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Items: 1 to 50 of 56

1.

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.

Weng T, Ko J, Masamha CP, Xia Z, Xiang Y, Chen NY, Molina JG, Collum S, Mertens TC, Luo F, Philip K, Davies J, Huang J, Wilson C, Thandavarayan RA, Bruckner BA, Jyothula SS, Volcik KA, Li L, Han L, Li W, Assassi S, Karmouty-Quintana H, Wagner EJ, Blackburn MR.

J Clin Invest. 2019 Feb 28;130. pii: 122106. doi: 10.1172/JCI122106.

2.

Alterations in cardiovascular function in an experimental model of lung fibrosis and pulmonary hypertension.

Darwiche T, Collum SD, Bi W, Reynolds JO, Wilson C, Wareing N, Hernandez AM, Mertens TCJ, Zhou Z, Pandit LM, Karmouty-Quintana H.

Exp Physiol. 2019 Jan 21. doi: 10.1113/EP087321. [Epub ahead of print]

PMID:
30663834
3.

Twik-2-/- mouse demonstrates pulmonary vascular heterogeneity in intracellular pathways for vasocontractility.

Kitagawa MG, Reynolds JO, Durgan D, Rodney G, Karmouty-Quintana H, Bryan R, Pandit LM.

Physiol Rep. 2019 Jan;7(1):e13950. doi: 10.14814/phy2.13950.

4.

Editorial: Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction.

Karmouty-Quintana H, Guignabert C, Kwapiszewska G, Ormiston ML.

Front Physiol. 2018 Dec 10;9:1777. doi: 10.3389/fphys.2018.01777. eCollection 2018. No abstract available.

5.

Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation.

Aherne CM, Collins CB, Rapp CR, Olli KE, Perrenoud L, Jedlicka P, Bowser JL, Mills TW, Karmouty-Quintana H, Blackburn MR, Eltzschig HK.

JCI Insight. 2018 Oct 18;3(20). pii: 121521. doi: 10.1172/jci.insight.121521.

6.

Low-dose administration of bleomycin leads to early alterations in lung mechanics.

Headley L, Bi W, Wilson C, Collum SD, Chavez M, Darwiche T, Mertens TCJ, Hernandez AM, Siddiqui SR, Rosenbaum S, Johnston RA, Karmouty-Quintana H.

Exp Physiol. 2018 Dec;103(12):1692-1703. doi: 10.1113/EP087322. Epub 2018 Oct 17.

PMID:
30260066
7.

Nanotherapeutics for Treatment of Pulmonary Arterial Hypertension.

Segura-Ibarra V, Wu S, Hassan N, Moran-Guerrero JA, Ferrari M, Guha A, Karmouty-Quintana H, Blanco E.

Front Physiol. 2018 Jul 13;9:890. doi: 10.3389/fphys.2018.00890. eCollection 2018. Review.

8.

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats.

Karuppagounder V, Bajpai A, Meng S, Arumugam S, Sreedhar R, Giridharan VV, Guha A, Bhimaraj A, Youker KA, Palaniyandi SS, Karmouty-Quintana H, Kamal F, Spiller KL, Watanabe K, Thandavarayan RA.

PLoS One. 2018 Jul 19;13(7):e0200697. doi: 10.1371/journal.pone.0200697. eCollection 2018.

9.

Early Career Members at the ERS International Congress 2017: highlights from the Assemblies.

Kahn N, Tomos I, Andrianopoulos V, Arikan H, van der Does A, Almendros I, Bonvivi S, Morgan A, Nenna R, Magouliotis D, Rutter M, De Soomer K, Nyberg A, Lundell S, Leceuvre K, Singanayagam A, Bostantzoglou C, Karmouty-Quintana H, De Brandt J.

Breathe (Sheff). 2017 Dec;13(4):e121-e129. doi: 10.1183/20734735.017617.

10.

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.

Mertens TCJ, Hanmandlu A, Tu L, Phan C, Collum SD, Chen NY, Weng T, Davies J, Liu C, Eltzschig HK, Jyothula SSK, Rajagopal K, Xia Y, Guha A, Bruckner BA, Blackburn MR, Guignabert C, Karmouty-Quintana H.

Front Physiol. 2018 Jun 1;9:555. doi: 10.3389/fphys.2018.00555. eCollection 2018.

11.

The Antifibrotic Effect of A2B Adenosine Receptor Antagonism in a Mouse Model of Dermal Fibrosis.

Karmouty-Quintana H, Molina JG, Philip K, Bellocchi C, Gudenkauf B, Wu M, Chen NY, Collum SD, Ko J, Agarwal SK, Assassi S, Zhong H, Blackburn MR, Weng T.

