arab JP, Karpen SJ, Dawson PA, Arrese M, Trauner M.

Hepatology. 2017 Jan;65(1):350-362. doi: 10.1002/hep.28709. Epub 2016 Aug 4. Review.


New-Onset Scleral Icterus in a School-Aged Female.

Thompson AB, Bilhartz JL, Abramowsky CR, Rapkin L, Karpen SJ, Berkowitz FE.

Clin Pediatr (Phila). 2017 Jan;56(1):93-96. doi: 10.1177/0009922816650599. Epub 2016 Jul 19. No abstract available.


Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia.

Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN).

J Pediatr. 2016 Mar;170:211-7.e1-2. doi: 10.1016/j.jpeds.2015.11.058. Epub 2015 Dec 24.


Inflammation-associated upregulation of the sulfated steroid transporter Slc10a6 in mouse liver and macrophage cell lines.

Kosters A, Abebe DF, Felix JC, Dawson PA, Karpen SJ.

Hepatol Res. 2016 Jul;46(8):794-803. doi: 10.1111/hepr.12609. Epub 2015 Nov 19.


Impaired cardiac and peripheral hemodynamic responses to inhaled β₂-agonist in cystic fibrosis.

Van Iterson EH, Karpen SR, Baker SE, Wheatley CM, Morgan WJ, Snyder EM.

Respir Res. 2015 Sep 5;16:103. doi: 10.1186/s12931-015-0270-y.


Nuancing insulin's actions in liver through rapid NCOR1 phosphorylation.

Karpen SJ.

Hepatology. 2015 Nov;62(5):1344-5. doi: 10.1002/hep.28014. Epub 2015 Aug 29. No abstract available.


Moderate intensity exercise mediates comparable increases in exhaled chloride as albuterol in individuals with cystic fibrosis.

Wheatley CM, Baker SE, Morgan MA, Martinez MG, Liu B, Rowe SM, Morgan WJ, Wong EC, Karpen SR, Snyder EM.

Respir Med. 2015 Aug;109(8):1001-11. doi: 10.1016/j.rmed.2015.05.018. Epub 2015 May 23.


Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome.

Kamath BM, Chen Z, Romero R, Fredericks EM, Alonso EM, Arnon R, Heubi J, Hertel PM, Karpen SJ, Loomes KM, Murray KF, Rosenthal P, Schwarz KB, Subbarao G, Teckman JH, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Magee JC; Childhood Liver Disease Research Network (ChiLDReN).

J Pediatr. 2015 Aug;167(2):390-6.e3. doi: 10.1016/j.jpeds.2015.04.077. Epub 2015 Jun 6.


Genetic contributors and modifiers of biliary atresia.

Mezina A, Karpen SJ.

Dig Dis. 2015;33(3):408-14. doi: 10.1159/000371694. Epub 2015 May 27. Review.


Effects of exercise intensity compared to albuterol in individuals with cystic fibrosis.

Wheatley CM, Baker SE, Morgan MA, Martinez MG, Morgan WJ, Wong EC, Karpen SR, Snyder EM.

Respir Med. 2015 Apr;109(4):463-74. doi: 10.1016/j.rmed.2014.12.002. Epub 2014 Dec 18.


Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis.

Mells JE, Fu PP, Kumar P, Smith T, Karpen SJ, Anania FA.

J Nutr Biochem. 2015 Mar;26(3):285-92. doi: 10.1016/j.jnutbio.2014.11.002. Epub 2014 Dec 6.


Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia.

Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE; Childhood Liver Disease Research and Education Network.

J Pediatr Gastroenterol Nutr. 2014 Dec;59(6):702-7. doi: 10.1097/MPG.0000000000000547.


P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy.

Tackett BC, Sun H, Mei Y, Maynard JP, Cheruvu S, Mani A, Hernandez-Garcia A, Vigneswaran N, Karpen SJ, Thevananther S.

Am J Physiol Gastrointest Liver Physiol. 2014 Dec 1;307(11):G1073-87. doi: 10.1152/ajpgi.00092.2014. Epub 2014 Oct 9.

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