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Items: 1 to 50 of 323

1.

De novo pulmonary small cell carcinomas and large cell neuroendocrine carcinomas harboring EGFR mutations: Lack of response to EGFR inhibitors.

Le X, Desai NV, Majid A, Karp RS, Huberman MS, Rangachari D, Kent MS, Gangadharan SP, Folch E, VanderLaan PA, Costa DB.

Lung Cancer. 2015 Apr;88(1):70-3. doi: 10.1016/j.lungcan.2015.02.003. Epub 2015 Feb 7.

2.

The Death of Burghardt Du Bois, 1899; Implications for Today.

Karp RJ, Gearing B.

J Natl Med Assoc. 2015 Feb;107(1):68-74. doi: 10.1016/S0027-9684(15)30011-0. Epub 2015 Dec 2.

PMID:
27282529
3.

Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape.

Marco E, Karp RL, Guo G, Robson P, Hart AH, Trippa L, Yuan GC.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5643-50. doi: 10.1073/pnas.1408993111. Epub 2014 Dec 15.

4.

In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing.

Tjin Tham Sjin R, Lee K, Walter AO, Dubrovskiy A, Sheets M, Martin TS, Labenski MT, Zhu Z, Tester R, Karp R, Medikonda A, Chaturvedi P, Ren Y, Haringsma H, Etter J, Raponi M, Simmons AD, Harding TC, Niu D, Nacht M, Westlin WF, Petter RC, Allen A, Singh J.

Mol Cancer Ther. 2014 Jun;13(6):1468-79. doi: 10.1158/1535-7163.MCT-13-0966. Epub 2014 Apr 10.

5.

Lack of evidence to support thromboprophylaxis in hospitalized medical patients with cancer.

Carrier M, Khorana AA, Moretto P, Le Gal G, Karp R, Zwicker JI.

Am J Med. 2014 Jan;127(1):82-6.e1. doi: 10.1016/j.amjmed.2013.09.015. Epub 2013 Oct 5.

PMID:
24384102
6.

Demonstrating Nutrient Cost Gradients: A Brooklyn Case Study.

Karp RJ, Wong G, Orsi M.

Int J Vitam Nutr Res. 2014;84(5-6):244-51. doi: 10.1024/0300-9831/a000210.

7.

Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.

Walter AO, Sjin RT, Haringsma HJ, Ohashi K, Sun J, Lee K, Dubrovskiy A, Labenski M, Zhu Z, Wang Z, Sheets M, St Martin T, Karp R, van Kalken D, Chaturvedi P, Niu D, Nacht M, Petter RC, Westlin W, Lin K, Jaw-Tsai S, Raponi M, Van Dyke T, Etter J, Weaver Z, Pao W, Singh J, Simmons AD, Harding TC, Allen A.

Cancer Discov. 2013 Dec;3(12):1404-15. doi: 10.1158/2159-8290.CD-13-0314. Epub 2013 Sep 24.

8.

Optimization criteria and biological process enrichment in homologous multiprotein modules.

Hodgkinson L, Karp RM.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10872-7. doi: 10.1073/pnas.1308621110. Epub 2013 Jun 11.

9.

Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans.

Evans EK, Tester R, Aslanian S, Karp R, Sheets M, Labenski MT, Witowski SR, Lounsbury H, Chaturvedi P, Mazdiyasni H, Zhu Z, Nacht M, Freed MI, Petter RC, Dubrovskiy A, Singh J, Westlin WF.

J Pharmacol Exp Ther. 2013 Aug;346(2):219-28. doi: 10.1124/jpet.113.203489. Epub 2013 May 24.

10.

Reactive intermediates in cytochrome p450 catalysis.

Krest CM, Onderko EL, Yosca TH, Calixto JC, Karp RF, Livada J, Rittle J, Green MT.

J Biol Chem. 2013 Jun 14;288(24):17074-81. doi: 10.1074/jbc.R113.473108. Epub 2013 Apr 30. Review.

11.

Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα.

Nacht M, Qiao L, Sheets MP, St Martin T, Labenski M, Mazdiyasni H, Karp R, Zhu Z, Chaturvedi P, Bhavsar D, Niu D, Westlin W, Petter RC, Medikonda AP, Singh J.

J Med Chem. 2013 Feb 14;56(3):712-21. doi: 10.1021/jm3008745. Epub 2013 Feb 5.

PMID:
23360348
12.

Reconstructing Boolean models of signaling.

Sharan R, Karp RM.

J Comput Biol. 2013 Mar;20(3):249-57. doi: 10.1089/cmb.2012.0241. Epub 2013 Jan 3.

13.
14.

Hard truths and a new strategy for addressing childhood obesity: let's start with the basics.

Karp RJ, Kral JG.

Child Obes. 2012 Dec;8(6):583. doi: 10.1089/chi.2012.0065. No abstract available.

PMID:
23181925
15.

Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays.

Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G, Sorger P.

Oncogene. 2013 Jul 18;32(29):3470-6. doi: 10.1038/onc.2012.378. Epub 2012 Sep 3.

16.

Comparing pedigree graphs.