Arthritis Rheumatol. 2018 Oct;70(10):1673-1684. doi: 10.1002/art.40554. Epub 2018 Aug 6.

PMID:
29771006
12.

Transforming Growth Factor-β and Bone Morphogenetic Protein 2 Regulation of MicroRNA-200 Family in Chronic Pancreatitis.

Yu P, Liu K, Gao X, Karmouty-Quintana H, Bailey JM, Cao Y, Ko TC.

Pancreas. 2018 Feb;47(2):252-256. doi: 10.1097/MPA.0000000000000980.

13.

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.

Xiang Y, Ye Y, Lou Y, Yang Y, Cai C, Zhang Z, Mills T, Chen NY, Kim Y, Muge Ozguc F, Diao L, Karmouty-Quintana H, Xia Y, Kellems RE, Chen Z, Blackburn MR, Yoo SH, Shyu AB, Mills GB, Han L.

J Natl Cancer Inst. 2018 Apr 1;110(4):379-389. doi: 10.1093/jnci/djx223.

14.

P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata CK, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Lazarowski ER, Blackburn MR, Idzko M.

Front Immunol. 2017 Aug 22;8:1028. doi: 10.3389/fimmu.2017.01028. eCollection 2017.

15.

Loss of CD73-mediated extracellular adenosine production exacerbates inflammation and abnormal alveolar development in newborn mice exposed to prolonged hyperoxia.

Li H, Karmouty-Quintana H, Chen NY, Mills T, Molina J, Blackburn MR, Davies J.

Pediatr Res. 2017 Aug 23. doi: 10.1038/pr.2017.176. [Epub ahead of print]

PMID:
28832580
16.

HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.

Philip K, Mills TW, Davies J, Chen NY, Karmouty-Quintana H, Luo F, Molina JG, Amione-Guerra J, Sinha N, Guha A, Eltzschig HK, Blackburn MR.

FASEB J. 2017 Nov;31(11):4745-4758. doi: 10.1096/fj.201700219R. Epub 2017 Jul 12.

17.

Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis.

Collum SD, Chen NY, Hernandez AM, Hanmandlu A, Sweeney H, Mertens TCJ, Weng T, Luo F, Molina JG, Davies J, Horan IP, Morrell NW, Amione-Guerra J, Al-Jabbari O, Youker K, Sun W, Rajadas J, Bollyky PL, Akkanti BH, Jyothula S, Sinha N, Guha A, Karmouty-Quintana H.

Br J Pharmacol. 2017 Oct;174(19):3284-3301. doi: 10.1111/bph.13947. Epub 2017 Aug 17.

18.

Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases.

Mertens TCJ, Karmouty-Quintana H, Taube C, Hiemstra PS.

Pulm Pharmacol Ther. 2017 Aug;45:101-113. doi: 10.1016/j.pupt.2017.05.008. Epub 2017 May 11. Review.

PMID:
28502841
19.

The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata K, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Blackburn MR, Idzko M.

Oncotarget. 2017 May 30;8(22):35962-35972. doi: 10.18632/oncotarget.16414.

20.

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension.

Segura-Ibarra V, Amione-Guerra J, Cruz-Solbes AS, Cara FE, Iruegas-Nunez DA, Wu S, Youker KA, Bhimaraj A, Torre-Amione G, Ferrari M, Karmouty-Quintana H, Guha A, Blanco E.

Int J Pharm. 2017 May 30;524(1-2):257-267. doi: 10.1016/j.ijpharm.2017.03.069. Epub 2017 Mar 28.

PMID:
28359821
21.

Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives.

Collum SD, Amione-Guerra J, Cruz-Solbes AS, DiFrancesco A, Hernandez AM, Hanmandlu A, Youker K, Guha A, Karmouty-Quintana H.

Can Respir J. 2017;2017:1430350. doi: 10.1155/2017/1430350. Epub 2017 Feb 13. Review.

22.

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.

Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y.

Nat Commun. 2017 Feb 7;8:14108. doi: 10.1038/ncomms14108.

23.

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.

Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y.

Circulation. 2016 Aug 2;134(5):405-21. doi: 10.1161/CIRCULATIONAHA.116.021311.

24.

Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.

Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y.

Cell Rep. 2016 Jun 28;16(1):106-119. doi: 10.1016/j.celrep.2016.05.080. Epub 2016 Jun 16.

25.

Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension.

