Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 79

1.

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses.

Phad GE, Pushparaj P, Tran K, Dubrovskaya V, Àdori M, Martinez-Murillo P, Vázquez Bernat N, Singh S, Dionne G, O'Dell S, Bhullar K, Narang S, Sorini C, Villablanca EJ, Sundling C, Murrell B, Mascola JR, Shapiro L, Pancera M, Martin M, Corcoran M, Wyatt RT, Karlsson Hedestam GB.

J Exp Med. 2019 Nov 8. pii: jem.20191155. doi: 10.1084/jem.20191155. [Epub ahead of print]

PMID:
31704807
2.

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.

Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schön A, Todd JP, Wang S, Wei H, Wu W; NISC Comparative Sequencing Program, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR.

Cell. 2019 Jul 25;178(3):567-584.e19. doi: 10.1016/j.cell.2019.06.030.

3.

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis.

Vázquez Bernat N, Corcoran M, Hardt U, Kaduk M, Phad GE, Martin M, Karlsson Hedestam GB.

Front Immunol. 2019 Apr 5;10:660. doi: 10.3389/fimmu.2019.00660. eCollection 2019.

4.

TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS.

Khoenkhoen S, Erikson E, Ádori M, Stark JM, Scholz JL, Cancro MP, Pedersen GK, Karlsson Hedestam GB.

Immunol Cell Biol. 2019 May;97(5):485-497. doi: 10.1111/imcb.12228. Epub 2019 Jan 30.

PMID:
30597621
5.

B-1a Cell Development in Splenectomized Neonatal Mice.

Pedersen GK, Li X, Khoenkhoen S, Ádori M, Beutler B, Karlsson Hedestam GB.

Front Immunol. 2018 Jul 30;9:1738. doi: 10.3389/fimmu.2018.01738. eCollection 2018.

6.

Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site.

Cheng HD, Grimm SK, Gilman MS, Gwom LC, Sok D, Sundling C, Donofrio G, Karlsson Hedestam GB, Bonsignori M, Haynes BF, Lahey TP, Maro I, von Reyn CF, Gorny MK, Zolla-Pazner S, Walker BD, Alter G, Burton DR, Robb ML, Krebs SJ, Seaman MS, Bailey-Kellogg C, Ackerman ME.

JCI Insight. 2018 Mar 8;3(5). pii: 97018. doi: 10.1172/jci.insight.97018.

7.

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice.

Soldemo M, Àdori M, Stark JM, Feng Y, Tran K, Wilson R, Yang L, Guenaga J, Wyatt RT, Karlsson Hedestam GB.

Front Immunol. 2017 Nov 27;8:1654. doi: 10.3389/fimmu.2017.01654. eCollection 2017.

8.

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, Choi JH, Dosenovic P, Karlsson MCI, Beutler B, Karlsson Hedestam GB.

J Immunol. 2018 Jan 15;200(2):775-787. doi: 10.4049/jimmunol.1700791. Epub 2017 Dec 8.

9.

Env-Specific Antibodies in Chronic Infection versus in Vaccination.

Soldemo M, Karlsson Hedestam GB.

Front Immunol. 2017 Sep 4;8:1057. doi: 10.3389/fimmu.2017.01057. eCollection 2017. Review.

10.

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.

Dubrovskaya V, Guenaga J, de Val N, Wilson R, Feng Y, Movsesyan A, Karlsson Hedestam GB, Ward AB, Wyatt RT.

PLoS Pathog. 2017 Sep 13;13(9):e1006614. doi: 10.1371/journal.ppat.1006614. eCollection 2017 Sep.

11.

HIV-1 Cross-Reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Nonhuman Primates.

Wang Y, O'Dell S, Turner HL, Chiang CI, Lei L, Guenaga J, Wilson R, Martinez-Murillo P, Doria-Rose N, Ward AB, Mascola JR, Wyatt RT, Karlsson Hedestam GB, Li Y.

J Virol. 2017 Oct 13;91(21). pii: e00910-17. doi: 10.1128/JVI.00910-17. Print 2017 Nov 1.

12.

PPAR-γ promotes type 2 immune responses in allergy and nematode infection.

Chen T, Tibbitt CA, Feng X, Stark JM, Rohrbeck L, Rausch L, Sedimbi SK, Karlsson MCI, Lambrecht BN, Karlsson Hedestam GB, Hendriks RW, Chambers BJ, Nylén S, Coquet JM.

