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Items: 1 to 50 of 223

1.

Ginseng for the treatment of diabetes and diabetes-related cardiovascular complications: a discussion of the evidence 1.

Karmazyn M, Gan XT.

Can J Physiol Pharmacol. 2019 Apr;97(4):265-276. doi: 10.1139/cjpp-2018-0440. Epub 2018 Nov 5. Review.

PMID:
30395481
2.

Leptin-induced cardiomyocyte hypertrophy is associated with enhanced mitochondrial fission.

Jong CJ, Yeung J, Tseung E, Karmazyn M.

Mol Cell Biochem. 2019 Apr;454(1-2):33-44. doi: 10.1007/s11010-018-3450-5. Epub 2018 Sep 24.

PMID:
30251118
3.

Cardioprotection by ginseng: experimental and clinical evidence and underlying mechanisms.

Gan XT, Karmazyn M.

Can J Physiol Pharmacol. 2018 Sep;96(9):859-868. doi: 10.1139/cjpp-2018-0192. Epub 2018 Jun 25. Review.

PMID:
29940129
4.
5.

Treatment of the cardiac hypertrophic response and heart failure with ginseng, ginsenosides, and ginseng-related products.

Karmazyn M, Gan XT.

Can J Physiol Pharmacol. 2017 Oct;95(10):1170-1176. doi: 10.1139/cjpp-2017-0092. Epub 2017 May 15. Review.

PMID:
28505464
6.

North American ginseng (Panax quinquefolius) suppresses β-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction.

Tang X, Gan XT, Rajapurohitam V, Huang CX, Xue J, Lui EM, Karmazyn M.

Can J Physiol Pharmacol. 2016 Dec;94(12):1325-1335. Epub 2016 Aug 17.

PMID:
27797280
7.

Cardiomyocyte Antihypertrophic Effect of Adipose Tissue Conditioned Medium from Rats and Its Abrogation by Obesity is Mediated by the Leptin to Adiponectin Ratio.

Bairwa SC, Rajapurohitam V, Gan XT, Mangat R, Proctor SD, Karmazyn M.

PLoS One. 2016 Jan 5;11(1):e0145992. doi: 10.1371/journal.pone.0145992. eCollection 2016.

8.

Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.

Gan XT, Rajapurohitam V, Xue J, Huang C, Bairwa S, Tang X, Chow JT, Liu MF, Chiu F, Sakamoto K, Wagner KU, Karmazyn M.

Am J Pathol. 2015 Dec;185(12):3202-10. doi: 10.1016/j.ajpath.2015.08.007.

9.

Identification of functional leptin receptors expressed in ventricular mitochondria.

Martinez-Abundis E, Rajapurohitam V, Gertler A, Karmazyn M.

Mol Cell Biochem. 2015 Oct;408(1-2):155-62. doi: 10.1007/s11010-015-2491-2. Epub 2015 Jun 30.

PMID:
26122392
10.

Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation.

Kilić A, Huang CX, Rajapurohitam V, Madwed JB, Karmazyn M.

J Pharmacol Exp Ther. 2014 Dec;351(3):492-9. doi: 10.1124/jpet.114.217091. Epub 2014 Sep 12.

PMID:
25216745
11.

CD73-TNAP crosstalk regulates the hypertrophic response and cardiomyocyte calcification due to α1 adrenoceptor activation.

Gan XT, Taniai S, Zhao G, Huang CX, Velenosi TJ, Xue J, Urquhart BL, Karmazyn M.

Mol Cell Biochem. 2014 Sep;394(1-2):237-46. doi: 10.1007/s11010-014-2100-9. Epub 2014 Jun 4.

PMID:
24894822
12.

Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat.

Gan XT, Ettinger G, Huang CX, Burton JP, Haist JV, Rajapurohitam V, Sidaway JE, Martin G, Gloor GB, Swann JR, Reid G, Karmazyn M.

Circ Heart Fail. 2014 May;7(3):491-9. doi: 10.1161/CIRCHEARTFAILURE.113.000978. Epub 2014 Mar 13.

PMID:
24625365
13.

The potential contribution of circulating and locally produced leptin to cardiac hypertrophy and failure.

Karmazyn M, Gan XT, Rajapurohitam V.

Can J Physiol Pharmacol. 2013 Nov;91(11):883-8. doi: 10.1139/cjpp-2013-0057. Epub 2013 May 8. Review.

PMID:
24117255
14.

Prevention of RhoA activation and cofilin-mediated actin polymerization mediates the antihypertrophic effect of adenosine receptor agonists in angiotensin II- and endothelin-1-treated cardiomyocytes.

Zeidan A, Gan XT, Thomas A, Karmazyn M.

Mol Cell Biochem. 2014 Jan;385(1-2):239-48. doi: 10.1007/s11010-013-1832-2. Epub 2013 Oct 6.

PMID:
24096734
15.

Identification of fat mass and obesity associated (FTO) protein expression in cardiomyocytes: regulation by leptin and its contribution to leptin-induced hypertrophy.

Gan XT, Zhao G, Huang CX, Rowe AC, Purdham DM, Karmazyn M.

