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Items: 15

1.

Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.

Li L, Okumu A, Dellos-Nolan S, Li Z, Karmahapatra S, English A, Yalowich JC, Wozniak DJ, Mitton-Fry MJ.

Bioorg Med Chem Lett. 2018 Aug 1;28(14):2477-2480. doi: 10.1016/j.bmcl.2018.06.003. Epub 2018 Jun 1.

PMID:
29871847
2.

Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR.

Bioorg Med Chem. 2018 May 15;26(9):2354-2364. doi: 10.1016/j.bmc.2018.03.033. Epub 2018 Mar 23.

PMID:
29656990
3.

The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform.

Kanagasabai R, Karmahapatra S, Kientz CA, Yu Y, Hernandez VA, Kania EE, Yalowich JC, Elton TS.

Mol Pharmacol. 2018 May;93(5):515-525. doi: 10.1124/mol.117.111567. Epub 2018 Mar 7.

PMID:
29514855
4.

Capsicodendrin from Cinnamosma fragrans Exhibits Antiproliferative and Cytotoxic Activity in Human Leukemia Cells: Modulation by Glutathione.

Karmahapatra S, Kientz C, Shetty S, Yalowich JC, Rakotondraibe LH.

J Nat Prod. 2018 Mar 23;81(3):625-629. doi: 10.1021/acs.jnatprod.7b00887. Epub 2018 Feb 6.

PMID:
29406734
5.

Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform.

Kanagasabai R, Serdar L, Karmahapatra S, Kientz CA, Ellis J, Ritke MK, Elton TS, Yalowich JC.

J Pharmacol Exp Ther. 2017 Jan;360(1):152-163. Epub 2016 Nov 10.

6.

Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.

Hasinoff BB, Wu X, Patel D, Kanagasabai R, Karmahapatra S, Yalowich JC.

J Pharmacol Exp Ther. 2016 Feb;356(2):397-409. doi: 10.1124/jpet.115.228650. Epub 2015 Dec 11.

7.

Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.

Dixon M, Woodrick J, Gupta S, Karmahapatra SK, Devito S, Vasudevan S, Dakshanamurthy S, Adhikari S, Yenugonda VM, Roy R.

Bioorg Med Chem. 2015 Mar 1;23(5):1102-11. doi: 10.1016/j.bmc.2014.12.067. Epub 2015 Jan 17. Erratum in: Bioorg Med Chem. 2015 Aug 1;23(15):5077.

8.

Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations.

Adhikari S, Chetram MA, Woodrick J, Mitra PS, Manthena PV, Khatkar P, Dakshanamurthy S, Dixon M, Karmahapatra SK, Nuthalapati NK, Gupta S, Narasimhan G, Mazumder R, Loffredo CA, Üren A, Roy R.

J Biol Chem. 2015 Feb 20;290(8):4966-80. doi: 10.1074/jbc.M114.627000. Epub 2014 Dec 23.

9.

Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis.

Karmahapatra SK, Saha T, Adhikari S, Woodrick J, Roy R.

Mol Cell Biochem. 2014 Mar;388(1-2):185-93. doi: 10.1007/s11010-013-1909-y. Epub 2013 Dec 15.

10.

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction.

Adhikari S, Karmahapatra SK, Karve TM, Bandyopadhyay S, Woodrick J, Manthena PV, Glasgow E, Byers S, Saha T, Uren A.

BMC Res Notes. 2012 Mar 9;5:134. doi: 10.1186/1756-0500-5-134.

11.

Alteration of some cellular function in amikacin resistant Pseudomonas aeruginosa transfected macrophages: a time dependent approach.

Chakraborty SP, Karmahapatra S, Das S, Roy S.

Asian Pac J Trop Biomed. 2011 Dec;1(6):482-7. doi: 10.1016/S2221-1691(11)60105-6.

12.

A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease.

Adhikari S, Manthena PV, Kota KK, Karmahapatra SK, Roy G, Saxena R, Uren A, Roy R.

Mol Cell Biochem. 2012 Mar;362(1-2):195-201. doi: 10.1007/s11010-011-1142-5. Epub 2011 Nov 1.

13.

TLR signaling-mediated differential histone modification at IL-10 and IL-12 promoter region leads to functional impairments in tumor-associated macrophages.

Banerjee S, Halder K, Bose A, Bhattacharya P, Gupta G, Karmahapatra S, Das S, Chaudhuri S, Bhattacharyya Majumdar S, Majumdar S.

Carcinogenesis. 2011 Dec;32(12):1789-97. doi: 10.1093/carcin/bgr208. Epub 2011 Sep 16.

PMID:
21926109
14.

Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress.

Chakraborty SP, Karmahapatra S, Sahu SK, Pramanik P, Roy S.

Patholog Res Int. 2011;2011:420198. doi: 10.4061/2011/420198. Epub 2011 Jul 20.

15.

Development of a novel assay for human tyrosyl DNA phosphodiesterase 2.

Adhikari S, Karmahapatra SK, Elias H, Dhopeshwarkar P, Williams RS, Byers S, Uren A, Roy R.

Anal Biochem. 2011 Sep 1;416(1):112-6. doi: 10.1016/j.ab.2011.05.008. Epub 2011 May 12.

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