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Items: 1 to 50 of 67

1.

i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.

Vural A, Nabar NR, Hwang IY, Sohn S, Park C, Karlsson MCI, Blumer JB, Kehrl JH.

J Immunol. 2019 Mar 1;202(5):1510-1520. doi: 10.4049/jimmunol.1801145. Epub 2019 Jan 25.

PMID:
30683698
2.

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.

Lloyd KA, Wigerblad G, Sahlström P, Garimella MG, Chemin K, Steen J, Titcombe PJ, Marklein B, Zhou D, Stålesen R, Ossipova E, Lundqvist C, Ekwall O, Rönnelid J, Mueller DL, Karlsson MCI, Kaplan MJ, Skriner K, Klareskog L, Wermeling F, Malmström V, Grönwall C.

Front Immunol. 2019 Jan 4;9:3033. doi: 10.3389/fimmu.2018.03033. eCollection 2018.

3.

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

Bönelt P, Wöhner M, Minnich M, Tagoh H, Fischer M, Jaritz M, Kavirayani A, Garimella M, Karlsson MC, Busslinger M.

EMBO J. 2019 Jan 15;38(2). pii: e100010. doi: 10.15252/embj.2018100010. Epub 2018 Nov 29.

4.

Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses.

Tripathi P, Sedimbi SK, Singh AK, Löfbom L, Issazadeh-Navikas S, Weiss S, Förster I, Karlsson MCI, Yrlid U, Kadri N, Cardell SL.

Eur J Immunol. 2019 Mar;49(3):443-453. doi: 10.1002/eji.201847647. Epub 2018 Dec 3.

PMID:
30427069
5.

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.

Gisterå A, Klement ML, Polyzos KA, Mailer RKW, Duhlin A, Karlsson MCI, Ketelhuth DFJ, Hansson GK.

Circulation. 2018 Nov 27;138(22):2513-2526. doi: 10.1161/CIRCULATIONAHA.118.034076.

6.

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.

Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, Dahdah A, Tibbitt CA, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI, Malin S.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):e145-e158. doi: 10.1161/ATVBAHA.118.310802.

7.

Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells-Brief Report.

Wilhelmson AS, Lantero Rodriguez M, Svedlund Eriksson E, Johansson I, Fogelstrand P, Stubelius A, Lindgren S, Fagman JB, Hansson GK, Carlsten H, Karlsson MCI, Ekwall O, Tivesten Å.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1519-1527. doi: 10.1161/ATVBAHA.118.311252. Epub 2018 May 31.

8.

Testosterone is an endogenous regulator of BAFF and splenic B cell number.

Wilhelmson AS, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler MB, Lianoglou S, Kapoor VN, Johansson ME, Fagman JB, Duhlin A, Tripathi P, Camponeschi A, Porse BT, Rolink AG, Nissbrandt H, Turley SJ, Carlsten H, Mårtensson IL, Karlsson MCI, Tivesten Å.

Nat Commun. 2018 May 25;9(1):2067. doi: 10.1038/s41467-018-04408-0.

9.

Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer.

La Fleur L, Boura VF, Alexeyenko A, Berglund A, Pontén V, Mattsson JSM, Djureinovic D, Persson J, Brunnström H, Isaksson J, Brandén E, Koyi H, Micke P, Karlsson MCI, Botling J.

Int J Cancer. 2018 Apr 18. doi: 10.1002/ijc.31545. [Epub ahead of print]

10.

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.

Chen X, Gustafsson S, Whitington T, Borné Y, Lorentzen E, Sun J, Almgren P, Su J, Karlsson R, Song J, Lu Y, Zhan Y, Hägg S, Svensson P, Smedby KE, Slager SL, Ingelsson E, Lindgren CM, Morris AP, Melander O, Karlsson T, de Faire U, Caidahl K, Engström G, Lind L, Karlsson MCI, Pedersen NL, Frostegård J, Magnusson PKE.

Hum Mol Genet. 2018 May 15;27(10):1809-1818. doi: 10.1093/hmg/ddy094.

PMID:
29547969
11.

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, Choi JH, Dosenovic P, Karlsson MCI, Beutler B, Karlsson Hedestam GB.