PLoS One. 2013 Sep 3;8(9):e74235. doi: 10.1371/journal.pone.0074235. eCollection 2013.

16.

Leptin as a cardiac pro-hypertrophic factor and its potential role in the development of heart failure.

Karmazyn M, Rajapurohitam V.

Curr Pharm Des. 2014;20(4):646-51. Review.

PMID:
23688017
17.

A model of poorly controlled type 1 Diabetes Mellitus and its treatment with aerobic exercise training.

Melling CW, Grisé KN, Hasilo CP, Fier B, Milne KJ, Karmazyn M, Noble EG.

Diabetes Metab. 2013 May;39(3):226-35. doi: 10.1016/j.diabet.2013.02.004. Epub 2013 Mar 19.

PMID:
23522732
18.

NHE-1: still a viable therapeutic target.

Karmazyn M.

J Mol Cell Cardiol. 2013 Aug;61:77-82. doi: 10.1016/j.yjmcc.2013.02.006. Epub 2013 Feb 18. Review.

PMID:
23429008
19.

Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation.

Rajapurohitam V, Izaddoustdar F, Martinez-Abundis E, Karmazyn M.

Cell Signal. 2012 Dec;24(12):2283-90. doi: 10.1016/j.cellsig.2012.07.025. Epub 2012 Aug 15.

PMID:
22917533
20.

The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis.

Martinez-Abundis E, Rajapurohitam V, Haist JV, Gan XT, Karmazyn M.

PLoS One. 2012;7(7):e41612. doi: 10.1371/journal.pone.0041612. Epub 2012 Jul 25.

21.

Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.

Huber JD, Bentzien J, Boyer SJ, Burke J, De Lombaert S, Eickmeier C, Guo X, Haist JV, Hickey ER, Kaplita P, Karmazyn M, Kemper R, Kennedy CA, Kirrane T, Madwed JB, Mainolfi E, Nagaraja N, Soleymanzadeh F, Swinamer A, Eldrup AB.

J Med Chem. 2012 Aug 23;55(16):7114-40. doi: 10.1021/jm300601d. Epub 2012 Aug 6.

PMID:
22803959
22.

Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.

Ma J, Wei M, Wang Q, Li J, Wang H, Liu W, Lacefield JC, Greer PA, Karmazyn M, Fan GC, Peng T.

J Biol Chem. 2012 Aug 10;287(33):27480-9. doi: 10.1074/jbc.M112.358929. Epub 2012 Jun 29.

23.

Ginseng reverses established cardiomyocyte hypertrophy and postmyocardial infarction-induced hypertrophy and heart failure.

Moey M, Gan XT, Huang CX, Rajapurohitam V, Martínez-Abundis E, Lui EM, Karmazyn M.

Circ Heart Fail. 2012 Jul 1;5(4):504-14. doi: 10.1161/CIRCHEARTFAILURE.112.967489. Epub 2012 May 10.

PMID:
22576957
24.

Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy.

Rajapurohitam V, Kilic A, Javadov S, Karmazyn M.

Mol Cell Biochem. 2012 Jul;366(1-2):287-97. doi: 10.1007/s11010-012-1307-x. Epub 2012 Apr 20.

PMID:
22527934
25.

Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation.

Gan XT, Hunter JC, Huang C, Xue J, Rajapurohitam V, Javadov S, Karmazyn M.

Mol Cell Biochem. 2012 Apr;363(1-2):323-33. doi: 10.1007/s11010-011-1185-7. Epub 2011 Dec 10.

PMID:
22160804
26.

Therapeutic potential of ginseng in the management of cardiovascular disorders.

Karmazyn M, Moey M, Gan XT.

Drugs. 2011 Oct 22;71(15):1989-2008. doi: 10.2165/11594300-000000000-00000. Review.

PMID:
21985167
28.

Activated NHE1 is required to induce early cardiac hypertrophy in mice.

Mraiche F, Oka T, Gan XT, Karmazyn M, Fliegel L.

Basic Res Cardiol. 2011 Jun;106(4):603-16. doi: 10.1007/s00395-011-0161-4. Epub 2011 Feb 27.

PMID:
21359875
29.

mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy.

Zeidan A, Hunter JC, Javadov S, Karmazyn M.

Mol Cell Biochem. 2011 Jun;352(1-2):99-108. doi: 10.1007/s11010-011-0744-2. Epub 2011 Feb 13.

PMID:
21318349
30.

Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation.

Guo J, Gan XT, Haist JV, Rajapurohitam V, Zeidan A, Faruq NS, Karmazyn M.

Circ Heart Fail. 2011 Jan;4(1):79-88. doi: 10.1161/CIRCHEARTFAILURE.110.957969. Epub 2010 Oct 22.

PMID:
20971938
31.

Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition.

Javadov S, Rajapurohitam V, Kilić A, Hunter JC, Zeidan A, Said Faruq N, Escobales N, Karmazyn M.

Basic Res Cardiol. 2011 Jan;106(1):99-109. doi: 10.1007/s00395-010-0122-3. Epub 2010 Oct 1.

PMID:
20886221
32.

A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway.

