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Items: 1 to 50 of 61

1.

The functional observational battery and modified Irwin test as global neurobehavioral assessments in the rat: Pharmacological validation data and a comparison of methods.

Redfern WS, Dymond A, Strang I, Storey S, Grant C, Marks L, Barnard C, Heys C, Moyser K, Greenwood K, Cobey D, Moore N, Karp NA, Prior H.

J Pharmacol Toxicol Methods. 2019 Jul - Aug;98:106591. doi: 10.1016/j.vascn.2019.106591. Epub 2019 May 27.

PMID:
31146025
2.

Feedback from the European Bioanalysis Forum liquid microsampling consortium: microsampling: assessing accuracy and precision of handheld pipettes and capillaries.

Hawthorne G, Dillen L, Barfield M, Cobb Z, Kandira A, Schroeter K, White S, Karp NA, Love I, Boutet V, Rohde M, Kranenborgh M, Timmerman P.

Bioanalysis. 2019 Mar;11(6):533-542. doi: 10.4155/bio-2019-0018. Epub 2019 Apr 11. Erratum in: Bioanalysis. 2019 Aug 8;:.

3.

onlineFDR: an R package to control the false discovery rate for growing data repositories.

Robertson DS, Wildenhain J, Javanmard A, Karp NA.

Bioinformatics. 2019 Mar 14. pii: btz191. doi: 10.1093/bioinformatics/btz191. [Epub ahead of print]

PMID:
30873526
4.

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

Duque-Correa MA, Karp NA, McCarthy C, Forman S, Goulding D, Sankaranarayanan G, Jenkins TP, Reid AJ, Cambridge EL, Ballesteros Reviriego C; Sanger Mouse Genetics Project; 3i consortium, Müller W, Cantacessi C, Dougan G, Grencis RK, Berriman M.

PLoS Pathog. 2019 Jan 14;15(1):e1007265. doi: 10.1371/journal.ppat.1007265. eCollection 2019 Jan.

5.

Sex bias in preclinical research and an exploration of how to change the status quo.

Karp NA, Reavey N.

Br J Pharmacol. 2018 Nov 12. doi: 10.1111/bph.14539. [Epub ahead of print] Review.

PMID:
30418665
6.

Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response.

Floc'h N, Guerriero ML, Ramos-Montoya A, Davies BR, Cairns J, Karp NA.

Dis Model Mech. 2018 Oct 31;11(11). pii: dmm036160. doi: 10.1242/dmm.036160.

7.

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.

Balmus G, Larrieu D, Barros AC, Collins C, Abrudan M, Demir M, Geisler NJ, Lelliott CJ, White JK, Karp NA, Atkinson J, Kirton A, Jacobsen M, Clift D, Rodriguez R; Sanger Mouse Genetics Project, Adams DJ, Jackson SP.

Nat Commun. 2018 Apr 27;9(1):1700. doi: 10.1038/s41467-018-03770-3.

8.

Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test.

Tse K, Sillito R, Keerie A, Collier R, Grant C, Karp NA, Vickers C, Chapman K, Armstrong JD, Redfern WS.

J Pharmacol Toxicol Methods. 2018 Nov - Dec;94(Pt 1):1-13. doi: 10.1016/j.vascn.2018.03.008. Epub 2018 Apr 1.

PMID:
29614333
9.

Reproducible preclinical research-Is embracing variability the answer?

Karp NA.

PLoS Biol. 2018 Mar 5;16(3):e2005413. doi: 10.1371/journal.pbio.2005413. eCollection 2018 Mar.

10.

Reproducibility and replicability of rodent phenotyping in preclinical studies.

Kafkafi N, Agassi J, Chesler EJ, Crabbe JC, Crusio WE, Eilam D, Gerlai R, Golani I, Gomez-Marin A, Heller R, Iraqi F, Jaljuli I, Karp NA, Morgan H, Nicholson G, Pfaff DW, Richter SH, Stark PB, Stiedl O, Stodden V, Tarantino LM, Tucci V, Valdar W, Williams RW, Würbel H, Benjamini Y.

Neurosci Biobehav Rev. 2018 Apr;87:218-232. doi: 10.1016/j.neubiorev.2018.01.003. Epub 2018 Jan 31. Review.

11.

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.

Speak AO, Swiatkowska A, Karp NA, Arends MJ, Adams DJ, van der Weyden L.

