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Items: 1 to 50 of 145

1.

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J.

Nat Chem Biol. 2019 Dec 9. doi: 10.1038/s41589-019-0411-6. [Epub ahead of print]

PMID:
31819272
2.

Deep learning for clustering of multivariate clinical patient trajectories with missing values.

de Jong J, Emon MA, Wu P, Karki R, Sood M, Godard P, Ahmad A, Vrooman H, Hofmann-Apitius M, Fröhlich H.

Gigascience. 2019 Nov 1;8(11). pii: giz134. doi: 10.1093/gigascience/giz134.

3.

The nonreceptor tyrosine kinase SYK induces autoinflammatory osteomyelitis in a mouse model of chronic recurrent multifocal osteomyelitis.

Dasari TK, Geiger R, Karki R, Banoth B, Sharma BR, Gurung P, Burton A, Kanneganti TD.

J Biol Chem. 2019 Nov 12. pii: jbc.RA119.010623. doi: 10.1074/jbc.RA119.010623. [Epub ahead of print]

4.

Correction to: Assessing climate boundary shifting under climate change scenarios across Nepal.

Talchabhadel R, Karki R.

Environ Monit Assess. 2019 Nov 1;191(12):707. doi: 10.1007/s10661-019-7907-0.

PMID:
31676988
5.

Quantifying mechanisms in neurodegenerative diseases (NDDs) using candidate mechanism perturbation amplitude (CMPA) algorithm.

Karki R, Kodamullil AT, Hoyt CT, Hofmann-Apitius M.

BMC Bioinformatics. 2019 Oct 11;20(1):494. doi: 10.1186/s12859-019-3101-1.

6.

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD.

Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11.

PMID:
31511697
7.

Role of AIM2 inflammasome in inflammatory diseases, cancer and infection.

Sharma BR, Karki R, Kanneganti TD.

Eur J Immunol. 2019 Nov;49(11):1998-2011. doi: 10.1002/eji.201848070. Epub 2019 Aug 14. Review.

PMID:
31372985
8.

Assessing climate boundary shifting under climate change scenarios across Nepal.

Talchabhadel R, Karki R.

Environ Monit Assess. 2019 Jul 29;191(8):520. doi: 10.1007/s10661-019-7644-4. Erratum in: Environ Monit Assess. 2019 Nov 1;191(12):707.

PMID:
31359147
9.

The NLRC4 inflammasome requires IRF8-dependent production of NAIPs.

Lee E, Karki R, Kanneganti TD.

Cell Stress. 2018 May 22;2(6):144-146. doi: 10.15698/cst2018.06.141.

10.

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.

Karki RG, Powers J, Mainolfi N, Anderson K, Belanger DB, Liu D, Ji N, Jendza K, Gelin CF, Mac Sweeney A, Solovay C, Delgado O, Crowley M, Liao SM, Argikar UA, Flohr S, La Bonte LR, Lorthiois EL, Vulpetti A, Brown A, Long D, Prentiss M, Gradoux N, de Erkenez A, Cumin F, Adams C, Jaffee B, Mogi M.

J Med Chem. 2019 May 9;62(9):4656-4668. doi: 10.1021/acs.jmedchem.9b00271. Epub 2019 Apr 30.

PMID:
30995036
11.

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, Zhang C, Valeur E, Sirockin F, Gerhartz B, Erbel P, Hughes N, Smith TM, Cumin F, Argikar UA, Haraldsson B, Mogi M, Sedrani R, Wiesmann C, Jaffee B, Maibaum J, Flohr S, Harrison R, Eder J.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. doi: 10.1073/pnas.1820892116. Epub 2019 Mar 29.

12.

Diverging inflammasome signals in tumorigenesis and potential targeting.

Karki R, Kanneganti TD.

Nat Rev Cancer. 2019 Apr;19(4):197-214. doi: 10.1038/s41568-019-0123-y. Review.

PMID:
30842595
13.

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Luo H, Mu WC, Karki R, Chiang HH, Mohrin M, Shin JJ, Ohkubo R, Ito K, Kanneganti TD, Chen D.

Cell Rep. 2019 Jan 22;26(4):945-954.e4. doi: 10.1016/j.celrep.2018.12.101.

14.

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers.

Govindaraju R, Karki R, Chandrashekarappa J, Santhanam M, Shankar AKK, Joshi HK, Divakar G.

Pharm Nanotechnol. 2019;7(1):39-56. doi: 10.2174/2211738507666190122121242.

15.

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD.

Nat Microbiol. 2019 Feb;4(2):316-327. doi: 10.1038/s41564-018-0298-0. Epub 2018 Dec 3.

16.

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida.

Zhu Q, Zheng M, Balakrishnan A, Karki R, Kanneganti TD.

J Immunol. 2018 Dec 15;201(12):3662-3668. doi: 10.4049/jimmunol.1800788. Epub 2018 Nov 7.

PMID:
30404813
17.

