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Items: 1 to 50 of 53

1.

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.

Labbé DP, Zadra G, Yang M, Reyes JM, Lin CY, Cacciatore S, Ebot EM, Creech AL, Giunchi F, Fiorentino M, Elfandy H, Syamala S, Karoly ED, Alshalalfa M, Erho N, Ross A, Schaeffer EM, Gibb EA, Takhar M, Den RB, Lehrer J, Karnes RJ, Freedland SJ, Davicioni E, Spratt DE, Ellis L, Jaffe JD, DʼAmico AV, Kantoff PW, Bradner JE, Mucci LA, Chavarro JE, Loda M, Brown M.

Nat Commun. 2019 Sep 25;10(1):4358. doi: 10.1038/s41467-019-12298-z.

2.

Ozone-induced changes in the serum metabolome: Role of the microbiome.

Cho Y, Osgood RS, Bell LN, Karoly ED, Shore SA.

PLoS One. 2019 Aug 27;14(8):e0221633. doi: 10.1371/journal.pone.0221633. eCollection 2019.

3.

Changes in Metabolites Present in Lung-Lining Fluid Following Exposure of Humans to Ozone.

Cheng W, Duncan KE, Ghio AJ, Ward-Caviness C, Karoly ED, Diaz-Sanchez D, Conolly RB, Devlin RB.

Toxicol Sci. 2018 Jun 1;163(2):430-439. doi: 10.1093/toxsci/kfy043.

4.

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

Waitkus MS, Pirozzi CJ, Moure CJ, Diplas BH, Hansen LJ, Carpenter AB, Yang R, Wang Z, Ingram BO, Karoly ED, Mohney RP, Spasojevic I, McLendon RE, Friedman HS, He Y, Bigner DD, Yan H.

Cancer Res. 2018 Jan 1;78(1):36-50. doi: 10.1158/0008-5472.CAN-17-1352. Epub 2017 Nov 2.

5.

A prospective study of serum metabolites and glioma risk.

Huang J, Weinstein SJ, Kitahara CM, Karoly ED, Sampson JN, Albanes D.

Oncotarget. 2017 Jul 31;8(41):70366-70377. doi: 10.18632/oncotarget.19705. eCollection 2017 Sep 19.

6.

Effect of acute ozone exposure on the lung metabolomes of obese and lean mice.

Mathews JA, Kasahara DI, Cho Y, Bell LN, Gunst PR, Karoly ED, Shore SA.

PLoS One. 2017 Jul 13;12(7):e0181017. doi: 10.1371/journal.pone.0181017. eCollection 2017.

7.

Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor.

Huang J, Mondul AM, Weinstein SJ, Karoly ED, Sampson JN, Albanes D.

Oncotarget. 2017 Jul 11;8(28):45190-45199. doi: 10.18632/oncotarget.16775.

8.

Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism.

James EL, Lane JA, Michalek RD, Karoly ED, Parkinson EK.

Sci Rep. 2016 Dec 7;6:38489. doi: 10.1038/srep38489.

9.

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sjögren RJ, Näslund E, Zierath JR, Krook A, Savage DB, Griffin JL, Chaturvedi N, Hingorani AD, Khaw KT, Barroso I, McCarthy MI, O'Rahilly S, Wareham NJ, Langenberg C.

PLoS Med. 2016 Nov 29;13(11):e1002179. doi: 10.1371/journal.pmed.1002179. eCollection 2016 Nov.

10.

Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial.

Mondul AM, Moore SC, Weinstein SJ, Evans AM, Karoly ED, Männistö S, Sampson JN, Albanes D.

J Nutr Metab. 2016;2016:6158436. Epub 2016 Oct 20.

11.

Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden.

Montrose DC, Zhou XK, McNally EM, Sue E, Yantiss RK, Gross SS, Leve ND, Karoly ED, Suen CS, Ling L, Benezra R, Pamer EG, Dannenberg AJ.

Cancer Prev Res (Phila). 2016 Sep;9(9):721-31. doi: 10.1158/1940-6207.CAPR-16-0095. Epub 2016 Jul 18.

12.

Probiotic Strain Bifidobacterium animalis subsp. lactis CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in Caenorhabditis elegans.

Martorell P, Llopis S, González N, Chenoll E, López-Carreras N, Aleixandre A, Chen Y, Karoly ED, Ramón D, Genovés S.

