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Items: 18

1.

Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice.

Pucilowska J, Vithayathil J, Pagani M, Kelly C, Karlo JC, Robol C, Morella I, Gozzi A, Brambilla R, Landreth GE.

J Neurosci. 2018 Jul 25;38(30):6640-6652. doi: 10.1523/JNEUROSCI.0515-17.2018. Epub 2018 Jun 22.

PMID:
29934348
2.

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE.

Mol Neurodegener. 2018 Jun 1;13(1):29. doi: 10.1186/s13024-018-0262-8.

3.

Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.

Casali BT, Corona AW, Mariani MM, Karlo JC, Ghosal K, Landreth GE.

J Neurosci. 2015 Jun 17;35(24):9173-81. doi: 10.1523/JNEUROSCI.1000-15.2015.

4.

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT.

J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2.

5.

The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway.

Pucilowska J, Vithayathil J, Tavares EJ, Kelly C, Karlo JC, Landreth GE.

J Neurosci. 2015 Feb 18;35(7):3190-200. doi: 10.1523/JNEUROSCI.4864-13.2015.

6.

The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model.

Grommes C, Karlo JC, Caprariello A, Blankenship D, Dechant A, Landreth GE.

Cancer Chemother Pharmacol. 2013 Apr;71(4):929-36. doi: 10.1007/s00280-013-2084-2. Epub 2013 Jan 29.

PMID:
23358645
7.
8.
9.

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.

Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE.

Science. 2012 Mar 23;335(6075):1503-6. doi: 10.1126/science.1217697. Epub 2012 Feb 9.

10.

The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation.

Fyffe-Maricich SL, Karlo JC, Landreth GE, Miller RH.

J Neurosci. 2011 Jan 19;31(3):843-50. doi: 10.1523/JNEUROSCI.3239-10.2011.

11.

Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis.

Srinivasan R, Zabuawala T, Huang H, Zhang J, Gulati P, Fernandez S, Karlo JC, Landreth GE, Leone G, Ostrowski MC.

PLoS One. 2009 Dec 14;4(12):e8283. doi: 10.1371/journal.pone.0008283.

12.

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.

Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17115-20. doi: 10.1073/pnas.0805239105. Epub 2008 Oct 24.

13.

Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.

Samuels IS, Karlo JC, Faruzzi AN, Pickering K, Herrup K, Sweatt JD, Saitta SC, Landreth GE.

J Neurosci. 2008 Jul 2;28(27):6983-95. doi: 10.1523/JNEUROSCI.0679-08.2008.

15.

Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha.

Combs CK, Bates P, Karlo JC, Landreth GE.

Neurochem Int. 2001 Nov-Dec;39(5-6):449-57.

PMID:
11578780
17.

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