J Immunol. 2018 Jan 15;200(2):775-787. doi: 10.4049/jimmunol.1700791. Epub 2017 Dec 8.

12.

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.

Svedin E, Utorova R, Hühn MH, Larsson PG, Stone VM, Garimella M, Lind K, Hägglöf T, Pincikova T, Laitinen OH, McInerney GM, Scholte B, Hjelte L, Karlsson MCI, Flodström-Tullberg M.

J Infect Dis. 2017 Dec 5;216(10):1308-1317. doi: 10.1093/infdis/jix474.

13.

PPAR-γ promotes type 2 immune responses in allergy and nematode infection.

Chen T, Tibbitt CA, Feng X, Stark JM, Rohrbeck L, Rausch L, Sedimbi SK, Karlsson MCI, Lambrecht BN, Karlsson Hedestam GB, Hendriks RW, Chambers BJ, Nylén S, Coquet JM.

Sci Immunol. 2017 Mar 10;2(9). pii: eaal5196. doi: 10.1126/sciimmunol.aal5196.

PMID:
28783701
14.

Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.

Forsell MNE, Kvastad L, Sedimbi SK, Andersson J, Karlsson MCI.

Front Immunol. 2017 Jun 30;8:738. doi: 10.3389/fimmu.2017.00738. eCollection 2017.

15.

The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype.

Lundgren S, Karnevi E, Elebro J, Nodin B, Karlsson MCI, Eberhard J, Leandersson K, Jirström K.

J Transl Med. 2017 Jul 3;15(1):152. doi: 10.1186/s12967-017-1256-y.

16.

Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system.

Karlsson MC, Gonzalez SF, Welin J, Fuxe J.

Mol Oncol. 2017 Jul;11(7):781-791. doi: 10.1002/1878-0261.12092. Epub 2017 Jun 26. Review.

17.

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.

Hägglöf T, Sedimbi SK, Yates JL, Parsa R, Salas BH, Harris RA, Leadbetter EA, Karlsson MC.

Nat Immunol. 2016 Dec;17(12):1407-1414. doi: 10.1038/ni.3583. Epub 2016 Oct 31.

PMID:
27798616
18.

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes.

Hiltbrunner S, Larssen P, Eldh M, Martinez-Bravo MJ, Wagner AK, Karlsson MC, Gabrielsson S.

Oncotarget. 2016 Jun 21;7(25):38707-38717. doi: 10.18632/oncotarget.9585.

19.

Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development.

Duhlin A, Chen Y, Wermeling F, Sedimbi SK, Lindh E, Shinde R, Halaby MJ, Kaiser Y, Winqvist O, McGaha TL, Karlsson MC.

J Immunol. 2016 Oct 1;197(7):2618-26. doi: 10.4049/jimmunol.1401129. Epub 2016 Aug 24.

20.

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.

Prokopec KE, Georgoudaki AM, Sohn S, Wermeling F, Grönlund H, Lindh E, Carroll MC, Karlsson MC.

J Immunol. 2016 Sep 15;197(6):2063-8. doi: 10.4049/jimmunol.1502282. Epub 2016 Aug 15.

21.

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.

Parsa R, Lund H, Georgoudaki AM, Zhang XM, Ortlieb Guerreiro-Cacais A, Grommisch D, Warnecke A, Croxford AL, Jagodic M, Becher B, Karlsson MC, Harris RA.

J Exp Med. 2016 Jul 25;213(8):1537-53. doi: 10.1084/jem.20150577. Epub 2016 Jul 18.

22.

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.

Baptista MA, Keszei M, Oliveira M, Sunahara KK, Andersson J, Dahlberg CI, Worth AJ, Liedén A, Kuo IC, Wallin RP, Snapper SB, Eidsmo L, Scheynius A, Karlsson MC, Bouma G, Burns SO, Forsell MN, Thrasher AJ, Nylén S, Westerberg LS.

Nat Commun. 2016 Jul 18;7:12175. doi: 10.1038/ncomms12175.

23.

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.

Georgoudaki AM, Prokopec KE, Boura VF, Hellqvist E, Sohn S, Östling J, Dahan R, Harris RA, Rantalainen M, Klevebring D, Sund M, Brage SE, Fuxe J, Rolny C, Li F, Ravetch JV, Karlsson MC.