J Agric Food Chem. 2016 May 4;64(17):3462-72. doi: 10.1021/acs.jafc.5b05934. Epub 2016 Apr 19.

PMID:
27054371
13.

Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans.

Miller DB, Ghio AJ, Karoly ED, Bell LN, Snow SJ, Madden MC, Soukup J, Cascio WE, Gilmour MI, Kodavanti UP.

Am J Respir Crit Care Med. 2016 Jun 15;193(12):1382-91. doi: 10.1164/rccm.201508-1599OC.

14.

Metabolomics of dates (Phoenix dactylifera) reveals a highly dynamic ripening process accounting for major variation in fruit composition.

Diboun I, Mathew S, Al-Rayyashi M, Elrayess M, Torres M, Halama A, Méret M, Mohney RP, Karoly ED, Malek J, Suhre K.

BMC Plant Biol. 2015 Dec 16;15:291. doi: 10.1186/s12870-015-0672-5.

15.

Metabolic signatures differentiate ovarian from colon cancer cell lines.

Halama A, Guerrouahen BS, Pasquier J, Diboun I, Karoly ED, Suhre K, Rafii A.

J Transl Med. 2015 Jul 14;13:223. doi: 10.1186/s12967-015-0576-z.

16.

Erratum to: A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control.

Yousri NA, Mook-Kanamori DO, El-Din Selim MM, Takiddin AH, Al-Homsi H, Al-Mahmoud KA, Karoly ED, Krumsiek J, Do KT, Neumaier U, Mook-Kanamori MJ, Rowe J, Chidiac OM, McKeon C, Al Muftah WA, Kader SA, Kastenmüller G, Suhre K.

Diabetologia. 2015 Sep;58(9):2199. doi: 10.1007/s00125-015-3682-9. No abstract available.

17.

Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours.

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.

Nat Commun. 2015 Jun 18;6:7605. doi: 10.1038/ncomms8605. No abstract available.

18.

A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control.

Yousri NA, Mook-Kanamori DO, Selim MM, Takiddin AH, Al-Homsi H, Al-Mahmoud KA, Karoly ED, Krumsiek J, Do KT, Neumaier U, Mook-Kanamori MJ, Rowe J, Chidiac OM, McKeon C, Al Muftah WA, Kader SA, Kastenmüller G, Suhre K.

Diabetologia. 2015 Aug;58(8):1855-67. doi: 10.1007/s00125-015-3636-2. Epub 2015 Jun 7. Erratum in: Diabetologia. 2015 Sep;58(9):2199. Do, Kieu Thinh [corrected to Do, Kieu Trinh].

19.

Urine Metabolite Profiles Predictive of Human Kidney Allograft Status.

Suhre K, Schwartz JE, Sharma VK, Chen Q, Lee JR, Muthukumar T, Dadhania DM, Ding R, Ikle DN, Bridges ND, Williams NM, Kastenmüller G, Karoly ED, Mohney RP, Abecassis M, Friedewald J, Knechtle SJ, Becker YT, Samstein B, Shaked A, Gross SS, Suthanthiran M.

J Am Soc Nephrol. 2016 Feb;27(2):626-36. doi: 10.1681/ASN.2015010107. Epub 2015 Jun 5.

20.

Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha-tocolpherol, beta-carotene cancer prevention (ATBC) study.

Mondul AM, Moore SC, Weinstein SJ, Karoly ED, Sampson JN, Albanes D.

Int J Cancer. 2015 Nov 1;137(9):2124-32. doi: 10.1002/ijc.29576. Epub 2015 May 9.

21.

Inhaled ozone (O3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats.

Miller DB, Karoly ED, Jones JC, Ward WO, Vallanat BD, Andrews DL, Schladweiler MC, Snow SJ, Bass VL, Richards JE, Ghio AJ, Cascio WE, Ledbetter AD, Kodavanti UP.

Toxicol Appl Pharmacol. 2015 Jul 15;286(2):65-79. doi: 10.1016/j.taap.2015.03.025. Epub 2015 Mar 31.

22.

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.

Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA.

Nat Commun. 2015 Mar 26;6:6692. doi: 10.1038/ncomms7692.

23.

Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease.

