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Autoantibodies to Chemokines and Cytokines Participate in the Regulation of Cancer and Autoimmunity.

Karin N.

Front Immunol. 2018 Mar 29;9:623. doi: 10.3389/fimmu.2018.00623. eCollection 2018. Review.


Correction: Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis.

Izhak L, Wildbaum G, Jung S, Stein A, Shaked Y, Karin N.

PLoS One. 2018 Apr 12;13(4):e0195170. doi: 10.1371/journal.pone.0195170. eCollection 2018.


Chemokines and cancer: new immune checkpoints for cancer therapy.

Karin N.

Curr Opin Immunol. 2018 Apr;51:140-145. doi: 10.1016/j.coi.2018.03.004. Epub 2018 Mar 24. Review.


CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N.

J Clin Invest. 2018 Mar 1;128(3):1200-1201. doi: 10.1172/JCI120358. Epub 2018 Mar 1. No abstract available.


Correction: Predominant Expression of CCL2 at the Tumor Site of Prostate Cancer Patients Directs a Selective Loss of Immunological Tolerance to CCL2 That Could Be Amplified in a Beneficial Manner.

Izhak L, Wildbaum G, Weinberg U, Shaked Y, Alami J, Dumont D, Friedman B, Stein A, Karin N.

J Immunol. 2018 Apr 1;200(7):2509-2510. doi: 10.4049/jimmunol.1800167. Epub 2018 Feb 23. No abstract available.


Correction: A Fusion Protein Encoding the Second Extracellular Domain of CCR5 Arrests Chemokine-Induced Cosignaling and Effectively Suppresses Ongoing Experimental Autoimmune Encephalomyelitis.

Sapir Y, Vitenshtein A, Barsheshet Y, Zohar Y, Wildbaum G, Karin N.

J Immunol. 2018 Apr 1;200(7):2507-2508. doi: 10.4049/jimmunol.1800166. Epub 2018 Feb 21. No abstract available.


Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity.

Karin N, Razon H.

Cytokine. 2018 Sep;109:24-28. doi: 10.1016/j.cyto.2018.02.012. Epub 2018 Feb 12.


CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development.

Hawila E, Razon H, Wildbaum G, Blattner C, Sapir Y, Shaked Y, Umansky V, Karin N.

Cell Rep. 2017 Nov 21;21(8):2212-2222. doi: 10.1016/j.celrep.2017.10.104.


CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions.

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, Utikal J, Karin N, Umansky V.

Cancer Res. 2018 Jan 1;78(1):157-167. doi: 10.1158/0008-5472.CAN-17-0348. Epub 2017 Oct 31.


CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N.

J Clin Invest. 2017 Oct 2;127(10):3913. doi: 10.1172/JCI97015. Epub 2017 Aug 28. No abstract available.


CCR8+FOXp3+ Treg cells as master drivers of immune regulation.

Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6086-6091. doi: 10.1073/pnas.1621280114. Epub 2017 May 22.


The antiangiogenic role of the pro-inflammatory cytokine interleukin-31.

Davidi S, Fremder E, Kan T, Raviv Z, Timaner M, Karin N, Hershkovitz D, Arohneim A, Shaked Y.

Oncotarget. 2017 Mar 7;8(10):16430-16444. doi: 10.18632/oncotarget.14857.


Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes.

Fishman S, Lewis MD, Siew LK, De Leenheer E, Kakabadse D, Davies J, Ziv D, Margalit A, Karin N, Gross G, Wong FS.

Mol Ther. 2017 Feb 1;25(2):456-464. doi: 10.1016/j.ymthe.2016.12.007. Epub 2017 Jan 18.


The cardiac maladaptive ATF3-dependent cross-talk between cardiomyocytes and macrophages is mediated by the IFNγ-CXCL10-CXCR3 axis.

Koren L, Barash U, Zohar Y, Karin N, Aronheim A.

Int J Cardiol. 2017 Feb 1;228:394-400. doi: 10.1016/j.ijcard.2016.11.159. Epub 2016 Nov 10.


The effect of lysophosphatidic acid using a hydrogel or collagen sponge carrier on bone healing in dogs.

Might KR, Martinez SA, Karin N, Lin G, Tarasevich B, Pool RR.

