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Angiotensin Type 1 Receptor Blockers in Heart Failure.

Singh KD, Karnik SS.

Curr Drug Targets. 2019 Aug 21. doi: 10.2174/1389450120666190821152000. [Epub ahead of print]


Effect of novel GPCR ligands on blood pressure and vascular homeostasis.

Jara ZP, Singh KD, Unal H, Desnoyer R, Yokota R, Pesquero JL, Casarini DE, Karnik SS.

Methods Cell Biol. 2019;149:215-238. doi: 10.1016/bs.mcb.2018.10.001. Epub 2018 Nov 20.


Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT1R Initiated by van der Waals Attraction.

Singh KD, Unal H, Desnoyer R, Karnik SS.

J Chem Inf Model. 2019 Jan 28;59(1):373-385. doi: 10.1021/acs.jcim.8b00583. Epub 2019 Jan 16.


Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5.

Wang Z, Yu G, Liu Y, Liu S, Aridor M, Huang Y, Hu Y, Wang L, Li S, Xiong H, Tang B, Li X, Cheng C, Chakrabarti S, Wang F, Wu Q, Karnik SS, Xu C, Chen Q, Wang QK.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3672-3684. doi: 10.1016/j.bbadis.2018.09.003. Epub 2018 Sep 6.


Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril.

Senanayake PD, Bonilha VL, W Peterson J, Yamada Y, Karnik SS, Daneshgari F, Brosnihan KB, Hollyfield JG.

J Renin Angiotensin Aldosterone Syst. 2018 Jul-Sep;19(3):1470320318789323. doi: 10.1177/1470320318789323.


Determinants of Antibiotic Consumption - Development of a Model using Partial Least Squares Regression based on Data from India.

Tamhankar AJ, Karnik SS, Stålsby Lundborg C.

Sci Rep. 2018 Apr 23;8(1):6421. doi: 10.1038/s41598-018-24883-1.


Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1.

Si W, Xie W, Deng W, Xiao Y, Karnik SS, Xu C, Chen Q, Wang QK.

FASEB J. 2018 Sep;32(9):5051-5062. doi: 10.1096/fj.201701543RR. Epub 2018 Apr 11.


The non-biphenyl-tetrazole angiotensin AT1 receptor antagonist eprosartan is a unique and robust inverse agonist of the active state of the AT1 receptor.

Takezako T, Unal H, Karnik SS, Node K.

Br J Pharmacol. 2018 Jun;175(12):2454-2469. doi: 10.1111/bph.14213. Epub 2018 May 6.


Connective tissue growth factor dependent collagen gene expression induced by MAS agonist AR234960 in human cardiac fibroblasts.

Chatterjee A, Barnard J, Moravec C, Desnoyer R, Tirupula K, Karnik SS.

PLoS One. 2017 Dec 29;12(12):e0190217. doi: 10.1371/journal.pone.0190217. eCollection 2017.


Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type 1 Receptor.

Singh KD, Unal H, Desnoyer R, Karnik SS.

J Chem Inf Model. 2018 Jan 22;58(1):182-193. doi: 10.1021/acs.jcim.7b00424. Epub 2017 Dec 27.


Current topics in angiotensin II type 1 receptor research: Focus on inverse agonism, receptor dimerization and biased agonism.

Takezako T, Unal H, Karnik SS, Node K.

Pharmacol Res. 2017 Sep;123:40-50. doi: 10.1016/j.phrs.2017.06.013. Epub 2017 Jun 23. Review.


Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22.

Karnik SS, Singh KD, Tirupula K, Unal H.

Br J Pharmacol. 2017 May;174(9):737-753. doi: 10.1111/bph.13742. Epub 2017 Mar 9. Review.


Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications.

Singh KD, Karnik SS.

J Cell Signal. 2016 Jun;1(2). pii: 111. Epub 2016 Apr 8.


Correction: Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation.

Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan ZH, Yong S, Vasanji A, Kinter M, Desnoyer R, Karnik SS.

PLoS One. 2016 May 4;11(5):e0155198. doi: 10.1371/journal.pone.0155198. eCollection 2016.


MAS C-Terminal Tail Interacting Proteins Identified by Mass Spectrometry- Based Proteomic Approach.

Tirupula KC, Zhang D, Osbourne A, Chatterjee A, Desnoyer R, Willard B, Karnik SS.

PLoS One. 2015 Oct 20;10(10):e0140872. doi: 10.1371/journal.pone.0140872. eCollection 2015.


G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation.

Tirupula KC, Ithychanda SS, Mohan ML, Naga Prasad SV, Qin J, Karnik SS.

Biochemistry. 2015 Nov 10;54(44):6673-83. doi: 10.1021/acs.biochem.5b00975. Epub 2015 Nov 2.


Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.

Zhang H, Unal H, Desnoyer R, Han GW, Patel N, Katritch V, Karnik SS, Cherezov V, Stevens RC.

