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Items: 22


A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis.

Mlih M, Khericha M, Birdwell C, West AP, Karpac J.

PLoS Biol. 2018 Jul 23;16(7):e2005796. doi: 10.1371/journal.pbio.2005796. eCollection 2018 Jul.


Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition.

Fuentes NR, Mlih M, Barhoumi R, Fan YY, Hardin P, Steele TJ, Behmer S, Prior IA, Karpac J, Chapkin RS.

Cancer Res. 2018 Jul 15;78(14):3899-3912. doi: 10.1158/0008-5472.CAN-18-0324. Epub 2018 May 16.


Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila.

Zhao X, Karpac J.

Curr Biol. 2017 Jul 10;27(13):1941-1955.e6. doi: 10.1016/j.cub.2017.06.004. Epub 2017 Jun 29.


Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction.

Luis NM, Wang L, Ortega M, Deng H, Katewa SD, Li PW, Karpac J, Jasper H, Kapahi P.

Cell Rep. 2016 Oct 25;17(5):1207-1216. doi: 10.1016/j.celrep.2016.10.003.


PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.

Guo L, Karpac J, Tran SL, Jasper H.

Cell. 2014 Jan 16;156(1-2):109-22. doi: 10.1016/j.cell.2013.12.018.


Promoting longevity by maintaining metabolic and proliferative homeostasis.

Wang L, Karpac J, Jasper H.

J Exp Biol. 2014 Jan 1;217(Pt 1):109-18. doi: 10.1242/jeb.089920. Review.


Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila.

Karpac J, Biteau B, Jasper H.

Cell Rep. 2013 Sep 26;4(6):1250-61. doi: 10.1016/j.celrep.2013.08.004. Epub 2013 Sep 12.


Aging: seeking mitonuclear balance.

Karpac J, Jasper H.

Cell. 2013 Jul 18;154(2):271-3. doi: 10.1016/j.cell.2013.06.046.


Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage.

Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H.

PLoS Genet. 2012;8(11):e1003045. doi: 10.1371/journal.pgen.1003045. Epub 2012 Nov 8.


Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage.

Karpac J, Younger A, Jasper H.

Dev Cell. 2011 Jun 14;20(6):841-54. doi: 10.1016/j.devcel.2011.05.011.


Metabolic homeostasis: HDACs take center stage.

Karpac J, Jasper H.

Cell. 2011 May 13;145(4):497-9. doi: 10.1016/j.cell.2011.04.017.


Regulation of Drosophila lifespan by JNK signaling.

Biteau B, Karpac J, Hwangbo D, Jasper H.

Exp Gerontol. 2011 May;46(5):349-54. doi: 10.1016/j.exger.2010.11.003. Epub 2010 Nov 25. Review.


Lifespan extension by preserving proliferative homeostasis in Drosophila.

Biteau B, Karpac J, Supoyo S, Degennaro M, Lehmann R, Jasper H.

PLoS Genet. 2010 Oct 14;6(10):e1001159. doi: 10.1371/journal.pgen.1001159.


JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila.

Karpac J, Hull-Thompson J, Falleur M, Jasper H.

Aging Cell. 2009 Jun;8(3):288-95. doi: 10.1111/j.1474-9726.2009.00476.x. Epub 2009 Apr 9.


Insulin and JNK: optimizing metabolic homeostasis and lifespan.

Karpac J, Jasper H.

Trends Endocrinol Metab. 2009 Apr;20(3):100-6. doi: 10.1016/j.tem.2008.11.004. Epub 2009 Feb 27. Review.


Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors.

Karpac J, Czyzewska K, Kern A, Brush RS, Anderson RE, Hochgeschwender U.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E446-55. doi: 10.1152/ajpendo.00762.2007. Epub 2008 Jun 17.


Pro-opiomelanocortin peptides and the adrenal gland.

Karpac J, Kern A, Hochgeschwender U.

Mol Cell Endocrinol. 2007 Feb;265-266:29-33. Epub 2006 Dec 15. Review.


Proopiomelanocortin heterozygous and homozygous null mutant mice develop pituitary adenomas.

Karpac J, Ostwald D, Li GY, Bui S, Hunnewell P, Brennan MB, Hochgeschwender U.

Cell Mol Biol (Noisy-le-grand). 2006 May 30;52(2):47-52.


Development, maintenance, and function of the adrenal gland in early postnatal proopiomelanocortin-null mutant mice.

Karpac J, Ostwald D, Bui S, Hunnewell P, Shankar M, Hochgeschwender U.

Endocrinology. 2005 Jun;146(6):2555-62. Epub 2005 Feb 24.


A radiographic study of condyle position at various depths of cut in dry skulls with axially corrected lateral tomograms.

Pandis N, Karpac J, Trevino R, Williams B.

Am J Orthod Dentofacial Orthop. 1991 Aug;100(2):116-22.


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