Vet Comp Orthop Traumatol. 2016 Jul 19;29(4):306-13. doi: 10.3415/VCOT-15-08-0137. Epub 2016 Jun 1.


Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encephalomyelitis.

Harris N, Koppel J, Zsila F, Juhas S, Il'kova G, Kogan FY, Lahmy O, Wildbaum G, Karin N, Zhuk R, Gregor P.

Inflamm Res. 2016 Apr;65(4):285-94. doi: 10.1007/s00011-016-0915-4. Epub 2016 Jan 21.


Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets.

Karin N, Wildbaum G, Thelen M.

J Leukoc Biol. 2016 Jun;99(6):857-62. doi: 10.1189/jlb.2MR0915-441R. Epub 2015 Dec 9. Review.


The Role of Chemokines in Shaping the Balance Between CD4(+) T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases.

Karin N, Wildbaum G.

Front Immunol. 2015 Nov 30;6:609. doi: 10.3389/fimmu.2015.00609. eCollection 2015. Review.


The role of chemokines in adjusting the balance between CD4+ effector T cell subsets and FOXp3-negative regulatory T cells.

Karin N, Wildbaum G.

Int Immunopharmacol. 2015 Oct;28(2):829-35. doi: 10.1016/j.intimp.2015.03.037. Epub 2015 Apr 20. Review.


Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes.

Teeguarden JG, Mikheev VB, Minard KR, Forsythe WC, Wang W, Sharma G, Karin N, Tilton SC, Waters KM, Asgharian B, Price OR, Pounds JG, Thrall BD.

Part Fibre Toxicol. 2014 Sep 30;11:46. doi: 10.1186/s12989-014-0046-4.


Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells.

Genetos DC, Wong A, Weber TJ, Karin NJ, Yellowley CE.

PLoS One. 2014 Sep 15;9(9):e107482. doi: 10.1371/journal.pone.0107482. eCollection 2014.


Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways.

Govey PM, Jacobs JM, Tilton SC, Loiselle AE, Zhang Y, Freeman WM, Waters KM, Karin NJ, Donahue HJ.

J Biomech. 2014 Jun 3;47(8):1838-45. doi: 10.1016/j.jbiomech.2014.03.022. Epub 2014 Mar 25.


CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R, Barsheshet Y, Karp CL, Karin N.

J Clin Invest. 2014 May;124(5):2009-22. doi: 10.1172/JCI71951. Epub 2014 Apr 8. Erratum in: J Clin Invest. 2018 Mar 1;128(3):1200-1201.


Heparanase enhances myeloma progression via CXCL10 downregulation.

Barash U, Zohar Y, Wildbaum G, Beider K, Nagler A, Karin N, Ilan N, Vlodavsky I.

Leukemia. 2014 Nov;28(11):2178-87. doi: 10.1038/leu.2014.121. Epub 2014 Apr 4.


Iron oxide nanoparticle agglomeration influences dose rates and modulates oxidative stress-mediated dose-response profiles in vitro.

Sharma G, Kodali V, Gaffrey M, Wang W, Minard KR, Karin NJ, Teeguarden JG, Thrall BD.

Nanotoxicology. 2014 Sep;8(6):663-75. doi: 10.3109/17435390.2013.822115. Epub 2013 Jul 31.


Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion.

Wildbaum G, Shahar E, Katz R, Karin N, Etzioni A, Pollack S.

J Allergy Clin Immunol. 2013 Sep;132(3):761-764. doi: 10.1016/j.jaci.2013.04.018. Epub 2013 Jun 20. No abstract available. Retraction in: J Allergy Clin Immunol. 2018 Mar;141(3):1167.


Impaired transcriptional response of the murine heart to cigarette smoke in the setting of high fat diet and obesity.

Tilton SC, Karin NJ, Webb-Robertson BJ, Waters KM, Mikheev V, Lee KM, Corley RA, Pounds JG, Bigelow DJ.

Chem Res Toxicol. 2013 Jul 15;26(7):1034-42. doi: 10.1021/tx400078b. Epub 2013 Jun 20.


Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns.

Tilton SC, Karin NJ, Tolic A, Xie Y, Lai X, Hamilton RF Jr, Waters KM, Holian A, Witzmann FA, Orr G.