Cell Rep. 2016 May 31;15(9):2000-11. doi: 10.1016/j.celrep.2016.04.084. Epub 2016 May 19.

24.

Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.

Smith LE, Olszewski MA, Georgoudaki AM, Wagner AK, Hägglöf T, Karlsson MC, Dominguez-Villar M, Garcia-Cozar F, Mueller S, Ravens I, Bernhardt G, Chambers BJ.

J Leukoc Biol. 2016 Oct;100(4):781-789. Epub 2016 Mar 31.

PMID:
27034402
25.
26.

Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells.

Vomhof-DeKrey EE, Yates J, Hägglöf T, Lanthier P, Amiel E, Veerapen N, Besra GS, Karlsson MC, Leadbetter EA.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12474-9. doi: 10.1073/pnas.1504790112. Epub 2015 Sep 21.

27.

Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies.

Dahlberg CI, Torres ML, Petersen SH, Baptista MA, Keszei M, Volpi S, Grasset EK, Karlsson MC, Walter JE, Snapper SB, Notarangelo LD, Westerberg LS.

J Autoimmun. 2015 Aug;62:81-92. doi: 10.1016/j.jaut.2015.06.003. Epub 2015 Jul 2.

28.

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.

Pang MF, Georgoudaki AM, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander JS, Nelson CM, Jakobsson L, Betsholtz C, Sund M, Karlsson MC, Fuxe J.

Oncogene. 2016 Feb 11;35(6):748-60. doi: 10.1038/onc.2015.133. Epub 2015 May 11.

29.

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response.

Grasset EK, Duhlin A, Agardh HE, Ovchinnikova O, Hägglöf T, Forsell MN, Paulsson-Berne G, Hansson GK, Ketelhuth DF, Karlsson MC.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2030-8. doi: 10.1073/pnas.1421227112. Epub 2015 Apr 6.

30.

Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosis.

Siegmann N, Worbs D, Effinger F, Bormann T, Gebhardt M, Ulrich M, Wermeling F, Müller-Hermelink E, Biedermann T, Tighe M, Edwards MJ, Caldwell C, Leadbetter E, Karlsson MC, Becker KA, Gulbins E, Döring G.

Cell Physiol Biochem. 2014;34(1):56-70. doi: 10.1159/000362984. Epub 2014 Jun 16.

31.

IL-18 in inflammatory and autoimmune disease.

Sedimbi SK, Hägglöf T, Karlsson MC.

Cell Mol Life Sci. 2013 Dec;70(24):4795-808. doi: 10.1007/s00018-013-1425-y. Epub 2013 Jul 27. Review.

PMID:
23892891
32.

Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization.

Forsell MN, Soldemo M, Dosenovic P, Wyatt RT, Karlsson MC, Karlsson Hedestam GB.

J Immunol. 2013 Jul 1;191(1):44-51. doi: 10.4049/jimmunol.1203087. Epub 2013 Jun 5.

33.

Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.

Gehrmann U, Hiltbrunner S, Georgoudaki AM, Karlsson MC, Näslund TI, Gabrielsson S.

Cancer Res. 2013 Jul 1;73(13):3865-76. doi: 10.1158/0008-5472.CAN-12-3918. Epub 2013 May 8.

34.

Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity.

Näslund TI, Gehrmann U, Qazi KR, Karlsson MC, Gabrielsson S.

J Immunol. 2013 Mar 15;190(6):2712-9. doi: 10.4049/jimmunol.1203082. Epub 2013 Feb 15.

35.

AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment.

Lindmark E, Chen Y, Georgoudaki AM, Dudziak D, Lindh E, Adams WC, Loré K, Winqvist O, Chambers BJ, Karlsson MC.

J Autoimmun. 2013 May;42:62-70. doi: 10.1016/j.jaut.2012.11.004. Epub 2012 Dec 21.

PMID:
23265639
36.

Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1.

Lindh E, Brännström J, Jones P, Wermeling F, Hässler S, Betterle C, Garty BZ, Stridsberg M, Herrmann B, Karlsson MC, Winqvist O.