Nat Protoc. 2017 Dec;12(12):2465-2477. doi: 10.1038/nprot.2017.118. Epub 2017 Nov 2.

PMID:
29095442
12.

The Experimental Design Assistant.

du Sert NP, Bamsey I, Bate ST, Berdoy M, Clark RA, Cuthill IC, Fry D, Karp NA, Macleod M, Moon L, Stanford SC, Lings B.

Nat Methods. 2017 Nov;14(11):1024-1025. doi: 10.1038/nmeth.4462. Epub 2017 Sep 28. No abstract available.

PMID:
28960183
13.

The Experimental Design Assistant.

Percie du Sert N, Bamsey I, Bate ST, Berdoy M, Clark RA, Cuthill I, Fry D, Karp NA, Macleod M, Moon L, Stanford SC, Lings B.

PLoS Biol. 2017 Sep 28;15(9):e2003779. doi: 10.1371/journal.pbio.2003779. eCollection 2017 Sep.

14.

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.

van der Weyden L, Karp NA, Swiatkowska A, Adams DJ, Speak AO.

Sci Data. 2017 Sep 12;4:170129. doi: 10.1038/sdata.2017.129.

15.

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project.

Redfern WS, Tse K, Grant C, Keerie A, Simpson DJ, Pedersen JC, Rimmer V, Leslie L, Klein SK, Karp NA, Sillito R, Chartsias A, Lukins T, Heward J, Vickers C, Chapman K, Armstrong JD.

PLoS One. 2017 Sep 6;12(9):e0181068. doi: 10.1371/journal.pone.0181068. eCollection 2017.

16.

IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.

Briend E, Ferguson GJ, Mori M, Damera G, Stephenson K, Karp NA, Sethi S, Ward CK, Sleeman MA, Erjefält JS, Finch DK.

Respir Res. 2017 Aug 22;18(1):159. doi: 10.1186/s12931-017-0641-7.

17.

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL; International Mouse Phenotyping Consortium, Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK.

Nat Commun. 2017 Jun 26;8:15475. doi: 10.1038/ncomms15475.

18.

The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice.

Ingvorsen C, Karp NA, Lelliott CJ.

Nutr Diabetes. 2017 Apr 10;7(4):e261. doi: 10.1038/nutd.2017.6.

19.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project, Spiegel S, Speak AO, Adams DJ.

Nature. 2017 Jan 12;541(7636):233-236. doi: 10.1038/nature20792. Epub 2017 Jan 4.

20.

Improving the Identification of Phenotypic Abnormalities and Sexual Dimorphism in Mice When Studying Rare Event Categorical Characteristics.

Karp NA, Heller R, Yaacoby S, White JK, Benjamini Y.

Genetics. 2017 Feb;205(2):491-501. doi: 10.1534/genetics.116.195388. Epub 2016 Dec 7.

21.

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L.

J Pathol. 2016 Jul;239(3):374-83. doi: 10.1002/path.4737. Epub 2016 May 30.

22.

Standardized Welfare Terms for the Zebrafish Community.

Goodwin N, Karp NA, Blackledge S, Clark B, Keeble R, Kovacs C, Murray KN, Price M, Thompson P, Bussell J.

Zebrafish. 2016 Jul;13 Suppl 1:S164-8. doi: 10.1089/zeb.2016.1248. Epub 2016 Apr 20.

23.

Evaluating and Optimizing Fish Health and Welfare During Experimental Procedures.

Goodwin N, Westall L, Karp NA, Hazlehurst D, Kovacs C, Keeble R, Thompson P, Collins R, Bussell J.

Zebrafish. 2016 Jul;13 Suppl 1:S127-31. doi: 10.1089/zeb.2015.1165. Epub 2016 Feb 25.

24.

Reporting phenotypes in mouse models when considering body size as a potential confounder.

Oellrich A, Meehan TF, Parkinson H, Sarntivijai S, White JK, Karp NA.

J Biomed Semantics. 2016 Feb 9;7:2. doi: 10.1186/s13326-016-0050-8. eCollection 2016. Review.

25.

A gene expression resource generated by genome-wide lacZ profiling in the mouse.

Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA, Souter L, Siragher E, Lillistone C, Green AL, Wardle-Jones H, Carragher DM, Karp NA, Smedley D, Adams NC; Sanger Institute Mouse Genetics Project, Bussell JN, Adams DJ, Ramírez-Solis R, Steel KP, Galli A, White JK.