Chen NY, D Collum S, Luo F, Weng T, Le TT, M Hernandez A, Philip K, Molina JG, Garcia-Morales LJ, Cao Y, Ko TC, Amione-Guerra J, Al-Jabbari O, Bunge RR, Youker K, Bruckner BA, Hamid R, Davies J, Sinha N, Karmouty-Quintana H.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L238-54. doi: 10.1152/ajplung.00142.2016. Epub 2016 Jun 17.

26.

Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.

Wirsdörfer F, de Leve S, Cappuccini F, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn MR, Westendorf AM, Stuschke M, Jendrossek V.

Cancer Res. 2016 May 15;76(10):3045-56. doi: 10.1158/0008-5472.CAN-15-2310. Epub 2016 Feb 26.

27.

Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis.

Luo F, Le NB, Mills T, Chen NY, Karmouty-Quintana H, Molina JG, Davies J, Philip K, Volcik KA, Liu H, Xia Y, Eltzschig HK, Blackburn MR.

FASEB J. 2016 Feb;30(2):874-83. doi: 10.1096/fj.15-274845. Epub 2015 Nov 2.

28.

Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension.

Garcia-Morales LJ, Chen NY, Weng T, Luo F, Davies J, Philip K, Volcik KA, Melicoff E, Amione-Guerra J, Bunge RR, Bruckner BA, Loebe M, Eltzschig HK, Pandit LM, Blackburn MR, Karmouty-Quintana H.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):574-83. doi: 10.1165/rcmb.2015-0145OC.

29.

STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation.

Pedroza M, Le TT, Lewis K, Karmouty-Quintana H, To S, George AT, Blackburn MR, Tweardy DJ, Agarwal SK.

FASEB J. 2016 Jan;30(1):129-40. doi: 10.1096/fj.15-273953. Epub 2015 Aug 31.

30.

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.

Hoegl S, Brodsky KS, Blackburn MR, Karmouty-Quintana H, Zwissler B, Eltzschig HK.

J Immunol. 2015 Aug 15;195(4):1815-24. doi: 10.4049/jimmunol.1401957. Epub 2015 Jul 17.

31.

Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis.

Weng T, Poth JM, Karmouty-Quintana H, Garcia-Morales LJ, Melicoff E, Luo F, Chen NY, Evans CM, Bunge RR, Bruckner BA, Loebe M, Volcik KA, Eltzschig HK, Blackburn MR.

Am J Respir Crit Care Med. 2014 Dec 15;190(12):1402-12. doi: 10.1164/rccm.201404-0744OC.

32.

Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension.

Karmouty-Quintana H, Philip K, Acero LF, Chen NY, Weng T, Molina JG, Luo F, Davies J, Le NB, Bunge I, Volcik KA, Le TT, Johnston RA, Xia Y, Eltzschig HK, Blackburn MR.

FASEB J. 2015 Jan;29(1):50-60. doi: 10.1096/fj.14-260182. Epub 2014 Oct 15.

33.

Adenosine promotes vascular barrier function in hyperoxic lung injury.

Davies J, Karmouty-Quintana H, Le TT, Chen NY, Weng T, Luo F, Molina J, Moorthy B, Blackburn MR.

Physiol Rep. 2014 Sep 28;2(9). pii: e12155. doi: 10.14814/phy2.12155. Print 2014 Sep 1.

34.

Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis.

Le TT, Karmouty-Quintana H, Melicoff E, Le TT, Weng T, Chen NY, Pedroza M, Zhou Y, Davies J, Philip K, Molina J, Luo F, George AT, Garcia-Morales LJ, Bunge RR, Bruckner BA, Loebe M, Seethamraju H, Agarwal SK, Blackburn MR.

J Immunol. 2014 Oct 1;193(7):3755-68. doi: 10.4049/jimmunol.1302470. Epub 2014 Aug 29.

35.

Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.

Dahm PH, Richards JB, Karmouty-Quintana H, Cromar KR, Sur S, Price RE, Malik F, Spencer CY, Barreno RX, Hashmi SS, Blackburn MR, Haque IU, Johnston RA.

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15;307(6):R621-33. doi: 10.1152/ajpregu.00205.2014. Epub 2014 Jul 9.

36.

Muc5b is required for airway defence.

Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM.

Nature. 2014 Jan 16;505(7483):412-6. doi: 10.1038/nature12807. Epub 2013 Dec 8.

37.

Adenosine A2B receptor and hyaluronan modulate pulmonary hypertension associated with chronic obstructive pulmonary disease.