Kirkpatrick B, Reshef Y, Finucane H, Jiang H, Zhu B, Karp RM.

J Comput Biol. 2012 Sep;19(9):998-1014. doi: 10.1089/cmb.2011.0254. Epub 2012 Aug 16.

PMID:
22897201
17.

Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis.

Mantha S, Karp R, Raghavan V, Terrin N, Bauer KA, Zwicker JI.

BMJ. 2012 Aug 7;345:e4944. doi: 10.1136/bmj.e4944. Review.

18.

Complex-linear invariants of biochemical networks.

Karp RL, Pérez Millán M, Dasgupta T, Dickenstein A, Gunawardena J.

J Theor Biol. 2012 Oct 21;311:130-8. doi: 10.1016/j.jtbi.2012.07.004. Epub 2012 Jul 16.

PMID:
22814477
19.

Relation of growth rate from birth to three months and four to six months to body mass index at ages four to six years.

Karp RJ, Winkfield-Royster T, Weedon J.

J Nutr Metab. 2012;2012:158643. doi: 10.1155/2012/158643. Epub 2012 Feb 22.

20.

Pedigree reconstruction using identity by descent.

Kirkpatrick B, Li SC, Karp RM, Halperin E.

J Comput Biol. 2011 Nov;18(11):1481-93. doi: 10.1089/cmb.2011.0156. Epub 2011 Oct 28.

PMID:
22035331
21.

Algorithms to detect multiprotein modularity conserved during evolution.

Hodgkinson L, Karp RM.

IEEE/ACM Trans Comput Biol Bioinform. 2012 Jul-Aug;9(4):1046-58. doi: 10.1109/TCBB.2011.125.

PMID:
21968956
22.

Diet and social disadvantage: the 'Medical Home' improves nutrition in childhood and diminishes likelihood of disease in adult life.

Karp RJ, Shlomovich M, Bruno L.

Maturitas. 2011 Oct;70(2):146-50. doi: 10.1016/j.maturitas.2011.06.018. Epub 2011 Aug 5. Review.

PMID:
21820827
23.

Review and application of group theory to molecular systems biology.

Rietman EA, Karp RL, Tuszynski JA.

Theor Biol Med Model. 2011 Jun 22;8:21. doi: 10.1186/1742-4682-8-21. Review.

24.

Response to Bell, et al. [The remarkably high prevalence of epilepsy and seizure history in fetal alcohol spectrum disorders. Alcohol Clin Exp Res 34:1084-1089.].

Karp RJ.

Alcohol Clin Exp Res. 2011 Jun;35(6):1017-8; author reply 1019. doi: 10.1111/j.1530-0277.2011.01537.x. Epub 2011 May 9. No abstract available.

PMID:
21554336
25.

Commentary: On W.C. Sullivan and his '[N]ote on the influence of maternal inebriety on the offspring'.

Karp RJ.

Int J Epidemiol. 2011 Apr;40(2):285-9. doi: 10.1093/ije/dyr004. No abstract available.

PMID:
21450685
26.

Letting the fox into the henhouse on the way to a regional health information network.

Karp RB.

Md Med. 2010 Autumn;11(4):5. No abstract available.

PMID:
21337965
27.

Cost effectiveness in clinical screening.

Karp RJ, Shepelyak Y.

Virtual Mentor. 2011 Apr 1;13(4):211-6. doi: 10.1001/virtualmentor.2011.13.4.ccas1-1104. No abstract available.

PMID:
23131324
28.

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.

Hagel M, Niu D, St Martin T, Sheets MP, Qiao L, Bernard H, Karp RM, Zhu Z, Labenski MT, Chaturvedi P, Nacht M, Westlin WF, Petter RC, Singh J.

Nat Chem Biol. 2011 Jan;7(1):22-4. doi: 10.1038/nchembio.492. Epub 2010 Nov 28.

PMID:
21113170
29.

DEGAS: de novo discovery of dysregulated pathways in human diseases.

Ulitsky I, Krishnamurthy A, Karp RM, Shamir R.

PLoS One. 2010 Oct 19;5(10):e13367. doi: 10.1371/journal.pone.0013367.

30.

Haplotype inference in complex pedigrees.

Kirkpatrick B, Halperin E, Karp RM.

J Comput Biol. 2010 Mar;17(3):269-80. doi: 10.1089/cmb.2009.0174.

PMID:
20377445
31.

Topology-free querying of protein interaction networks.

Bruckner S, Hüffner F, Karp RM, Shamir R, Sharan R.

J Comput Biol. 2010 Mar;17(3):237-52. doi: 10.1089/cmb.2009.0170.

PMID:
20377443
32.

Genome-wide association data reveal a global map of genetic interactions among protein complexes.

Hannum G, Srivas R, Guénolé A, van Attikum H, Krogan NJ, Karp RM, Ideker T.

PLoS Genet. 2009 Dec;5(12):e1000782. doi: 10.1371/journal.pgen.1000782. Epub 2009 Dec 24.

33.

The NIH Human Microbiome Project.