Sci Immunol. 2017 Mar 10;2(9). pii: eaal5196. doi: 10.1126/sciimmunol.aal5196.

PMID:
28783701
13.

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach.

Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, Àdori M, Feng Y, Phad GE, Vázquez Bernat N, Bale S, Ingale J, Dubrovskaya V, O'Dell S, Pramanik L, Spångberg M, Corcoran M, Loré K, Mascola JR, Wyatt RT, Karlsson Hedestam GB.

Immunity. 2017 May 16;46(5):804-817.e7. doi: 10.1016/j.immuni.2017.04.021.

14.

Evolution of B cell analysis and Env trimer redesign.

Karlsson Hedestam GB, Guenaga J, Corcoran M, Wyatt RT.

Immunol Rev. 2017 Jan;275(1):183-202. doi: 10.1111/imr.12515. Review.

15.

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity.

Corcoran MM, Phad GE, Vázquez Bernat N, Stahl-Hennig C, Sumida N, Persson MA, Martin M, Karlsson Hedestam GB.

Nat Commun. 2016 Dec 20;7:13642. doi: 10.1038/ncomms13642.

16.

CD138 and CD31 Double-Positive Cells Comprise the Functional Antibody-Secreting Plasma Cell Compartment in Primate Bone Marrow.

Martinez-Murillo P, Pramanik L, Sundling C, Hultenby K, Wretenberg P, Spångberg M, Karlsson Hedestam GB.

Front Immunol. 2016 Jun 27;7:242. doi: 10.3389/fimmu.2016.00242. eCollection 2016.

17.

High-Resolution Longitudinal Study of HIV-1 Env Vaccine-Elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence.

Wang Y, Sundling C, Wilson R, O'Dell S, Chen Y, Dai K, Phad GE, Zhu J, Xiao Y, Mascola JR, Karlsson Hedestam GB, Wyatt RT, Li Y.

J Immunol. 2016 May 1;196(9):3729-43. doi: 10.4049/jimmunol.1502543. Epub 2016 Mar 21.

18.

Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens.

Pedersen GK, Ádori M, Stark JM, Khoenkhoen S, Arnold C, Beutler B, Karlsson Hedestam GB.

Front Immunol. 2016 Mar 1;7:65. doi: 10.3389/fimmu.2016.00065. eCollection 2016.

19.

Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.

Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB 3rd, Karlsson Hedestam GB, Haynes B, Sodroski J.

J Virol. 2016 Apr 29;90(10):5031-5046. doi: 10.1128/JVI.03211-15. Print 2016 May 15.

20.

HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation.

Dai K, Khan SN, Wang Y, He L, Guenaga J, Ingale J, Sundling C, O'Dell S, McKee K, Phad G, Corcoran M, Wilson R, Mascola JR, Zhu J, Li Y, Karlsson Hedestam GB, Wyatt RT.

Sci Rep. 2016 Feb 16;6:20987. doi: 10.1038/srep20987.

21.

Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis.

Dai K, He L, Khan SN, O'Dell S, McKee K, Tran K, Li Y, Sundling C, Morris CD, Mascola JR, Karlsson Hedestam GB, Wyatt RT, Zhu J.

MBio. 2015 Nov 3;6(6):e01375-15. doi: 10.1128/mBio.01375-15.

22.

Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.

Coquet JM, Schuijs MJ, Smyth MJ, Deswarte K, Beyaert R, Braun H, Boon L, Karlsson Hedestam GB, Nutt SL, Hammad H, Lambrecht BN.

Immunity. 2015 Aug 18;43(2):318-30. doi: 10.1016/j.immuni.2015.07.015.

23.

NF-κB signaling in B-1 cell development.

Pedersen GK, Ádori M, Karlsson Hedestam GB.

Ann N Y Acad Sci. 2015 Dec;1362:39-47. doi: 10.1111/nyas.12800. Epub 2015 Jun 11. Review.

PMID:
26096766
24.

Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization.

Phad GE, Vázquez Bernat N, Feng Y, Ingale J, Martinez Murillo PA, O'Dell S, Li Y, Mascola JR, Sundling C, Wyatt RT, Karlsson Hedestam GB.

J Immunol. 2015 Jun 15;194(12):5903-14. doi: 10.4049/jimmunol.1500122. Epub 2015 May 11.

25.

Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.

Baharom F, Thomas S, Bieder A, Hellmér M, Volz J, Sandgren KJ, McInerney GM, Karlsson Hedestam GB, Mellman I, Smed-Sörensen A.

