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Items: 36

1.

Dissociable neural systems for unconditioned acute and sustained fear.

Hudson M, Seppälä K, Putkinen V, Sun L, Glerean E, Karjalainen T, Karlsson HK, Hirvonen J, Nummenmaa L.

Neuroimage. 2020 Jan 8:116522. doi: 10.1016/j.neuroimage.2020.116522. [Epub ahead of print]

2.

Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice.

Borg ML, Massart J, Schönke M, De Castro Barbosa T, Guo L, Wade M, Alsina-Fernandez J, Miles R, Ryan A, Bauer S, Coskun T, O'Farrell E, Niemeier EM, Chibalin AV, Krook A, Karlsson HK, Brozinick JT, Zierath JR.

Diabetes. 2019 Jul;68(7):1403-1414. doi: 10.2337/db18-1237. Epub 2019 Apr 22.

3.

Effects of bariatric surgery on retinal microvascular architecture in obese patients.

Viljanen A, Soinio M, Cheung CY, Hannukainen JC, Karlsson HK, Wong TY, Hughes AD, Salminen P, Nuutila P, Vesti E, Tapp RJ.

Int J Obes (Lond). 2019 Sep;43(9):1675-1680. doi: 10.1038/s41366-018-0242-7. Epub 2018 Dec 5.

PMID:
30518825
4.

Opioidergic Regulation of Emotional Arousal: A Combined PET-fMRI Study.

Karjalainen T, Seppälä K, Glerean E, Karlsson HK, Lahnakoski JM, Nuutila P, Jääskeläinen IP, Hari R, Sams M, Nummenmaa L.

Cereb Cortex. 2019 Aug 14;29(9):4006-4016. doi: 10.1093/cercor/bhy281.

PMID:
30475982
5.

The effect of bariatric surgery on intraocular pressure.

Viljanen A, Hannukainen JC, Soinio M, Karlsson HK, Salminen P, Nuutila P, Vesti E.

Acta Ophthalmol. 2018 Dec;96(8):849-852. doi: 10.1111/aos.13826. Epub 2018 Sep 20.

6.

Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain.

Joutsa J, Karlsson HK, Majuri J, Nuutila P, Helin S, Kaasinen V, Nummenmaa L.

Psychiatry Res Neuroimaging. 2018 Jun 30;276:41-45. doi: 10.1016/j.pscychresns.2018.03.006. Epub 2018 Mar 9.

PMID:
29655552
7.

Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery-induced weight loss.

Dadson P, Hannukainen JC, Din MU, Lahesmaa M, Kalliokoski KK, Iozzo P, Pihlajamäki J, Karlsson HK, Parkkola R, Salminen P, Virtanen KA, Nuutila P.

Diabetes Obes Metab. 2018 May;20(5):1280-1288. doi: 10.1111/dom.13233. Epub 2018 Feb 22.

PMID:
29377423
8.

Erratum. Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese. Diabetes 2013;62:2747-2751.

Tuulari JJ, Karlsson HK, Hirvonen J, Hannukainen JC, Bucci M, Helmiö M, Ovaska J, Soinio M, Salminen P, Savisto N, Nummenmaa L, Nuutila P.

Diabetes. 2017 Oct;66(10):2724. doi: 10.2337/db17-er10a. Epub 2017 Aug 1. No abstract available.

9.

Dissociable Roles of Cerebral μ-Opioid and Type 2 Dopamine Receptors in Vicarious Pain: A Combined PET-fMRI Study.

Karjalainen T, Karlsson HK, Lahnakoski JM, Glerean E, Nuutila P, Jääskeläinen IP, Hari R, Sams M, Nummenmaa L.

Cereb Cortex. 2017 Aug 1;27(8):4257-4266. doi: 10.1093/cercor/bhx129.

PMID:
28541428
10.

Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: effects of bariatric surgery.

Dadson P, Ferrannini E, Landini L, Hannukainen JC, Kalliokoski KK, Vaittinen M, Honka H, Karlsson HK, Tuulari JJ, Soinio M, Salminen P, Parkkola R, Pihlajamäki J, Iozzo P, Nuutila P.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E175-E182. doi: 10.1152/ajpendo.00044.2017. Epub 2017 Apr 11.

11.

Bariatric surgery normalizes brain opioid receptors.

Karlsson HK, Tuulari JJ, Tuominen L, Hirvonen J, Honka H, Parkkola R, Helin S, Salminen P, Nuutila P, Nummenmaa L.

Mol Psychiatry. 2016 Aug;21(8):989. doi: 10.1038/mp.2016.116. No abstract available.

PMID:
27439757
12.

Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese: A Voxel-Based Morphometric Study.

Tuulari JJ, Karlsson HK, Antikainen O, Hirvonen J, Pham T, Salminen P, Helmiö M, Parkkola R, Nuutila P, Nummenmaa L.

Hum Brain Mapp. 2016 Nov;37(11):3745-3756. doi: 10.1002/hbm.23272.

PMID:
27400738
13.

Weight loss after bariatric surgery normalizes brain opioid receptors in morbid obesity.

Karlsson HK, Tuulari JJ, Tuominen L, Hirvonen J, Honka H, Parkkola R, Helin S, Salminen P, Nuutila P, Nummenmaa L.

Mol Psychiatry. 2016 Aug;21(8):1057-62. doi: 10.1038/mp.2015.153. Epub 2015 Oct 13.

PMID:
26460230
14.

Obesity is associated with decreased μ-opioid but unaltered dopamine D2 receptor availability in the brain.

Karlsson HK, Tuominen L, Tuulari JJ, Hirvonen J, Parkkola R, Helin S, Salminen P, Nuutila P, Nummenmaa L.

J Neurosci. 2015 Mar 4;35(9):3959-65. doi: 10.1523/JNEUROSCI.4744-14.2015.