Nanotoxicology. 2014 Aug;8(5):533-48. doi: 10.3109/17435390.2013.803624. Epub 2013 Jun 7.


The role of vitamin D receptor in innate and adaptive immunity: a study in hereditary vitamin D-resistant rickets patients.

Tiosano D, Wildbaum G, Gepstein V, Verbitsky O, Weisman Y, Karin N, Eztioni A.

J Clin Endocrinol Metab. 2013 Apr;98(4):1685-93. doi: 10.1210/jc.2012-3858. Epub 2013 Mar 12.


Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin.

Tilton SC, Waters KM, Karin NJ, Webb-Robertson BJ, Zangar RC, Lee KM, Bigelow DJ, Pounds JG, Corley RA.

Toxicol Appl Pharmacol. 2013 Mar 1;267(2):137-48. doi: 10.1016/j.taap.2012.12.020. Epub 2013 Jan 7.


The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications.

Shachar I, Karin N.

J Leukoc Biol. 2013 Jan;93(1):51-61. doi: 10.1189/jlb.0612293. Epub 2012 Sep 4. Review.


Injectable and thermosensitive PLGA-g-PEG hydrogels containing hydroxyapatite: preparation, characterization and in vitro release behavior.

Lin G, Cosimbescu L, Karin NJ, Tarasevich BJ.

Biomed Mater. 2012 Apr;7(2):024107. doi: 10.1088/1748-6041/7/2/024107. Epub 2012 Mar 29.


Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: implications for medical exposures.

von Neubeck C, Shankaran H, Karin NJ, Kauer PM, Chrisler WB, Wang X, Robinson RJ, Waters KM, Tilton SC, Sowa MB.

Environ Mol Mutagen. 2012 May;53(4):247-59. doi: 10.1002/em.21682. Epub 2012 Feb 20.


Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis.

Izhak L, Wildbaum G, Jung S, Stein A, Shaked Y, Karin N.

PLoS One. 2012;7(1):e28305. doi: 10.1371/journal.pone.0028305. Epub 2012 Jan 18. Erratum in: PLoS One. 2018 Apr 12;13(4):e0195170.


Reactive oxygen species alter autocrine and paracrine signaling.

Zangar RC, Bollinger N, Weber TJ, Tan RM, Markillie LM, Karin NJ.

Free Radic Biol Med. 2011 Dec 1;51(11):2041-7. doi: 10.1016/j.freeradbiomed.2011.09.001. Epub 2011 Sep 10.


Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.

Liu L, Okada S, Kong XF, Kreins AY, Cypowyj S, Abhyankar A, Toubiana J, Itan Y, Audry M, Nitschke P, Masson C, Toth B, Flatot J, Migaud M, Chrabieh M, Kochetkov T, Bolze A, Borghesi A, Toulon A, Hiller J, Eyerich S, Eyerich K, Gulácsy V, Chernyshova L, Chernyshov V, Bondarenko A, Grimaldo RM, Blancas-Galicia L, Beas IM, Roesler J, Magdorf K, Engelhard D, Thumerelle C, Burgel PR, Hoernes M, Drexel B, Seger R, Kusuma T, Jansson AF, Sawalle-Belohradsky J, Belohradsky B, Jouanguy E, Bustamante J, Bué M, Karin N, Wildbaum G, Bodemer C, Lortholary O, Fischer A, Blanche S, Al-Muhsen S, Reichenbach J, Kobayashi M, Rosales FE, Lozano CT, Kilic SS, Oleastro M, Etzioni A, Traidl-Hoffmann C, Renner ED, Abel L, Picard C, Maródi L, Boisson-Dupuis S, Puel A, Casanova JL.

J Exp Med. 2011 Aug 1;208(8):1635-48. doi: 10.1084/jem.20110958. Epub 2011 Jul 4.


Regulation of gene expression and subcellular protein distribution in MLO-Y4 osteocytic cells by lysophosphatidic acid: Relevance to dendrite outgrowth.

Waters KM, Jacobs JM, Gritsenko MA, Karin NJ.

Bone. 2011 Jun 1;48(6):1328-35. doi: 10.1016/j.bone.2011.02.020. Epub 2011 Feb 26.


Purinergic signaling is required for fluid shear stress-induced NF-κB translocation in osteoblasts.

