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Items: 32


Comparison of the impact of bovine milk β-casein variants on digestive comfort in females self-reporting dairy intolerance: a randomized controlled trial.

Milan AM, Shrestha A, Karlström HJ, Martinsson JA, Nilsson NJ, Perry JK, Day L, Barnett MPG, Cameron-Smith D.

Am J Clin Nutr. 2020 Jan 1;111(1):149-160. doi: 10.1093/ajcn/nqz279.


Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

Coupland K, Lendahl U, Karlström H.

Stroke. 2018 Nov;49(11):2793-2800. doi: 10.1161/STROKEAHA.118.021560. Review. No abstract available.


Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression.

Panahi M, Yousefi Mesri N, Samuelsson EB, Coupland KG, Forsell C, Graff C, Tikka S, Winblad B, Viitanen M, Karlström H, Sundström E, Behbahani H.

J Cell Mol Med. 2018 Jun;22(6):3016-3024. doi: 10.1111/jcmm.13534. Epub 2018 Mar 13.


Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.

Stanga S, Vrancx C, Tasiaux B, Marinangeli C, Karlström H, Kienlen-Campard P.

J Cell Mol Med. 2018 Feb;22(2):823-833. doi: 10.1111/jcmm.13364. Epub 2017 Oct 10.


Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production.

Leal NS, Schreiner B, Pinho CM, Filadi R, Wiehager B, Karlström H, Pizzo P, Ankarcrona M.

J Cell Mol Med. 2016 Sep;20(9):1686-95. doi: 10.1111/jcmm.12863. Epub 2016 May 20.


Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

Wanngren J, Lara P, Ojemalm K, Maioli S, Moradi N, Chen L, Tjernberg LO, Lundkvist J, Nilsson I, Karlström H.

FEBS Open Bio. 2014 Apr 24;4:393-406. doi: 10.1016/j.fob.2014.04.006. eCollection 2014.


Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.

Schedin-Weiss S, Inoue M, Teranishi Y, Yamamoto NG, Karlström H, Winblad B, Tjernberg LO.

PLoS One. 2013 May 24;8(5):e63962. doi: 10.1371/journal.pone.0063962. Print 2013.


Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.

Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A, Lund J, Arvidsson PI, De Strooper B, Lendahl U, Lundkvist J.

J Neurosci. 2012 Nov 28;32(48):17297-305. doi: 10.1523/JNEUROSCI.1451-12.2012.


Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.

Wanngren J, Ottervald J, Parpal S, Portelius E, Strömberg K, Borgegård T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlström H.

J Biol Chem. 2012 Sep 21;287(39):32640-50. Epub 2012 Jul 31.


Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.

Hedskog L, Brohede J, Wiehager B, Pinho CM, Revathikumar P, Lilius L, Glaser E, Graff C, Karlström H, Ankarcrona M.

J Alzheimers Dis. 2012;31(3):527-36. doi: 10.3233/JAD-2012-120580.


Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Pamrén A, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Näslund J, Karlström H.

J Biol Chem. 2011 Sep 9;286(36):31153-8. doi: 10.1074/jbc.C111.235267. Epub 2011 Jul 18.


Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.

Frånberg J, Svensson AI, Winblad B, Karlström H, Frykman S.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):564-8. doi: 10.1016/j.bbrc.2010.12.029. Epub 2010 Dec 10.


γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.

Hedskog L, Petersen CA, Svensson AI, Welander H, Tjernberg LO, Karlström H, Ankarcrona M.

J Cell Mol Med. 2011 Oct;15(10):2150-63. doi: 10.1111/j.1582-4934.2010.01208.x.


Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.

Luty AA, Kwok JB, Dobson-Stone C, Loy CT, Coupland KG, Karlström H, Sobow T, Tchorzewska J, Maruszak A, Barcikowska M, Panegyres PK, Zekanowski C, Brooks WS, Williams KL, Blair IP, Mather KA, Sachdev PS, Halliday GM, Schofield PR.

Ann Neurol. 2010 Nov;68(5):639-49. doi: 10.1002/ana.22274.


gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.

Frånberg J, Karlström H, Winblad B, Tjernberg LO, Frykman S.

PLoS One. 2010 Mar 19;5(3):e9772. doi: 10.1371/journal.pone.0009772.


The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H.

J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27.


Variable phenotype of Alzheimer's disease with spastic paraparesis.

Karlstrom H, Brooks WS, Kwok JB, Broe GA, Kril JJ, McCann H, Halliday GM, Schofield PR.

J Neurochem. 2008 Feb;104(3):573-83. Epub 2007 Nov 6. Review.


No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis.

Karlstrom H, Kwok JB, Gregory GC, Hallupp M, Brooks WS, Schofield PR.

Neuroreport. 2007 Aug 6;18(12):1267-9.


Presenilin dependence of phospholipase C and protein kinase C signaling.

Dehvari N, Cedazo-Minguez A, Isacsson O, Nilsson T, Winblad B, Karlström H, Benedikz E, Cowburn RF.

J Neurochem. 2007 Aug;102(3):848-57. Epub 2007 Apr 16.


Generation and phenotypic characterization of a galanin overexpressing mouse.

Holmberg K, Kuteeva E, Brumovsky P, Kahl U, Karlström H, Lucas GA, Rodriguez J, Westerblad H, Hilke S, Theodorsson E, Berge OG, Lendahl U, Bartfai T, Hökfelt T.

Neuroscience. 2005;133(1):59-77.


Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

Lundkvist J, Zhu S, Hansson EM, Schweinhardt P, Miao Q, Beatus P, Dannaeus K, Karlström H, Johansson CB, Viitanen M, Rozell B, Spenger C, Mohammed A, Kalimo H, Lendahl U.

Genesis. 2005 Jan;41(1):13-22.


Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.

Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J.

J Biol Chem. 2004 Jun 4;279(23):23925-32. Epub 2004 Mar 29.


Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.

Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J.

J Neurochem. 2004 Apr;89(1):44-53.


APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J.

Exp Cell Res. 2003 Jul 1;287(1):1-9.


A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17119-24. Epub 2002 Dec 13.


Notch receptor cleavage depends on but is not directly executed by presenilins.

Taniguchi Y, Karlström H, Lundkvist J, Mizutani T, Otaka A, Vestling M, Bernstein A, Donoviel D, Lendahl U, Honjo T.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4014-9. Epub 2002 Mar 12.


A sensitive and quantitative assay for measuring cleavage of presenilin substrates.

Karlström H, Bergman A, Lendahl U, Näslund J, Lundkvist J.

J Biol Chem. 2002 Mar 1;277(9):6763-6. Epub 2001 Dec 13.


Generalized potential of adult neural stem cells.

Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlström H, Lendahl U, Frisén J.

Science. 2000 Jun 2;288(5471):1660-3.


Mapping of nrdA and nrdB in Escherichia coli K-12.

Fuchs JA, Karlström HO.

J Bacteriol. 1976 Dec;128(3):810-4.


A mutant of Escherichia coli defective in ribonucleosidediphosphate reductase. 2. Characterization of the enzymatic defect.

Fuchs JA, Karlström HO.

Eur J Biochem. 1973 Feb 1;32(3):457-62. No abstract available.


Defective gene product in dnaF mutant of Escherichia coli.

Fuchs JA, Karlström HO, Warner HR, Reichard P.

Nat New Biol. 1972 Jul 19;238(81):69-71. No abstract available.


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