15.

The effects of bariatric surgery on pancreatic lipid metabolism and blood flow.

Honka H, Koffert J, Hannukainen JC, Tuulari JJ, Karlsson HK, Immonen H, Oikonen V, Tolvanen T, Soinio M, Salminen P, Kudomi N, Mari A, Iozzo P, Nuutila P.

J Clin Endocrinol Metab. 2015 May;100(5):2015-23. doi: 10.1210/jc.2014-4236. Epub 2015 Mar 3.

PMID:
25734253
16.

Neural circuits for cognitive appetite control in healthy and obese individuals: an fMRI study.

Tuulari JJ, Karlsson HK, Hirvonen J, Salminen P, Nuutila P, Nummenmaa L.

PLoS One. 2015 Feb 6;10(2):e0116640. doi: 10.1371/journal.pone.0116640. eCollection 2015.

17.

Obesity is associated with white matter atrophy: a combined diffusion tensor imaging and voxel-based morphometric study.

Karlsson HK, Tuulari JJ, Hirvonen J, Lepomäki V, Parkkola R, Hiltunen J, Hannukainen JC, Soinio M, Pham T, Salminen P, Nuutila P, Nummenmaa L.

Obesity (Silver Spring). 2013 Dec;21(12):2530-7. doi: 10.1002/oby.20386. Epub 2013 Jun 11.

18.

Weight loss after bariatric surgery reverses insulin-induced increases in brain glucose metabolism of the morbidly obese.

Tuulari JJ, Karlsson HK, Hirvonen J, Hannukainen JC, Bucci M, Helmiö M, Ovaska J, Soinio M, Salminen P, Savisto N, Nummenmaa L, Nuutila P.

Diabetes. 2013 Aug;62(8):2747-51. doi: 10.2337/db12-1460. Epub 2013 Mar 14. Erratum in: Diabetes. 2017 Oct;66(10 ):2724.

19.

Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.

Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR.

J Biol Chem. 2011 Oct 7;286(40):34567-74. doi: 10.1074/jbc.M111.268292. Epub 2011 Aug 26.

20.

Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle.

Deshmukh AS, Long YC, de Castro Barbosa T, Karlsson HK, Glund S, Zavadoski WJ, Gibbs EM, Koistinen HA, Wallberg-Henriksson H, Zierath JR.

Diabetologia. 2010 Jun;53(6):1142-50. doi: 10.1007/s00125-010-1716-x. Epub 2010 Mar 27.

21.

Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation.

Peck GR, Chavez JA, Roach WG, Budnik BA, Lane WS, Karlsson HK, Zierath JR, Lienhard GE.

J Biol Chem. 2009 Oct 30;284(44):30016-23. doi: 10.1074/jbc.M109.035568. Epub 2009 Sep 9.

22.

Kinetics of GLUT4 trafficking in rat and human skeletal muscle.

Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD.

Diabetes. 2009 Apr;58(4):847-54. doi: 10.2337/db08-1539. Epub 2009 Feb 2.

23.

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.

Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.

J Cell Sci. 2008 Mar 1;121(Pt 5):675-84. doi: 10.1242/jcs.025312. Epub 2008 Feb 12.

24.

Insulin signaling and glucose transport in insulin resistant human skeletal muscle.

Karlsson HK, Zierath JR.

Cell Biochem Biophys. 2007;48(2-3):103-13. Review.

PMID:
17709880
25.

The second extracellular loop of alpha2A-adrenoceptors contributes to the binding of yohimbine analogues.

Laurila JM, Xhaard H, Ruuskanen JO, Rantanen MJ, Karlsson HK, Johnson MS, Scheinin M.

Br J Pharmacol. 2007 Aug;151(8):1293-304. Epub 2007 Jun 11.

26.

Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes.

O'Gorman DJ, Karlsson HK, McQuaid S, Yousif O, Rahman Y, Gasparro D, Glund S, Chibalin AV, Zierath JR, Nolan JJ.

Diabetologia. 2006 Dec;49(12):2983-92. Epub 2006 Sep 26.

PMID:
17019595
27.

Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients.

Fritz T, Krämer DK, Karlsson HK, Galuska D, Engfeldt P, Zierath JR, Krook A.

Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):492-8.

PMID:
16752430
28.

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.

Biochem J. 2006 Jul 1;397(1):223-31.

29.

Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients.

Karlsson HK, Ahlsén M, Zierath JR, Wallberg-Henriksson H, Koistinen HA.

Diabetes. 2006 May;55(5):1283-8.

30.

IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.

Bouzakri K, Karlsson HK, Vestergaard H, Madsbad S, Christiansen E, Zierath JR.

Diabetes. 2006 Mar;55(3):785-91.

31.

Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise.

Blomstrand E, Eliasson J, Karlsson HK, Köhnke R.

J Nutr. 2006 Jan;136(1 Suppl):269S-73S. doi: 10.1093/jn/136.1.269S. Review.

PMID:
16365096
32.

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects.

Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H.

Diabetes. 2005 Jun;54(6):1692-7.

33.

Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study.

Karlsson HK, Hällsten K, Björnholm M, Tsuchida H, Chibalin AV, Virtanen KA, Heinonen OJ, Lönnqvist F, Nuutila P, Zierath JR.

Diabetes. 2005 May;54(5):1459-67.

34.
35.

Insulin signaling defects in type 2 diabetes.

Leng Y, Karlsson HK, Zierath JR.

Rev Endocr Metab Disord. 2004 May;5(2):111-7. Review. No abstract available.

PMID:
15041786
36.

Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise.

Karlsson HK, Nilsson PA, Nilsson J, Chibalin AV, Zierath JR, Blomstrand E.

Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E1-7. Epub 2004 Mar 2.

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