James EL, Michalek RD, Pitiyage GN, de Castro AM, Vignola KS, Jones J, Mohney RP, Karoly ED, Prime SS, Parkinson EK.

J Proteome Res. 2015 Apr 3;14(4):1854-71. doi: 10.1021/pr501221g. Epub 2015 Feb 26.

24.

Large-scaled metabolic profiling of human dermal fibroblasts derived from pseudoxanthoma elasticum patients and healthy controls.

Kuzaj P, Kuhn J, Michalek RD, Karoly ED, Faust I, Dabisch-Ruthe M, Knabbe C, Hendig D.

PLoS One. 2014 Sep 29;9(9):e108336. doi: 10.1371/journal.pone.0108336. eCollection 2014.

25.

Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.

Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V.

Cancer Metab. 2014 Aug 18;2:13. doi: 10.1186/2049-3002-2-13. eCollection 2014. Erratum in: Cancer Metab. 2014;2:24.

26.

Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study.

Niewczas MA, Sirich TL, Mathew AV, Skupien J, Mohney RP, Warram JH, Smiles A, Huang X, Walker W, Byun J, Karoly ED, Kensicki EM, Berry GT, Bonventre JV, Pennathur S, Meyer TW, Krolewski AS.

Kidney Int. 2014 May;85(5):1214-24. doi: 10.1038/ki.2013.497. Epub 2014 Jan 15.

27.

1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control.

Mook-Kanamori DO, Selim MM, Takiddin AH, Al-Homsi H, Al-Mahmoud KA, Al-Obaidli A, Zirie MA, Rowe J, Yousri NA, Karoly ED, Kocher T, Sekkal Gherbi W, Chidiac OM, Mook-Kanamori MJ, Abdul Kader S, Al Muftah WA, McKeon C, Suhre K.

J Clin Endocrinol Metab. 2014 Mar;99(3):E479-83. doi: 10.1210/jc.2013-3596. Epub 2014 Jan 1. Erratum in: J Clin Endocrinol Metab. 2017 Oct 1;102(10 ):3867.

PMID:
24423354
28.

Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.

Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V.

Cancer Metab. 2014 Nov 4;2:24. doi: 10.1186/2049-3002-2-24. eCollection 2014.

29.

Inactivation of metabolic genes causes short- and long-range dys-regulation in Escherichia coli metabolic network.

Barupal DK, Lee SJ, Karoly ED, Adhya S.

PLoS One. 2013 Dec 5;8(12):e78360. doi: 10.1371/journal.pone.0078360. eCollection 2013.

30.

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S.

J Clin Invest. 2014 Jan;124(1):398-412. doi: 10.1172/JCI71180. Epub 2013 Dec 9.

31.

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, Roychoudhuri R, Palmer DC, Muranski P, Karoly ED, Mohney RP, Klebanoff CA, Lal A, Finkel T, Restifo NP, Gattinoni L.

J Clin Invest. 2013 Oct;123(10):4479-88. doi: 10.1172/JCI69589. Epub 2013 Sep 16.

32.

Landscape of the mitochondrial Hsp90 metabolome in tumours.

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.

Nat Commun. 2013;4:2139. doi: 10.1038/ncomms3139. Erratum in: Nat Commun. 2015;6:7605.

33.

HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer.

Burkhart RA, Pineda DM, Chand SN, Romeo C, Londin ER, Karoly ED, Cozzitorto JA, Rigoutsos I, Yeo CJ, Brody JR, Winter JM.

RNA Biol. 2013 Aug;10(8):1312-23. doi: 10.4161/rna.25274. Epub 2013 Jun 13.

34.

Metabolomic profile of response to supplementation with β-carotene in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.

Mondul AM, Sampson JN, Moore SC, Weinstein SJ, Evans AM, Karoly ED, Virtamo J, Albanes D.

Am J Clin Nutr. 2013 Aug;98(2):488-93. doi: 10.3945/ajcn.113.062778. Epub 2013 Jun 26.

35.

The human ΔNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function.

Lin SC, Karoly ED, Taatjes DJ.

Aging Cell. 2013 Oct;12(5):863-72. doi: 10.1111/acel.12108. Epub 2013 Jun 25.

36.

Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.

Chaudhri VK, Salzler GG, Dick SA, Buckman MS, Sordella R, Karoly ED, Mohney R, Stiles BM, Elemento O, Altorki NK, McGraw TE.

