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Items: 43

1.

Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol.

Bostedor RG, Karkas JD, Arison BH, Bansal VS, Vaidya S, Germershausen JI, Kurtz MM, Bergstrom JD.

J Biol Chem. 1997 Apr 4;272(14):9197-203.

2.

Evaluation of retinal toxicity and liposome encapsulation of the anti-CMV drug 2'-nor-cyclic GMP.

Shakiba S, Assil KK, Listhaus AD, Munguia D, Flores-Aguilar M, Vuong C, Wiley CA, Tolman RL, Karkas JD, Bergeron-Lynn G, et al.

Invest Ophthalmol Vis Sci. 1993 Sep;34(10):2903-10.

PMID:
8395482
3.

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

Bergstrom JD, Kurtz MM, Rew DJ, Amend AM, Karkas JD, Bostedor RG, Bansal VS, Dufresne C, VanMiddlesworth FL, Hensens OD, et al.

Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):80-4.

5.

Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.

Bourne N, Bravo FJ, Ashton WT, Meurer LC, Tolman RL, Karkas JD, Stanberry LR.

Antimicrob Agents Chemother. 1992 Sep;36(9):2020-4.

6.

Intestinal and hepatic cholesterogenesis in hypercholesterolemic dyslipidemia of experimental diabetes in dogs.

Kwong LK, Feingold KR, Peric-Golia L, Le T, Karkas JD, Alberts AW, Wilson DE.

Diabetes. 1991 Dec;40(12):1630-9.

PMID:
1756903
7.

Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin.

Chao Y, Chen JS, Hunt VM, Kuron GW, Karkas JD, Liou R, Alberts AW.

Eur J Clin Pharmacol. 1991;40 Suppl 1:S11-4. Review.

PMID:
2044637
8.
9.

Lovastatin versus bezafibrate: efficacy, tolerability, and effect on urinary mevalonate.

Beil FU, Schrameyer-Wernecke A, Beisiegel U, Greten H, Karkas JD, Liou R, Alberts AW, Eckardt HG, Till AE.

Cardiology. 1990;77 Suppl 4:22-32.

PMID:
2073669
10.

Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.

Sheares BT, White SS, Molowa DT, Chan K, Ding VD, Kroon PA, Bostedor RG, Karkas JD.

Biochemistry. 1989 Oct 3;28(20):8129-35.

PMID:
2690933
11.

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo.

Germershausen JI, Hunt VM, Bostedor RG, Bailey PJ, Karkas JD, Alberts AW.

Biochem Biophys Res Commun. 1989 Feb 15;158(3):667-75. Erratum in: Biochem Biophys Res Commun 1991 Jan 31;174(2):1053.

PMID:
2493245
12.

Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.

Ashton WT, Meurer LC, Cantone CL, Field AK, Hannah J, Karkas JD, Liou R, Patel GF, Perry HC, Wagner AF, et al.

J Med Chem. 1988 Dec;31(12):2304-15.

PMID:
2848125
13.

Inhibition of human purine nucleoside phosphorylase by acyclic nucleosides and nucleotides.

Stein JM, Stoeckler JD, Li SY, Tolman RL, MacCoss M, Chen A, Karkas JD, Ashton WT, Parks RE Jr.

Biochem Pharmacol. 1987 Apr 15;36(8):1237-44.

PMID:
3109438
14.

Stereochemical considerations in the enzymatic phosphorylation and antiviral activity of acyclonucleosides. I. Phosphorylation of 2'-nor-2'-deoxyguanosine.

Karkas JD, Germershausen J, Tolman RL, MacCoss M, Wagner AF, Liou R, Bostedor R.

Biochim Biophys Acta. 1987 Jan 30;911(2):127-35.

PMID:
3026484
15.

Efficacy of 2'-nor-cyclicGMP in treatment of experimental herpes virus infections.

Field AK, Davies ME, DeWitt CM, Perry HC, Schofield TL, Karkas JD, Germershausen J, Wagner AF, Cantone CL, MacCoss M, et al.

Antiviral Res. 1986 Oct;6(6):329-41.

PMID:
3022643
16.

Comparison of the modes of antiviral action of 2'-nor-deoxyguanosine and its cyclic phosphate, 2'-nor-cyclic GMP.

Germershausen J, Bostedor R, Liou R, Field AK, Wagner AF, MacCoss M, Tolman RL, Karkas JD.

Antimicrob Agents Chemother. 1986 Jun;29(6):1025-31.

17.

Enzymatic phosphorylation of the antiherpetic agent 9-[(2,3-dihydroxy-1-propoxy)methyl]guanine.

Karkas JD, Ashton WT, Canning LF, Liou R, Germershausen J, Bostedor R, Arison B, Field AK, Tolman RL.

J Med Chem. 1986 May;29(5):842-8.

PMID:
3009816
18.