Kilic A, Rajapurohitam V, Sandberg SM, Zeidan A, Hunter JC, Said Faruq N, Lee CY, Burnett JC Jr, Karmazyn M.

Cardiovasc Res. 2010 Dec 1;88(3):434-42. doi: 10.1093/cvr/cvq254. Epub 2010 Aug 2.

33.

Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.

Xue J, Mraiche F, Zhou D, Karmazyn M, Oka T, Fliegel L, Haddad GG.

Physiol Genomics. 2010 Aug;42(3):374-83. doi: 10.1152/physiolgenomics.00064.2010. Epub 2010 May 11.

34.

Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes.

Pang T, Rajapurohitam V, Cook MA, Karmazyn M.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1382-90. doi: 10.1152/ajpheart.00424.2009. Epub 2010 Feb 26.

35.

Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.

Pang T, Gan XT, Freeman DJ, Cook MA, Karmazyn M.

Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H545-53. doi: 10.1152/ajpheart.00417.2009. Epub 2009 Dec 4.

36.

Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.

Hunter JC, Zeidan A, Javadov S, Kilić A, Rajapurohitam V, Karmazyn M.

J Mol Cell Cardiol. 2009 Dec;47(6):810-8. doi: 10.1016/j.yjmcc.2009.09.012. Epub 2009 Sep 30.

PMID:
19799911
37.

Sodium-hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytes.

Gan XT, Gong XQ, Xue J, Haist JV, Bai D, Karmazyn M.

Cardiovasc Res. 2010 Jan 1;85(1):79-89. doi: 10.1093/cvr/cvp283. Erratum in: Cardiovasc Res. 2018 Feb 1;114(2):311.

PMID:
19687166
38.

Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases.

Javadov S, Karmazyn M, Escobales N.

J Pharmacol Exp Ther. 2009 Sep;330(3):670-8. doi: 10.1124/jpet.109.153213. Epub 2009 Jun 9.

PMID:
19509316
39.

Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease.

Majumdar P, Chen S, George B, Sen S, Karmazyn M, Chakrabarti S.

Diabetes Metab Res Rev. 2009 Jul;25(5):452-63. doi: 10.1002/dmrr.964.

PMID:
19391127
40.

Endothelial nitric oxide synthase promotes bone marrow stromal cell migration to the ischemic myocardium via upregulation of stromal cell-derived factor-1alpha.

Li N, Lu X, Zhao X, Xiang FL, Xenocostas A, Karmazyn M, Feng Q.

Stem Cells. 2009 Apr;27(4):961-70. doi: 10.1002/stem.6. Erratum in: Stem Cells. 2013 May;31(5):1030.

41.

Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.

Javadov S, Rajapurohitam V, Kilić A, Zeidan A, Choi A, Karmazyn M.

J Mol Cell Cardiol. 2009 Jun;46(6):998-1007. doi: 10.1016/j.yjmcc.2008.12.023. Epub 2009 Jan 20.

PMID:
19318234
42.

Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy.

Kilić A, Javadov S, Karmazyn M.

J Mol Cell Cardiol. 2009 Mar;46(3):360-9. doi: 10.1016/j.yjmcc.2008.11.018. Epub 2008 Dec 10.

PMID:
19111554
43.

Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways.

Stanbouly S, Kirshenbaum LA, Jones DL, Karmazyn M.

J Pharmacol Exp Ther. 2008 Oct;327(1):105-13. doi: 10.1124/jpet.108.140228. Epub 2008 Jul 23.

PMID:
18650245
44.

Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart.

Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A.

Cardiovasc Res. 2008 Jul 15;79(2):279-86. doi: 10.1093/cvr/cvn115. Epub 2008 May 12. Review.

PMID:
18474523
45.

A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart.

Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, Karmazyn M.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H441-6. doi: 10.1152/ajpheart.91537.2007. Epub 2008 May 9.

46.

The role of NHE-1 in myocardial hypertrophy and remodelling.

Karmazyn M, Kilić A, Javadov S.

J Mol Cell Cardiol. 2008 Apr;44(4):647-53. doi: 10.1016/j.yjmcc.2008.01.005. Epub 2008 Feb 9. Review.

PMID:
18329039
47.

Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia.

Chen L, Zhang J, Gan TX, Chen-Izu Y, Hasday JD, Karmazyn M, Balke CW, Scharf SM.

J Appl Physiol (1985). 2008 Jan;104(1):218-23. Epub 2007 Nov 15.

48.

Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei.

Zeidan A, Javadov S, Chakrabarti S, Karmazyn M.

Cardiovasc Res. 2008 Jan;77(1):64-72. Epub 2007 Sep 19.

PMID:
18006472
49.

NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.

Javadov S, Choi A, Rajapurohitam V, Zeidan A, Basnakian AG, Karmazyn M.

Cardiovasc Res. 2008 Jan 15;77(2):416-24. Epub 2007 Oct 18.

PMID:
18006455
50.

Leptin as a cardiac hypertrophic factor: a potential target for therapeutics.

Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A.

Trends Cardiovasc Med. 2007 Aug;17(6):206-11. Review.

PMID:
17662916

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