J Autoimmun. 2013 May;42:1-6. doi: 10.1016/j.jaut.2012.10.001. Epub 2012 Nov 1.

PMID:
23122533
37.

TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation.

Fuxe J, Karlsson MC.

Semin Cancer Biol. 2012 Oct;22(5-6):455-61. doi: 10.1016/j.semcancer.2012.05.004. Epub 2012 May 22. Review.

PMID:
22627188
38.

Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii.

Swedin L, Arrighi R, Andersson-Willman B, Murray A, Chen Y, Karlsson MC, Georén SK, Tkach AV, Shvedova AA, Fadeel B, Barragan A, Scheynius A.

Part Fibre Toxicol. 2012 May 23;9:16. doi: 10.1186/1743-8977-9-16.

39.

BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.

Dosenovic P, Soldemo M, Scholz JL, O'Dell S, Grasset EK, Pelletier N, Karlsson MC, Mascola JR, Wyatt RT, Cancro MP, Karlsson Hedestam GB.

J Immunol. 2012 Jun 15;188(12):6018-26. doi: 10.4049/jimmunol.1200466. Epub 2012 May 4.

40.

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.

Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3909-14. doi: 10.1073/pnas.1117736109. Epub 2012 Feb 21.

41.

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.

Enoksson SL, Grasset EK, Hägglöf T, Mattsson N, Kaiser Y, Gabrielsson S, McGaha TL, Scheynius A, Karlsson MC.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1399-407. doi: 10.1073/pnas.1107830108. Epub 2011 Dec 1.

42.

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

Mattsson J, Yrlid U, Stensson A, Schön K, Karlsson MC, Ravetch JV, Lycke NY.

J Immunol. 2011 Oct 1;187(7):3641-52. doi: 10.4049/jimmunol.1101107. Epub 2011 Aug 31.

43.

The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients.

Chen Y, Lind Enoksson S, Johansson C, Karlsson MA, Lundeberg L, Nilsson G, Scheynius A, Karlsson MC.

PLoS One. 2011;6(7):e22202. doi: 10.1371/journal.pone.0022202. Epub 2011 Jul 13.

44.

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.

McGaha TL, Chen Y, Ravishankar B, van Rooijen N, Karlsson MC.

Blood. 2011 May 19;117(20):5403-12. doi: 10.1182/blood-2010-11-320028. Epub 2011 Mar 28.

45.

Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis.

Carnrot C, Prokopec KE, Råsbo K, Karlsson MC, Kleinau S.

Cell Mol Immunol. 2011 Jul;8(4):296-304. doi: 10.1038/cmi.2011.2. Epub 2011 Feb 28.

46.

Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity.

Jordö ED, Wermeling F, Chen Y, Karlsson MC.

Mol Immunol. 2011 Jun;48(11):1307-18. doi: 10.1016/j.molimm.2011.01.010. Epub 2011 Feb 17. Review.

PMID:
21333356
47.

Invariant NKT cells limit activation of autoreactive CD1d-positive B cells.

Wermeling F, Lind SM, Jordö ED, Cardell SL, Karlsson MC.

J Exp Med. 2010 May 10;207(5):943-52. doi: 10.1084/jem.20091314. Epub 2010 May 3.

48.

A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses.

Chen Y, Wermeling F, Sundqvist J, Jonsson AB, Tryggvason K, Pikkarainen T, Karlsson MC.

Eur J Immunol. 2010 May;40(5):1451-60. doi: 10.1002/eji.200939891.

49.

AIRE deficiency leads to impaired iNKT cell development.

Lindh E, Rosmaraki E, Berg L, Brauner H, Karlsson MC, Peltonen L, Höglund P, Winqvist O.

J Autoimmun. 2010 Feb;34(1):66-72. doi: 10.1016/j.jaut.2009.07.002. Epub 2009 Aug 3.

PMID:
19651488
50.

IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema.

Lind SM, Kuylenstierna C, Moll M, D Jordö E, Winqvist O, Lundeberg L, Karlsson MA, T Linder M, Johansson C, Scheynius A, Sandberg JK, Karlsson MC.

Eur J Immunol. 2009 Aug;39(8):2293-301. doi: 10.1002/eji.200839195.

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