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

Papillon JPN, Nakajima K, Adair CD, Hempel J, Jouk AO, Karki RG, Mathieu S, Möbitz H, Ntaganda R, Smith T, Visser M, Hill SE, Hurtado FK, Chenail G, Bhang HC, Bric A, Xiang K, Bushold G, Gilbert T, Vattay A, Dooley J, Costa EA, Park I, Li A, Farley D, Lounkine E, Yue QK, Xie X, Zhu X, Kulathila R, King D, Hu T, Vulic K, Cantwell J, Luu C, Jagani Z.

J Med Chem. 2018 Nov 21;61(22):10155-10172. doi: 10.1021/acs.jmedchem.8b01318. Epub 2018 Oct 31.

PMID:
30339381
18.

Elevated end-diastolic wall stress after acute myocardial infarction predicts adverse cardiovascular outcomes and longer hospital length of stay.

Mosleh W, Elango K, Shah T, Chaudhari M, Gandhi S, Kattel S, Karki R, Khalil C, Frodey K, Dahal S, Okeeffe C, Aljebaje Z, Nagahama M, Punnanithinont N, Sharma UC.

Echocardiography. 2018 Nov;35(11):1721-1728. doi: 10.1111/echo.14136. Epub 2018 Sep 16.

PMID:
30220086
19.

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.

Balakrishnan A, Karki R, Berwin B, Yamamoto M, Kanneganti TD.

Cell Death Discov. 2018 Jun 27;4:3. doi: 10.1038/s41420-018-0068-z. eCollection 2018. Erratum in: Cell Death Discov. 2019 Jul 10;5:116.

20.

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice.

Sharma BR, Karki R, Lee E, Zhu Q, Gurung P, Kanneganti TD.

Cell Death Differ. 2019 Mar;26(4):741-750. doi: 10.1038/s41418-018-0159-7. Epub 2018 Jul 23.

PMID:
30038386
21.

The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study.

Mosleh W, Chaudhari MR, Sonkawade S, Mahajan S, Khalil C, Frodey K, Shah T, Dahal S, Karki R, Katkar R, Blankesteijn WM, Page B, Pokharel S, Kim M, Sharma UC.

Biomark Insights. 2018 May 3;13:1177271918771969. doi: 10.1177/1177271918771969. eCollection 2018.

22.

Arrhythmias in Patients ≥80 Years of Age: Pathophysiology, Management, and Outcomes.

Curtis AB, Karki R, Hattoum A, Sharma UC.

J Am Coll Cardiol. 2018 May 8;71(18):2041-2057. doi: 10.1016/j.jacc.2018.03.019. Review.

23.

Phytochemical profile and pharmacological activity of Aegle marmelos Linn.

Manandhar B, Paudel KR, Sharma B, Karki R.

J Integr Med. 2018 May;16(3):153-163. doi: 10.1016/j.joim.2018.04.007. Epub 2018 Apr 21. Review.

PMID:
29709412
24.

GABAA Receptor Availability Changes Underlie Symptoms in Isolated Cervical Dystonia.

Berman BD, Pollard RT, Shelton E, Karki R, Smith-Jones PM, Miao Y.

Front Neurol. 2018 Apr 4;9:188. doi: 10.3389/fneur.2018.00188. eCollection 2018.

25.

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD.

Cell. 2018 May 3;173(4):920-933.e13. doi: 10.1016/j.cell.2018.02.055. Epub 2018 Mar 22.

26.

Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection.

Zhu Q, Man SM, Karki R, Malireddi RKS, Kanneganti TD.

Cell Rep. 2018 Mar 20;22(12):3168-3174. doi: 10.1016/j.celrep.2018.02.096.

27.

Malting and fermentation effects on antinutritional components and functional characteristics of sorghum flour.

Ojha P, Adhikari R, Karki R, Mishra A, Subedi U, Karki TB.

Food Sci Nutr. 2017 Nov 12;6(1):47-53. doi: 10.1002/fsn3.525. eCollection 2018 Jan.

28.

ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.

Place DE, Samir P, Karki R, Briard B, Vogel P, Kanneganti TD.

Am J Pathol. 2018 Apr;188(4):1021-1030. doi: 10.1016/j.ajpath.2017.12.006. Epub 2018 Jan 31.

29.

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Sharma D, Malik A, Guy CS, Karki R, Vogel P, Kanneganti TD.

Gastroenterology. 2018 Mar;154(4):948-964.e8. doi: 10.1053/j.gastro.2017.11.276. Epub 2017 Dec 2.

30.

Folate-PEG Conjugates of a Far-Red Light-Activatable Paclitaxel Prodrug to Improve Selectivity toward Folate Receptor-Positive Cancer Cells.

Thapa P, Li M, Karki R, Bio M, Rajaputra P, Nkepang G, Woo S, You Y.

ACS Omega. 2017 Oct 31;2(10):6349-6360. doi: 10.1021/acsomega.7b01105. Epub 2017 Oct 4.

31.

Comorbidity Analysis between Alzheimer's Disease and Type 2 Diabetes Mellitus (T2DM) Based on Shared Pathways and the Role of T2DM Drugs.

Karki R, Kodamullil AT, Hofmann-Apitius M.

J Alzheimers Dis. 2017;60(2):721-731. doi: 10.3233/JAD-170440.