Dis Model Mech. 2015 Nov;8(11):1467-78. doi: 10.1242/dmm.021238. Epub 2015 Aug 20.

26.

Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.

Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Herrington CS, Day MJ, Brayton CF, Bolon B, Whitelaw B, White ES, Everitt JI, Arends MJ.

J Pathol. 2016 Jan;238(2):359-67. doi: 10.1002/path.4642. Epub 2015 Nov 28. Review.

PMID:
26387837
27.

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

de Angelis MH, Nicholson G, Selloum M, White J, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl M, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, El Fertak L, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A; EUMODIC Consortium, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD.

Nat Genet. 2015 Sep;47(9):969-978. doi: 10.1038/ng.3360. Epub 2015 Jul 27.

28.

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data.

Kurbatova N, Mason JC, Morgan H, Meehan TF, Karp NA.

PLoS One. 2015 Jul 6;10(7):e0131274. doi: 10.1371/journal.pone.0131274. eCollection 2015.

29.

Applying the ARRIVE Guidelines to an In Vivo Database.

Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, Smedley D, Jacobsen J, Mott RF, Iyer V, Matthews P, Melvin DG, Wells S, Flenniken AM, Masuya H, Wakana S, White JK, Lloyd KC, Reynolds CL, Paylor R, West DB, Svenson KL, Chesler EJ, de Angelis MH, Tocchini-Valentini GP, Sorg T, Herault Y, Parkinson H, Mallon AM, Brown SD.

PLoS Biol. 2015 May 20;13(5):e1002151. doi: 10.1371/journal.pbio.1002151. eCollection 2015 May.

30.

Corrigendum to "Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia" [Experimental Hematology, Vol. 42, Issue 12, p1053-1058.e1].

Salsbury G, Cambridge EL, McIntyre Z, Arends MJ, Karp NA, Isherwood C, Shannon C, Hooks Y; Sanger Mouse Genetics Project, Ramirez-Solis R, Adams DJ, White JK, Speak AO.

Exp Hematol. 2015 May;43(5):424. doi: 10.1016/j.exphem.2015.03.002. Epub 2015 Apr 1. No abstract available.

31.

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

Balmus G, Karp NA, Ng BL, Jackson SP, Adams DJ, McIntyre RE.

Nat Protoc. 2015 Jan;10(1):205-15. doi: 10.1038/nprot.2015.010. Epub 2014 Dec 31.

32.

A common control group - optimising the experiment design to maximise sensitivity.

Bate S, Karp NA.

PLoS One. 2014 Dec 11;9(12):e114872. doi: 10.1371/journal.pone.0114872. eCollection 2014.

33.

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

Karp NA, Speak AO, White JK, Adams DJ, Hrabé de Angelis M, Hérault Y, Mott RF.

PLoS One. 2014 Oct 24;9(10):e111239. doi: 10.1371/journal.pone.0111239. eCollection 2014.

34.

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.

Salsbury G, Cambridge EL, McIntyre Z, Arends MJ, Karp NA, Isherwood C, Shannon C, Hooks Y; Sanger Mouse Genetics Project, Ramirez-Solis R, Adams DJ, White JK, Speak AO.

Exp Hematol. 2014 Dec;42(12):1053-8.e1. doi: 10.1016/j.exphem.2014.07.269. Epub 2014 Aug 12. Erratum in: Exp Hematol. 2015 May;43(5):424. Exp Hematol. 2015 May;43(5):424.

35.

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.

Adissu HA, Estabel J, Sunter D, Tuck E, Hooks Y, Carragher DM, Clarke K, Karp NA; Sanger Mouse Genetics Project, Newbigging S, Jones N, Morikawa L, White JK, McKerlie C.

Dis Model Mech. 2014 May;7(5):515-24. doi: 10.1242/dmm.015263. Epub 2014 Mar 20.

36.

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

Maguire S, Estabel J, Ingham N, Pearson S, Ryder E, Carragher DM, Walker N; Sanger MGP Slc25a21 Project Team, Bussell J, Chan WI, Keane TM, Adams DJ, Scudamore CL, Lelliott CJ, Ramírez-Solis R, Karp NA, Steel KP, White JK, Gerdin AK.

PLoS One. 2014 Mar 18;9(3):e91807. doi: 10.1371/journal.pone.0091807. eCollection 2014.