Karmouty-Quintana H, Weng T, Garcia-Morales LJ, Chen NY, Pedroza M, Zhong H, Molina JG, Bunge R, Bruckner BA, Xia Y, Johnston RA, Loebe M, Zeng D, Seethamraju H, Belardinelli L, Blackburn MR.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1038-47. doi: 10.1165/rcmb.2013-0089OC.

38.

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease.

Weng T, Karmouty-Quintana H, Garcia-Morales LJ, Molina JG, Pedroza M, Bunge RR, Bruckner BA, Loebe M, Seethamraju H, Blackburn MR.

FASEB J. 2013 May;27(5):2013-26. doi: 10.1096/fj.12-222067. Epub 2013 Feb 7.

39.

Adenosine signaling during acute and chronic disease states.

Karmouty-Quintana H, Xia Y, Blackburn MR.

J Mol Med (Berl). 2013 Feb;91(2):173-81. doi: 10.1007/s00109-013-0997-1. Epub 2013 Jan 23. Review.

40.

Immunomodulatory effects of feeding with Bifidobacterium longum on allergen-induced lung inflammation in the mouse.

MacSharry J, O'Mahony C, Shalaby KH, Sheil B, Karmouty-Quintana H, Shanahan F, Martin JG.

Pulm Pharmacol Ther. 2012 Aug;25(4):325-34. doi: 10.1016/j.pupt.2012.05.011. Epub 2012 Jun 13.

PMID:
22705947
41.

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease.

Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR.

FASEB J. 2012 Jun;26(6):2546-57. doi: 10.1096/fj.11-200907. Epub 2012 Mar 13.

42.

Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.

Karmouty-Quintana H, Siddiqui S, Hassan M, Tsuchiya K, Risse PA, Xicota-Vila L, Marti-Solano M, Martin JG.

Am J Physiol Lung Cell Mol Physiol. 2012 Apr 15;302(8):L736-45. doi: 10.1152/ajplung.00050.2011. Epub 2012 Jan 27.

43.

Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.

Pedroza M, Schneider DJ, Karmouty-Quintana H, Coote J, Shaw S, Corrigan R, Molina JG, Alcorn JL, Galas D, Gelinas R, Blackburn MR.

PLoS One. 2011;6(7):e22667. doi: 10.1371/journal.pone.0022667. Epub 2011 Jul 25.

44.

Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycin-induced lung injury.

Zhou Y, Schneider DJ, Morschl E, Song L, Pedroza M, Karmouty-Quintana H, Le T, Sun CX, Blackburn MR.

J Immunol. 2011 Jan 15;186(2):1097-106. doi: 10.4049/jimmunol.1002907. Epub 2010 Dec 13.

45.

Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma.

McGovern TK, Powell WS, Day BJ, White CW, Govindaraju K, Karmouty-Quintana H, Lavoie N, Tan JJ, Martin JG.

Respir Res. 2010 Oct 6;11:138. doi: 10.1186/1465-9921-11-138.

46.

Sustained steroid release in pulmonary inflammation model.

Karmouty-Quintana H, Tamimi F, McGovern TK, Grover LM, Martin JG, Barralet JE.

Biomaterials. 2010 Aug;31(23):6050-9. doi: 10.1016/j.biomaterials.2010.04.025. Epub 2010 May 15.

PMID:
20472285
47.

In vivo assessments of mucus dynamics in the rat lung using a Gd-Cy5.5-bilabeled contrast agent for magnetic resonance and optical imaging.

Blé FX, Schmidt P, Cannet C, Kneuer R, Karmouty-Quintana H, Bergmann R, Coote K, Danahay H, Zurbruegg S, Gremlich HU, Beckmann N.

Magn Reson Med. 2009 Nov;62(5):1164-74. doi: 10.1002/mrm.22130.

48.

Time course of airway remodelling after an acute chlorine gas exposure in mice.

Tuck SA, Ramos-Barbón D, Campbell H, McGovern T, Karmouty-Quintana H, Martin JG.

Respir Res. 2008 Aug 14;9:61. doi: 10.1186/1465-9921-9-61.

49.

Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging.

Blé FX, Cannet C, Zurbruegg S, Karmouty-Quintana H, Bergmann R, Frossard N, Trifilieff A, Beckmann N.

Radiology. 2008 Sep;248(3):834-43. doi: 10.1148/radiol.2482071452. Epub 2008 Jul 22.

PMID:
18647843
50.

In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.

Karmouty-Quintana H, Blé FX, Cannet C, Zurbruegg S, Fozard JR, Page CP, Beckmann N.

Br J Pharmacol. 2008 Jul;154(5):1063-72. doi: 10.1038/bjp.2008.174. Epub 2008 May 12.

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