J Immunol. 2015 May 1;194(9):4422-30. doi: 10.4049/jimmunol.1402671. Epub 2015 Mar 23.

26.

Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation.

Martinez P, Sundling C, O'Dell S, Mascola JR, Wyatt RT, Karlsson Hedestam GB.

Sci Rep. 2015 Mar 12;5:8925. doi: 10.1038/srep08925.

27.

Real-time resolution of point mutations that cause phenovariance in mice.

Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E440-9. doi: 10.1073/pnas.1423216112. Epub 2015 Jan 20.

28.

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.

Zeng M, Hu Z, Shi X, Li X, Zhan X, Li XD, Wang J, Choi JH, Wang KW, Purrington T, Tang M, Fina M, DeBerardinis RJ, Moresco EM, Pedersen G, McInerney GM, Karlsson Hedestam GB, Chen ZJ, Beutler B.

Science. 2014 Dec 19;346(6216):1486-92. doi: 10.1126/science.346.6216.1486. Retraction in: Science. 2017 Oct 27;358(6362):458.

29.

Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.

Klein F, Nogueira L, Nishimura Y, Phad G, West AP Jr, Halper-Stromberg A, Horwitz JA, Gazumyan A, Liu C, Eisenreich TR, Lehmann C, Fätkenheuer G, Williams C, Shingai M, Martin MA, Bjorkman PJ, Seaman MS, Zolla-Pazner S, Karlsson Hedestam GB, Nussenzweig MC.

J Exp Med. 2014 Nov 17;211(12):2361-72. doi: 10.1084/jem.20141050. Epub 2014 Nov 10.

30.

Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.

Dosenovic P, Ádori M, Adams WC, Pedersen GK, Soldemo M, Beutler B, Karlsson Hedestam GB.

Immunol Cell Biol. 2015 Feb;93(2):136-46. doi: 10.1038/icb.2014.82. Epub 2014 Oct 14.

PMID:
25310967
31.

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.

Pedersen GK, Àdori M, Khoenkhoen S, Dosenovic P, Beutler B, Karlsson Hedestam GB.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4119-26. doi: 10.1073/pnas.1415866111. Epub 2014 Sep 16.

32.

HIV-1 Env-specific memory and germinal center B cells in C57BL/6 mice.

Soldemo M, Pedersen GK, Karlsson Hedestam GB.

Viruses. 2014 Sep 5;6(9):3400-14. doi: 10.3390/v6093400.

33.

HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization.

Navis M, Tran K, Bale S, Phad GE, Guenaga J, Wilson R, Soldemo M, McKee K, Sundling C, Mascola J, Li Y, Wyatt RT, Karlsson Hedestam GB.

PLoS Pathog. 2014 Aug 28;10(8):e1004337. doi: 10.1371/journal.ppat.1004337. eCollection 2014 Aug.

34.

A simple and safe technique for longitudinal bone marrow aspiration in cynomolgus and rhesus macaques.

Spångberg M, Martinez P, Fredlund H, Karlsson Hedestam GB, Sundling C.

J Immunol Methods. 2014 Jun;408:137-41. doi: 10.1016/j.jim.2014.05.004. Epub 2014 May 17.

PMID:
24846526
35.

Single-cell and deep sequencing of IgG-switched macaque B cells reveal a diverse Ig repertoire following immunization.

Sundling C, Zhang Z, Phad GE, Sheng Z, Wang Y, Mascola JR, Li Y, Wyatt RT, Shapiro L, Karlsson Hedestam GB.

J Immunol. 2014 Apr 15;192(8):3637-44. doi: 10.4049/jimmunol.1303334. Epub 2014 Mar 12.

36.

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign.

Tran K, Poulsen C, Guenaga J, de Val N, Wilson R, Sundling C, Li Y, Stanfield RL, Wilson IA, Ward AB, Karlsson Hedestam GB, Wyatt RT.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):E738-47. doi: 10.1073/pnas.1319512111. Epub 2014 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1159. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7). doi:10.1073/pnas.1403776111. de Val Alda, Natalia [corrected to de Val, Natalia].

37.

Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.

Feng Y, Forsell MN, Flynn B, Adams W, Loré K, Seder R, Wyatt RT, Karlsson Hedestam GB.

Virology. 2013 Nov;446(1-2):56-65. doi: 10.1016/j.virol.2013.07.028. Epub 2013 Aug 15.

38.

Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates.

Chakrabarti BK, Feng Y, Sharma SK, McKee K, Karlsson Hedestam GB, Labranche CC, Montefiori DC, Mascola JR, Wyatt RT.