37.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.

Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H.

Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9. doi: 10.1093/nar/gkt977. Epub 2013 Nov 4.

38.

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC; Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP.

Cell. 2013 Jul 18;154(2):452-64. doi: 10.1016/j.cell.2013.06.022.

39.

High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.

Podrini C, Cambridge EL, Lelliott CJ, Carragher DM, Estabel J, Gerdin AK, Karp NA, Scudamore CL; Sanger Mouse Genetics Project, Ramirez-Solis R, White JK.

Mamm Genome. 2013 Jun;24(5-6):240-51. doi: 10.1007/s00335-013-9456-0. Epub 2013 May 28.

40.

Robust and sensitive analysis of mouse knockout phenotypes.

Karp NA, Melvin D; Sanger Mouse Genetics Project, Mott RF.

PLoS One. 2012;7(12):e52410. doi: 10.1371/journal.pone.0052410. Epub 2012 Dec 26.

41.

Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.

Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H, Edwards A, Arends MJ, Miró X, White JK, Désir J, Abramowicz M, Dentici ML, Lepri F, Hofmann K, Har-Zahav A, Ryder E, Karp NA, Estabel J, Gerdin AK, Podrini C, Ingham NJ, Altmüller J, Nürnberg G, Frommolt P, Abdelhak S, Pasmanik-Chor M, Konen O, Kelley RI, Shohat M, Nürnberg P, Flint J, Steel KP, Hoppe T, Kubisch C, Adams DJ, Borck G.

Am J Hum Genet. 2012 Dec 7;91(6):998-1010. doi: 10.1016/j.ajhg.2012.10.011. Epub 2012 Nov 29.

42.

The fallacy of ratio correction to address confounding factors.

Karp NA, Segonds-Pichon A, Gerdin AK, Ramírez-Solis R, White JK.

Lab Anim. 2012 Jul;46(3):245-52. doi: 10.1258/la.2012.012003.

43.

Optimising experimental design for high-throughput phenotyping in mice: a case study.

Karp NA, Baker LA, Gerdin AK, Adams NC, Ramírez-Solis R, White JK.

Mamm Genome. 2010 Oct;21(9-10):467-76. doi: 10.1007/s00335-010-9279-1. Epub 2010 Aug 27.

44.

Addressing accuracy and precision issues in iTRAQ quantitation.

Karp NA, Huber W, Sadowski PG, Charles PD, Hester SV, Lilley KS.

Mol Cell Proteomics. 2010 Sep;9(9):1885-97. doi: 10.1074/mcp.M900628-MCP200. Epub 2010 Apr 10.

45.

Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock.

Deery MJ, Maywood ES, Chesham JE, Sládek M, Karp NA, Green EW, Charles PD, Reddy AB, Kyriacou CP, Lilley KS, Hastings MH.

Curr Biol. 2009 Dec 15;19(23):2031-6. doi: 10.1016/j.cub.2009.10.024. Epub 2009 Nov 12.

46.

Gel-based proteomics approach to the study of metabolic changes in pear tissue during storage.

Pedreschi R, Hertog M, Robben J, Lilley KS, Karp NA, Baggerman G, Vanderleyden J, Nicolaï B.

J Agric Food Chem. 2009 Aug 12;57(15):6997-7004. doi: 10.1021/jf901432h.

PMID:
19722581
47.

Investigating sample pooling strategies for DIGE experiments to address biological variability.

Karp NA, Lilley KS.

Proteomics. 2009 Jan;9(2):388-97. doi: 10.1002/pmic.200800485.

PMID:
19105178
48.

Comparison of DIGE and post-stained gel electrophoresis with both traditional and SameSpots analysis for quantitative proteomics.

Karp NA, Feret R, Rubtsov DV, Lilley KS.

Proteomics. 2008 Mar;8(5):948-60. doi: 10.1002/pmic.200700812.

PMID:
18246571
49.

Design and analysis issues in quantitative proteomics studies.

Karp NA, Lilley KS.

Proteomics. 2007 Sep;7 Suppl 1:42-50.

PMID:
17893850
50.

Glucocorticoid signaling synchronizes the liver circadian transcriptome.

Reddy AB, Maywood ES, Karp NA, King VM, Inoue Y, Gonzalez FJ, Lilley KS, Kyriacou CP, Hastings MH.

Hepatology. 2007 Jun;45(6):1478-88.

PMID:
17538967

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