32.

Sex Determination From the Bicondylar Width of the Femur: A Nepalese Study Using Digital X-ray Images.

Singh PK, Karki RK, Palikh AK, Menezes RG.

Kathmandu Univ Med J (KUMJ). 2016 Jul-Sept.;14(55):198-201.

PMID:
28814678
33.

Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models.

Kodamullil AT, Iyappan A, Karki R, Madan S, Younesi E, Hofmann-Apitius M.

J Alzheimers Dis. 2017;59(3):1045-1055. doi: 10.3233/JAD-170255. Review.

34.

Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment.

Domingo-Fernández D, Kodamullil AT, Iyappan A, Naz M, Emon MA, Raschka T, Karki R, Springstubbe S, Ebeling C, Hofmann-Apitius M.

Bioinformatics. 2017 Nov 15;33(22):3679-3681. doi: 10.1093/bioinformatics/btx399.

35.

NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer.

Karki R, Malireddi RKS, Zhu Q, Kanneganti TD.

Cell Cycle. 2017 Jul 3;16(13):1243-1251. doi: 10.1080/15384101.2017.1317414. Epub 2017 Jun 9.

36.

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.

Man SM, Karki R, Kanneganti TD.

Immunol Rev. 2017 May;277(1):61-75. doi: 10.1111/imr.12534. Review.

37.

Differential roles of caspase-1 and caspase-11 in infection and inflammation.

Man SM, Karki R, Briard B, Burton A, Gingras S, Pelletier S, Kanneganti TD.

Sci Rep. 2017 Mar 27;7:45126. doi: 10.1038/srep45126.

38.

Medicinal Chemistry Profiling of Monocyclic 1,2-Azaborines.

Zhao P, Nettleton DO, Karki RG, Zécri FJ, Liu SY.

ChemMedChem. 2017 Mar 7;12(5):358-361. doi: 10.1002/cmdc.201700047. Epub 2017 Feb 21.

39.

Eruption Pattern of Dentition and Its Medico-legal Significance.

Karki RK.

Kathmandu Univ Med J (KUMJ). 2016 Apr-Jun;14(54):103-106.

PMID:
28166063
40.

Inflammasomes and Cancer.

Karki R, Man SM, Kanneganti TD.

Cancer Immunol Res. 2017 Feb;5(2):94-99. doi: 10.1158/2326-6066.CIR-16-0269. Epub 2017 Jan 16. Review.

41.

Using Drugs as Molecular Probes: A Computational Chemical Biology Approach in Neurodegenerative Diseases.

Emon MA, Kodamullil AT, Karki R, Younesi E, Hofmann-Apitius M.

J Alzheimers Dis. 2017;56(2):677-686. doi: 10.3233/JAD-160222.

42.

NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.

Karki R, Man SM, Malireddi RKS, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P, Kanneganti TD.

Nature. 2016 Dec 22;540(7634):583-587. doi: 10.1038/nature20597. Epub 2016 Dec 12.

43.

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

Kuriakose T, Man SM, Malireddi RK, Karki R, Kesavardhana S, Place DE, Neale G, Vogel P, Kanneganti TD.

Sci Immunol. 2016 Aug 5;1(2). pii: aag2045. Epub 2016 Aug 12.

44.

Mortality Patterns among Hospital Deaths.

Karki RK.

Kathmandu Univ Med J (KUMJ). 2016 Jan-Mar;14(53):65-68.

PMID:
27892444
45.

High-risk carotid plaques identified by CT-angiogram can predict acute myocardial infarction.

Mosleh W, Adib K, Natdanai P, Carmona-Rubio A, Karki R, Paily J, Ahmed MA, Vakkalanka S, Madam N, Gudleski GD, Chung C, Sharma UC.

Int J Cardiovasc Imaging. 2017 Apr;33(4):561-568. doi: 10.1007/s10554-016-1019-5. Epub 2016 Nov 19.

46.

IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis.

Malik A, Sharma D, Zhu Q, Karki R, Guy CS, Vogel P, Kanneganti TD.

J Clin Invest. 2016 Dec 1;126(12):4469-4481. doi: 10.1172/JCI88625. Epub 2016 Oct 24.

47.

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M, Kanneganti TD.

Cell. 2016 Oct 6;167(2):382-396.e17. doi: 10.1016/j.cell.2016.09.012. Epub 2016 Sep 29.

48.

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development.

Sharma BR, Gautam LN, Adhikari D, Karki R.

Phytother Res. 2017 Jan;31(1):3-26. doi: 10.1002/ptr.5732. Epub 2016 Sep 26. Review.

PMID:
27667670
49.

Phytochemical profile and biological activity of Juglans regia.

Panth N, Paudel KR, Karki R.

J Integr Med. 2016 Sep;14(5):359-73. doi: 10.1016/S2095-4964(16)60274-1. Review.

PMID:
27641607
50.

Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats.

Puttegowda VD, Karki R, Goli D, Jha SK, Mudagal MP.

Scientifica (Cairo). 2016;2016:7623193. doi: 10.1155/2016/7623193. Epub 2016 Aug 9.

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