J Virol. 2013 Dec;87(24):13239-51. doi: 10.1128/JVI.01247-13. Epub 2013 Sep 25. Erratum in: J Virol. 2015 Jan;89(1):887.

39.

Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization.

Forsell MN, Soldemo M, Dosenovic P, Wyatt RT, Karlsson MC, Karlsson Hedestam GB.

J Immunol. 2013 Jul 1;191(1):44-51. doi: 10.4049/jimmunol.1203087. Epub 2013 Jun 5.

40.

Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation.

Sandgren KJ, Smed-Sörensen A, Forsell MN, Soldemo M, Adams WC, Liang F, Perbeck L, Koup RA, Wyatt RT, Karlsson Hedestam GB, Loré K.

J Immunol. 2013 Jul 1;191(1):60-9. doi: 10.4049/jimmunol.1202489. Epub 2013 May 31.

41.

Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae.

Kuri T, Sörensen AS, Thomas S, Karlsson Hedestam GB, Normark S, Henriques-Normark B, McInerney GM, Plant L.

Cell Microbiol. 2013 Aug;15(8):1385-400. doi: 10.1111/cmi.12122. Epub 2013 Mar 14.

42.

Immunization of macaques with soluble HIV type 1 and influenza virus envelope glycoproteins results in a similarly rapid contraction of peripheral B-cell responses after boosting.

Sundling C, Martinez P, Soldemo M, Spångberg M, Bengtsson KL, Stertman L, Forsell MN, Karlsson Hedestam GB.

J Infect Dis. 2013 Feb 1;207(3):426-31. doi: 10.1093/infdis/jis696. Epub 2012 Nov 16.

PMID:
23162135
43.

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection.

Panas MD, Varjak M, Lulla A, Eng KE, Merits A, Karlsson Hedestam GB, McInerney GM.

Mol Biol Cell. 2012 Dec;23(24):4701-12. doi: 10.1091/mbc.E12-08-0619. Epub 2012 Oct 19.

44.

Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells.

Sundling C, Phad G, Douagi I, Navis M, Karlsson Hedestam GB.

J Immunol Methods. 2012 Dec 14;386(1-2):85-93. doi: 10.1016/j.jim.2012.09.003. Epub 2012 Sep 16.

PMID:
22989932
45.

High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site.

Sundling C, Li Y, Huynh N, Poulsen C, Wilson R, O'Dell S, Feng Y, Mascola JR, Wyatt RT, Karlsson Hedestam GB.

Sci Transl Med. 2012 Jul 11;4(142):142ra96. doi: 10.1126/scitranslmed.3003752.

46.

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

Arnold CN, Pirie E, Dosenovic P, McInerney GM, Xia Y, Wang N, Li X, Siggs OM, Karlsson Hedestam GB, Beutler B.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12286-93. doi: 10.1073/pnas.1209134109. Epub 2012 Jul 3.

47.

BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.

Dosenovic P, Soldemo M, Scholz JL, O'Dell S, Grasset EK, Pelletier N, Karlsson MC, Mascola JR, Wyatt RT, Cancro MP, Karlsson Hedestam GB.

J Immunol. 2012 Jun 15;188(12):6018-26. doi: 10.4049/jimmunol.1200466. Epub 2012 May 4.

48.

Accumulation of autophagosomes in Semliki Forest virus-infected cells is dependent on expression of the viral glycoproteins.

Eng KE, Panas MD, Murphy D, Karlsson Hedestam GB, McInerney GM.

J Virol. 2012 May;86(10):5674-85. doi: 10.1128/JVI.06581-11. Epub 2012 Mar 21.

49.

Attenuation of CD4+ T-cell function by human adenovirus type 35 is mediated by the knob protein.

Adams WC, Berenson RJ, Karlsson Hedestam GB, Lieber A, Koup RA, Loré K.

J Gen Virol. 2012 Jun;93(Pt 6):1339-44. doi: 10.1099/vir.0.039222-0. Epub 2012 Feb 22.

PMID:
22357750
50.

Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site.

Feng Y, McKee K, Tran K, O'Dell S, Schmidt SD, Phogat A, Forsell MN, Karlsson Hedestam GB, Mascola JR, Wyatt RT.

J Biol Chem. 2012 Feb 17;287(8):5673-86. doi: 10.1074/jbc.M111.317776. Epub 2011 Dec 13.

Supplemental Content

Loading ...
Support Center