Genetos DC, Karin NJ, Geist DJ, Donahue HJ, Duncan RL.

Exp Cell Res. 2011 Apr 1;317(6):737-44. doi: 10.1016/j.yexcr.2011.01.007. Epub 2011 Jan 13.


A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis.

Sapir Y, Vitenshtein A, Barsheshet Y, Zohar Y, Wildbaum G, Karin N.

J Immunol. 2010 Aug 15;185(4):2589-99. doi: 10.4049/jimmunol.1000666. Epub 2010 Jul 16. Erratum in: J Immunol. 2018 Feb 21;:.


The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease.

Karin N.

J Leukoc Biol. 2010 Sep;88(3):463-73. doi: 10.1189/jlb.0909602. Epub 2010 May 25. Review.


Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17.

Wildbaum G, Zohar Y, Karin N.

Am J Pathol. 2010 Jun;176(6):2764-75. doi: 10.2353/ajpath.2010.090855. Epub 2010 Apr 9.


Predominant expression of CCL2 at the tumor site of prostate cancer patients directs a selective loss of immunological tolerance to CCL2 that could be amplified in a beneficial manner.

Izhak L, Wildbaum G, Weinberg U, Shaked Y, Alami J, Dumont D, Friedman B, Stein A, Karin N.

J Immunol. 2010 Jan 15;184(2):1092-101. doi: 10.4049/jimmunol.0902725. Epub 2009 Dec 7. Erratum in: J Immunol. 2010 May 1;184(9):5414. Uri, Weinberg [corrected to Weinberg, Uri]; Friedman, Boris [added]. J Immunol. 2018 Feb 23;:.


Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor-alpha and interferon-alpha.

Bergman R, Ramon M, Wildbaum G, Avitan-Hersh E, Mayer E, Shemer A, Karin N.

J Dermatol Sci. 2009 Dec;56(3):163-7. doi: 10.1016/j.jdermsci.2009.08.006. Epub 2009 Oct 2.


A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Izhak L, Wildbaum G, Zohar Y, Anunu R, Klapper L, Elkeles A, Seagal J, Yefenof E, Ayalon-Soffer M, Karin N.

J Immunol. 2009 Jul 1;183(1):732-9. doi: 10.4049/jimmunol.0802746. Epub 2009 Jun 17.


Selective autoantibody production against CCL3 is associated with human type 1 diabetes mellitus and serves as a novel biomarker for its diagnosis.

Shehadeh N, Pollack S, Wildbaum G, Zohar Y, Shafat I, Makhoul R, Daod E, Hakim F, Perlman R, Karin N.

J Immunol. 2009 Jun 15;182(12):8104-9. doi: 10.4049/jimmunol.0803348.


Lysophosphatidic acid-induced ERK activation and chemotaxis in MC3T3-E1 preosteoblasts are independent of EGF receptor transactivation.

Karagiosis SA, Chrisler WB, Bollinger N, Karin NJ.

J Cell Physiol. 2009 Jun;219(3):716-23. doi: 10.1002/jcp.21720.


Macrophage responses to silica nanoparticles are highly conserved across particle sizes.

Waters KM, Masiello LM, Zangar RC, Tarasevich BJ, Karin NJ, Quesenberry RD, Bandyopadhyay S, Teeguarden JG, Pounds JG, Thrall BD.

Toxicol Sci. 2009 Feb;107(2):553-69. doi: 10.1093/toxsci/kfn250. Epub 2008 Dec 10.


A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins.

Merianda TT, Lin AC, Lam JS, Vuppalanchi D, Willis DE, Karin N, Holt CE, Twiss JL.

Mol Cell Neurosci. 2009 Feb;40(2):128-42. doi: 10.1016/j.mcn.2008.09.008. Epub 2008 Oct 22.


Automated time-lapse microscopy and high-resolution tracking of cell migration.

Fotos JS, Patel VP, Karin NJ, Temburni MK, Koh JT, Galileo DS.

Cytotechnology. 2006 May;51(1):7-19. doi: 10.1007/s10616-006-9006-7. Epub 2006 Aug 8.


CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.

Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N.

J Exp Med. 2008 Oct 27;205(11):2643-55. doi: 10.1084/jem.20080730. Epub 2008 Oct 13.

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