Synthesis and antiherpetic activity of (S)-, (R)-, and (+/-)-9-[(2,3-dihydroxy-1-propoxy)methyl]guanine, linear isomers of 2'-nor-2'-deoxyguanosine.

Ashton WT, Canning LF, Reynolds GF, Tolman RL, Karkas JD, Liou R, Davies ME, DeWitt CM, Perry HC, Field AK.

J Med Chem. 1985 Jul;28(7):926-33.

PMID:
2989523
19.

2'-Nor-cGMP: a seco-cyclic nucleotide with powerful anti-DNA-viral activity.

Tolman RL, Field AK, Karkas JD, Wagner AF, Germershausen J, Crumpacker C, Scolnick EM.

Biochem Biophys Res Commun. 1985 May 16;128(3):1329-35.

PMID:
2988534
20.
21.

9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.

Field AK, Davies ME, DeWitt C, Perry HC, Liou R, Germershausen J, Karkas JD, Ashton WT, Johnston DB, Tolman RL.

Proc Natl Acad Sci U S A. 1983 Jul;80(13):4139-43.

22.

Activation by thymidine kinase and potent antiherpetic activity of 2'-nor-2'-deoxyguanosine (2'NDG).

Ashton WT, Karkas JD, Field AK, Tolman RL.

Biochem Biophys Res Commun. 1982 Oct 29;108(4):1716-21. No abstract available.

PMID:
6295389
23.

Preparative high speed gel permeation chromatography of proteins on Toyopearl HW55F.

Germershausen J, Karkas JD.

Biochem Biophys Res Commun. 1981 Apr 15;99(3):1020-7. No abstract available.

PMID:
7247940
24.

A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties.

Karkas JD, Margulies L, Chargaff E.

J Biol Chem. 1975 Nov 25;250(22):8657-63.

25.

A new method of assay for polynucleotide ligase.

Karkas JD.

Biochim Biophys Acta. 1974 Apr 10;340(4):452-62. No abstract available.

PMID:
4364839
26.

Reverse transcription by Escherichia coli DNA polymerase I.

Karkas JD.

Proc Natl Acad Sci U S A. 1973 Dec;70(12):3834-8.

27.

Mechanism of DNA replication by highly purified DNA polymerase of chicken embryo.

Stavrianopoulos JG, Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1972 Sep;69(9):2609-13.

28.

Coupling of replication to transcription in vitro.

Karkas JD.

Proc Natl Acad Sci U S A. 1972 Aug;69(8):2288-91.

29.

DNA polymerase of chicken embryo: purification and properties.

Stavrianopoulos JG, Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1972 Jul;69(7):1781-5.

30.

Action of DNA polymerase I of Escherichia coli with DNA-RNA hybrids as templates.

Karkas JD, Stavrianopoulos JG, Chargaff E.

Proc Natl Acad Sci U S A. 1972 Feb;69(2):398-402.

31.

Nucleic acid polymerases of the developing chicken embryo: a DNA polymerase preferring a hybrid template.

Stavrianopoulos JG, Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1971 Sep;68(9):2207-11.

32.

Template properties of complementary fractions of denatured microbial deoxyribonucleic acids.

Karkas JD, Rudner R, Chargaff E.

Proc Natl Acad Sci U S A. 1970 Apr;65(4):1049-56.

33.

Separation of microbial deoxyribonucleic acids into complementary strands.

Rudner R, Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1969 May;63(1):152-9.

34.

Separation of B. subtilis DNA into complementary strands. 3. Direct analysis.

Rudner R, Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1968 Jul;60(3):921-2. No abstract available.

35.
36.

Separation of B. subtilis DNA into complementary strands, I. Biological properties.

Rudner R, Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1968 Jun;60(2):630-5. No abstract available.

37.

Template functions in the enzymic formation of polyribonucleotides. IV. Denatured DNA as template.

Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1967 Oct;58(4):1645-51. No abstract available.

38.

Template functions in the enzymic formation of polyribonucleotides. 3. Apurinic acid as template.

Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1966 Oct;56(4):1241-6. No abstract available.

39.
40.

Template functions in the enzymic formation of polyribonucleotides, I. Integrity of the DNA template.

Karkas JD, Chargaff E.

Proc Natl Acad Sci U S A. 1966 Aug;56(2):664-71. No abstract available.

41.

Studies on the specification of accessory biochemical characters, as exemplified by the fatty acid patterns of various strains of Escherichia coli.

Karkas JD, Türler H, Chargaff E.

Biochim Biophys Acta. 1965 Nov 15;111(1):96-109. No abstract available.

PMID:
5325811
42.

STUDIES ON THE STABILITY OF SIMPLE DERIVATIVES OF SIALIC ACID.

KARKAS JD, CHARGAFF E.

J Biol Chem. 1964 Apr;239:949-57. No abstract available.

43.

Methylation studies on ax-brain mucolipid.

KARKAS JD, CHARGAFF E.

Biochim Biophys Acta. 1960 Aug 12;42:359-60. No abstract available.

PMID:
13751486

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