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Items: 19


B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.

Rieder SA, Wang J, White N, Qadri A, Menard C, Stephens G, Karnell JL, Rudd CE, Kolbeck R.

Cell Mol Immunol. 2020 Jan 31. doi: 10.1038/s41423-020-0361-7. [Epub ahead of print]


SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus.

Smith MA, Henault J, Karnell JL, Parker ML, Riggs JM, Sinibaldi D, Taylor DK, Ettinger R, Grant EP, Sanjuan MA, Kolbeck R, Petri MA, Casey KA.

Sci Rep. 2019 Oct 8;9(1):14433. doi: 10.1038/s41598-019-50231-y.


Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis.

Gonzalez Cardona J, Smith MD, Wang J, Kirby L, Schott JT, Davidson T, Karnell JL, Whartenby KA, Calabresi PA.

PLoS One. 2019 Sep 6;14(9):e0221747. doi: 10.1371/journal.pone.0221747. eCollection 2019.


A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.

Karnell JL, Albulescu M, Drabic S, Wang L, Moate R, Baca M, Oganesyan V, Gunsior M, Thisted T, Yan L, Li J, Xiong X, Eck SC, de Los Reyes M, Yusuf I, Streicher K, Müller-Ladner U, Howe D, Ettinger R, Herbst R, Drappa J.

Sci Transl Med. 2019 Apr 24;11(489). pii: eaar6584. doi: 10.1126/scitranslmed.aar6584.


Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.

Varkey R, Du Q, Karnell JL, Xiao X, Casey KA, Woods R, Rosenthal K, Wilson S, Dall'Acqua WF, Wu H, Herbst R, Ettinger R, Damschroder M.

PLoS One. 2019 Jan 25;14(1):e0211236. doi: 10.1371/journal.pone.0211236. eCollection 2019.


Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond.

Karnell JL, Rieder SA, Ettinger R, Kolbeck R.

Adv Drug Deliv Rev. 2019 Feb 15;141:92-103. doi: 10.1016/j.addr.2018.12.005. Epub 2018 Dec 13. Review.


IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.

Wang S, Wang J, Kumar V, Karnell JL, Naiman B, Gross PS, Rahman S, Zerrouki K, Hanna R, Morehouse C, Holoweckyj N, Liu H; Autoimmunity Molecular Medicine Team, Manna Z, Goldbach-Mansky R, Hasni S, Siegel R, Sanjuan M, Streicher K, Cancro MP, Kolbeck R, Ettinger R.

Nat Commun. 2018 May 1;9(1):1758. doi: 10.1038/s41467-018-03750-7.


Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus.

Riggs JM, Hanna RN, Rajan B, Zerrouki K, Karnell JL, Sagar D, Vainshtein I, Farmer E, Rosenthal K, Morehouse C, de Los Reyes M, Schifferli K, Liang M, Sanjuan MA, Sims GP, Kolbeck R.

Lupus Sci Med. 2018 Apr 5;5(1):e000261. doi: 10.1136/lupus-2018-000261. eCollection 2018.


Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models.

Panda SK, Facchinetti V, Voynova E, Hanabuchi S, Karnell JL, Hanna RN, Kolbeck R, Sanjuan MA, Ettinger R, Liu YJ.

J Clin Invest. 2018 May 1;128(5):1873-1887. doi: 10.1172/JCI97333. Epub 2018 Apr 3.


Role of CD11c+ T-bet+ B cells in human health and disease.

Karnell JL, Kumar V, Wang J, Wang S, Voynova E, Ettinger R.

Cell Immunol. 2017 Nov;321:40-45. doi: 10.1016/j.cellimm.2017.05.008. Epub 2017 Jul 11. Review.


Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses.

Ettinger R, Karnell JL, Henault J, Panda SK, Riggs JM, Kolbeck R, Sanjuan MA.

Autoimmunity. 2017 Feb;50(1):25-36. doi: 10.1080/08916934.2017.1280670. Review.


Autoimmune manifestations in aged mice arise from early-life immune dysregulation.

Mahmoud TI, Wang J, Karnell JL, Wang Q, Wang S, Naiman B, Gross P, Brohawn PZ, Morehouse C, Aoyama J, Wasserfall C, Carter L, Atkinson MA, Serreze DV, Braley-Mullen H, Mustelin T, Kolbeck R, Herbst R, Ettinger R.

Sci Transl Med. 2016 Oct 19;8(361):361ra137.


Self-reactive IgE exacerbates interferon responses associated with autoimmunity.

Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA.

Nat Immunol. 2016 Feb;17(2):196-203. doi: 10.1038/ni.3326. Epub 2015 Dec 21.


Discerning the kinetics of autoimmune manifestations in a model of Sjögren's syndrome.

Karnell JL, Mahmoud TI, Herbst R, Ettinger R.

Mol Immunol. 2014 Dec;62(2):277-82. doi: 10.1016/j.molimm.2014.05.006. Epub 2014 Jun 5.


CD19 and CD32b differentially regulate human B cell responsiveness.

Karnell JL, Dimasi N, Karnell FG 3rd, Fleming R, Kuta E, Wilson M, Wu H, Gao C, Herbst R, Ettinger R.

J Immunol. 2014 Feb 15;192(4):1480-90. doi: 10.4049/jimmunol.1301361. Epub 2014 Jan 17.


Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease.

Finch DK, Ettinger R, Karnell JL, Herbst R, Sleeman MA.

Eur J Clin Invest. 2013 May;43(5):501-9. doi: 10.1111/eci.12063. Epub 2013 Mar 20. Review.


The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory.

Karnell JL, Ettinger R.

Front Immunol. 2012 Jan 24;3:2. doi: 10.3389/fimmu.2012.00002. eCollection 2012.


Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation.

Karnell JL, Karnell FG 3rd, Stephens GL, Rajan B, Morehouse C, Li Y, Swerdlow B, Wilson M, Goldbach-Mansky R, Groves C, Coyle AJ, Herbst R, Ettinger R.

J Immunol. 2011 Oct 1;187(7):3603-12. doi: 10.4049/jimmunol.1003319. Epub 2011 Aug 26.


Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.

Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA.

J Clin Invest. 2010 Jul;120(7):2497-507. doi: 10.1172/JCI42382.

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