J Biol Chem. 2015 Dec 4;290(49):29127-39. doi: 10.1074/jbc.M115.689000. Epub 2015 Sep 29.


International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].

Karnik SS, Unal H, Kemp JR, Tirupula KC, Eguchi S, Vanderheyden PM, Thomas WG.

Pharmacol Rev. 2015 Oct;67(4):754-819. doi: 10.1124/pr.114.010454. Review. Erratum in: Pharmacol Rev. 2015 Oct;67(4):820.


Structure-Function Basis of Attenuated Inverse Agonism of Angiotensin II Type 1 Receptor Blockers for Active-State Angiotensin II Type 1 Receptor.

Takezako T, Unal H, Karnik SS, Node K.

Mol Pharmacol. 2015 Sep;88(3):488-501. doi: 10.1124/mol.115.099176. Epub 2015 Jun 29.


Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.

Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U, Sawaya MR, Xu Q, Messerschmidt M, Williams GJ, Boutet S, Yefanov OM, White TA, Wang C, Ishchenko A, Tirupula KC, Desnoyer R, Coe J, Conrad CE, Fromme P, Stevens RC, Katritch V, Karnik SS, Cherezov V.

Cell. 2015 May 7;161(4):833-44. doi: 10.1016/j.cell.2015.04.011. Epub 2015 Apr 23.


A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A.

Ithychanda SS, Fang X, Mohan ML, Zhu L, Tirupula KC, Naga Prasad SV, Wang YX, Karnik SS, Qin J.

J Biol Chem. 2015 Mar 27;290(13):8527-38. doi: 10.1074/jbc.M114.633446. Epub 2015 Feb 9.


Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3.

Dasgupta M, Unal H, Willard B, Yang J, Karnik SS, Stark GR.

J Biol Chem. 2014 Oct 31;289(44):30763-71. doi: 10.1074/jbc.M114.603894. Epub 2014 Sep 12.


Atypical signaling and functional desensitization response of MAS receptor to peptide ligands.

Tirupula KC, Desnoyer R, Speth RC, Karnik SS.

PLoS One. 2014 Jul 28;9(7):e103520. doi: 10.1371/journal.pone.0103520. eCollection 2014.


Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system.

Kemp JR, Unal H, Desnoyer R, Yue H, Bhatnagar A, Karnik SS.

J Mol Cell Cardiol. 2014 Oct;75:25-39. doi: 10.1016/j.yjmcc.2014.06.008. Epub 2014 Jun 27.


Constitutive activity in the angiotensin II type 1 receptor: discovery and applications.

Unal H, Karnik SS.

Adv Pharmacol. 2014;70:155-74. doi: 10.1016/B978-0-12-417197-8.00006-7. Review.


Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers.

Miura S, Nakao N, Hanzawa H, Matsuo Y, Saku K, Karnik SS.

PLoS One. 2013 Nov 8;8(11):e79914. doi: 10.1371/journal.pone.0079914. eCollection 2013.


Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation.

Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan ZH, Yong S, Vasanji A, Kinter M, Desnoyer R, Karnik SS.

PLoS One. 2013;8(1):e52689. doi: 10.1371/journal.pone.0052689. Epub 2013 Jan 9. Erratum in: PLoS One. 2016;11(5):e0155198.


Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor.

Unal H, Jagannathan R, Bhatnagar A, Tirupula K, Desnoyer R, Karnik SS.

J Biol Chem. 2013 Jan 4;288(1):540-51. doi: 10.1074/jbc.M112.392514. Epub 2012 Nov 8.


Unique binding behavior of the recently approved angiotensin II receptor blocker azilsartan compared with that of candesartan.

Miura S, Okabe A, Matsuo Y, Karnik SS, Saku K.

Hypertens Res. 2013 Feb;36(2):134-9. doi: 10.1038/hr.2012.147. Epub 2012 Oct 4. Erratum in: Hypertens Res. 2013 May;36(5):476.


Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor.

Miura S, Kiya Y, Hanzawa H, Nakao N, Fujino M, Imaizumi S, Matsuo Y, Yanagisawa H, Koike H, Komuro I, Karnik SS, Saku K.

PLoS One. 2012;7(6):e37974. doi: 10.1371/journal.pone.0037974. Epub 2012 Jun 14. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/158ee8e2-b9da-4d86-9085-457700f96b92.


Mechanism of GPCR-directed autoantibodies in diseases.

Unal H, Jagannathan R, Karnik SS.

Adv Exp Med Biol. 2012;749:187-99. doi: 10.1007/978-1-4614-3381-1_13. No abstract available.


Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3.

Yue H, Tanaka K, Furukawa T, Karnik SS, Li W.

Biochim Biophys Acta. 2012 Aug;1823(8):1316-23. doi: 10.1016/j.bbamcr.2012.05.025. Epub 2012 Jun 2.


Angiotensin II receptor-induced cardiac remodeling in mice without angiotensin II.