NIH HMP Working Group, Peterson J, Garges S, Giovanni M, McInnes P, Wang L, Schloss JA, Bonazzi V, McEwen JE, Wetterstrand KA, Deal C, Baker CC, Di Francesco V, Howcroft TK, Karp RW, Lunsford RD, Wellington CR, Belachew T, Wright M, Giblin C, David H, Mills M, Salomon R, Mullins C, Akolkar B, Begg L, Davis C, Grandison L, Humble M, Khalsa J, Little AR, Peavy H, Pontzer C, Portnoy M, Sayre MH, Starke-Reed P, Zakhari S, Read J, Watson B, Guyer M.

Genome Res. 2009 Dec;19(12):2317-23. doi: 10.1101/gr.096651.109. Epub 2009 Oct 9.

34.

Fostering translation of genetics research: an NIDDK perspective.

Akolkar B, Karp R, Kimmel PL, McKeon C, Rasooly RS.

Per Med. 2009 Sep;6(5):579-588. doi: 10.2217/pme.09.41.

PMID:
29783302
35.

TORQUE: topology-free querying of protein interaction networks.

Bruckner S, Hüffner F, Karp RM, Shamir R, Sharan R.

Nucleic Acids Res. 2009 Jul;37(Web Server issue):W106-8. doi: 10.1093/nar/gkp474. Epub 2009 Jun 2.

36.

Iron deficiency, obesity, and food insecurity.

Karp RJ, Kersey M, Cutts DB.

Arch Pediatr Adolesc Med. 2008 Dec;162(12):1194-5; author reply 1195-6. doi: 10.1001/archpedi.162.12.1194-b. No abstract available.

PMID:
19047551
37.

Association mapping and significance estimation via the coalescent.

Kimmel G, Karp RM, Jordan MI, Halperin E.

Am J Hum Genet. 2008 Dec;83(6):675-83. doi: 10.1016/j.ajhg.2008.10.017. Epub 2008 Nov 20.

38.

Failure to thrive: recalling Milton Levine and Heinrich Finkelstein.

Karp RJ, Chlosta S.

Pediatr Ann. 2008 Nov;37(11):766-70. No abstract available.

PMID:
19024844
39.

Social class and diet quality.

Karp RJ.

Am J Clin Nutr. 2008 Oct;88(4):1177-8; author reply 1178-9. No abstract available.

PMID:
18842810
40.

eQED: an efficient method for interpreting eQTL associations using protein networks.

Suthram S, Beyer A, Karp RM, Eldar Y, Ideker T.

Mol Syst Biol. 2008;4:162. doi: 10.1038/msb.2008.4. Epub 2008 Mar 4.

41.

An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis.

Lazarus DD, Doyle EG, Bernier SG, Rogers AB, Labenski MT, Wakefield JD, Karp RM, Clark EJ, Lorusso J, Hoyt JG, Thompson CD, Hannig G, Westlin WF.

Inflamm Res. 2008 Jan;57(1):18-27. doi: 10.1007/s00011-007-7075-5.

PMID:
18209961
42.

A randomization test for controlling population stratification in whole-genome association studies.

Kimmel G, Jordan MI, Halperin E, Shamir R, Karp RM.

Am J Hum Genet. 2007 Nov;81(5):895-905. Epub 2007 Sep 12.

43.

HAPLOPOOL: improving haplotype frequency estimation through DNA pools and phylogenetic modeling.

Kirkpatrick B, Armendariz CS, Karp RM, Halperin E.

Bioinformatics. 2007 Nov 15;23(22):3048-55. Epub 2007 Sep 25.

PMID:
17895275
44.

Comparing protein interaction networks via a graph match-and-split algorithm.

Narayanan M, Karp RM.

J Comput Biol. 2007 Sep;14(7):892-907.

PMID:
17803369
45.

Outreach to immigrant communities: teaching pediatric residents about access to health care.

Karp RJ, Rhee D, Feldman D, Bouchkouj N.

J Health Care Poor Underserved. 2007 Aug;18(3):510-5.

PMID:
17675709
46.

Mauriac syndrome in a 3-year-old boy.

Mahesh S, Karp RJ, Castells S, Quintos JB.

Endocr Pract. 2007 Jan-Feb;13(1):63-6.

PMID:
17360304
47.

Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458.

Hannig G, Bernier SG, Hoyt JG, Doyle B, Clark E, Karp RM, Lorusso J, Westlin WF.

Arthritis Rheum. 2007 Mar;56(3):850-60.

48.

Poverty, food insecurity, and obesity in children.

Meyers AF, Karp RJ, Kral JG.

Pediatrics. 2006 Nov;118(5):2265-6. No abstract available.

PMID:
17079609
49.

Keynote address: the role of algorithmic research in computational genomics.

Karp RM.

Proc IEEE Comput Soc Bioinform Conf. 2003;2:10-1.

PMID:
16826642
50.

A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.

Cooper AC, Karp RM, Clark EJ, Taghizadeh NR, Hoyt JG, Labenski MT, Murray MJ, Hannig G, Westlin WF, Thompson CD.

Clin Cancer Res. 2006 Apr 15;12(8):2583-90.

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