Mol Cancer Res. 2013 Jun;11(6):579-92. doi: 10.1158/1541-7786.MCR-12-0437-T. Epub 2013 Mar 8.

37.

Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury.

Dulin JN, Karoly ED, Wang Y, Strobel HW, Grill RJ.

J Neurosci. 2013 Jan 9;33(2):652-64. doi: 10.1523/JNEUROSCI.6128-11.2013.

38.

Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia.

Montrose DC, Zhou XK, Kopelovich L, Yantiss RK, Karoly ED, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Dec;5(12):1358-67. doi: 10.1158/1940-6207.CAPR-12-0160. Epub 2012 Sep 7.

39.

Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer.

Saylor PJ, Karoly ED, Smith MR.

Clin Cancer Res. 2012 Jul 1;18(13):3677-85. doi: 10.1158/1078-0432.CCR-11-3209. Epub 2012 May 15.

40.

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations.

Quijano C, Cao L, Fergusson MM, Romero H, Liu J, Gutkind S, Rovira II, Mohney RP, Karoly ED, Finkel T.

Cell Cycle. 2012 Apr 1;11(7):1383-92. doi: 10.4161/cc.19800. Epub 2012 Apr 1.

41.

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.

Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B, Yan H.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3270-5. doi: 10.1073/pnas.1019393108. Epub 2011 Feb 2.

42.

Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter.

Huang YC, Karoly ED, Dailey LA, Schmitt MT, Silbajoris R, Graff DW, Devlin RB.

J Toxicol Environ Health A. 2011;74(5):296-312. doi: 10.1080/15287394.2010.516238.

PMID:
21240730
43.

Metabolomics for early detection of drug-induced kidney injury: review of the current status.

Boudonck KJ, Rose DJ, Karoly ED, Lee DP, Lawton KA, Lapinskas PJ.

Bioanalysis. 2009 Dec;1(9):1645-63. doi: 10.4155/bio.09.142. Review.

PMID:
21083109
44.

Metabolomic differences in heart failure patients with and without major depression.

Steffens DC, Wei Jiang, Krishnan KR, Karoly ED, Mitchell MW, O'Connor CM, Kaddurah-Daouk R.

J Geriatr Psychiatry Neurol. 2010 Jun;23(2):138-46. doi: 10.1177/0891988709358592. Epub 2010 Jan 25.

45.

Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line.

Huang YC, Li Z, Hyseni X, Schmitt M, Devlin RB, Karoly ED, Soukup JM.

Genomic Med. 2008 Dec;2(3-4):113-25. doi: 10.1007/s11568-009-9080-y. Epub 2009 May 15.

46.

One-month diesel exhaust inhalation produces hypertensive gene expression pattern in healthy rats.

Gottipolu RR, Wallenborn JG, Karoly ED, Schladweiler MC, Ledbetter AD, Krantz T, Linak WP, Nyska A, Johnson JA, Thomas R, Richards JE, Jaskot RH, Kodavanti UP.

Environ Health Perspect. 2009 Jan;117(1):38-46. doi: 10.1289/ehp.11647. Epub 2008 Sep 12.

47.

The role of particulate matter-associated zinc in cardiac injury in rats.

Kodavanti UP, Schladweiler MC, Gilmour PS, Wallenborn JG, Mandavilli BS, Ledbetter AD, Christiani DC, Runge MS, Karoly ED, Costa DL, Peddada S, Jaskot R, Richards JH, Thomas R, Madamanchi NR, Nyska A.

Environ Health Perspect. 2008 Jan;116(1):13-20. doi: 10.1289/ehp.10379.

48.

Assessing the role of particulate matter size and composition on gene expression in pulmonary cells.

Graff DW, Schmitt MT, Dailey LA, Duvall RM, Karoly ED, Devlin RB.

Inhal Toxicol. 2007;19 Suppl 1:23-8.

PMID:
17886046
49.

Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.

Karoly ED, Li Z, Dailey LA, Hyseni X, Huang YC.

Environ Health Perspect. 2007 Apr;115(4):535-40. Epub 2007 Jan 8.

50.

Ontogeny of transcription profiles during mouse early craniofacial development.

Karoly ED, Schmid JE, Hunter ES 3rd.

Reprod Toxicol. 2005 Jan-Feb;19(3):339-52.

PMID:
15686869

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