Karnik SS, Unal H.

Hypertension. 2012 Mar;59(3):542-4. doi: 10.1161/HYPERTENSIONAHA.111.189423. Epub 2012 Jan 30. No abstract available.


Domain coupling in GPCRs: the engine for induced conformational changes.

Unal H, Karnik SS.

Trends Pharmacol Sci. 2012 Feb;33(2):79-88. doi: 10.1016/ Epub 2011 Oct 29. Review.


Abilities of candesartan and other AT(1) receptor blockers to impair angiotensin II-induced AT(1) receptor activation after wash-out.

Kiya Y, Miura S, Matsuo Y, Karnik SS, Saku K.

J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):76-83. doi: 10.1177/1470320311417478. Epub 2011 Aug 8.


AT1 receptor induced alterations in histone H2A reveal novel insights into GPCR control of chromatin remodeling.

Jagannathan R, Kaveti S, Desnoyer RW, Willard B, Kinter M, Karnik SS.

PLoS One. 2010 Sep 3;5(9):e12552. doi: 10.1371/journal.pone.0012552.


A small difference in the molecular structure of angiotensin II receptor blockers induces AT₁ receptor-dependent and -independent beneficial effects.

Fujino M, Miura S, Kiya Y, Tominaga Y, Matsuo Y, Karnik SS, Saku K.

Hypertens Res. 2010 Oct;33(10):1044-52. doi: 10.1038/hr.2010.135. Epub 2010 Jul 29.


Ilizarov wound closure method for traumatic soft tissue defects.

Bibbo C, Karnik SS, Albright JT.

Foot Ankle Int. 2010 Jul;31(7):628-33. doi: 10.3113/FAI.2010.0628. No abstract available.


Review: angiotensin II type 1 receptor blockers: class effects versus molecular effects.

Miura S, Karnik SS, Saku K.

J Renin Angiotensin Aldosterone Syst. 2011 Mar;12(1):1-7. doi: 10.1177/1470320310370852. Epub 2010 Jul 5. Review.


MicroRNAs--regulators of signaling networks in dilated cardiomyopathy.

Naga Prasad SV, Karnik SS.

J Cardiovasc Transl Res. 2010 Jun;3(3):225-34. doi: 10.1007/s12265-010-9177-7. Epub 2010 May 1. Review.


Clinical and pharmacotherapeutic relevance of the double-chain domain of the angiotensin II type 1 receptor blocker olmesartan.

Kiya Y, Miura S, Fujino M, Imaizumi S, Karnik SS, Saku K.

Clin Exp Hypertens. 2010 Jan;32(2):129-36. doi: 10.3109/10641960903254430.


Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor.

Unal H, Jagannathan R, Bhat MB, Karnik SS.

J Biol Chem. 2010 May 21;285(21):16341-50. doi: 10.1074/jbc.M109.094870. Epub 2010 Mar 18.


Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors.

Miura S, Matsuo Y, Kiya Y, Karnik SS, Saku K.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):85-90. doi: 10.1016/j.bbrc.2009.11.008. Epub 2009 Nov 5.


A protein tyrosine phosphatase inhibitor, pervanadate, inhibits angiotensin II-Induced beta-arrestin cleavage.

Jang SH, Hwang SA, Kim M, Yun SH, Kim MS, Karnik SS, Lee C.

Mol Cells. 2009 Jul 31;28(1):25-30. doi: 10.1007/s10059-009-0104-1. Epub 2009 Jul 8.


Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy.

Yue H, Li W, Desnoyer R, Karnik SS.

Cardiovasc Res. 2010 Jan 1;85(1):90-9. doi: 10.1093/cvr/cvp285.


Site-specific cleavage of G protein-coupled receptor-engaged beta-arrestin. Influence of the AT1 receptor conformation on scissile site selection.

Lee C, Bhatt S, Shukla A, Desnoyer RW, Yadav SP, Kim M, Jang SH, Karnik SS.

J Biol Chem. 2008 Aug 1;283(31):21612-20. doi: 10.1074/jbc.M803062200. Epub 2008 May 27.


Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state.

Miura S, Kiya Y, Kanazawa T, Imaizumi S, Fujino M, Matsuo Y, Karnik SS, Saku K.

Mol Endocrinol. 2008 Jan;22(1):139-46. Epub 2007 Sep 27.


Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.

Ramchandran R, Takezako T, Saad Y, Stull L, Fink B, Yamada H, Dikalov S, Harrison DG, Moravec C, Karnik SS.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19087-92. Epub 2006 Dec 5.


Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor.

Miura S, Fujino M, Hanzawa H, Kiya Y, Imaizumi S, Matsuo Y, Tomita S, Uehara Y, Karnik SS, Yanagisawa H, Koike H, Komuro I, Saku K.

J Biol Chem. 2006 Jul 14;281(28):19288-95. Epub 2006 May 10.

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